Huaibin Cai

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:2. 2012
  2. pmc ALS2/alsin knockout mice and motor neuron diseases
    Huaibin Cai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 3707, USA
    Neurodegener Dis 5:359-66. 2008
  3. pmc Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress
    Huaibin Cai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:7567-74. 2005
  4. pmc Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:807-27. 2009
  5. pmc Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking
    Chen Lai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 3707, USA
    J Neurosci 26:11798-806. 2006
  6. pmc The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
    Lizhen Wang
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Neurosci 28:3384-91. 2008
  7. pmc Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis
    Loukia Parisiadou
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    J Neurosci 29:13971-80. 2009
  8. pmc MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
    Hyun Jin Cho
    Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 22:608-20. 2013
  9. pmc Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
    Chen Lai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Brain 2:23. 2009
  10. pmc Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1
    Xian Lin
    Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:9248-64. 2012

Detail Information

Publications29

  1. pmc Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:2. 2012
    ..We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses in the kidney of aged mice...
  2. pmc ALS2/alsin knockout mice and motor neuron diseases
    Huaibin Cai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 3707, USA
    Neurodegener Dis 5:359-66. 2008
    ..In this review, we summarize and reconcile major findings of ALS2(-/-) mice and attempt to place these results within the larger context of modeling recessive movement disorders in mice...
  3. pmc Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress
    Huaibin Cai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 25:7567-74. 2005
    ..These observations suggest that loss of ALS2 function is insufficient to cause major motor deficits or motor neuron degeneration in a mouse model but predisposes neurons to oxidative stress...
  4. pmc Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:807-27. 2009
    ....
  5. pmc Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking
    Chen Lai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 3707, USA
    J Neurosci 26:11798-806. 2006
    ....
  6. pmc The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
    Lizhen Wang
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Neurosci 28:3384-91. 2008
    ..Therefore, inhibition of LRRK2 kinase activity can be achieved by blocking Hsp90-mediated chaperone activity and Hsp90 inhibitors may serve as potential anti-PD drugs...
  7. pmc Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis
    Loukia Parisiadou
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    J Neurosci 29:13971-80. 2009
    ..These data support a model in which the G2019S mutation of LRRK2 causes a gain-of-function effect that perturbs the homeostasis of pERM and F-actin in sprouting neurites critical for neuronal morphogenesis...
  8. pmc MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
    Hyun Jin Cho
    Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 22:608-20. 2013
    ....
  9. pmc Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
    Chen Lai
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Brain 2:23. 2009
    ....
  10. pmc Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1
    Xian Lin
    Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:9248-64. 2012
    ....
  11. pmc Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice
    Xing Long Gu
    Units of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, Maryland 20892, USA
    Mol Brain 3:12. 2010
    ..The pathological consequence of astrocytic accumulation of alpha-synuclein, however, is unclear...
  12. pmc The G59S mutation in p150(glued) causes dysfunction of dynactin in mice
    Chen Lai
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:13982-90. 2007
    ..Our findings indicate that the G59S mutation in p150(glued) abrogates the normal function of p150(glued) and accelerates motor neuron degeneration...
  13. pmc Alsin and the molecular pathways of amyotrophic lateral sclerosis
    Jayanth Chandran
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892 3707, USA
    Mol Neurobiol 36:224-31. 2007
    ..In this review, we summarize recent clinical and molecular reports regarding alsin and attempt to place these results within the larger context of motor neuron disease...
  14. pmc Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease
    Dong Gyu Jo
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Aging 31:917-25. 2010
    ..Our findings suggest that gamma-secretase mediates oxidative stress-induced expression of BACE1 resulting in excessive Abeta production in AD...
  15. pmc Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function
    Jayanth S Chandran
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, USA
    Neurobiol Dis 29:505-14. 2008
    ..Taken together, our findings suggest that loss of DJ-1 leads to progressive behavioral changes without significant alterations in nigrostriatal dopaminergic and spinal motor systems...
  16. pmc Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, United States
    Neurobiol Aging 28:1628-30. 2007
    ..Our data suggest that deficiency in the ALS2 gene does not affect the pathogenesis of SOD1(G93A) mice...
  17. pmc Activation of protein kinase C modulates BACE1-mediated beta-secretase activity
    Lizhen Wang
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 3707, USA
    Neurobiol Aging 29:357-67. 2008
    ....
  18. pmc Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function
    Elizabeth A Erie
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1202, USA
    J Neuroimmunol 182:226-31. 2007
    ..Our findings reveal a novel function of the ALS2 gene in the lymphopoiesis and hematopoiesis, suggesting that the immune system is involved in the pathogenesis of ALS2...
  19. pmc RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
    Marcel P van der Brug
    Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD 20892 3707, USA
    Proc Natl Acad Sci U S A 105:10244-9. 2008
    ..These data implicate a single mechanism for the pleiotropic effects of DJ-1 in different model systems, namely that the protein binds multiple RNA targets in an oxidation-dependent manner...
  20. pmc Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans
    Joyce van de Leemput
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 3:e108. 2007
    ..We show here that heterozygous deletion of the 5' part of the ITPR1 gene, encompassing exons 1-10, 1-40, and 1-44 in three studied families, underlies SCA15 in humans...
  21. doi request reprint DJ-1 is essential for long-term depression at hippocampal CA1 synapses
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Neuromolecular Med 10:40-5. 2008
    ..The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit...
  22. doi request reprint The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
    Zhihua Liu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:1063-70. 2011
    ..Thus, our study defines a new step in the control of NFAT activation that involves an immunoregulatory function of LRRK2 and has important implications for inflammatory bowel disease...
  23. pmc Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity
    Monia B Hammer
    Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 92:245-51. 2013
    ..2618G>A [p.Arg873His]) were identified, probably resulting in nonfunctional enzyme. This study suggests GBA2 mutations are a cause of recessive spastic ataxia and responsible for a form of glucosylceramide storage disease in humans...
  24. pmc Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Antioxid Redox Signal 12:819-27. 2010
    ..These data suggest a role of GPx4 in neurodegenerative diseases through its function in removal of lipid hydroperoxides...
  25. pmc In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function
    Ning Cheng
    Developmental Neural Plasticity Unit, National Institute of Neurological Disorders and Stroke, and Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda Maryland 20892, USA
    J Neurosci 31:13699-704. 2011
    ..Thus, we propose that this unique in vivo model will not only help determine the mechanisms underlying AD-related neurodegeneration but also serve as a platform to test possible treatments...
  26. ncbi request reprint Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina
    Kun Xiong
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Exp Brain Res 181:435-46. 2007
    ..In addition, plaque constituents such as Fe(3+) and Abeta42f may participate in a self-enforcing cycle of amyloidogenesis via BACE upregulation...
  27. pmc BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
    Fiona M Laird
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:11693-709. 2005
    ....
  28. ncbi request reprint Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals
    Tong Li
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neurosci 23:3272-7. 2003
    ....
  29. ncbi request reprint Genetically engineered mouse models of neurodegenerative diseases
    Philip C Wong
    Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205 2196, USA
    Nat Neurosci 5:633-9. 2002
    ..We anticipate that, in the future, therapies based on understanding disease mechanisms will be identified and tested in mouse model systems...