J L Cadet

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat
    Irina N Krasnova
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e8790. 2010
  2. pmc Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Research Branch, National Institute of Drug Abuse, National Institutes of Health NIH Department of Health and Human Services DHHS, Intramural Research Program, Baltimore, MD, USA
    PLoS ONE 4:e6092. 2009
  3. pmc Long-term protective effects of methamphetamine preconditioning against single-day methamphetamine toxic challenges
    A B Hodges
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Curr Neuropharmacol 9:35-9. 2011
  4. pmc Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19179. 2011
  5. pmc Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways
    Genevieve Beauvais
    Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28946. 2011
  6. pmc Enhanced upregulation of CRH mRNA expression in the nucleus accumbens of male rats after a second injection of methamphetamine given thirty days later
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 9:e84665. 2014
  7. pmc Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens
    Tracey A Martin
    Molecular Neuropsychiatry Research Branch, NIH NIDA Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34236. 2012
  8. doi request reprint Neuropathology of substance use disorders
    Jean Lud Cadet
    NIDA Intramural Research Program, Molecular Neuropsychiatry Research Branch, NIDA NIH DHHS, 251 Bayview Boulevard, Baltimore, MD, 21224, USA
    Acta Neuropathol 127:91-107. 2014
  9. pmc Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    BMC Genomics 14:545. 2013
  10. pmc Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD, USA
    PLoS ONE 4:e7812. 2009

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat
    Irina N Krasnova
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e8790. 2010
    ..These results suggest that meth self-administration by rats is associated with long-term biochemical changes that are reminiscent of those observed in post-mortem brain tissues of chronic meth abusers...
  2. pmc Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Research Branch, National Institute of Drug Abuse, National Institutes of Health NIH Department of Health and Human Services DHHS, Intramural Research Program, Baltimore, MD, USA
    PLoS ONE 4:e6092. 2009
    ..Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain...
  3. pmc Long-term protective effects of methamphetamine preconditioning against single-day methamphetamine toxic challenges
    A B Hodges
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Curr Neuropharmacol 9:35-9. 2011
    ..These results are consistent with the idea that METH pretreatment renders the brain refractory to METH-induced degeneration of brain monoaminergic systems...
  4. pmc Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Bethesda, Maryland, United States of America
    PLoS ONE 6:e19179. 2011
    ..The combined increases in Otx2 and Pitx3 expression after METH preconditioning might represent, in part, some of the mechanisms that served to protect against METH-induced striatal dopamine depletion observed after METH preconditioning...
  5. pmc Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways
    Genevieve Beauvais
    Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28946. 2011
    ..These findings indicate that METH-induced activation of striatal ER and mitochondrial stress pathways might be more related to activation of SCH23390-sensitive receptors...
  6. pmc Enhanced upregulation of CRH mRNA expression in the nucleus accumbens of male rats after a second injection of methamphetamine given thirty days later
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 9:e84665. 2014
    ..The METH-induced changes in oxytocin expression also suggest the possibility that this neuropeptide might play a significant role in the neuroplastic and affiliative effects of this drug. ..
  7. pmc Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens
    Tracey A Martin
    Molecular Neuropsychiatry Research Branch, NIH NIDA Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34236. 2012
    ..The causal role that HATs and HDACs might play in METH-induced gene expression needs to be investigated further...
  8. doi request reprint Neuropathology of substance use disorders
    Jean Lud Cadet
    NIDA Intramural Research Program, Molecular Neuropsychiatry Research Branch, NIDA NIH DHHS, 251 Bayview Boulevard, Baltimore, MD, 21224, USA
    Acta Neuropathol 127:91-107. 2014
    ..Elucidation of the biological bases of addiction will help to develop better therapeutic approaches to these patient populations. ..
  9. pmc Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    BMC Genomics 14:545. 2013
    ..METH is an illicit drug of abuse that influences gene expression in the rat striatum. Histone modifications regulate gene transcription...
