Research Topics
Genomes and Genes
| Joseph H CallicottSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophreniaJoseph H Callicott
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:8627-32. 2005....
Dysfunctional prefrontal regional specialization and compensation in schizophreniaHao Yang Tan
Unit on Functional MRI, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Dr, Rm 4C 216, MSC 1364, Bethesda, MD 20892 1364, USA
Am J Psychiatry 163:1969-77. 2006....- Age-related alterations in default mode network: impact on working memory performanceFabio Sambataro
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Neurobiol Aging 31:839-52. 2010..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand... - Effect of catechol-O-methyltransferase val158met genotype on attentional controlGiuseppe Blasi
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 25:5038-45. 2005..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC... - Age-related alterations in simple declarative memory and the effect of negative stimulus valenceVishnu P Murty
National Institutes of Health, Bethesda, MD, USA
J Cogn Neurosci 21:1920-33. 2009.... - Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic riskRoberta Rasetti
Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
Am J Psychiatry 166:216-25. 2009..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed... - Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblingsRobyn A Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
Biol Psychiatry 63:465-74. 2008..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry... - The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphologyLukas Pezawas
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 24:10099-102. 2004.... 
Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controlsKristin K Nicodemus
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:991-1001. 2010..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis...- Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memoryHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:13393-401. 2007..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM... - Neural correlates of probabilistic category learning in patients with schizophreniaThomas W Weickert
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:1244-54. 2009.... - No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expressionHeike Tost
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
Biol Psychiatry 68:105-7. 2010..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures... - Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMTStefano Marenco
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1708-17. 2010..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia... - Genetic variation in CACNA1C affects brain circuitries related to mental illnessKristin L Bigos
Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:939-45. 2010..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored... - Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humansHao Yang Tan
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 118:2200-8. 2008..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis... - Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthoodFabio Sambataro
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 66:540-8. 2009.... - Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortexDevon C Nixon
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:1006-8. 2011.... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performanceAhmad R Hariri
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
J Neurosci 23:6690-4. 2003..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans... - Allelic variation in RGS4 impacts functional and structural connectivity in the human brainJoshua W Buckholtz
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
J Neurosci 27:1584-93. 2007..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness... - Brain regions underlying response inhibition and interference monitoring and suppressionGiuseppe Blasi
CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982-1379, USA
Eur J Neurosci 23:1658-64. 2006..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control... - Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimagingKristin K Nicodemus
Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Hum Genet 127:441-52. 2010.... - Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain functionHao Yang Tan
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:12536-41. 2007..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia... - Modulatory effects of modafinil on neural circuits regulating emotion and cognitionRoberta Rasetti
Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:2101-9. 2010.... - The G72/G30 gene complex and cognitive abnormalities in schizophreniaTerry E Goldberg
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
Neuropsychopharmacology 31:2022-32. 2006..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses... - Impact of interacting functional variants in COMT on regional gray matter volume in human brainRobyn Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroimage 45:44-51. 2009.... - Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatmentHao Yang Tan
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
Brain 135:1436-45. 2012..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment... - Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognitionAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
J Clin Invest 117:672-82. 2007..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia... - Genetic variation in FGF20 modulates hippocampal biologyHerve Lemaitre
Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 30:5992-7. 2010..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging... - Instability of prefrontal signal processing in schizophreniaGeorg Winterer
Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr, MSC 1379, Bethesda, MD 20892, USA
Am J Psychiatry 163:1960-8. 2006..CONCLUSIONS: These findings suggest that unstable cortical signal processing underlies classic abnormal cortical activation patterns as well as psychosis in schizophrenia... - Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804ARoberta Rasetti
Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 68:1207-17. 2011..However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear... - Tolcapone improves cognition and cortical information processing in normal human subjectsJose A Apud
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
Neuropsychopharmacology 32:1011-20. 2007..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex... - Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and functionLucas Kempf
