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Genomes and Genes | J L CadetSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Amphetamine recapitulates developmental programs in the zebrafishJean Lud Cadet
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse IRP, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
Genome Biol 10:231. 2009..Addictive drugs hijack the human brain's 'reward' systems. A zebrafish model of addiction has recently been used to query changes in gene expression during this process...
Neurotoxicity of substituted amphetamines: molecular and cellular mechanismsJean Lud Cadet
Molecular Neuropsychiatry Branch, DHHS NIH NIDA, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Neurotox Res 11:183-202. 2007..Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans...- Interactions of HIV and methamphetamine: cellular and molecular mechanisms of toxicity potentiationJ L Cadet
Molecular Neuropsychiatry Branch, NIH NIDA Intramural Research Program, Baltimore, MD 21224, USA
Neurotox Res 12:181-204. 2007..The role of reactive microgliosis in METH- and in HIV-induced toxicity is also discussed... - Cellular and molecular neurobiology of brain preconditioningJean Lud Cadet
Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Mol Neurobiol 39:50-61. 2009..The present review highlights some of these findings and suggests that a better understanding of these mechanisms will inform treatment of a number of neuropsychiatric disorders... - Molecular neurotoxicological models of Parkinsonism: focus on genetic manipulation of miceJ L Cadet
Molecular Neuropsychiatry Section, National Institutes of Health National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, 21224, Baltimore, MD 21224, USA
Parkinsonism Relat Disord 8:85-90. 2001.... - Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian ratsJean Lud Cadet
Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
PLoS ONE 5:e15643. 2010..Our results also implicate 5-HT as a potential player in these METH-induced alterations in gene expression because the METH injection also caused significant increases in 5-HIAA/5-HT ratios on the DA-depleted side... - Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegenerationJean Lud Cadet
Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD 21224, USA
CNS Neurol Disord Drug Targets 9:526-38. 2010..Future studies using more selective agonist and antagonist agents and the use of genetically modified animals should help to further clarify the role of these receptors in the normal physiology and in pathological events that involve DA... - Comorbid mood, psychosis, and marijuana abuse disorders: a theoretical reviewNatascha Wilson
DHHS NIH NIDA Intramural Research Program, Molecular Neuropsychiatry Research Branch, 251 Bayview Boulevard, Baltimore, MD 21224, USA
J Addict Dis 28:309-19. 2009..The hope is that this article will serve as a spring board for further discussions among practitioners who treat these patients. Greater interactions between caretakers are bound to impact the care of our patients in a very positive way... - Methamphetamine preconditioning: differential protective effects on monoaminergic systems in the rat brainJean Lud Cadet
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse NIH DHHS, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Neurotox Res 15:252-9. 2009..Further studies will need to evaluate the cellular and molecular bases for these differential responses... - Distinct gene expression signatures in the striata of wild-type and heterozygous c-fos knockout mice following methamphetamine administration: evidence from cDNA array analysesJean Lud Cadet
Molecular Neuropsychiatry Section, Intramural Research Program, NIH NIDA, PO Box 5180, Baltimore, MD 21224, USA
Synapse 44:211-26. 2002..These results support the idea that the c-fos knockout genotype may render the animals unable to trigger multicomponent responses in order to protect against the multifaceted toxic effects of this illicit neurotoxin... - Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatumJean Lud Cadet
Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD, USA
PLoS ONE 4:e7812. 2009..Further analysis of the molecular and cellular pathways regulated by these genes should help to provide some insight into the neuroadaptive potentials of the brain when repeatedly exposed to drugs of abuse... - Temporal profiling of methamphetamine-induced changes in gene expression in the mouse brain: evidence from cDNA arrayJ L Cadet
Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, Maryland 21224, USA
Synapse 41:40-8. 2001..These observations are of clinical relevance because of the recent identification of degenerative changes in the brains of METH abusers... - Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosisJean Lud Cadet
Molecular Neuropsychiatry Branch, NIH, NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