  10. pmc Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD, USA
    PLoS ONE 4:e7812. 2009
    ..Further analysis of the molecular and cellular pathways regulated by these genes should help to provide some insight into the neuroadaptive potentials of the brain when repeatedly exposed to drugs of abuse...
  11. pmc Comorbid mood, psychosis, and marijuana abuse disorders: a theoretical review
    Natascha Wilson
    DHHS NIH NIDA Intramural Research Program, Molecular Neuropsychiatry Research Branch, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    J Addict Dis 28:309-19. 2009
    ..The hope is that this article will serve as a spring board for further discussions among practitioners who treat these patients. Greater interactions between caretakers are bound to impact the care of our patients in a very positive way...
  12. pmc Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 9:526-38. 2010
    ..Future studies using more selective agonist and antagonist agents and the use of genetically modified animals should help to further clarify the role of these receptors in the normal physiology and in pathological events that involve DA...
  13. ncbi request reprint Distinct gene expression signatures in the striata of wild-type and heterozygous c-fos knockout mice following methamphetamine administration: evidence from cDNA array analyses
    Jean Lud Cadet
    Molecular Neuropsychiatry Section, Intramural Research Program, NIH NIDA, PO Box 5180, Baltimore, MD 21224, USA
    Synapse 44:211-26. 2002
    ..These results support the idea that the c-fos knockout genotype may render the animals unable to trigger multicomponent responses in order to protect against the multifaceted toxic effects of this illicit neurotoxin...
  14. pmc Amphetamine recapitulates developmental programs in the zebrafish
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse IRP, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Genome Biol 10:231. 2009
    ..Addictive drugs hijack the human brain's 'reward' systems. A zebrafish model of addiction has recently been used to query changes in gene expression during this process...
  15. ncbi request reprint Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIH, NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    FASEB J 17:1775-88. 2003
    ..Studies that use more comprehensive approaches to gene expression profiling should allow us to draw more instructive molecular portraits of the complex plastic and degenerative effects of this drug...
  16. pmc Cellular and molecular neurobiology of brain preconditioning
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Mol Neurobiol 39:50-61. 2009
    ..The present review highlights some of these findings and suggests that a better understanding of these mechanisms will inform treatment of a number of neuropsychiatric disorders...
  17. ncbi request reprint Interactions of HIV and methamphetamine: cellular and molecular mechanisms of toxicity potentiation
    J L Cadet
    Molecular Neuropsychiatry Branch, NIH NIDA Intramural Research Program, Baltimore, MD 21224, USA
    Neurotox Res 12:181-204. 2007
    ..The role of reactive microgliosis in METH- and in HIV-induced toxicity is also discussed...
  18. ncbi request reprint Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, DHHS NIH NIDA, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Neurotox Res 11:183-202. 2007
    ..Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans...
  19. ncbi request reprint Serial analysis of gene expression in the rat striatum following methamphetamine administration
    Ning Sheng Cai
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institute of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1074:13-30. 2006
    ..These results indicate that METH toxicity is mediated, in part, by drug-induced perturbations of physiological processes that are dependent on normal pH and CO(2) homeostasis...
  20. ncbi request reprint Methamphetamine-induced neuronal apoptosis involves the activation of multiple death pathways. Review
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIH NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurotox Res 8:199-206. 2005
    ..These neuropathological observations have also been reported in models of drug-induced neuroplastic alterations used to mimic drug addiction (Nestler, 2001)...
  21. pmc Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian rats
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 5:e15643. 2010
    ..Our results also implicate 5-HT as a potential player in these METH-induced alterations in gene expression because the METH injection also caused significant increases in 5-HIAA/5-HT ratios on the DA-depleted side...
  22. ncbi request reprint Temporal profiling of methamphetamine-induced changes in gene expression in the mouse brain: evidence from cDNA array
    J L Cadet
    Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, Maryland 21224, USA
    Synapse 41:40-8. 2001
    ..These observations are of clinical relevance because of the recent identification of degenerative changes in the brains of METH abusers...
