Kevin Camphausen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Predictive value of tumor recurrence using urinary vascular endothelial factor levels in patients receiving radiation therapy for Glioblastoma Multiforme (GBM)
    Andra V Krauze
    National Cancer Institute NIH, Bethesda, MD, USA
    Biomark Res 1:29. 2013
  2. pmc Bringing the heavy: carbon ion therapy in the radiobiological and clinical context
    Cody D Schlaff
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center Room B3B100, Bethesda, MD 20892, USA
    Radiat Oncol 9:88. 2014
  3. pmc Correlation of plasma FL expression with bone marrow irradiation dose
    Mary Sproull
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58558. 2013
  4. pmc A novel rodent model of spinal metastasis and spinal cord compression
    Zion Zibly
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    BMC Neurosci 13:137. 2012
  5. pmc The relationship of vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer
    Sung Yong Oh
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    BMC Cancer 13:43. 2013
  6. pmc Preclinical models in radiation oncology
    Jenna Kahn
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Radiat Oncol 7:223. 2012
  7. pmc Post-radiation increase in VEGF enhances glioma cell motility in vitro
    Whoon Jong Kil
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Radiat Oncol 7:25. 2012
  8. pmc Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study
    Nicole L Simone
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 CRC, Room B2 3561, Bethesda, Maryland 20892, USA
    Radiat Oncol 2:19. 2007
  9. pmc Neuropsychological testing and biomarkers in the management of brain metastases
    Andrew Baschnagel
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 CRC, Room B2 3561, Bethesda, Maryland, 20892, USA
    Radiat Oncol 3:26. 2008
  10. pmc Microarray analysis in clinical oncology: pre-clinical optimization using needle core biopsies from xenograft tumors
    Elizabeth M Goley
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    BMC Cancer 4:20. 2004

Detail Information

Publications106 found, 100 shown here

  1. pmc Predictive value of tumor recurrence using urinary vascular endothelial factor levels in patients receiving radiation therapy for Glioblastoma Multiforme (GBM)
    Andra V Krauze
    National Cancer Institute NIH, Bethesda, MD, USA
    Biomark Res 1:29. 2013
    ..We examine the feasibility of collecting and analyzing urinary VEGF levels in a prospective, multi-institutional trial (Radiation Therapy Oncology Group, RTOG, 0611) as well as the role of VEGF as a marker of tumor recurrence...
  2. pmc Bringing the heavy: carbon ion therapy in the radiobiological and clinical context
    Cody D Schlaff
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive Magnuson Clinical Center Room B3B100, Bethesda, MD 20892, USA
    Radiat Oncol 9:88. 2014
    ..With the existing data available we believe that the expansion of carbon ion facilities into the United States is warranted. ..
  3. pmc Correlation of plasma FL expression with bone marrow irradiation dose
    Mary Sproull
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58558. 2013
    ..In the current study, we examine plasma FL response to total body and partial body irradiation in mice and its relationship with irradiation dose, time of collection and pattern of bone marrow exposure...
  4. pmc A novel rodent model of spinal metastasis and spinal cord compression
    Zion Zibly
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    BMC Neurosci 13:137. 2012
    ..In this study, we present a highly reproducible rodent model that can be used for different types of cancers while mimicking the natural course of human metastatic spinal cord compression syndrome...
  5. pmc The relationship of vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer
    Sung Yong Oh
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    BMC Cancer 13:43. 2013
    ....
  6. pmc Preclinical models in radiation oncology
    Jenna Kahn
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Radiat Oncol 7:223. 2012
    ..Although every model has its limitations, each has played a significant role in preclinical testing. Continued advances in preclinical models will allow for the identification and application of targets for radiation in the clinic...
  7. pmc Post-radiation increase in VEGF enhances glioma cell motility in vitro
    Whoon Jong Kil
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Radiat Oncol 7:25. 2012
    ..VEGFs are well-known mitogens and can be up-regulated after RT. Here, we examine the effect of irradiation-induced VEGF on glioma cell motility...
  8. pmc Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study
    Nicole L Simone
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 CRC, Room B2 3561, Bethesda, Maryland 20892, USA
    Radiat Oncol 2:19. 2007
    ..The goal of this pilot study is to determine if Pirfenidone, a novel regulator of cytokine gene expression, has the potential to ameliorate established radiation-induced fibrosis...
