Affiliation: National Institutes of Health
Brzeska H, Hwang K, Korn E. Acanthamoeba myosin IC colocalizes with phosphatidylinositol 4,5-bisphosphate at the plasma membrane due to the high concentration of negative charge. J Biol Chem. 2008;283:32014-23 pubmed publisher
..In agreement with this, AMIC colocalizes with PIP2 at dynamic, protrusive regions of the plasma membrane. We discuss the possibility that AMIC binding to PIP2 may initiate the formation of a multiprotein complex at the plasma membrane. ..
Brzeska H, Guag J, Remmert K, Chacko S, Korn E. An experimentally based computer search identifies unstructured membrane-binding sites in proteins: application to class I myosins, PAKS, and CARMIL. J Biol Chem. 2010;285:5738-47 pubmed publisher
Brzeska H, Guag J, Preston G, Titus M, Korn E. Molecular basis of dynamic relocalization of Dictyostelium myosin IB. J Biol Chem. 2012;287:14923-36 pubmed publisher
..Motor activity is not essential, but the actin binding site in the head is important. Thus, dynamic relocalization of DMIB is determined principally by the local PIP(2)/PIP(3) concentration in the plasma membrane and cytoplasmic F-actin...