  23. ncbi request reprint Serum withdrawal potentiates the toxic effects of methamphetamine in vitro
    J L Cadet
    Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 914:82-91. 2000
    ..These data provide further support for the ideas that METH can cause ROS-mediated apoptosis...
  24. ncbi request reprint Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of mice
    J L Cadet
    Molecular Neuropsychiatry Section, National Institutes of Health National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, 21224, Baltimore, MD 21224, USA
    Parkinsonism Relat Disord 8:85-90. 2001
    ....
  25. ncbi request reprint Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen species
    J L Cadet
    Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, Maryland 21224, USA
    Synapse 35:228-33. 2000
    ..Furthermore, overexpression of bcl-2 caused significant protection against DA-induced apoptosis. These results are discussed in terms of their support for a role of bcl-2 in the development of Parkinson's disease...
  26. pmc Methamphetamine preconditioning: differential protective effects on monoaminergic systems in the rat brain
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse NIH DHHS, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Neurotox Res 15:252-9. 2009
    ..Further studies will need to evaluate the cellular and molecular bases for these differential responses...
  27. ncbi request reprint Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53
    T Hayashi
    Molecular Neuropsychiatry Section, Intramural Research Program, National Institute on Drug Abuse/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Synapse 39:305-12. 2001
    ..The results also indicate an apparent discordance between the protein level of p53 and the neurotoxicity caused by a high dose of METH. Synapse 39:305-312, 2001. Published 2001 Wiley-Liss, Inc...
  28. ncbi request reprint Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation
    I N Krasnova
    Molecular Neuropsychiatry Section, NIH/NIDA Intramural Research Program, Baltimore, MD 21224, USA
    Neuroscience 107:265-74. 2001
    ..Thus, these observations provide evidence for possible complex interactions between thermoregulation and free radical load in the long-term neurotoxic effects of this illicit drug of abuse...
  29. ncbi request reprint Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine
    S Izenwasser
    Psychobiology Section, National Institute on Drug Abuse, Division of Intramural Research, Baltimore, MD 21224, USA
    Eur J Pharmacol 373:187-93. 1999
    ..Furthermore, it is possible that the inhibition of serotonin uptake by cocaine may contribute to the adaptations in behavioral activity that are seen during chronic treatment...
  30. ncbi request reprint Null mutation of c-fos causes exacerbation of methamphetamine-induced neurotoxicity
    X Deng
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 19:10107-15. 1999
    ..These data suggest that c-fos induction in response to toxic doses of methamphetamine might be involved in protective mechanisms against this drug-induced neurotoxicity...
  31. pmc A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats
    Z X Xi
    Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, BRC Room 05A705, Baltimore, MD 21224, USA
    Neuroscience 161:392-402. 2009
    ....
  32. ncbi request reprint Methamphetamine causes differential regulation of pro-death and anti-death Bcl-2 genes in the mouse neocortex
    S Jayanthi
    Molecular Neuropsychiatry Section, NIDA-IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    FASEB J 15:1745-52. 2001
    ..These results thus support the notion that injections of toxic doses of METH trigger the activation of the programmed death pathway in the mammalian brain...
  33. ncbi request reprint Involvement of free radicals in MDMA-induced neurotoxicity in mice
    J L Cadet
    Molecular Neuropsychiatry Section, Division of Intramural Research, Baltimore, MD 21224, USA
    Ann Med Interne (Paris) 152:IS57-9. 2001
    ..These data are in agreement with the implication of free radicals and consequenty of oxidative stress in the mode of action of MDMA...
  34. ncbi request reprint Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats
    Y Wang
    National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
    Stroke 32:2170-8. 2001
    ..The purpose of this study was to determine whether there was a neuroprotective effect of BMP6 in vivo and in vitro...
  35. pmc Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders
    Y Ayhan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 16:293-306. 2011
    ..The multiple and diverse abnormalities detected in mutant DISC1 mice are reminiscent of findings in major mental diseases...
