M B Burg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Factors affecting counteraction by methylamines of urea effects on aldose reductase
    M B Burg
    National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:6517-22. 1999
  2. ncbi request reprint Response of renal inner medullary epithelial cells to osmotic stress
    Maurice B Burg
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1603, USA
    Comp Biochem Physiol A Mol Integr Physiol 133:661-6. 2002
  3. ncbi request reprint Macromolecular crowding as a cell volume sensor
    M B Burg
    National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
    Cell Physiol Biochem 10:251-6. 2000
  4. ncbi request reprint Renal osmoregulatory transport of compatible organic osmolytes
    M B Burg
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Curr Opin Nephrol Hypertens 6:430-3. 1997
  5. pmc Intracellular organic osmolytes: function and regulation
    Maurice B Burg
    Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 283:7309-13. 2008
  6. ncbi request reprint Cellular response to hyperosmotic stresses
    Maurice B Burg
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Physiol Rev 87:1441-74. 2007
  7. ncbi request reprint Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 289:F506-11. 2005
  8. ncbi request reprint Betaine transporter cDNA cloning and effect of osmolytes on its mRNA induction
    J D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 270:C650-4. 1996
  9. pmc Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP
    Margarita Kunin
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12108. 2010
  10. ncbi request reprint Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1
    Ye Chen
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 292:F981-92. 2007

Collaborators

Detail Information

Publications57

  1. pmc Factors affecting counteraction by methylamines of urea effects on aldose reductase
    M B Burg
    National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:6517-22. 1999
    ..We conclude that counteraction of urea effects on enzymes by methylamines can depend on ion concentration, pH, the specific methylamine and substrate, and identity of even a single amino acid in the enzyme...
  2. ncbi request reprint Response of renal inner medullary epithelial cells to osmotic stress
    Maurice B Burg
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1603, USA
    Comp Biochem Physiol A Mol Integr Physiol 133:661-6. 2002
    ..We conclude that a more gradual increase in osmolality provides time for accumulation of organic osmolytes and activation of heat shock protein, previously known to be important for cell survival...
  3. ncbi request reprint Macromolecular crowding as a cell volume sensor
    M B Burg
    National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
    Cell Physiol Biochem 10:251-6. 2000
    ....
  4. ncbi request reprint Renal osmoregulatory transport of compatible organic osmolytes
    M B Burg
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Curr Opin Nephrol Hypertens 6:430-3. 1997
    ..This transport is osmotically regulated by changes in transcription of the transporters and by post-translational modifications. Most of the original studies were in vitro, but these processes are increasingly being examined in vivo...
  5. pmc Intracellular organic osmolytes: function and regulation
    Maurice B Burg
    Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 283:7309-13. 2008
    ....
  6. ncbi request reprint Cellular response to hyperosmotic stresses
    Maurice B Burg
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Physiol Rev 87:1441-74. 2007
    ....
  7. ncbi request reprint Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Renal Physiol 289:F506-11. 2005
    ..In conclusion, activation of ATM contributes to high NaCl-induced nuclear translocation of TonEBP/OREBP...
  8. ncbi request reprint Betaine transporter cDNA cloning and effect of osmolytes on its mRNA induction
    J D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol 270:C650-4. 1996
    ..Because the aldose reductase gene is controlled in a similar fashion, we surmise that the two genes share a common signal for induction...
  9. pmc Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP
    Margarita Kunin
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12108. 2010
    ..Hypertonicity, such as induced by high NaCl, increases the activity of the transcription factor TonEBP/OREBP whose target genes increase osmoprotective organic osmolytes and heat shock proteins...
  10. ncbi request reprint Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1
    Ye Chen
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 292:F981-92. 2007
    ..PARP-1 expression reduces TonEBP/OREBP transcriptional activity and the activity of its transactivating domain. Hsp90 enhances those activities and sustains the increased abundance of TonEBP/OREBP protein in cells exposed to high NaCl...
  11. ncbi request reprint Distinct regulation of osmoprotective genes in yeast and mammals. Aldose reductase osmotic response element is induced independent of p38 and stress-activated protein kinase/Jun N-terminal kinase in rabbit kidney cells
    D Kultz
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 0951, USA
    J Biol Chem 272:13165-70. 1997
    ..This finding stands in contrast to the requirement for the HOG1 pathway for hyperosmotically induced activation of yeast GPD1...
  12. pmc Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP
    Carlos E Irarrazabal
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 107:906-11. 2010
    ....
  13. pmc Cloning, genomic organization, and osmotic response of the aldose reductase gene
    J D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:10742-6. 1994
    ..Identification and characterization of OREs within this fragment and their associated trans-acting factors should reveal the molecular mechanisms of gene regulation in osmotic stress...
  14. ncbi request reprint Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 291:F341-9. 2006
    ....
  15. ncbi request reprint Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells
    L Michea
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 278:F209-18. 2000
    ..We conclude that elevated NaCl and/or urea reduces the number of proliferating mIMCD3 cells by slowing the transit through the S phase, by cell cycle delay in the G(2)M and G(1), and by inducing apoptotic cell death...
