John R Bucher

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Regulatory forum opinion piece: Tox21 and toxicologic pathology
    John R Bucher
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 41:125-7. 2013
  2. ncbi request reprint Inhalation toxicity and carcinogenicity studies of cobalt sulfate
    J R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 49:56-67. 1999
  3. ncbi request reprint Human carcinogenic risk evaluation, Part V: The national toxicology program vision for assessing the human carcinogenic hazard of chemicals
    John R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:363-6. 2004
  4. ncbi request reprint The National Toxicology Program rodent bioassay: designs, interpretations, and scientific contributions
    John R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 22709, USA
    Ann N Y Acad Sci 982:198-207. 2002
  5. pmc Current approaches toward chemical mixture studies at the National Institute of Environmental Health Sciences and the U.S. National Toxicology Program
    J R Bucher
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 106:1295-8. 1998
  6. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated citral in rats and mice
    N B Ress
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:198-206. 2003
  7. pmc Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds"
    Nigel J Walker
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27705, USA
    Environ Health Perspect 113:43-8. 2005
  8. pmc Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats
    Nigel J Walker
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Natinal Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Nutr Food Res 50:934-44. 2006
  9. ncbi request reprint A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen
    Nancy R Bordelon
    National Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    J Appl Toxicol 25:514-21. 2005
  10. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008

Detail Information

Publications44

  1. doi request reprint Regulatory forum opinion piece: Tox21 and toxicologic pathology
    John R Bucher
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 41:125-7. 2013
    ..Toxicologic pathology has an important ongoing role in establishing the validity of this transformation, and may ultimately benefit as a discipline through an enhanced understanding of chemically induced disease mechanisms...
  2. ncbi request reprint Inhalation toxicity and carcinogenicity studies of cobalt sulfate
    J R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 49:56-67. 1999
    ..Adrenal pheochromocytomas were increased in female rats, and possibly in male rats...
  3. ncbi request reprint Human carcinogenic risk evaluation, Part V: The national toxicology program vision for assessing the human carcinogenic hazard of chemicals
    John R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:363-6. 2004
    ....
  4. ncbi request reprint The National Toxicology Program rodent bioassay: designs, interpretations, and scientific contributions
    John R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 22709, USA
    Ann N Y Acad Sci 982:198-207. 2002
    ..David P. Rall of the National Institute of Environmental Health Sciences for their foresight and wisdom in creating and nurturing these bioassay programs...
  5. pmc Current approaches toward chemical mixture studies at the National Institute of Environmental Health Sciences and the U.S. National Toxicology Program
    J R Bucher
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 106:1295-8. 1998
    ..Complementing these studies is an increased emphasis on physiologically based pharmacokinetic modeling, an activity central to the proper interpretation of chemical mixture studies...
  6. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated citral in rats and mice
    N B Ress
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:198-206. 2003
    ..However, the incidences were within the NTP historical control range and could not be clearly related to citral administration...
  7. pmc Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds"
    Nigel J Walker
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27705, USA
    Environ Health Perspect 113:43-8. 2005
    ..These data support the use of the TEF approach for dioxin cancer risk assessments...
  8. pmc Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats
    Nigel J Walker
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Natinal Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Nutr Food Res 50:934-44. 2006
    ..This may result from differences in the experimental protocols as well as divergence in the biological behavior of the different stocks of Sprague-Dawley rat strains used...
  9. ncbi request reprint A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen
    Nancy R Bordelon
    National Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    J Appl Toxicol 25:514-21. 2005
    ..The purpose of this article is to review the data developed for predicting the carcinogenicity of DAAB...
  10. pmc Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice
    Matthew D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:783-94. 2008
    ..These data suggest that in the initial study, H. hepaticusinfluenced the induction of hepatocellular neoplasms in males, but not in females...
  11. pmc alpha 2u-globulin nephropathy and renal tumors in national toxicology program studies
    Adriana M Doi
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:533-40. 2007
    ....
  12. pmc Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure
    Matthew D Stout
    Toxicology Operations Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 244:209-19. 2008
    ..Hepatocellular adenomas, and adenoma or carcinoma (combined) were increased in male and female mice exposed to 1800ppm. There were also treatment-related increases in multiple adenomas in both sexes...
  13. ncbi request reprint Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice
    N B Ress
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:287-96. 2003
    ..5 mg/m3 (dust) (National Institute for Occupational Safety and Health, NIOSH Pocket Guide to Chemical Hazards, U.S. Department of Health and Human Services, Washington, DC, 1997, p. 328)...