  36. ncbi request reprint Marijuana abusers are at increased risk for stroke. Preliminary evidence from cerebrovascular perfusion data
    R I Herning
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Ann N Y Acad Sci 939:413-5. 2001
    ..These findings suggest that cerebral perfusion observed in 18-30 year old marijuana abusers is comparable to that of normal 60 year-olds. Thus, chronic abuse of marijuana might be a risk factor for stroke...
  37. ncbi request reprint Direct interactions of methamphetamine with the nucleus
    M Asanuma
    Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, MD, USA
    Brain Res Mol Brain Res 80:237-43. 2000
    ..The present study is the first demonstration that METH can have direct effects on DNA-binding protein complex by redistributing not only in the cytosol but also into the nucleus...
  38. pmc Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats
    F Saint-Preux
    Molecular Neuropsychiatry Research Branch, NIDA IRP, Baltimore, MD 21224, USA
    Neuroscience 243:89-96. 2013
    ..The significance of these changes in IEG expression and in other molecular markers in fostering co-morbid METH and nicotine abuse needs to be further evaluated...
  39. ncbi request reprint Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation. Requirement for cytosolic distribution
    C C Matthews
    Department of Neurology, University of Maryland, School of Medicine, and Veteran s Affairs Medical Center, Baltimore, MD, 21201, USA
    J Mol Neurosci 14:155-66. 2000
    ..Access to the site where toxic superoxides are generated or their targets may be necessary for the protective function of SOD1...
  40. pmc Heavy marijuana users show increased serum apolipoprotein C-III levels: evidence from proteomic analyses
    S Jayanthi
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, BRC, Baltimore, MD 21224, USA
    Mol Psychiatry 15:101-12. 2010
    ..In any case, because apoC-III is a cardiovascular risk factor, the increased levels observed in MJ users might explain, in part, the cardiac and cerebral abnormalities reported in these patients...
  41. ncbi request reprint Profile of genes showing increased expression following dopamine and methamphetamine exposure in an immortalized neuronal cell line
    N S Cai
    Molecular Neuropsychiatry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Restor Neurol Neurosci 18:57-65. 2001
    ..More biochemical studies are needed to investigate DA-independent METH deleterious events in the central nervous system...
  42. ncbi request reprint Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy)
    S Jayanthi
    Molecular Neuropsychiatry Section, NIH NIDA, Bethesda, MD 20892, USA
    Neuroscience 91:1379-87. 1999
    ..Consequently, there might be further overproduction of free radicals with associated peroxidative damage to cell membranes and associated terminal degeneration...
  43. pmc Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:868-73. 2005
    ..These observations indicate that METH causes some of its neurodegenerative effects, in part, via stimulation of the Fas-mediated cell death pathway consequent to FasL up-regulation mediated by activation of multiple TFs...
  44. ncbi request reprint Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway
    Irina N Krasnova
    Molecular Neuropsychiatry Branch, NIDA IRP, DHHS NIH, Baltimore, Maryland, USA
    FASEB J 19:851-3. 2005
    ....
  45. ncbi request reprint Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals
    A M Andrews
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Mol Pharmacol 50:1511-9. 1996
    ....
  46. ncbi request reprint Sex-related differences in a gambling task and its neurological correlates
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Cereb Cortex 14:1226-32. 2004
    ..These results also provide further evidence of sexual dimorphism in neurocognitive performance and brain function...
  47. ncbi request reprint Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex
    I N Krasnova
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Genes Brain Behav 7:193-202. 2008
    ..Differences in the transcriptional responses in the hippocampus and cortex suggest the primary importance of the hippocampus for recent memory processing associated with cocaine-induced CPP...
  48. ncbi request reprint Methamphetamine causes coordinate regulation of Src, Cas, Crk, and the Jun N-terminal kinase-Jun pathway
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Section, Intramural Research Program, National Institutes of Health National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Mol Pharmacol 61:1124-31. 2002
    ..These values returned to baseline by 1 week after drug treatment. These results are discussed in terms of their support for a possible role of the activation of the JNK/Jun pathway in the pathophysiological effects of METH...