Department of Health and Human Services, Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 4:e1000252. 2008..Our findings suggest a role for functional genetic variation in POX on neostriatal-frontal circuits mediating risk and protection for schizophrenia... - Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 TeslaAlexa J Stern
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 64:856-62. 2008.... - Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or downJoseph H Callicott
Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
Am J Psychiatry 160:2209-15. 2003..The authors' goal was to explore this phenomenon... - Neurophysiological correlates of age-related changes in working memory capacityVenkata S Mattay
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neurosci Lett 392:32-7. 2006..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs... - A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophreniaStephen J Huffaker
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Nat Med 15:509-18. 2009..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target... - Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophreniaStefano Marenco
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
Neuropsychopharmacology 37:499-507. 2012..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC... - Enuresis as a premorbid developmental marker of schizophreniaThomas M Hyde
Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
Brain 131:2489-98. 2008..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors... - Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophreniaJoseph H Callicott
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
Am J Psychiatry 160:709-19. 2003..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified... - Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamineVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4S-235, Bethesda, MD 20982-1379, USA
Proc Natl Acad Sci U S A 100:6186-91. 2003..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine... - Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophreniaHao Yang Tan
Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Cereb Cortex 17:i171-81. 2007.... - Prefrontal cognitive systems in schizophrenia: towards human genetic brain mechanismsHao Yang Tan
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
Cogn Neuropsychiatry 14:277-98. 2009..The imaging genetics platform therefore could extend understanding of genetic mechanisms of human cognitive brain processes relevant to neuropsychiatric disease... - Neural mechanisms of genetic risk for impulsivity and violence in humansAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
Proc Natl Acad Sci U S A 103:6269-74. 2006.... - Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imagingAlessandro Bertolino
Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:906-13. 2003..As suggested by other studies, neuronal pathology in the hippocampus may be involved in the pathophysiology of bipolar disorder and in susceptibility to psychosis... - The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionMichael F Egan
Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
Cell 112:257-69. 2003..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF... - Effect of Schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteersEugenia Radulescu
Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 38:341-9. 2013..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia... - False positives in imaging geneticsAndreas Meyer-Lindenberg
Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
Neuroimage 40:655-61. 2008..In fact, our observations indicate that these statistical thresholds are conservative... - An expanded role for functional neuroimaging in schizophreniaJoseph H Callicott
Unit on Functional MRI Clinical Brain Disorders, Branch NIMH NIH, Building 10, Room 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
Curr Opin Neurobiol 13:256-60. 2003..By examining recent findings and efforts to link these findings to genes, this article will review these exciting developments in schizophrenia research... - Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memoryMichael F Glabus
Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
Cereb Cortex 13:1352-61. 2003..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM... - Cortical systems associated with covert music rehearsalFrederick J P Langheim
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Neuroimage 16:901-8. 2002..These data implicate an associative network independent of primary sensorimotor and auditory activity, likely representing the cortical elements most intimately linked to music production... - Normal aging modulates prefrontoparietal networks underlying multiple memory processesFabio Sambataro
Brain Center for Motor and Social Cognition, Istituto Italiano di Tecnologia, 43100 Parma, Italy
Eur J Neurosci 36:3559-67. 2012..Our results are in line with the dedifferentiation hypothesis of neurocognitive aging, thereby suggesting a decreased specialization of the brain networks supporting different memory networks... - Brain imaging as an approach to phenotype characterization for genetic studies of schizophreniaJoseph H Callicott
Clinical Brain Disorders Branch, NIMH/NIH, Bethesda, MD, USA
Methods Mol Med 77:227-47. 2003 - Dopaminergic modulation of cortical function in patients with Parkinson's diseaseVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
Ann Neurol 51:156-64. 2002.... - The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophreniaMitsuyuki Matsumoto
Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
Proc Natl Acad Sci U S A 105:6133-8. 2008..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy... - Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophreniaAlessandro Bertolino
Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
Am J Psychiatry 161:1798-805. 2004.... - Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapineAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Biol Psychiatry 56:190-7. 2004.... - Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performanceAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Psychiatry Res 147:221-6. 2006..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex... - Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorderAlessandro Bertolino
Department of Psychiatry and Neurological Sciences, University of Bari, Italy
Am J Psychiatry 160:483-9. 2003..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits... - Dissociating the effects of Sternberg working memory demands in prefrontal cortexMario Altamura
Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
Psychiatry Res 154:103-14. 2007..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas...