Joseph H Callicott

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity
    Joseph H Callicott
    Clinical Brain Disorders Branch, Division of Intramural Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1379, USA
    J Clin Invest 123:2961-4. 2013
  2. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
  3. ncbi request reprint Dysfunctional prefrontal regional specialization and compensation in schizophrenia
    Hao Yang Tan
    Unit on Functional MRI, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Dr, Rm 4C 216, MSC 1364, Bethesda, MD 20892 1364, USA
    Am J Psychiatry 163:1969-77. 2006
  4. pmc Age-related alterations in default mode network: impact on working memory performance
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 31:839-52. 2010
  5. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
  6. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
  7. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
  8. doi request reprint Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
  9. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008
  10. ncbi request reprint The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004

Detail Information

Publications64

  1. doi request reprint DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity
    Joseph H Callicott
    Clinical Brain Disorders Branch, Division of Intramural Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1379, USA
    J Clin Invest 123:2961-4. 2013
    ..78)and connectivity (d = 0.57) during a recognition memory task. These data highlight the importance of epistatic models in understanding genetic association with complex brain phenotypes...
  2. pmc Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    ....
  3. ncbi request reprint Dysfunctional prefrontal regional specialization and compensation in schizophrenia
    Hao Yang Tan
    Unit on Functional MRI, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Dr, Rm 4C 216, MSC 1364, Bethesda, MD 20892 1364, USA
    Am J Psychiatry 163:1969-77. 2006
    ....
  4. pmc Age-related alterations in default mode network: impact on working memory performance
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 31:839-52. 2010
    ..These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand...
  5. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  6. pmc Age-related alterations in simple declarative memory and the effect of negative stimulus valence
    Vishnu P Murty
    National Institutes of Health, Bethesda, MD, USA
    J Cogn Neurosci 21:1920-33. 2009
    ....
  7. pmc Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, IRP, NIMH, NIH, Rm 4S 235, 10 Center Dr, Bethesda, MD 20892, USA
    Am J Psychiatry 166:216-25. 2009
    ..The purpose of the present study was to examine amygdala response to threatening faces among healthy siblings of schizophrenia patients in whom a subtler heritable deficit might be observed...
  8. doi request reprint Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls
    Kristin K Nicodemus
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:991-1001. 2010
    ..NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis...
  9. pmc Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings
    Robyn A Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
    Biol Psychiatry 63:465-74. 2008
    ..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry...
  10. ncbi request reprint The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004
    ....
  11. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    Ahmad R Hariri
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1384, USA
    J Neurosci 23:6690-4. 2003
    ..These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of BDNF signaling on hippocampal function in experimental animals are important in humans...
  12. ncbi request reprint Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13393-401. 2007
    ..These findings add to the integration of dopaminergic signaling in basic cortical assemblies with their roles in specific human brain networks during the orchestration of information processing in WM...
  13. pmc Neural correlates of probabilistic category learning in patients with schizophrenia
    Thomas W Weickert
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:1244-54. 2009
    ....
  14. pmc Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT
    Stefano Marenco
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:1708-17. 2010
    ..The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia...
  15. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  16. doi request reprint Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex
    Devon C Nixon
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:1006-8. 2011
    ....
  17. pmc No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1379, USA
    Biol Psychiatry 68:105-7. 2010
    ..In the largest neuroimaging intermediate phenotype study reported so far, we evaluated the effect of rs7341475 on an extended array of different neuroscientific measures...
  18. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  19. pmc Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:540-8. 2009
    ....
  20. pmc Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 118:2200-8. 2008
    ..These data implicate AKT1 in modulating human prefrontal-striatal structure and function and suggest that the mechanism of this effect may be coupled to dopaminergic signaling and relevant to the expression of psychosis...
  21. pmc Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
    Hao Yang Tan
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:12536-41. 2007
    ..These findings extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and GRM3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia...
  22. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  23. doi request reprint Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging
    Kristin K Nicodemus
    Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 127:441-52. 2010
    ....
  24. ncbi request reprint Allelic variation in RGS4 impacts functional and structural connectivity in the human brain
    Joshua W Buckholtz
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1364, USA
    J Neurosci 27:1584-93. 2007
    ..These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness...
  25. doi request reprint Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers
    Sophia C Magalona
    Clinical Brain Disorders Branch CBDB, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bethesda, MD, USA
    CNS Drugs 27:663-73. 2013
    ..The dorsal cingulate (dCC) and prefrontal (PFC) cortices play critical roles in attention. Evidence indicates that catechol-O-methyltransferase (COMT) modulates dopaminergic tone in the PFC and dCC...