  49. pmc Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in mice
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Neurosci Res 65:160-5. 2009
    ....
  50. ncbi request reprint Methamphetamine administration causes death of dopaminergic neurons in the mouse olfactory bulb
    Xiaolin Deng
    Molecular Neuropsychiatry Branch, Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    Biol Psychiatry 61:1235-43. 2007
    ..In the rodent brain, toxic doses of METH cause damage of dopaminergic terminals and apoptosis of nondopaminergic neurons. The olfactory bulb (OB) is a brain region that is rich with dopaminergic neurons and terminals...
  51. ncbi request reprint Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout mice
    H Mann
    Molecular Neuropsychiatry Section, NIDA, Addiction Research Center, Baltimore, MD 21224, USA
    Brain Res 769:340-6. 1997
    ....
  52. ncbi request reprint The regulation of cerebral blood flow during intravenous cocaine administration in cocaine abusers
    R I Herning
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 890:489-94. 1999
    ..The present results elucidate the time course of cocaine's acute cerebrovascular effects and provide a better understanding of etiology of cocaine-related stroke and transient ischemic attacks...
  53. ncbi request reprint Effects of methamphetamine-induced neurotoxicity on the development of neural circuitry: a hypothesis
    D O Frost
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St, Baltimore, MD 21201, USA
    Brain Res Brain Res Rev 34:103-18. 2000
    ..Consideration of these data suggest the types of neural circuit alterations that may result from exposure of the developing brain to methamphetamine and that may underlie functional defects...
  54. ncbi request reprint Antiviral medications improve cerebrovascular perfusion in HIV+ non-drug users and HIV+ cocaine abusers
    R I Herning
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Ann N Y Acad Sci 939:405-12. 2001
    ..The antiviral medications appear to have a direct neuroprotective effect in addition to their antiviral effects. The neuroprotective role of antiviral medications requires further investigation...
  55. ncbi request reprint Methamphetamine causes widespread apoptosis in the mouse brain: evidence from using an improved TUNEL histochemical method
    X Deng
    NIH/NIDA-IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Mol Brain Res 93:64-9. 2001
    ..These results further confirmed the presence of METH-induced deleterious effects in nondopaminergic neurons. The significance of these findings is also discussed...
  56. ncbi request reprint Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 80:101-10. 2002
    ..The ability of folate deficiency and elevated homocysteine levels to sensitize dopaminergic neurons to environmental toxins suggests a mechanism whereby dietary folate may influence risk for PD...
  57. ncbi request reprint cDNA array analysis of gene expression profiles in the striata of wild-type and Cu/Zn superoxide dismutase transgenic mice treated with neurotoxic doses of amphetamine
    Irina N Krasnova
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    FASEB J 16:1379-88. 2002
    ..These results support the view that the use of global array analysis of gene expression will help to identify novel molecular mediators of AMPH-induced neurodegeneration...
  58. ncbi request reprint Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades
    Subramaniam Jayanthi
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, DHHS, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    FASEB J 18:238-51. 2004
    ..These findings indicate that METH causes neuronal apoptosis in part via cross-talks between ER- and mitochondria-generated processes, which cause activation of both caspase-dependent and -independent pathways...
  59. ncbi request reprint Fas-induced apoptosis of glioma cells is associated with down-regulation of the hSCO1 protein, a subunit of complex IV
    S Jayanthi
    Molecular Neuropsychiatry Section, NIDA-IRP, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Mol Brain Res 91:131-6. 2001
    ..These observations are discussed in terms of their support for an important role of mitochondrial events in Fas-induced apoptosis...
  60. doi request reprint Molecular bases of methamphetamine-induced neurodegeneration
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, NIDA Intramural Research Program, NIH DHHS, Baltimore, Maryland 21224, USA
    Int Rev Neurobiol 88:101-19. 2009
    ..Better understanding of the cellular and molecular mechanisms involved in METH toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of psychostimulant use disorders in humans...