  9. pmc Neuropsychological testing and biomarkers in the management of brain metastases
    Andrew Baschnagel
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 CRC, Room B2 3561, Bethesda, Maryland, 20892, USA
    Radiat Oncol 3:26. 2008
    ....
  10. pmc Microarray analysis in clinical oncology: pre-clinical optimization using needle core biopsies from xenograft tumors
    Elizabeth M Goley
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    BMC Cancer 4:20. 2004
    ..RNA representative of the original RNA profile? 2) what is the minimum amount of total RNA required to perform a representative amplification? 3) are the direct and indirect methods of labeling the hybridization probe equivalent?..
  11. ncbi request reprint Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 114:380-6. 2005
    ..Moreover, the VA-mediated increase in radiation-induced cell killing seemed to involve the inhibition of DNA DSB repair...
  12. ncbi request reprint Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:6066-71. 2004
    ..Because HDAC modulation has been shown to enhance the radiosensitivity of tumor cells in vitro, we investigated the effects of the HDAC inhibitor MS-275 on the radioresponse of DU145 prostate carcinoma xenografts...
  13. ncbi request reprint Combining radiation and molecular targeting in cancer therapy
    Kevin Camphausen
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Biol Ther 3:247-50. 2004
    ..Finally, an alternative approach to combining radiation and molecular targeting is to exploit radiation-induced gene expression to induce targets for other modalities or to increase their effectiveness...
  14. ncbi request reprint Isoprostane levels in the urine of patients with prostate cancer receiving radiotherapy are not elevated
    Kevin Camphausen
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1002, USA
    Int J Radiat Oncol Biol Phys 58:1536-9. 2004
    ....
  15. ncbi request reprint Angiogenesis inhibitors and radiotherapy of primary tumours
    Kevin Camphausen
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Clinical Cancer Center, National Cancer Institute, National Institutes of Health, Building 10 B3B69, Bethesda, MD, USA
    Expert Opin Biol Ther 2:477-81. 2002
    ..This review will then explore the promising evidence and rationale for combining antiangiogenic drugs and radiotherapy to enhance local control...
  16. ncbi request reprint Orthotopic growth of human glioma cells quantitatively and qualitatively influences radiation-induced changes in gene expression
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute and National Institutes of Neurological Disorder and Stroke, Bethesda, Maryland 20892, USA
    Cancer Res 65:10389-93. 2005
    ..Moreover, they suggest that investigations of the functional consequence of radiation-induced gene expression will require accounting for experimental growth conditions...
  17. ncbi request reprint Inhibition of histone deacetylation: a strategy for tumor radiosensitization
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Clin Oncol 25:4051-6. 2007
    ..HDAC inhibitors are in clinical trials as single modalities, in combination with chemotherapeutic agents, and recently, in combination with radiotherapy...
  18. ncbi request reprint Portrait of an editorial board member: Judah Folkman: the father of modern angiogenesis
    Kevin Camphausen
    Radiation Oncology Branch, Radiation Oncology Sciences Program, National Cancer Institute, National Institutes of Health, Bldg 10, Bethesda, MD 20892, USA
    Cell Cycle 1:296-7. 2002
  19. pmc Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts
    Andrew Baschnagel
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Cancer Ther 8:1589-95. 2009
    ..There was a greater than additive improvement in survival in our intracranial model. Combining vorinostat with radiation may be a potential treatment option for patients with breast cancer who develop brain metastases...
  20. ncbi request reprint Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
    Elizabeth E A Bull
    Molecular Radiation Therapeutics Branch, Radiation Oncology Branch, Developmental Therapeutics Program, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 10:8077-84. 2004
    ..Therefore, we have investigated the effects of the orally bioavailable Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) on the radiosensitivity of human tumor cells in vitro and grown as tumor xenografts...
  21. pmc Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score
    Nicole L Simone
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 70:90-5. 2008
    ..To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score...
  22. pmc In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
    Eun Joo Chung
    Office of the Director, NIH, Bethesda, MD, USA
    Clin Cancer Res 15:3050-7. 2009
    ..The MAP kinase pathway is also activated after exposure to ionizing radiation. We investigated the effects of AZD6244 (ARRY-142886), an inhibitor of MAP kinase/extracellular signal-regulated kinase 1/2, on radiation response...