  14. ncbi request reprint Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice
    Michelle J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicology 204:123-40. 2004
    ..Treatment-related nonneoplastic lesions did not occur in mice. Treatment-related neoplastic lesions did not occur in rats or mice...
  15. ncbi request reprint Effects of glutaraldehyde in a 2-year inhalation study in rats and mice
    A P van Birgelen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina Battelle Pacific Northwest, Richland, Washington
    Toxicol Sci 55:195-205. 2000
    ..However, exposure to glutaraldehyde resulted in considerable non-neoplastic lesions in the noses of rats and mice...
  16. pmc Carcinogenesis studies of benzophenone in rats and mice
    M C Rhodes
    National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, United States
    Food Chem Toxicol 45:843-51. 2007
    ....
  17. ncbi request reprint Inhalation toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether in rats and mice
    Adriana M Doi
    National Institute of Environmental Health Sciences, 79 Alexander Dr, Mail Drop EC 34, Research Triangle Park, NC 27709, USA
    Toxicology 199:1-22. 2004
    ..Exposure to PGMBE also produced increases in hepatic tumors in male and female mice...
  18. pmc Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies
    Ronald L Melnick
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:130-5. 2008
    ..Pharmacokinetic models and mechanistic hypotheses may provide insights into the biological behavior of the agent; however, they must be adequately tested before being used to evaluate human cancer risk...
  19. ncbi request reprint 14-Week toxicity and cell proliferation of methyleugenol administered by gavage to F344 rats and B6C3F1 mice
    K M Abdo
    National Institute of Environmental Health Sciences, Research, Triangle Park, NC 27709, USA
    Food Chem Toxicol 39:303-16. 2001
    ..Based on mortality, body weight gain, clinical chemistry and gross and microscopic evaluation of tissues of rats and mice, the no-observed-effect level (NOEL) of methyleugenol for both species was estimated at 10 mg/kg...
  20. ncbi request reprint Toxicity characterization of environmental chemicals by the US National Toxicology Program: an overview
    Rajendra S Chhabra
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Hyg Environ Health 206:437-45. 2003
    ..These databases are available from the NTP web site (http://ntp-server.niehs.nih.gov) and are accessed over 100000 times a month from around the world...
  21. ncbi request reprint Influence of functional group substitutions on the carcinogenicity of anthraquinone in rats and mice: analysis of long-term bioassays by the National Cancer Institute and the National Toxicology Program
    Adriana M Doi
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health B Crit Rev 8:109-26. 2005
    ..Multiple amino substitutions diminished, while bromine substitutions enhanced the carcinogenicity induced by anthraquinone and extended the target organs to include forestomach and lung...
  22. pmc Toxicology. Transforming environmental health protection
    Francis S Collins
    National Human Genome Research Institute NHGRI, National Institutes of Health, Bethesda, MD 20892, USA
    Science 319:906-7. 2008
  23. pmc A 21st century paradigm for evaluating the health hazards of nanoscale materials?
    Nigel J Walker
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 110:251-4. 2009
    ....
  24. ncbi request reprint Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies
    J R Hailey
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:602-11. 1998
    ..hepaticus and that hepatitis may be important in the pathogenesis. Therefore, interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. hepaticus-associated hepatitis...
  25. ncbi request reprint Toxicity of 3,3',4,4'-tetrachloroazoxybenzene in rats and mice
    A P van Birgelen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 156:206-21. 1999
    ..No no-observed-adverse-effect level was reached in male or female rats or mice...
  26. ncbi request reprint Pharmacodynamic responses of F344 rats to the mouse hepatocarcinogen oxazepam in a 90-day feed study
    M L Cunningham
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 149:41-8. 1998
    ..These data indicate that the rat excretes oxazepam kinetically (rate and route) similar to humans, but the mouse produces metabolites similar to humans...
  27. ncbi request reprint Toxicology and carcinogenesis studies of p,p'-dichlorodiphenyl sulfone in rats and mice
    R S Chhabra
    National Institute of Environmental Health Sciences, 111 Alexander Drive, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 60:28-37. 2001
    ..A no-observed-adverse-effect level (NOAEL) of 30 ppm DDS in the diet (1.5 mg/kg body weight) was established for rats. DDS was not carcinogenic in these studies...
  28. ncbi request reprint Tg.AC genetically altered mouse: assay working group overview of available data
    W C Eastin
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27713 2233, USA
    Toxicol Pathol 29:60-80. 2001
    ..Based on the observed responses in these studies, it was concluded by the AWG that the Tg.AC model was not overly sensitive and possesses utility as an adjunct to the battery of toxicity studies used to establish human carcinogenic risk...