  61. ncbi request reprint Decision-making in a risk-taking task: a PET study
    Monique Ernst
    Intramural Research Program of the National Institute on Drug Abuse, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 26:682-91. 2002
    ..The findings provide a framework for future investigations of decision-making in maladaptive behaviors...
  62. ncbi request reprint The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?
    Eric T Moolchan
    Clinical Pharmacology and Therapeutics Research Branch, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore MD, 21224, USA
    Addict Behav 27:101-13. 2002
    ..Disagreements between the FTND and the DSM are likely to become greater with the changes in the DSM-IV...
  63. pmc Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulb
    Fidelis E Atianjoh
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, NIH DHHS, Baltimore, MD 21224, USA
    Eur J Pharmacol 589:94-7. 2008
    ..These results show that the toxic effects of amphetamine involve the olfactory bulb in addition to the striatum. These observations need to be taken into consideration when discussing the clinical course of amphetamine addiction...
  64. ncbi request reprint Altered brain tissue composition in heavy marijuana users
    John A Matochik
    Intramural Research Program, Neuroimaging Research Branch, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 77:23-30. 2005
    ..045). Our preliminary results suggest evidence of possible structural differences in the brain of heavy marijuana users, and localize regions for further investigation of the effects of marijuana in the brain...
  65. ncbi request reprint Cerebral blood flow pulsatility deficits in HIV+ poly substance abusers: differences associated with antiviral medications
    Ronald I Herning
    Molecular Neuropsychiatry Section, Division of Intramural Research, National Institute on Drug Abuse, National Institutes of Health, PO Box 5180, Baltimore, MD 21224, USA
    Drug Alcohol Depend 65:129-35. 2002
    ..Nevertheless, more studies will be needed before any conclusion can be reached regarding possible beneficial effects of these agents on the cerebral vasculature...
  66. ncbi request reprint Mice with partial deficiency of c-Jun show attenuation of methamphetamine-induced neuronal apoptosis
    Xiaolin Deng
    Molecular Neuropsychiatry Section, National Institutes of Health National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    Mol Pharmacol 62:993-1000. 2002
    ..In contrast, methamphetamine-induced hyperthermia was essentially identical in the two genotypes. When taken together, our data support the hypothesis that c-Jun is involved in methamphetamine-induced apoptosis...
  67. ncbi request reprint Analysis of ecstasy (MDMA)-induced transcriptional responses in the rat cortex
    Nathalie Thiriet
    Molecular Neuropsychiatry Section, NIDA NIH, Baltimore, Maryland, USA
    FASEB J 16:1887-94. 2002
    ..Our observations indicate that cortical cells respond to the acute administration of MDMA by modulating transcription of several genes that might lead to long-term changes in the brain...
  68. ncbi request reprint Methamphetamine-induced gene expression profiles in the striatum of male rat pups exposed to the drug in utero
    Pierre Antoine H Noailles
    Molecular Neuropsychiatry Branch, NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Dev Brain Res 147:153-62. 2003
    ..Thus, during development, METH exposure in utero might cause significant long-term changes in gene expression that might constitute, in part, some of the substrates for the behavioral and cognitive anomalies reported in the literature...
  69. ncbi request reprint Nicotine dependence criteria of the DIS and DSM-III-R: a factor analysis
    Aleksandras Radzius
    National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
    Nicotine Tob Res 6:303-8. 2004
    ....
  70. pmc An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection
    Xianmin Zeng
    Intramural Research Program IRP, Cellular Neurobiology Research Branch, Department of Health and Human Services DHHS, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, MD, USA
    Neuropsychopharmacology 31:2708-15. 2006
    ....
  71. ncbi request reprint A factor analysis of the Fagerström Test for Nicotine Dependence (FTND)
    Aleksandras Radzius
    Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224, USA
    Nicotine Tob Res 5:255-40. 2003
    ..These two dimensions may provide indirect assessment of a smoker's daily nicotine intake. Testing this hypothesis requires correlation of biomarkers and responses to specific items of the FTND...