FASEB J 17:1775-88. 2003..Studies that use more comprehensive approaches to gene expression profiling should allow us to draw more instructive molecular portraits of the complex plastic and degenerative effects of this drug... - Serial analysis of gene expression in the rat striatum following methamphetamine administrationNing Sheng Cai
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institute of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Ann N Y Acad Sci 1074:13-30. 2006..These results indicate that METH toxicity is mediated, in part, by drug-induced perturbations of physiological processes that are dependent on normal pH and CO(2) homeostasis... - Serum withdrawal potentiates the toxic effects of methamphetamine in vitroJ L Cadet
Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 914:82-91. 2000..These data provide further support for the ideas that METH can cause ROS-mediated apoptosis... - Methamphetamine-induced neuronal apoptosis involves the activation of multiple death pathways. ReviewJean Lud Cadet
Molecular Neuropsychiatry Branch, NIH NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurotox Res 8:199-206. 2005..These neuropathological observations have also been reported in models of drug-induced neuroplastic alterations used to mimic drug addiction (Nestler, 2001)... - Bcl-2 overexpression attenuates dopamine-induced apoptosis in an immortalized neural cell line by suppressing the production of reactive oxygen speciesJ L Cadet
Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, Maryland 21224, USA
Synapse 35:228-33. 2000..Furthermore, overexpression of bcl-2 caused significant protection against DA-induced apoptosis. These results are discussed in terms of their support for a role of bcl-2 in the development of Parkinson's disease... - Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulationI N Krasnova
Molecular Neuropsychiatry Section, NIH/NIDA Intramural Research Program, Baltimore, MD 21224, USA
Neuroscience 107:265-74. 2001..Thus, these observations provide evidence for possible complex interactions between thermoregulation and free radical load in the long-term neurotoxic effects of this illicit drug of abuse... - Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53T Hayashi
Molecular Neuropsychiatry Section, Intramural Research Program, National Institute on Drug Abuse/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Synapse 39:305-12. 2001..The results also indicate an apparent discordance between the protein level of p53 and the neurotoxicity caused by a high dose of METH. Synapse 39:305-312, 2001. Published 2001 Wiley-Liss, Inc... - Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaineS Izenwasser
Psychobiology Section, National Institute on Drug Abuse, Division of Intramural Research, Baltimore, MD 21224, USA
Eur J Pharmacol 373:187-93. 1999..Furthermore, it is possible that the inhibition of serotonin uptake by cocaine may contribute to the adaptations in behavioral activity that are seen during chronic treatment... 
A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in ratsZ X Xi
Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, BRC Room 05A705, Baltimore, MD 21224, USA
Neuroscience 161:392-402. 2009....- Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disordersY Ayhan
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Mol Psychiatry 16:293-306. 2011..The multiple and diverse abnormalities detected in mutant DISC1 mice are reminiscent of findings in major mental diseases... - Methamphetamine causes differential regulation of pro-death and anti-death Bcl-2 genes in the mouse neocortexS Jayanthi
Molecular Neuropsychiatry Section, NIDA-IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
FASEB J 15:1745-52. 2001..These results thus support the notion that injections of toxic doses of METH trigger the activation of the programmed death pathway in the mammalian brain... - Involvement of free radicals in MDMA-induced neurotoxicity in miceJ L Cadet
Molecular Neuropsychiatry Section, Division of Intramural Research, Baltimore, MD 21224, USA
Ann Med Interne (Paris) 152:IS57-9. 2001..These data are in agreement with the implication of free radicals and consequenty of oxidative stress in the mode of action of MDMA... - Marijuana abusers are at increased risk for stroke. Preliminary evidence from cerebrovascular perfusion dataR I Herning
Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Ann N Y Acad Sci 939:413-5. 2001..These findings suggest that cerebral perfusion observed in 18-30 year old marijuana abusers is comparable to that of normal 60 year-olds. Thus, chronic abuse of marijuana might be a risk factor for stroke... - Bone morphogenetic protein-6 reduces ischemia-induced brain damage in ratsY Wang
National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
Stroke 32:2170-8. 2001..The purpose of this study was to determine whether there was a neuroprotective effect of BMP6 in vivo and in vitro... - Null mutation of c-fos causes exacerbation of methamphetamine-induced neurotoxicityX Deng
Molecular Neuropsychiatry Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurosci 19:10107-15. 1999..These data suggest that c-fos induction in response to toxic doses of methamphetamine might be involved in protective mechanisms against this drug-induced neurotoxicity... - Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation. Requirement for cytosolic distributionC C Matthews
