Genomes and Genes
Affiliation: National Institutes of Health
- Neuregulin and ErbB receptor signaling pathways in the nervous systemA Buonanno
Section on Molecular Neurobiology, Building 49, Room 5A 38, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
Curr Opin Neurobiol 11:287-96. 2001..How this combinatorial network - comprising many neuregulin ligands that signal through distinct combinations of dimeric ErbB receptors - elicits its multitude of biological effects is beginning to be resolved...
- Gene regulation by patterned electrical activity during neural and skeletal muscle developmentA Buonanno
Unit on Molecular Neurobiology Laboratory on Developmental Neurobiology Unit on Molecular Neurobiology Building 49 Room 5A 38 National Institutes of Health Bethesda Maryland 20892 USA
Curr Opin Neurobiol 9:110-20. 1999..Recent studies have addressed the importance of spatial heterogeneity or of temporal changes in calcium levels for the regulation of gene expression...
- Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneuronsM Longart
Section on Molecular Neurobiology, NICHD, Bethesda, MD 20892, USA
Brain Res Bull 73:210-9. 2007..These results enhance our understanding of the regulation of ErbB-4--mediated signaling at glutamatergic synapses...
- Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcriptionS Calvo
Section on Molecular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell Biol 21:8490-503. 2001..These results suggest a role for GTF3 as a regulator of slow TnI expression during early stages of muscle development and suggest how it could contribute to Williams-Beuren syndrome...
- [Neuregulins: A family of factors with critical functions during nervous system development and in the cellular transformation and differentiation]M Longart
Section on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
Rev Neurol 34:91-7. 2002..These factors are also involved in nervous system disorders, and in the generation and progression of tumors...
- Regulation of prothrombin, thrombin receptor, and protease nexin-1 expression during development and after denervation in muscleS Kim
Laboratory of Developmental Neurobiology, NICHD NIH, Bethesda, Maryland 20892, USA
J Neurosci Res 53:304-11. 1998..An elevated level of local thrombin or thrombin-like activity might result from the decreased inhibitory activity of PN-1 during the period of peak synapse elimination in muscle development...
- The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapsesR A Garcia
Unit on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:3596-601. 2000..As discussed, the interactions found between receptor tyrosine kinases and MAGUKs at neuronal synapses may have important implications for activity-dependent plasticity...
- Upstream sequences of the myogenin gene convey responsiveness to skeletal muscle denervation in transgenic miceA Buonanno
Laboratory of Developmental Neurobiology, National Institutes of Health, Bethesda, MD 20892
Nucleic Acids Res 21:5684-93. 1993....
- The MyoD family of myogenic factors is regulated by electrical activity: isolation and characterization of a mouse Myf-5 cDNAA Buonanno
Unit on Molecular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
Nucleic Acids Res 20:539-44. 1992..Using extracellular electrodes to directly stimulate in situ the soleus muscle of rats, we found that 'electrical activity' per se, in absence of the nerve, represses the increases of myogenic factor mRNAs associated with denervation...
- Distinct N-methyl-D-aspartate receptor 2B subunit gene sequences confer neural and developmental specific expressionM Sasner
Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
J Biol Chem 271:21316-22. 1996..These studies provide insight into the molecular mechanisms regulating the switch of NMDA receptor subunit expression in the cerebellum, which ultimately account for the physiological changes in receptor function during development...
- ErbB transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous systemK M Gerecke
Department of Neurobiology, The University of Alabama at Birmingham, 1720 Seventh Avenue South, Birmingham, AL 35294-0017, USA
J Comp Neurol 433:86-100. 2001..The continued expression of NRGs and their erbB receptors in mature brain also implies that these molecules perform important functions in the brain throughout life...
- Expression of RAPsyn (43K protein) and nicotinic acetylcholine receptor genes is not coordinately regulated in mouse muscleD E Frail
Department of Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110
Neuron 2:1077-86. 1989..We conclude that the expression of RAPsyn and the acetylcholine receptor is not coordinately regulated in mouse muscle...