  72. ncbi request reprint Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortex
    Irina N Krasnova
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health DHHS, Bethesda, MD 20892, USA
    Neurotox Res 11:107-30. 2007
    ..Our results point towards specific molecular targets that might be involved in disease process mediated by altered developmental DA regulation...
  73. ncbi request reprint p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
    Wenzhen Duan
    Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann Neurol 52:597-606. 2002
    ..Our findings demonstrate a pivotal role for p53 in experimental parkinsonism and identify a novel class of synthetic p53 inhibitors with clinical potential...
  74. ncbi request reprint Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging study
    John A Matochik
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuroimage 19:1095-102. 2003
    ..These results extend our previous findings of defective frontal cortical activation (indexed by cerebral blood flow) in cocaine abusers to include abnormalities in gray matter tissue density in the same frontal cortical regions...
  75. pmc Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Endocrinology 148:4318-33. 2007
    ....
  76. ncbi request reprint Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addiction
    Eric T Moolchan
    Teen Tobacco Addiction Research Clinic, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    Pediatrics 115:e407-14. 2005
    ..To determine the safety and efficacy of the nicotine patch and gum for adolescents who want to quit smoking...
  77. ncbi request reprint Paroxetine retards disease onset and progression in Huntingtin mutant mice
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Ann Neurol 55:590-4. 2004
    ..Paroxetine was beneficial when treatment was initiated before or after the onset of motor dysfunction, suggesting a potential for such antidepressant drugs in the treatment of presymptomatic and symptomatic HD patients...
  78. doi request reprint Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice
    J Xiao
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Neuroscience 206:39-48. 2012
    ..These observations are consistent with heterogeneity of neuropsychiatric outcomes of the infection in humans...
  79. pmc Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003
    ..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...
  80. pmc Differential effects of methamphetamine and SCH23390 on the expression of members of IEG families of transcription factors in the rat striatum
    Genevieve Beauvais
    Molecular Neuropsychiatry Research Branch, NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Brain Res 1318:1-10. 2010
    ..The SCH23390-mediated suppression of basal fra-1, egr-1, and egr-2 mRNA levels suggests that their basal expression in the striatum might be dependent on tonic stimulation of the DA D1 receptor...
  81. pmc Mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (MDMA) in striatum
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard Suite 200, Room 05A 721, Baltimore, MD 21224, USA
    Neurotox Res 18:200-9. 2010
    ..Increased DA turnover via monoamine oxidase in mdr1a +/+ vs -/- mice might increase exposure to neurotoxic reactive oxygen species...
  82. pmc Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:312-22. 2008
    ..Additionally, the effective levels of sertraline are comparable to the safe levels achievable in humans. The findings suggest that sertraline is a potential candidate for treatment of HD patients...
  83. ncbi request reprint Methamphetamine induces apoptosis in an immortalized rat striatal cell line by activating the mitochondrial cell death pathway
    Xiaolin Deng
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 42:837-45. 2002
    ....
  84. pmc Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 114:323-34. 2010
    ..The data further suggest that modification of dietary energy intake could provide a novel potential approach to addiction treatments...
  85. pmc Methamphetamine toxicity and messengers of death
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
    Brain Res Rev 60:379-407. 2009
    ....
  86. doi request reprint The combination of methamphetamine and of the HIV protein, Tat, induces death of the human neuroblastoma cell line, SH-SY5Y
    Ning Sheng Cai
    Molecular Neuropsychiatry Branch, NIH National Institute of Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
    Synapse 62:551-2. 2008
    ..These results suggest the possibility of using this model to elucidate cellular and molecular mechanisms involved in the potentiation of clinical effects observed in patient populations of HIV-positive METH-abusing patients...
  87. ncbi request reprint Dose-related neurocognitive effects of marijuana use
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, MD 21224, USA
    Neurology 59:1337-43. 2002
    ..Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use...