Department of Neurology, University of Maryland, School of Medicine, and Veteran s Affairs Medical Center, Baltimore, MD, 21201, USA
J Mol Neurosci 14:155-66. 2000..Access to the site where toxic superoxides are generated or their targets may be necessary for the protective function of SOD1... - Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy)S Jayanthi
Molecular Neuropsychiatry Section, NIH NIDA, Bethesda, MD 20892, USA
Neuroscience 91:1379-87. 1999..Consequently, there might be further overproduction of free radicals with associated peroxidative damage to cell membranes and associated terminal degeneration... - Direct interactions of methamphetamine with the nucleusM Asanuma
Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, MD, USA
Brain Res Mol Brain Res 80:237-43. 2000..The present study is the first demonstration that METH can have direct effects on DNA-binding protein complex by redistributing not only in the cytosol but also into the nucleus... - Profile of genes showing increased expression following dopamine and methamphetamine exposure in an immortalized neuronal cell lineN S Cai
Molecular Neuropsychiatry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Restor Neurol Neurosci 18:57-65. 2001..More biochemical studies are needed to investigate DA-independent METH deleterious events in the central nervous system... - Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosisSubramaniam Jayanthi
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 102:868-73. 2005..These observations indicate that METH causes some of its neurodegenerative effects, in part, via stimulation of the Fas-mediated cell death pathway consequent to FasL up-regulation mediated by activation of multiple TFs... - Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathwayIrina N Krasnova
Molecular Neuropsychiatry Branch, NIDA-IRP, DHHS/NIH, Baltimore, Maryland, USA
FASEB J 19:851-3. 2005.... - Sex-related differences in a gambling task and its neurological correlatesK I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Cereb Cortex 14:1226-32. 2004..These results also provide further evidence of sexual dimorphism in neurocognitive performance and brain function... - Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortexI N Krasnova
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
Genes Brain Behav 7:193-202. 2008..Differences in the transcriptional responses in the hippocampus and cortex suggest the primary importance of the hippocampus for recent memory processing associated with cocaine-induced CPP... - Heavy marijuana users show increased serum apolipoprotein C-III levels: evidence from proteomic analysesS Jayanthi
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, BRC, Baltimore, MD 21224, USA
Mol Psychiatry 15:101-12. 2010..In any case, because apoC-III is a cardiovascular risk factor, the increased levels observed in MJ users might explain, in part, the cardiac and cerebral abnormalities reported in these patients... - Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in miceIrina N Krasnova
Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
Neurosci Res 65:160-5. 2009.... - Methamphetamine administration causes death of dopaminergic neurons in the mouse olfactory bulbXiaolin Deng
Molecular Neuropsychiatry Branch, Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
Biol Psychiatry 61:1235-43. 2007..In the rodent brain, toxic doses of METH cause damage of dopaminergic terminals and apoptosis of nondopaminergic neurons. The olfactory bulb (OB) is a brain region that is rich with dopaminergic neurons and terminals... - Methamphetamine causes coordinate regulation of Src, Cas, Crk, and the Jun N-terminal kinase-Jun pathwaySubramaniam Jayanthi
Molecular Neuropsychiatry Section, Intramural Research Program, National Institutes of Health/National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
Mol Pharmacol 61:1124-31. 2002..These values returned to baseline by 1 week after drug treatment. These results are discussed in terms of their support for a possible role of the activation of the JNK/Jun pathway in the pathophysiological effects of METH... - The regulation of cerebral blood flow during intravenous cocaine administration in cocaine abusersR I Herning
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 890:489-94. 1999..The present results elucidate the time course of cocaine's acute cerebrovascular effects and provide a better understanding of etiology of cocaine-related stroke and transient ischemic attacks... - Antiviral medications improve cerebrovascular perfusion in HIV+ non-drug users and HIV+ cocaine abusersR I Herning
Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Ann N Y Acad Sci 939:405-12. 2001..The antiviral medications appear to have a direct neuroprotective effect in addition to their antiviral effects. The neuroprotective role of antiviral medications requires further investigation... - Methamphetamine causes widespread apoptosis in the mouse brain: evidence from using an improved TUNEL histochemical methodX Deng