  26. pmc Modulatory effects of modafinil on neural circuits regulating emotion and cognition
    Roberta Rasetti
    Clinical Brain Disorders Branch Genes, Cognition, and Psychosis Program, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:2101-9. 2010
    ....
  27. pmc Impact of interacting functional variants in COMT on regional gray matter volume in human brain
    Robyn Honea
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuroimage 45:44-51. 2009
    ....
  28. ncbi request reprint The G72/G30 gene complex and cognitive abnormalities in schizophrenia
    Terry E Goldberg
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD, USA
    Neuropsychopharmacology 31:2022-32. 2006
    ..We present evidence that SNP variations in the G72 gene region increase risk of cognitive impairment in schizophrenia. SNP variations were not strongly associated with clinical diagnosis in family-based analyses...
  29. pmc Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers
    Eugenia Radulescu
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 38:341-9. 2013
    ..The findings in females and during the emotional memory paradigm are consistent with modulation by SREB2 of brain circuitries implicated in mood regulation and may be relevant to neuropsychiatric conditions other than schizophrenia...
  30. ncbi request reprint Neurophysiological correlates of age-related changes in working memory capacity
    Venkata S Mattay
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurosci Lett 392:32-7. 2006
    ..As cognitive demand increases, however, they are pushed past a threshold beyond which physiological compensation cannot be made and, a decline in performance occurs...
  31. pmc Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892, USA
    Brain 135:1436-45. 2012
    ..Thus, we suggest that genetic modulation of DRD2-AKT1-related prefrontal-subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment...
  32. pmc Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, and Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health NIMH, NIH, Bethesda, MD 20892, USA
    J Clin Invest 117:672-82. 2007
    ..Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia...
  33. pmc Genetic variation in FGF20 modulates hippocampal biology
    Herve Lemaitre
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:5992-7. 2010
    ..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging...
  34. ncbi request reprint Instability of prefrontal signal processing in schizophrenia
    Georg Winterer
    Genes, Cognition and Psychosis Program, NIH, NIMH, 10 Center Dr, MSC 1379, Bethesda, MD 20892, USA
    Am J Psychiatry 163:1960-8. 2006
    ....
  35. doi request reprint Effects of neuregulin 3 genotype on human prefrontal cortex physiology
    Heike Tost
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 61859 Mannheim, Germany, Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205, Departments of Psychiatry, Neurology, and Neuroscience and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and Departments of Psychiatry and Cell and Developmental Biology, University of Colorado, School of Medicine, Aurora, Colorado 80045
    J Neurosci 34:1051-6. 2014
    ..Our data indicate a complex modulation of brain physiology by rs10748842, which does not fit the simple inefficiency model of risk association in DLPFC and suggests that other neurobiological mechanisms are involved. ..
  36. doi request reprint Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A
    Roberta Rasetti
    Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:1207-17. 2011
    ..However, whether these patterns are trait phenomena linked to genetic risk for illness is unclear...
  37. ncbi request reprint Tolcapone improves cognition and cortical information processing in normal human subjects
    Jose A Apud
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA
    Neuropsychopharmacology 32:1011-20. 2007
    ..Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex...
  38. ncbi request reprint Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down
    Joseph H Callicott
    Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
    Am J Psychiatry 160:2209-15. 2003
    ..The authors' goal was to explore this phenomenon...
  39. pmc Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function
    Lucas Kempf
    Department of Health and Human Services, Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000252. 2008
    ..Our findings suggest a role for functional genetic variation in POX on neostriatal-frontal circuits mediating risk and protection for schizophrenia...
  40. pmc Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla
    Alexa J Stern
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 64:856-62. 2008
    ....
  41. pmc A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    Stephen J Huffaker
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Med 15:509-18. 2009
    ..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target...
  42. pmc Investigation of anatomical thalamo-cortical connectivity and FMRI activation in schizophrenia
    Stefano Marenco
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Neuropsychopharmacology 37:499-507. 2012
    ..These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC...
  43. pmc Enuresis as a premorbid developmental marker of schizophrenia
    Thomas M Hyde
    Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
    Brain 131:2489-98. 2008
    ..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors...
  44. ncbi request reprint Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia
    Joseph H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
    Am J Psychiatry 160:709-19. 2003
    ..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified...
  45. pmc Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Room 4s 235, Bethesda, MD 20982 1379, USA
    Proc Natl Acad Sci U S A 100:6186-91. 2003
    ..Further, individuals with the met/met catechol O-methyltransferase genotype appear to be at increased risk for an adverse response to amphetamine...