  88. pmc Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 30:10752-62. 2010
    ..Our findings reveal novel roles for MAOs and serotonin in the regulation of IPC proliferation in the developing brain...
  89. doi request reprint Differential neurochemical consequences of an escalating dose-binge regimen followed by single-day multiple-dose methamphetamine challenges
    Devon L Graham
    Molecular Neuropsychiatry Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 105:1873-85. 2008
    ..Therefore, pre-treatment-induced partial protection against monoamine depletion is probably not because of attenuated METH-induced hyperthermia in those rats...
  90. pmc Sleep disturbance in heavy marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep 31:901-8. 2008
    ..To determine if recently abstinent, heavy marijuana (MJ) users show differences in polysomnographic (PSG) measures compared with a drug-free control group...
  91. pmc Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responses
    Bronwen Martin
    Laboratory of Neurosciences, Research Resources Branch, NIA, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 284:2493-511. 2009
    ....
  92. ncbi request reprint Chronic methamphetamine increases fighting in mice
    Boris P Sokolov
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 77:319-26. 2004
    ..Thus, intermittent administration of METH might be useful as a pharmacological model to study the biochemical and molecular bases of aggressiveness...
  93. pmc EEG and cerebral blood flow velocity abnormalities in chronic cocaine users
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Clin EEG Neurosci 40:39-42. 2009
    ..EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence...
  94. pmc Contribution of substance abuse and HIV infection to psychiatric distress in an inner-city African-American population
    C U Nnadi
    Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Natl Med Assoc 94:336-43. 2002
    ..Treatment of these patients may be more successful if both sets of needs are addressed with matched interventions...
  95. ncbi request reprint Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms
    Johnalyn Lyles
    Molecular Neuropsychiatry Branch, National Institutes of Health National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 42:155-68. 2003
    ..Much remains to be done in order to clarify the molecular and biochemical pathways involved in the long-term neuroplastic changes associated with MDMA abuse...
  96. ncbi request reprint RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain
    C B Goodman
    Clinical Psychopharmacology Section, NIDA NIH Addiction Research Center, Baltimore, Maryland 21224
    Synapse 16:59-65. 1994
    ..PCP had high affinity at PCP site 1 (IC50 = 92 nM) and PCP site 2 (IC50 = 117 nM), and was moderately potent in all BAT-related measures except [3H]nisoxetine binding.(ABSTRACT TRUNCATED AT 250 WORDS)..
  97. pmc Implications of plasma Delta9-tetrahydrocannabinol, 11-hydroxy-THC, and 11-nor-9-carboxy-THC concentrations in chronic cannabis smokers
    Erin L Karschner
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 33:469-77. 2009
    ..THC's presence in plasma for seven days of abstinence suggests its detection may not indicate recent use in daily cannabis users...
  98. ncbi request reprint Characteristics of African American teenage smokers who request cessation treatment: implications for addressing health disparities
    Eric T Moolchan
    Intramural Research Program, Teen Tobacco Addiction Treatment Research Clinic, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Arch Pediatr Adolesc Med 157:533-8. 2003
    ..Ethnoracial disparities in both tobacco-related mortality and treatment outcome for smoking cessation have been reported among adults, but there is a dearth of information on ethnoracial differences among adolescent smokers...
  99. pmc Extended urinary Delta9-tetrahydrocannabinol excretion in chronic cannabis users precludes use as a biomarker of new drug exposure
    Ross H Lowe
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Suite 05A721, Baltimore, MD 21224, USA
    Drug Alcohol Depend 105:24-32. 2009
    ..Delta9-Tetrahydrocannabinol (THC) and 11-hydroxy-THC (11-OH-THC) concentrations in urine following Escherichia coli beta-glucuronidase hydrolysis were proposed as biomarkers of recent (within 8h) cannabis use...
  100. ncbi request reprint Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 325:191-4. 2002
    ....