NIH/NIDA-IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Mol Brain Res 93:64-9. 2001..These results further confirmed the presence of METH-induced deleterious effects in nondopaminergic neurons. The significance of these findings is also discussed... - Effects of methamphetamine-induced neurotoxicity on the development of neural circuitry: a hypothesisD O Frost
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St, Baltimore, MD 21201, USA
Brain Res Brain Res Rev 34:103-18. 2000..Consideration of these data suggest the types of neural circuit alterations that may result from exposure of the developing brain to methamphetamine and that may underlie functional defects... - Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's diseaseWenzhen Duan
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
J Neurochem 80:101-10. 2002..The ability of folate deficiency and elevated homocysteine levels to sensitize dopaminergic neurons to environmental toxins suggests a mechanism whereby dietary folate may influence risk for PD... - Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascadesSubramaniam Jayanthi
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, DHHS, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
FASEB J 18:238-51. 2004..These findings indicate that METH causes neuronal apoptosis in part via cross-talks between ER- and mitochondria-generated processes, which cause activation of both caspase-dependent and -independent pathways... - cDNA array analysis of gene expression profiles in the striata of wild-type and Cu/Zn superoxide dismutase transgenic mice treated with neurotoxic doses of amphetamineIrina N Krasnova
Molecular Neuropsychiatry Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
FASEB J 16:1379-88. 2002..These results support the view that the use of global array analysis of gene expression will help to identify novel molecular mediators of AMPH-induced neurodegeneration... - Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatumSubramaniam Jayanthi
Molecular Neuropsychiatry Research Branch, National Institute of Drug Abuse, National Institutes of Health NIH Department of Health and Human Services DHHS, Intramural Research Program, Baltimore, MD, USA
PLoS ONE 4:e6092. 2009..Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain... - Fas-induced apoptosis of glioma cells is associated with down-regulation of the hSCO1 protein, a subunit of complex IVS Jayanthi
Molecular Neuropsychiatry Section, NIDA-IRP, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Mol Brain Res 91:131-6. 2001..These observations are discussed in terms of their support for an important role of mitochondrial events in Fas-induced apoptosis... - Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout miceH Mann
Molecular Neuropsychiatry Section, NIDA, Addiction Research Center, Baltimore, MD 21224, USA
Brain Res 769:340-6. 1997.... - Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminalsA M Andrews
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Mol Pharmacol 50:1511-9. 1996.... - Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addictionEric T Moolchan
Teen Tobacco Addiction Research Clinic, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
Pediatrics 115:e407-14. 2005..To determine the safety and efficacy of the nicotine patch and gum for adolescents who want to quit smoking... - Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excessBronwen Martin
Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Endocrinology 148:4318-33. 2007.... - An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotectionXianmin Zeng
Intramural Research Program IRP, Cellular Neurobiology Research Branch, Department of Health and Human Services DHHS, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, MD, USA
Neuropsychopharmacology 31:2708-15. 2006.... - Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulbFidelis E Atianjoh
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, NIH DHHS, Baltimore, MD 21224, USA
Eur J Pharmacol 589:94-7. 2008..These results show that the toxic effects of amphetamine involve the olfactory bulb in addition to the striatum. These observations need to be taken into consideration when discussing the clinical course of amphetamine addiction... - Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortexIrina N Krasnova
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health DHHS, Bethesda, MD 20892, USA
Neurotox Res 11:107-30. 2007..Our results point towards specific molecular targets that might be involved in disease process mediated by altered developmental DA regulation... - Molecular bases of methamphetamine-induced neurodegenerationJean Lud Cadet
Molecular Neuropsychiatry Branch, NIDA Intramural Research Program, NIH DHHS, Baltimore, Maryland 21224, USA