  23. ncbi request reprint Accuracy of 3D volumetric image registration based on CT, MR and PET/CT phantom experiments
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA
    J Appl Clin Med Phys 9:2781. 2008
    ..35 mm for PET/CT images. This accuracy is consistent with the detection limit, suggesting an absence of detectable systematic error. This 3DVIR technique provides a superior alternative to the 3P fusion method for clinical applications...
  24. ncbi request reprint Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine
    Hideaki Dote
    Molecular Radiation Therapeutics Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 11:4571-9. 2005
    ..These results indicate that zebularine can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect may involve an inhibition of DNA repair...
  25. pmc Early observed transient prostate-specific antigen elevations on a pilot study of external beam radiation therapy and fractionated MRI guided high dose rate brachytherapy boost
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, NIH DHHS, Bldg 10, CRC Rm B2 3561, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Radiat Oncol 1:28. 2006
    ..To report early observation of transient PSA elevations on this pilot study of external beam radiation therapy and magnetic resonance imaging (MRI) guided high dose rate (HDR) brachytherapy boost...
  26. pmc A pilot safety trial investigating a vector-based vaccine targeting carcinoembryonic antigen in combination with radiotherapy in patients with gastrointestinal malignancies metastatic to the liver
    James L Gulley
    National Cancer Institute, National Institutes of Health, Center for Cancer Research, Laboratory of Tumor Immunology and Biology, 10 Center Dr, 8B09 MSC 1750, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 11:1409-18. 2011
    ..This pilot study evaluated the tolerability of a vector-based vaccine targeting carcinoembryonic antigen (CEA) in combination with radiation therapy in patients with gastrointestinal malignancies metastatic to the liver...
  27. ncbi request reprint Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275
    Kevin Camphausen
    Radiation Oncology Branch and Molecular Radiation Therapeutics Branch, Radiation Oncology Sciences Program, Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 64:316-21. 2004
    ..These results indicate that MS-275 can enhance radiosensitivity and suggest that this effect may involve an inhibition of DNA repair...
  28. ncbi request reprint The requirement of multimodal therapy (vaccine, local tumor radiation, and reduction of suppressor cells) to eliminate established tumors
    Chie Kudo-Saito
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:4533-44. 2005
    ..The elimination of well-established tumors often proves elusive. Here we show that a multimodal immune-based therapy can be successfully employed to eliminate established tumors...
  29. ncbi request reprint Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells
    Lorena de la Peña
    Molecular Radiation Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA
    Mol Cancer Ther 5:1504-10. 2006
    ..These results suggest that, although Akt may influence the radiosensitivity of other tumor types, it does not seem to be a target for glioma cell radiosensitization...
  30. ncbi request reprint In vivo tumor imaging in mice with near-infrared labeled endostatin
    Deborah Citrin
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cancer Ther 3:481-8. 2004
    ..5 will migrate from a distant i.p. injection site to a tumor. These data indicate that endostatin-Cy5.5 is appropriate for selectively imaging tumors in uninjured experimental animals...
  31. ncbi request reprint Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 65:1008-13. 2006
    ..Our goal was to test the ability of intrarectal amifostine to limit symptoms of radiation proctitis...
  32. ncbi request reprint ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition
    Hideaki Dote
    Molecular Radiation Therapeutics and Radiation Oncology Branches, National Cancer Institute, Bethesda, Maryland 20892 7440, USA
    Cancer Res 65:6967-75. 2005
    ..These results suggest that, whereas the loss of ErbB1 signaling may be necessary for 17DMAG-induced radiosensitization, it is not sufficient...
  33. ncbi request reprint In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone)
    Christopher A Barker
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 12:2912-8. 2006
    ..Unlike previously investigated RR inhibitors, Triapine potently inhibits both RR holoenzymes. Therefore, the effects of Triapine on tumor cell radiosensitivity were investigated...
  34. ncbi request reprint Evaluation of chelating agents as anti-angiogenic therapy through copper chelation
    Kevin Camphausen
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3B69, Bethesda, MD 20892 1002, USA
    Bioorg Med Chem 12:5133-40. 2004
    ....