  16. pmc Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 107:7072-7. 2010
    ..Thus, TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP...
  17. ncbi request reprint Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer/osmotic response element-binding protein transactivating activity
    Carlos E Irarrazabal
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Biol Chem 283:2554-63. 2008
    ..AP-1 reporter only if the AP-1 site is intact. Thus, AP-1 is part of the TonEBP/OREBP enhanceosome, and its role in high NaCl-induced activation of TonEBP/OREBP may require p38 activity...
  18. pmc Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
    E D Kwon
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:15074-9. 1999
    ....
  19. ncbi request reprint Hypertonic stress response
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room 6N260, Bethesda, MD 20892 1603, USA
    Mutat Res 569:65-74. 2005
    ..How high NaCl causes the DNA breaks and how the cells survive them is conjectural at this point. We discuss possible answers to these questions, based on current knowledge about induction and processing of DNA breaks...
  20. ncbi request reprint Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Division of Nephrology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 289:F377-85. 2005
    ..We conclude that the high NaCl-induced increase in ROS, including superoxide, contributes to activation of TonEBP/OREBP by increasing its transactivation...
  21. pmc c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892 1603
    FASEB J 24:4325-35. 2010
    ..Thus, c-Abl is the kinase responsible for high NaCl-induced phosphorylation of TonEBP/OREBP-Y143, which contributes to its increased activity...
  22. ncbi request reprint Molecular cloning of cDNA coding for kidney aldose reductase. Regulation of specific mRNA accumulation by NaCl-mediated osmotic stress
    A Garcia-Perez
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
    J Biol Chem 264:16815-21. 1989
    ..The induction of aldose reductase mRNA by osmotic stress was reversible. Our finding of increased abundance of a specific mRNA in direct response to hyperosmotic stress represents the first report of such an effect in animals...
  23. ncbi request reprint Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2
    D Kultz
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    J Biol Chem 273:13645-51. 1998
    ....
  24. pmc Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
    E D Kwon
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 1N105, Building 9, 9 Memorial Drive, MSC 0951 Bethesda, MD 20892 0951, USA
    Proc Natl Acad Sci U S A 94:8099-103. 1997
    ..Additionally, the syngeneic murine model that we introduce provides a comprehensive system for further testing of immune-based treatments for prostate cancer...
  25. pmc Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
    Carlos E Irarrazabal
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 103:8882-7. 2006
    ....
  26. ncbi request reprint The saltiness of the sea breaks DNA in marine invertebrates: possible implications for animal evolution
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 5:1320-3. 2006
    ..We speculate that, since DNA breaks cause mutations, salinity might have important background effects on the rate and course of evolution...
  27. pmc Knockout of Ku86 accelerates cellular senescence induced by high NaCl
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Aging (Albany NY) 1:245-53. 2009
    ..We conclude that Ku86 deficiency accelerates high NaCl(-) induced cellular senescence,particularly in the renal medulla where NaCl normally is high...
  28. pmc Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 103:15260-5. 2006
    ....
  29. ncbi request reprint Tonicity-regulated gene expression
    Joan D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Methods Enzymol 428:279-96. 2007
    ..This chapter presents protocols for measuring the transcriptional activity of TonEBP/OREBP and determining its subcellular localization, its binding to OREs, and activity of its transactivation domain...
  30. ncbi request reprint High NaCl promotes cellular senescence
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cell Cycle 6:3108-13. 2007
    ..We conclude that high NaCl accelerates cellular senescence and aging, most likely secondary to the DNA breaks and oxidative damage that it causes...
  31. pmc MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta
    Xiaoming Zhou
    Division of Nephrology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 105:5620-5. 2008
    ....
  32. pmc Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Dept of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 295:F1678-88. 2008
    ..We conclude that gammaH2AX induction and MRN activation in response to high NaCl are associated with apoptosis, not DNA repair...
  33. pmc What's new about osmotic regulation of glycerophosphocholine
    Morgan Gallazzini
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Physiology (Bethesda) 24:245-9. 2009
    ..We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance...
  34. pmc GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC
    Morgan Gallazzini
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20982, USA
    Proc Natl Acad Sci U S A 105:11026-31. 2008
    ..We conclude that GDPD5 is a GPC-PDE that contributes to osmotic regulation of cellular GPC...
  35. ncbi request reprint DNA damage and osmotic regulation in the kidney
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 289:F2-7. 2005
    ..Furthermore, we consider that the persistent DNA damage may be a sensor of hypertonicity that activates ATM kinase to provide a signal that contributes to protective osmotic regulation...
  36. pmc Ku86 preserves chromatin integrity in cells adapted to high NaCl
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, and Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:10730-5. 2005
    ..We propose that Ku86 ameliorates the effects of high NaCl-induced DNA breaks in adapted cells by supporting alignment of the broken ends of the DNA and thus maintaining integrity of the fragmented chromatin...