Int Rev Neurobiol 88:101-19. 2009..Better understanding of the cellular and molecular mechanisms involved in METH toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of psychostimulant use disorders in humans... - Altered brain tissue composition in heavy marijuana usersJohn A Matochik
Intramural Research Program, Neuroimaging Research Branch, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Drug Alcohol Depend 77:23-30. 2005..045). Our preliminary results suggest evidence of possible structural differences in the brain of heavy marijuana users, and localize regions for further investigation of the effects of marijuana in the brain... - Analysis of ecstasy (MDMA)-induced transcriptional responses in the rat cortexNathalie Thiriet
Molecular Neuropsychiatry Section, NIDA/NIH, Baltimore, Maryland, USA
FASEB J 16:1887-94. 2002..Our observations indicate that cortical cells respond to the acute administration of MDMA by modulating transcription of several genes that might lead to long-term changes in the brain... - p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonismWenzhen Duan
Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Ann Neurol 52:597-606. 2002..Our findings demonstrate a pivotal role for p53 in experimental parkinsonism and identify a novel class of synthetic p53 inhibitors with clinical potential... - Decision-making in a risk-taking task: a PET studyMonique Ernst
Intramural Research Program of the National Institute on Drug Abuse, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 26:682-91. 2002..The findings provide a framework for future investigations of decision-making in maladaptive behaviors... - A factor analysis of the Fagerström Test for Nicotine Dependence (FTND)Aleksandras Radzius
Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224, USA
Nicotine Tob Res 5:255-40. 2003..These two dimensions may provide indirect assessment of a smoker's daily nicotine intake. Testing this hypothesis requires correlation of biomarkers and responses to specific items of the FTND... - Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging studyJohn A Matochik
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuroimage 19:1095-102. 2003..These results extend our previous findings of defective frontal cortical activation (indexed by cerebral blood flow) in cocaine abusers to include abnormalities in gray matter tissue density in the same frontal cortical regions... - Methamphetamine-induced gene expression profiles in the striatum of male rat pups exposed to the drug in uteroPierre Antoine H Noailles
Molecular Neuropsychiatry Branch, NIDA/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Dev Brain Res 147:153-62. 2003..Thus, during development, METH exposure in utero might cause significant long-term changes in gene expression that might constitute, in part, some of the substrates for the behavioral and cognitive anomalies reported in the literature... - Paroxetine retards disease onset and progression in Huntingtin mutant miceWenzhen Duan
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
Ann Neurol 55:590-4. 2004..Paroxetine was beneficial when treatment was initiated before or after the onset of motor dysfunction, suggesting a potential for such antidepressant drugs in the treatment of presymptomatic and symptomatic HD patients... - The Fagerstrom Test for Nicotine Dependence and the Diagnostic Interview Schedule: do they diagnose the same smokers?Eric T Moolchan
Clinical Pharmacology and Therapeutics Research Branch, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore MD, 21224, USA
Addict Behav 27:101-13. 2002..Disagreements between the FTND and the DSM are likely to become greater with the changes in the DSM-IV... - Cerebral blood flow pulsatility deficits in HIV+ poly substance abusers: differences associated with antiviral medicationsRonald I Herning
Molecular Neuropsychiatry Section, Division of Intramural Research, National Institute on Drug Abuse, National Institutes of Health, PO Box 5180, Baltimore, MD 21224, USA
Drug Alcohol Depend 65:129-35. 2002..Nevertheless, more studies will be needed before any conclusion can be reached regarding possible beneficial effects of these agents on the cerebral vasculature... - Nicotine dependence criteria of the DIS and DSM-III-R: a factor analysisAleksandras Radzius
National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA
Nicotine Tob Res 6:303-8. 2004.... - Mice with partial deficiency of c-Jun show attenuation of methamphetamine-induced neuronal apoptosisXiaolin Deng
Molecular Neuropsychiatry Section, National Institutes of Health/National Institute on Drug Abuse-Intramural Research Program, Baltimore, Maryland 21224, USA
Mol Pharmacol 62:993-1000. 2002..In contrast, methamphetamine-induced hyperthermia was essentially identical in the two genotypes. When taken together, our data support the hypothesis that c-Jun is involved in methamphetamine-induced apoptosis... - Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in miceJ Xiao