  35. pmc Intra- and inter-radiation therapist reproducibility of daily isocenter verification using prostatic fiducial markers
    Karen L Ullman
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bldg 10, CRC Rm B2 SW 3500, 9000 Rockville Pike, Bethesda, MD, 20892, USA
    Radiat Oncol 1:2. 2006
    ..We sought to determine the intra- and inter-radiation therapist reproducibility of a previously established matching technique for daily verification and correction of isocenter position relative to intraprostatic fiducial markers (FM)...
  36. pmc Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation
    Anita T Tandle
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Cancer 49:3020-8. 2013
    ..This study suggests that PLK1 is an important therapeutic target for GBM and can enhance radiosensitivity in GBM...
  37. ncbi request reprint Transcriptional signature of flavopiridol-induced tumor cell death
    Xing Lu
    Molecular Radiation Therapeutics Branch, National Cancer Institute, Bethesda, Maryland 20892 1002, USA
    Mol Cancer Ther 3:861-72. 2004
    ..Moreover, the identification of a set of gene expression changes in four human tumor cell lines suggests that such a transcriptome may be applicable to investigations of flavopiridol pharmacodynamics...
  38. ncbi request reprint External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:4328-37. 2004
    ..Thus, these studies demonstrate a new paradigm for the use of local tumor irradiation in combination with active specific vaccine therapy to elicit durable antitumor responses of established tumors...
  39. pmc Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant
    Robert J Lechleider
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 14:5284-91. 2008
    ..We hypothesized that a "metronomic" dose of interleukin 2 (IL-2) as a biological adjuvant would cause less toxicity while maintaining immunologic response...
  40. pmc A dosimetric comparison of four treatment planning methods for high grade glioma
    Leor Zach
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive Building 10, CRC, Bethesda, MD 20892, USA
    Radiat Oncol 4:45. 2009
    ..The purpose of the current study was to compare normal tissue sparing and tumor coverage using four different radiotherapy planning methods in patients with high grade glioma...
  41. doi request reprint Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks
    Diane Palmieri
    Women s Cancers Section, Laboratory of Molecular Pharmacology, Genetics Branch, National Cancer Institute NIH, Bethesda, Maryland, USA
    Clin Cancer Res 15:6148-57. 2009
    ..We report the pharmacokinetic, efficacy, and mechanism of action studies for the histone deactylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in a preclinical model of brain metastasis of triple-negative breast cancer...
  42. ncbi request reprint Evaluation of copper chelation agents as anti-angiogenic therapy
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3B69, Bethesda, MD 20892 1002, USA
    Bioorg Med Chem 11:4287-93. 2003
    ....
  43. pmc Influence of in vivo growth on human glioma cell line gene expression: convergent profiles under orthotopic conditions
    Kevin Camphausen
    Radiation Oncology Branch and Molecular Radiation Therapeutics Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8287-92. 2005
    ....
  44. pmc Parameters favorable to intraprostatic radiation dose escalation in men with localized prostate cancer
    Nadine Housri
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 80:614-20. 2011
    ..To identify , within the framework of a current Phase I trial, whether factors related to intraprostatic cancer lesions (IPLs) or individual patients predict the feasibility of high-dose intraprostatic irradiation...
  45. pmc The use of chelated radionuclide (samarium-153-ethylenediaminetetramethylenephosphonate) to modulate phenotype of tumor cells and enhance T cell-mediated killing
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 14:4241-9. 2008
    ..This study explored the possibility that exposure to palliative doses of a radiopharmaceutical agent could alter the phenotype of tumor cells to render them more susceptible to T cell-mediated killing...
  46. ncbi request reprint Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy
    Thierry M Muanza
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 62:1316-21. 2005
    ..This study strives to compare early measures of bowel toxicity in patients with prostate cancer receiving definitive or adjuvant 3D conformal external beam radiation therapy and concurrent daily endorectal application of amifostine...
  47. pmc Chemoirradiation for glioblastoma multiforme: the national cancer institute experience
    Jennifer Ho
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e70745. 2013
    ..While there is variability in survival based on several established prognostic factors, the prognostic utility of other factors such as tumor size and location are not well established...