  46. doi request reprint Altered hippocampal-parahippocampal function during stimulus encoding: a potential indicator of genetic liability for schizophrenia
    Roberta Rasetti
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland
    JAMA Psychiatry 71:236-47. 2014
    ..Therefore, measuring hippocampal-parahippocampal function with neuroimaging represents a potentially useful approach to understanding genetic mechanisms that confer risk for schizophrenia. ..
  47. ncbi request reprint Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia
    Hao Yang Tan
    Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Cereb Cortex 17:i171-81. 2007
    ....
  48. ncbi request reprint Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:906-13. 2003
    ..The objective of this study was to assess possible NAA reductions in hippocampus and prefrontal regions in patients with bipolar disorder...
  49. pmc Neural mechanisms of genetic risk for impulsivity and violence in humans
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, Neuroimaging Core Facility, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Proc Natl Acad Sci U S A 103:6269-74. 2006
    ....
  50. doi request reprint Prefrontal cognitive systems in schizophrenia: towards human genetic brain mechanisms
    Hao Yang Tan
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA
    Cogn Neuropsychiatry 14:277-98. 2009
    ..The imaging genetics platform therefore could extend understanding of genetic mechanisms of human cognitive brain processes relevant to neuropsychiatric disease...
  51. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  52. ncbi request reprint Interindividual differences in functional interactions among prefrontal, parietal and parahippocampal regions during working memory
    Michael F Glabus
    Unit on Integrative Neuroimaging, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD, 20892 1365, USA
    Cereb Cortex 13:1352-61. 2003
    ..These results demonstrate that individual behavioral characteristics are reflected in specific neurofunctional patterns at the system level and that these can be captured by analytical techniques such as SEM...
  53. doi request reprint False positives in imaging genetics
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Neuroimage 40:655-61. 2008
    ..In fact, our observations indicate that these statistical thresholds are conservative...
  54. ncbi request reprint An expanded role for functional neuroimaging in schizophrenia
    Joseph H Callicott
    Unit on Functional MRI Clinical Brain Disorders, Branch NIMH NIH, Building 10, Room 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
    Curr Opin Neurobiol 13:256-60. 2003
    ..By examining recent findings and efforts to link these findings to genes, this article will review these exciting developments in schizophrenia research...
  55. ncbi request reprint Brain imaging as an approach to phenotype characterization for genetic studies of schizophrenia
    Joseph H Callicott
    Clinical Brain Disorders Branch, NIMH NIH, Bethesda, MD, USA
    Methods Mol Med 77:227-47. 2003
  56. ncbi request reprint Cortical systems associated with covert music rehearsal
    Frederick J P Langheim
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
    Neuroimage 16:901-8. 2002
    ..These data implicate an associative network independent of primary sensorimotor and auditory activity, likely representing the cortical elements most intimately linked to music production...
  57. pmc Normal aging modulates prefrontoparietal networks underlying multiple memory processes
    Fabio Sambataro
    Brain Center for Motor and Social Cognition, Istituto Italiano di Tecnologia, 43100 Parma, Italy
    Eur J Neurosci 36:3559-67. 2012
    ..Our results are in line with the dedifferentiation hypothesis of neurocognitive aging, thereby suggesting a decreased specialization of the brain networks supporting different memory networks...
  58. ncbi request reprint Dopaminergic modulation of cortical function in patients with Parkinson's disease
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
    Ann Neurol 51:156-64. 2002
    ....
  59. ncbi request reprint Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    Alessandro Bertolino
    Department of Psychiatry and Neurological Sciences, University of Bari, Italy
    Am J Psychiatry 160:483-9. 2003
    ..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits...
  60. ncbi request reprint Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapine
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 56:190-7. 2004
    ..The objective of the present longitudinal study was to evaluate whether such cortical abnormalities represent state or trait phenomena of the disorder...
  61. ncbi request reprint Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    Alessandro Bertolino
    Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
    Am J Psychiatry 161:1798-805. 2004
    ....
  62. ncbi request reprint Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Psychiatry Res 147:221-6. 2006
    ..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex...
  63. ncbi request reprint Dissociating the effects of Sternberg working memory demands in prefrontal cortex
    Mario Altamura
    Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
    Psychiatry Res 154:103-14. 2007
    ..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas...
  64. pmc The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
    Mitsuyuki Matsumoto
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 105:6133-8. 2008
    ..Our data implicate SREB2 as a potential risk factor for psychiatric disorders and its pathway as a target for psychiatric therapy...