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Neuroscience 206:39-48. 2012..These observations are consistent with heterogeneity of neuropsychiatric outcomes of the infection in humans... - Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making taskK I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuroimage 19:1085-94. 2003..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence... - Long-term protective effects of methamphetamine preconditioning against single-day methamphetamine toxic challengesA B Hodges
Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Curr Neuropharmacol 9:35-9. 2011..These results are consistent with the idea that METH pretreatment renders the brain refractory to METH-induced degeneration of brain monoaminergic systems... - Methamphetamine toxicity and messengers of deathIrina N Krasnova
Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
Brain Res Rev 60:379-407. 2009.... - Mice lacking multidrug resistance protein 1a show altered dopaminergic responses to methylenedioxymethamphetamine (MDMA) in striatumKarl B Scheidweiler
Chemistry and Drug Metabolism, Intramural Research Program, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard Suite 200, Room 05A 721, Baltimore, MD 21224, USA
Neurotox Res 18:200-9. 2010..Increased DA turnover via monoamine oxidase in mdr1a +/+ vs -/- mice might increase exposure to neurotoxic reactive oxygen species... - Methamphetamine induces apoptosis in an immortalized rat striatal cell line by activating the mitochondrial cell death pathwayXiaolin Deng
Molecular Neuropsychiatry Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropharmacology 42:837-45. 2002.... - Differential effects of methamphetamine and SCH23390 on the expression of members of IEG families of transcription factors in the rat striatumGenevieve Beauvais
Molecular Neuropsychiatry Research Branch, NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Brain Res 1318:1-10. 2010..The SCH23390-mediated suppression of basal fra-1, egr-1, and egr-2 mRNA levels suggests that their basal expression in the striatum might be dependent on tonic stimulation of the DA D1 receptor... - Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the ratIrina N Krasnova
National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America
PLoS ONE 5:e8790. 2010..These results suggest that meth self-administration by rats is associated with long-term biochemical changes that are reminiscent of those observed in post-mortem brain tissues of chronic meth abusers... - Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behaviorXiangru Xu
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
J Neurochem 114:323-34. 2010..The data further suggest that modification of dietary energy intake could provide a novel potential approach to addiction treatments... - Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's diseaseWenzhen Duan
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
Neurobiol Dis 30:312-22. 2008..Additionally, the effective levels of sertraline are comparable to the safe levels achievable in humans. The findings suggest that sertraline is a potential candidate for treatment of HD patients... - The combination of methamphetamine and of the HIV protein, Tat, induces death of the human neuroblastoma cell line, SH-SY5YNing Sheng Cai
Molecular Neuropsychiatry Branch, NIH National Institute of Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
Synapse 62:551-2. 2008..These results suggest the possibility of using this model to elucidate cellular and molecular mechanisms involved in the potentiation of clinical effects observed in patient populations of HIV-positive METH-abusing patients... - Dose-related neurocognitive effects of marijuana useK I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, MD 21224, USA
Neurology 59:1337-43. 2002..Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use... - Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanismsJohnalyn Lyles
Molecular Neuropsychiatry Branch, National Institutes of Health/National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Brain Res Rev 42:155-68. 2003..Much remains to be done in order to clarify the molecular and biochemical pathways involved in the long-term neuroplastic changes associated with MDMA abuse... - Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal developmentAiwu Cheng
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurosci 30:10752-62. 2010..Our findings reveal novel roles for MAOs and serotonin in the regulation of IPC proliferation in the developing brain... - EEG and cerebral blood flow velocity abnormalities in chronic cocaine usersMarc L Copersino
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA
Clin EEG Neurosci 40:39-42. 2009..EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence... - Chronic methamphetamine increases fighting in miceBoris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Pharmacol Biochem Behav 77:319-26. 2004..Thus, intermittent administration of METH might be useful as a pharmacological model to study the biochemical and molecular bases of aggressiveness... - Differential neurochemical consequences of an escalating dose-binge regimen followed by single-day multiple-dose methamphetamine challengesDevon L Graham