  48. pmc The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells
    Thomas J Hayman
    Authors Affiliations University of South Florida Morsani College of Medicine, Tampa, Florida and Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland
    Clin Cancer Res 20:110-9. 2014
    ..Given the regulatory role of mTOR in gene translation, in this study, we defined the effects of the clinically relevant, ATP-competitive mTOR inhibitor, INK128 on the radiosensitivity of pancreatic carcinoma cell lines...
  49. ncbi request reprint Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy
    Linda W Chan
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3 B69, Bethesda, MD, 20892 1002, USA
    J Clin Oncol 22:499-506. 2004
    ....
  50. doi request reprint In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016
    Andrea L Russo
    Radiation Oncology Branch, National Cancer Institute, 10 Center Drive 3B42, Bethesda, MD, USA
    Clin Cancer Res 15:607-12. 2009
    ..Because PARP inhibition has been shown to enhance tumor cell sensitivity to radiation, we investigated the in vitro and in vivo effects of the novel PARP inhibitor E7016...
  51. ncbi request reprint Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA
    Mol Cancer Ther 3:409-16. 2004
    ..These results indicate that flavopiridol can enhance radiosensitivity of human tumor cells and suggest that this effect may involve an inhibition of DNA repair...
  52. pmc High throughput evaluation of gamma-H2AX
    Dane Avondoglio
    Radiation Oncology Branch, National Cancer Institute, National Cancer Institute, Bethesda, Maryland, USA
    Radiat Oncol 4:31. 2009
    ..The results show that our assay utilizes significantly less time and labor, has greater intra-assay reproducibility and has a greater dynamic range of gamma-H2AX versus irradiation dose...
  53. pmc Transrectal prostate biopsy and fiducial marker placement in a standard 1.5T magnetic resonance imaging scanner
    Robert C Susil
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 175:113-20. 2006
    ..We investigated the accuracy and feasibility of a system that provides transrectal needle access to the prostate concurrent with 1.5 Tesla MRI which previously has not been possible...
  54. pmc System for prostate brachytherapy and biopsy in a standard 1.5 T MRI scanner
    Robert C Susil
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Magn Reson Med 52:683-7. 2004
    ..Because 1.5 T MR images are directly acquired during the interventional procedure, dependence on deformable registration is reduced and online image quality is maximized...
  55. pmc Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma
    Uma T Shankavaram
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Mol Med 16:545-54. 2012
    ....
  56. ncbi request reprint Inhibition of hsp90 compromises the DNA damage response to radiation
    Hideaki Dote
    Molecular Radiation Therapeutics and Radiation Oncology Branches, National Cancer Institute, Bethesda, Maryland
    Cancer Res 66:9211-20. 2006
    ..These data indicate that Hsp90 can contribute to the DNA damage response to radiation affecting both DNA repair and cell cycle checkpoint activation...
  57. doi request reprint Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 54:1963-78. 2009
    ..28 +/- 0.44 and 0.82 +/- 0.30, respectively) and location-dependent phase shifts. This novel approach establishes the foundation for developing an external volumetric respiratory surrogate...
  58. doi request reprint Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Room 8B09, Bethesda, MD 20892, USA
    Cancer Immunol Immunother 57:1173-83. 2008
    ..These results show that systemic radiotherapy in the form of radiolabeled mAb, in combination with vaccine, promotes effective antitumor response, which may have implications in the design of future clinical trials...
  59. doi request reprint Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain
    Yongzhen Qian
    Laboratory Animal Sciences Program, SAIC Frederick, NCI, NIH, Frederick, MD, USA
    Clin Exp Metastasis 28:899-908. 2011
    ..These data indicate Plk1 may be a new druggable target for the prevention of breast cancer brain metastases...
  60. ncbi request reprint Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity
    Jeffery S Russell
    Molecular Radiation Therapeutics Branch, Radiation Oncology Science Program, National Cancer Institute, EPN 6015A, 6130 Executive Boulevard, Bethesda, MD 20892 7440, USA
    Cancer Res 63:7377-83. 2003
    ....
  61. pmc Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas
    Bronwyn Stall
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Radiat Oncol 5:5. 2010
    ..Although these sequences have inherent physical differences there is limited data on the clinical and dosimetric impact of using either or both sequences...
  62. doi request reprint Urine analysis and protein networking identify met as a marker of metastatic prostate cancer
    Andrea L Russo
    Radiation Oncology Branch, National Cancer Institute, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Clin Cancer Res 15:4292-8. 2009
    ..Metastatic prostate cancer is a major cause of death of men in the United States. Expression of met, a receptor tyrosine kinase, has been associated with progression of prostate cancer...
  63. doi request reprint In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide
    Whoon Jong Kil
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 14:931-8. 2008
    ....
  64. pmc Astrocytes enhance the invasion potential of glioblastoma stem-like cells
    Barbara H Rath
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    PLoS ONE 8:e54752. 2013
    ..These data suggest that astrocytes enhance the invasion of CD133+ GSCs and provide additional support for a critical role of brain microenvironment in the regulation of GBM biology...
  65. ncbi request reprint Inverse treatment planning based on MRI for HDR prostate brachytherapy
    Deborah Citrin
    Radiation Oncology Branch, CCR, NCI, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 61:1267-75. 2005
    ..To develop and optimize a technique for inverse treatment planning based solely on magnetic resonance imaging (MRI) during high-dose-rate brachytherapy for prostate cancer...
  66. ncbi request reprint A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma
    Michael W Brown
    Radiation Oncology Branch, CCR, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Int J Radiat Oncol Biol Phys 65:274-83. 2006
    ..To perform an analysis of three-dimensional conformal radiation therapy (3D-CRT), sequential boost intensity-modulated radiation therapy (IMRTs), and integrated boost IMRT (IMRTi) for dose escalation in unresectable pancreatic carcinoma...
  67. ncbi request reprint Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer
    James L Gulley
    Laboratory of Tumor Immunology and Biology, Medical Oncology Clinical Research Unit, Radiation Oncology Branch, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:3353-62. 2005
    ..One potential solution is the utilization of a well-tolerated systemic therapy (e.g., vaccine) in concert with local therapy...
  68. ncbi request reprint Tumor-directed radiation and the immunotoxin SS1P in the treatment of mesothelin-expressing tumor xenografts
    Raffit Hassan
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 12:4983-8. 2006
    ..The goal of this study was to determine if radiation therapy in combination with the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) would result in enhanced antitumor activity against mesothelin-expressing xenografts in nude mice...
  69. ncbi request reprint Histone deacetylation as a target for radiosensitization
    David Cerna
    Molecular Radiation Therapeutics Branch, National Cancer Institute, Bethesda Maryland 20892, USA
    Curr Top Dev Biol 73:173-204. 2006
    ..Whereas HDAC inhibitors are currently in clinical trials as single modalities and in combination with chemotherapeutic agents, recent results suggest that these compounds may also enhance the antitumor effectiveness of radiotherapy...
  70. pmc Radiosensitization by the novel DNA intercalating agent vosaroxin
    Ira K Gordon
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Radiat Oncol 7:26. 2012
    ..To evaluate vosaroxin as a clinically applicable radiation sensitizer, we investigated its effects on tumor cell radiosensitivity in vitro and in vivo...
  71. ncbi request reprint Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes
    Xing Lu
    Molecular Radiation Therapeutics Branch, National Cancer Institute, 6130 Executive Boulevard, Rockville, MD 20892 7440, USA
    Cancer Res 66:1052-61. 2006
    ..Thus, the radiation-induced translational control of a subset of mRNAs seems to be a fundamental component of cellular radioresponse...
  72. doi request reprint A novel analytical approach to the prediction of respiratory diaphragm motion based on external torso volume change
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Phys Med Biol 54:4113-30. 2009
    ..This analytical approach provides a patient-independent technique to calculate the patient-specific diaphragm motion, using the anatomical and respiratory volumetric constraints...
  73. ncbi request reprint In vivo tumor imaging using a near-infrared-labeled endostatin molecule
    Deborah Citrin
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, National Cancer Institute NIH, Building 10, 10 Center Drive, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 58:536-41. 2004
    ..The goal of this study was to determine whether endostatin labeled with a NIR probe (Cy5.5) could be detected in an animal after intraperitoneal injection and whether it would selectively localize in a tumor...