  29. pmc Carcinogenesis studies of cresols in rats and mice
    J M Sanders
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
    Toxicology 257:33-9. 2009
    ..However, given the minimal chemical-related neoplastic response in these studies, it was concluded that there was no clear evidence of carcinogenicity in male rats or female mice exposed to the cresol mixture...
  30. ncbi request reprint The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens
    W C Eastin
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233, USA
    Toxicol Pathol 26:461-73. 1998
    ....
  31. ncbi request reprint Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice
    M J Hooth
    National Institute of Environmental Health Sciences, Mail Drop EC 35, 79 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 42:1757-68. 2004
    ..Squamous cell papillomas and carcinomas of the forestomach were observed in male and female mice but the incidences were within the NTP historical control range and were not considered to be related to trans-cinnamaldehyde exposure...
  32. ncbi request reprint Toxicity of 3,3',4,4'-tetrachloroazobenzene in rats and mice
    A P van Birgelen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA
    Toxicol Appl Pharmacol 156:147-59. 1999
    ....
  33. pmc Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A
    Linda S Birnbaum
    National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1640-4. 2012
    ..However, research gaps have precluded a full understanding of the effects of BPA in humans and engendered controversies surrounding the chemical's potential toxicity...
  34. doi request reprint A new approach to synergize academic and guideline-compliant research: The CLARITY-BPA research program
    Thaddeus T Schug
    National Institute of Environmental Health Sciences National Institutes of Health, Division of Extramural Research, Research Triangle Park, NC 27709, United States Electronic address
    Reprod Toxicol 40:35-40. 2013
    ....
  35. ncbi request reprint Oral and dermal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cutaneous papillomas and squamous cell carcinomas in female hemizygous Tg.AC transgenic mice
    Michael E Wyde
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 82:34-45. 2004
    ..Differences in response between the routes of exposure may reflect pharmacokinetic differences in the delivery of TCDD to the skin over the duration of the study...
  36. doi request reprint Commentary: update on animal models for NTP studies
    Angela P King-Herbert
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences National Toxicology Program NIEHS NTP, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 38:180-1. 2010
    ..The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies...
  37. ncbi request reprint Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity
    Nancy B Ress
    National Institute of Environmental Health Sciences, 79 Alexander Drive, Mail Drop EC 34, Research Triangle Park, Triangle Park, NC 27709, USA
    Mutat Res 521:201-8. 2002
    ..The results are consistent with a prediction of carcinogenicity for DAAB...
  38. pmc Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review
    Kristina A Thayer
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:779-89. 2012
    ....
  39. ncbi request reprint Inhalation of tetranitromethane causes nasal passage irritation and pulmonary carcinogenesis in rodents
    J R Bucher
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Cancer Lett 57:95-101. 1991
    ..The extent of the lung tumor response, and the low concentrations of tetranitromethane required for this response, are unprecedented in National Toxicology Program (NTP) studies...
  40. ncbi request reprint Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice
    Burhan I Ghanayem
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 68:59-68. 2002
    ..This was also considered an equivocal result. In conclusion, these studies demonstrated that acrylonitrile causes multiple carcinogenic effects after gavage administration to male and female B6C3F1 mice for 2 years...
  41. ncbi request reprint Early changes in sex hormones are not evident in mice exposed to the uterine carcinogens chloroethane or bromoethane
    J R Bucher
    National Institute of Environmental Health Sciences, Mantech Inc, Research Triangle Park, North Carolina
    Toxicol Appl Pharmacol 130:169-73. 1995
    ..Thus, the findings suggest that early changes in circulating sex hormones are not important contributing factors in the uterine neoplasia caused by these chemicals...
  42. ncbi request reprint Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?
    J M Mathews
    Research Triangle Institute, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 146:255-60. 1997
    ..The increase in breath components observed following inhibition of CYP2E1 suggests that VOCs in breath can reflect the activity of that isozyme in vivo...
  43. ncbi request reprint Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1,2-dichloroethylene
    J M Mathews
    Research Triangle Institute, Research Triangle Park, North Carolina 27709, and National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 11:778-85. 1998
    ..DCE is an effective, relatively nontoxic inhibitor of P450 2E1 in vivo and in vitro that has greater selectivity than other agents currently used...
  44. ncbi request reprint A framework for human relevance analysis of information on carcinogenic modes of action
    M E Bette Meek
    Health Canada, Ottawa, Ontario, Canada
    Crit Rev Toxicol 33:591-653. 2003
    ..By providing a systematic approach to using MOA data, the HRF offers a new tool for the scientific community's overall effort to enhance the predictive power, reliability and transparency of cancer risk assessment...