Research Topics
| Susan K BuchananSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
A structural comparison of human serum transferrin and human lactoferrinJeremy Wally
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
Biometals 20:249-62. 2007..Comparison of the recently solved crystal structure of iron-free human serum transferrin to that of human lactoferrin provides insight into these differences...- Bacterial metal detectorsSusan K Buchanan
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Mol Microbiol 58:1205-9. 2005..The new structure extends our knowledge of transporter architecture and suggests how signalling may occur across the outer membrane... - Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein importSusan K Buchanan
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
EMBO J 26:2594-604. 2007..Functional data using full-length colicin Ia show that colicin I receptor is necessary for cell surface binding, and suggest that the receptor participates in translocation of colicin Ia across the outer membrane... - Structural insights into Ail-mediated adhesion in Yersinia pestisSatoshi Yamashita
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
Structure 19:1672-82. 2011..We also evaluated the contribution of laminin to delivery of Yops to HEp-2 cells. This work constitutes a structural description of how a bacterial outer membrane protein uses a multivalent approach to bind host cells... 
Structure of the OmpA-like domain of RmpM from Neisseria meningitidisSylvestre Grizot
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Mol Microbiol 51:1027-37. 2004....- Structural basis for iron piracy by pathogenic NeisseriaNicholas Noinaj
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 483:53-8. 2012..Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process... - Structural evidence for iron-free citrate and ferric citrate binding to the TonB-dependent outer membrane transporter FecAWyatt W Yue
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Biol 332:353-68. 2003.... - TonB-dependent transporters: regulation, structure, and functionNicholas Noinaj
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Microbiol 64:43-60. 2010..However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered... - Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosisJames W Fairman
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Structure 20:1233-43. 2012..We then use this set of sequences along with our structural data to find and map the evolutionarily constrained residues within the β domain... - Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporterTravis J Barnard
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD 20892, USA
J Mol Biol 415:128-42. 2012..Together, these findings provide insight into factors important for asparagine cyclization, a mechanism broadly used for protein cleavage... - Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factorsBenjamin E Brooks
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1778:1930-45. 2008..coli. Homologues from other Gram-negative bacteria suggest that these two signaling mechanisms and variations on these mechanisms may be the general schemes by which ECF sigma factors are regulated in Gram-negative bacteria... - Structural engineering of a phage lysin that targets gram-negative pathogensPetra Lukacik
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:9857-62. 2012.... - Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetaseNicholas Noinaj
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Bacteriol 194:499-508. 2012.... - The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor bindingJeremy Wally
NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:24934-44. 2006..In addition, we evaluate potential interactions between apo-hTF and the human transferrin receptor... - Autotransporter structure reveals intra-barrel cleavage followed by conformational changesTravis J Barnard
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Struct Mol Biol 14:1214-20. 2007.... - The structural biology of β-barrel membrane proteins: a summary of recent reportsJames W Fairman
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Curr Opin Struct Biol 21:523-31. 2011..However, they demonstrate many of the advancements made within the field of transmembrane protein structure in the past few years... - The crystal structure of BamB suggests interactions with BamA and its role within the BAM complexNicholas Noinaj
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
J Mol Biol 407:248-60. 2011..This may facilitate integration of newly synthesized OMPs into the outer membrane... - Crystallization of integral membrane proteinsTravis J Barnard
National Institutes of Health, Bethesda, Maryland, USA
Curr Protoc Protein Sci . 2007..These protocols were established for outer membrane proteins, but can be used for inner membrane proteins as well. Advice on alternative protocols, detergent selection, and optimization of crystallization conditions is provided... 
Using a bacteriocin structure to engineer a phage lysin that targets Yersinia pestisPetra Lukacik
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochem Soc Trans 40:1503-6. 2012..This work provides a template for engineering phage lysins against a wide variety of bacterial pathogens...- Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plagueB Joseph Hinnebusch
Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Infect Immun 79:4984-9. 2011..pestis F1 antigen. The Y. pestis Ail protein is an important bubonic plague virulence factor that inhibits the innate immune response, in particular the recruitment of a protective PMN response to the infected lymph node... - The transferrin-iron import system from pathogenic Neisseria speciesNicholas Noinaj
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Microbiol 86:246-57. 2012.... - Colicin biologyEric Cascales
Laboratoire d Ingenierie des Systemes Macromoleculaires, Institut de Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, UPR 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
Microbiol Mol Biol Rev 71:158-229. 2007..The mechanisms of inhibition by specific and cognate immunity proteins are presented. Finally, the use of colicins as laboratory or biotechnological tools and their mode of evolution are discussed... - Recognition of iron-free siderophores by TonB-dependent iron transportersIsabelle J Schalk
Département des Récepteurs et Protéines Membranaires, UPR 9050, CNRS, ESBS, Bld Sébastien Brant, F 67 400 Illkirch, Strasbourg, France
Mol Microbiol 54:14-22. 2004....