  74. ncbi request reprint A pilot trial of a carcinoembryonic antigen/ TRICOM-based vaccine and radiation to liver metastases in patients with carcinoembryonic antigen-positive solid tumors
    Christoph M Ahlers
    Medical Oncology Branch, Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health 20892, USA
    Clin Colorectal Cancer 6:72-5. 2006
  75. ncbi request reprint Correction of motion-induced misalignment in co-registered PET/CT and MRI (T1/T2/FLAIR) head images for stereotactic radiosurgery
    Guang Li
    Radiation Oncology Branch, Center for Clinical Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Appl Clin Med Phys 12:3306. 2010
    ....
  76. ncbi request reprint Combining radiotherapy and angiogenesis inhibitors: clinical trial design
    Deborah Citrin
    Radiation Oncology Branch, NCI, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 64:15-25. 2006
    ..We discuss important considerations for designing clinical trials of angiogenesis inhibitors with RT...
  77. ncbi request reprint Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin: a multitarget approach to radiosensitization
    Jeffery S Russell
    Molecular Radiation Therapeutics Branch, Radiation Oncology Science Program, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 9:3749-55. 2003
    ..Therefore, in an attempt to increase the probability and/or degree of radiosensitization, we have begun to investigate a multitarget approach using the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG)...
  78. pmc Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
    Ian M Buchanan
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Cell Mol Med 15:1999-2006. 2011
    ..Modulation of Met signalling with AMG102 may prove a novel radiation sensitizing strategy. Our data indicate that DNA repair processes downstream of Met are impaired leading to increased cell death through mitotic catastrophe...
  79. pmc Enhancement of 5-fluorouracil-induced in vitro and in vivo radiosensitization with MEK inhibition
    Mary Ellen Urick
    Radiation Oncology Branch and Radiation Biology Branch, National Institutes of Health, Bethesda, Maryland, USA
    Clin Cancer Res 17:5038-47. 2011
    ..We previously reported radiosensitization with selumetinib, an inhibitor of MEK1/2. The purpose of the current study was to evaluate if selumetinib could enhance radiosensitivity induced by 5-FU...
  80. pmc Post-collection, pre-measurement variables affecting VEGF levels in urine biospecimens
    Robert M Hayward
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1002, USA
    J Cell Mol Med 12:343-50. 2008
    ..In addition, we recommend the use of samples within five freeze-thaw cycles...
  81. pmc Nanoscintillator conjugates as photodynamic therapy-based radiosensitizers: calculation of required physical parameters
    Nicole Y Morgan
    Laboratory of Bioengineering and Physical Science, NIBIB, National Institutes of Health, Bethesda, Maryland 20892, USA
    Radiat Res 171:236-44. 2009
    ..Even so, the efficacy of the combination therapy will likely be restricted to X-ray energies below 300 keV, which limits the application to brachytherapy...
  82. pmc Surgical management of melanoma brain metastases in patients treated with immunotherapy
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 3D20, Bethesda, Maryland 20892, USA
    J Neurosurg 115:30-6. 2011
    ..The authors undertook this study to determine the effectiveness of resection and the effects of immunotherapy on brain metastasis management...
  83. pmc A pilot feasibility study of TNFerade™ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer
    Deborah Citrin
    Section of Translational Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Oncology 79:382-8. 2010
    ....
  84. ncbi request reprint Development of investigational radiation modifiers
    A Dimitrios Colevas
    National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 95:646-51. 2003
  85. ncbi request reprint A novel 3D volumetric voxel registration technique for volume-view-guided image registration of multiple imaging modalities
    Guang Li
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 63:261-73. 2005
    ..To provide more clinically useful image registration with improved accuracy and reduced time, a novel technique of three-dimensional (3D) volumetric voxel registration of multimodality images is developed...
  86. ncbi request reprint Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma
    Carter Van Waes
    Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 63:1400-12. 2005
    ....
  87. ncbi request reprint Clinical trial of endorectal amifostine for radioprotection in patients with prostate cancer: rationale and early results
    Cynthia Menard
    Radiation Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Semin Oncol 30:63-7. 2003
    ..The initial trial will proceed until 18 patients are accrued, at which time an interval evaluation of both early and late toxicity endpoints will be conducted...
  88. pmc Topology of the heterogeneous nature of the extracellular matrix on stochastic modeling of tumor-induced angiogenesis
    Franck Amyot
    Laboratory of Integrative and Medical Biophysics, Section on Biomedical Stochastic Physics, National Institute of Child Health and Human Development, National Institutes of Health, 9 South Drive, Bethesda, MD 20892, USA
    Microvasc Res 77:87-95. 2009
    ..Our simulations show after two branching events, the vascular network is very likely to reach the tumor...
  89. ncbi request reprint Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy
    Mala Chakraborty
    Laboratory of Tumor Immunology and Biology and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:6338-47. 2003
    ....
  90. ncbi request reprint Optical imaging of mice in oncologic research
    Deborah Citrin
    Imaging and Molecular Theraputics Section, Radiation Oncology and Vascular Biology Faculty, National Cancer Institute, Bethesda, MD USA
    Expert Rev Anticancer Ther 4:857-64. 2004
    ..Furthermore, the availability of mice genetically altered to express photo and fluorescent proteins have spurred tremendous growth in this area of research...
  91. pmc Infratentorial craniospinal irradiation for von Hippel-Lindau: a retrospective study supporting a new treatment for patients with CNS hemangioblastomas
    Charles B Simone
    National Institutes of Health, National Cancer Institute, Radiation Oncology Branch, Bethesda, MD 20892, USA
    Neuro Oncol 13:1030-6. 2011
    ..ICSRT was well tolerated, can decrease hemangioblastoma growth rate, and is a potential therapeutic option for VHL patients that warrants further investigation...
  92. ncbi request reprint Angiogenic tumor markers, antiangiogenic agents and radiation therapy
    Linda W Chan
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda MD, USA
    Expert Rev Anticancer Ther 3:357-66. 2003
    ..Strategic combination therapy, selecting for tumor type and angiogenic profile, may result in the realization of the promise and potential of antiangiogenic therapy...
  93. pmc An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement
    Cynthia Menard
    National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Imaging 4:63-6. 2005
    ..Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patients with prostate cancer...
  94. ncbi request reprint Antiangiogenic therapy through copper chelation
    Mary Sproull
    Imaging and Molecular Therapeutics Section, Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, B3B69, Bethesda, MD, USA
    Expert Opin Ther Targets 7:405-9. 2003
    ..This review will describe the historical use of anticopper therapy for the treatment of Wilson's disease and evaluate some of the new anticopper compounds currently under consideration for use in antiangiogenic therapy...
  95. pmc MRI-guided HDR prostate brachytherapy in standard 1.5T scanner
    Cynthia Menard
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 59:1414-23. 2004
    ..This pilot study was performed to determine the feasibility and dosimetric quality achieved when placing high-dose-rate prostate brachytherapy catheters under MRI guidance in a standard "closed-bore" 1.5T scanner...
  96. ncbi request reprint Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
    Suparna Bonthala Wedam
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, 8901 Wisconsin Avenue, Building 8, Rm 5101, Bethesda, MD 20889 5015, USA
    J Clin Oncol 24:769-77. 2006
    ..Bevacizumab, a recombinant humanized monoclonal antibody to VEGF, was administered to previously untreated patients to evaluate parameters of angiogenesis...
  97. ncbi request reprint Advancement of antiangiogenic and vascular disrupting agents combined with radiation
    Deborah Citrin
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA
    Cancer Treat Res 139:153-71. 2008
  98. pmc Radiation-induced gene translation profiles reveal tumor type and cancer-specific components
    Sandhya Kumaraswamy
    Drug Discovery Program and Division of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Res 68:3819-26. 2008
    ....
  99. ncbi request reprint Optimal scheduling of radiotherapy and angiogenic inhibitors
    Ayla Ergun
    Operations Research Center, MIT, Cambridge, MA 02139, USA
    Bull Math Biol 65:407-24. 2003
    ....
  100. pmc Postradiation sensitization of the histone deacetylase inhibitor valproic acid
    Prakash Chinnaiyan
    Radiation Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Clin Cancer Res 14:5410-5. 2008
    ..We now expand on these studies to determine whether postirradiation exposure alone affects radiosensitivity...
  101. ncbi request reprint Inhibition of Hsp90: a multitarget approach to radiosensitization
    Kevin Camphausen
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 13:4326-30. 2007
    ..This review summarizes the preclinical data available on Hsp90 inhibition and cellular radiosensitivity. Results generated to date suggest that Hsp90 inhibition can provide a multitarget approach to tumor radiosensitization...