  37. ncbi request reprint Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, Maryland 20892, USA
    Am J Physiol Renal Physiol 283:F302-8. 2002
    ..We conclude that immortalization and continued DNA replication account for part of the previously observed difference in osmotic tolerance between IM cells in vivo and in cell culture but that other factors must also be involved...
  38. ncbi request reprint Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 283:F792-8. 2002
    ..We conclude that gradual changes in osmolality, e.g., in vivo, allow cells to survive much greater changes than do the step changes routinely used in cell culture experiments...
  39. pmc Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration
    Joan D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:739-44. 2002
    ..Thus, the 983 C-terminal amino acids of TonEBP/OREBP contain a TAD that is regulated osmotically, apparently by tonicity-dependent phosphorylation...
  40. pmc cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein
    Joan D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:16800-5. 2002
    ....
  41. pmc Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, and Gene Response Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:184-9. 2002
    ..We propose that the rapid initiation of G(2) delay by p38 kinase after hypertonicity protects the cells by decreasing the level of DNA breaks caused by aberrant mitosis entry...
  42. ncbi request reprint High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10, Rm 6N260, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 285:F266-74. 2003
    ....
  43. ncbi request reprint Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 285:F688-93. 2003
    ..4) TonEBP abundance and activity are regulated by factors other than tonicity in some tissues...
  44. ncbi request reprint Greater tolerance of renal medullary cells for a slow increase in osmolality is associated with enhanced expression of HSP70 and other osmoprotective genes
    Qi Cai
    National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10, Rm 6N319, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 286:F58-67. 2004
    ..We speculate that poorer survival of p2mIME cells with a step than with linear increase in NaCl and urea is accounted for, at least in part, by urea-induced suppression of protective genes, particularly HSP70...
  45. pmc Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 101:2317-22. 2004
    ..Thus, both in cell culture and in vivo, although cells adapt to high NaCl, their DNA is damaged and its repair is inhibited...
  46. ncbi request reprint Living with DNA breaks is an everyday reality for cells adapted to high NaCl
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Cell Cycle 3:561-3. 2004
    ....
  47. pmc ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP
    Carlos E Irarrazabal
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 101:8809-14. 2004
    ..In conclusion, signaling via ATM is necessary for full activation of TonEBP/OREBP by high NaCl, but it is not sufficient...
  48. pmc High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA
    Zheng Zhang
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:9491-6. 2004
    ..iii) In mIMCD3 cells a normal plasma concentration of urea causes carbonylation, and carbonylation increases over the uremic range of urea concentration, indicating that urea can contribute directly to the carbonylation found in uremia...
  49. pmc Drying and salting send different messages
    Joan D Ferraris
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    J Physiol 558:3. 2004
  50. ncbi request reprint High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA
    Qi Cai
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 289:F803-7. 2005
    ..We concluded that 1) hypertonicity stabilizes TonEBP/OREBP mRNA, contributing to its increase, and 2) stabilization depends on the presence of the 5'-UTR...
  51. ncbi request reprint Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells
    Luis Michea
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Am J Physiol Renal Physiol 282:F981-90. 2002
    ..Adding urea to 700 mosmol/kgH(2)O does not change NADH or TMRM fluorescence. We conclude that extreme acute hypertonicity causes a mitochondrial dysfunction involved in the initiation of apoptosis...
  52. pmc Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells
    G M Rocha
    Laboratory of Kidney and Electrolytes Metabolism, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:5317-22. 2001
    ..Such effects of APAF might account for renal medullary cell death in vivo and development of uroepithelial tumors from surviving cells that have chromosomal aberrations...
  53. ncbi request reprint Toxicity of acetaminophen, salicylic acid, and caffeine for first-passage rat renal inner medullary collecting duct cells
    Qi Cai
    Laboratory of Kidney and Electrolytes Metabolism, National Heart, Lung, and Blood Institute Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892 1603, USA
    J Pharmacol Exp Ther 306:35-42. 2003
    ....
  54. ncbi request reprint Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP
    Xiaoming Zhou
    Div of Nephrology, Uniformed Services Univ of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 290:F1169-76. 2006
    ..We conclude that high NaCl increases mitochondrial ROS production, which contributes to the activation of TonEBP/OREBP by increasing its transactivating activity...
  55. ncbi request reprint Cell cycle delay and apoptosis in response to osmotic stress
    N I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, Bethesda, MD 20892-1603, USA
    Comp Biochem Physiol A Mol Integr Physiol 130:411-20. 2001
    ..The possible mechanisms of the protection action of p53 against hypertonic stress are discussed...
  56. ncbi request reprint Osmotic stress and DNA damage
    Natalia I Dmitrieva
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Methods Enzymol 428:241-52. 2007
    ..This chapter also discusses how specifics of the protocols influence the conclusions about types of DNA damage and what the limitations of these methods are for detecting different types of DNA damage...
  57. ncbi request reprint Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells
    Devulapalli Chakravarty
    The Whitney Laboratory, University of Florida, St Augustine, Florida 32080, USA
    Am J Physiol Renal Physiol 283:F1020-9. 2002
    ..These data associate all known GADD45 isoforms with the hypertonicity phenotype of renal IM cells...