Molecular Neuropsychiatry Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurochem 105:1873-85. 2008..Therefore, pre-treatment-induced partial protection against monoamine depletion is probably not because of attenuated METH-induced hyperthermia in those rats... - Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responsesBronwen Martin
Laboratory of Neurosciences, Research Resources Branch, NIA, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
J Biol Chem 284:2493-511. 2009.... - Sleep disturbance in heavy marijuana usersKaren I Bolla
Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
Sleep 31:901-8. 2008..To determine if recently abstinent, heavy marijuana (MJ) users show differences in polysomnographic (PSG) measures compared with a drug-free control group... - Contribution of substance abuse and HIV infection to psychiatric distress in an inner-city African-American populationC U Nnadi
Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Natl Med Assoc 94:336-43. 2002..Treatment of these patients may be more successful if both sets of needs are addressed with matched interventions... - RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brainC B Goodman
Clinical Psychopharmacology Section, NIDA NIH Addiction Research Center, Baltimore, Maryland 21224
Synapse 16:59-65. 1994..PCP had high affinity at PCP site 1 (IC50 = 92 nM) and PCP site 2 (IC50 = 117 nM), and was moderately potent in all BAT-related measures except [3H]nisoxetine binding.(ABSTRACT TRUNCATED AT 250 WORDS).. - Implications of plasma Delta9-tetrahydrocannabinol, 11-hydroxy-THC, and 11-nor-9-carboxy-THC concentrations in chronic cannabis smokersErin L Karschner
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Anal Toxicol 33:469-77. 2009..THC's presence in plasma for seven days of abstinence suggests its detection may not indicate recent use in daily cannabis users... - Characteristics of African American teenage smokers who request cessation treatment: implications for addressing health disparitiesEric T Moolchan
Intramural Research Program, Teen Tobacco Addiction Treatment Research Clinic, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Arch Pediatr Adolesc Med 157:533-8. 2003..Our findings also highlight the importance of ethnocultural issues in treatment research that aims to address health disparities... - Extended urinary Delta9-tetrahydrocannabinol excretion in chronic cannabis users precludes use as a biomarker of new drug exposureRoss H Lowe
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Suite 05A721, Baltimore, MD 21224, USA
Drug Alcohol Depend 105:24-32. 2009..Delta9-Tetrahydrocannabinol (THC) and 11-hydroxy-THC (11-OH-THC) concentrations in urine following Escherichia coli beta-glucuronidase hydrolysis were proposed as biomarkers of recent (within 8h) cannabis use... - Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatumNathalie Thiriet
Centre National de la Recherche Scientifique 6187, University of Poitiers, 86000 Poitiers, France
J Neurosci 25:5273-9. 2005..Given the similarity between the cell death patterns induced by METH and by disorders such as Huntington's disease, our results suggest that NPY analogs might be useful therapeutic agents against some neurodegenerative processes... - Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brainJing Yu
Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
J Neurochem 83:613-22. 2002..This finding could lead to novel therapeutic strategies to offset drug addictions as well as in the treatment of a number of disorders including Parkinson's and Huntington's diseases... - Ontogeny of neurokinin-1 receptor mediation of methamphetamine neurotoxicity in the striatum of the mouse brainJing Yu
Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
Ann N Y Acad Sci 965:247-53. 2002.... - Histological evidence supporting a role for the striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the mouse brainJing Yu
Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Ave, Rm. 927HN, New York, NY 10021, USA
Brain Res 1007:124-31. 2004..These findings represent a new direction in the study of the mechanism of toxicity to METH and could be useful in the treatment of some neurological disorders... - Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic miceMasato Asanuma
Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
Neurosci Lett 325:191-4. 2002.... - Environmental enrichment during adolescence regulates gene expression in the striatum of miceNathalie Thiriet
Institut de Biologie et Physiologie Cellulaires, University of Poitiers, 40 Avenue du Recteur Pineau, Poitiers, France
Brain Res 1222:31-41. 2008..The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported... - The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addictionJonathan M Flanagan
Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 215, La Jolla, CA 92037, USA
Hum Genet 120:581-8. 2006..Moreover, this mutation appears to have arisen early in human evolution and this study validates the previous link between the FAAH P129T variant and vulnerability to addiction of multiple different drugs...