Paul Brown

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication
    P Brown
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3418-21. 2000
  2. ncbi request reprint Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Czechoslowacka Street 8 10 pl 92 216 Lodz, Poland
    Int J Biochem Cell Biol 36:2473-90. 2004
  3. ncbi request reprint The modern landscape of transfusion-related iatrogenic Creutzfeldt-Jakob disease and blood screening tests
    Paul Brown
    National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Hematol 11:351-6. 2004
  4. pmc Ultra-high-pressure inactivation of prion infectivity in processed meat: a practical method to prevent human infection
    Paul Brown
    National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:6093-7. 2003
  5. ncbi request reprint Drug therapy in human and experimental transmissible spongiform encephalopathy
    Paul Brown
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4122, USA
    Neurology 58:1720-5. 2002
  6. ncbi request reprint The pathogenesis of transmissible spongiform encephalopathy: routes to the brain and the erection of therapeutic barricades
    P Brown
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4122, USA
    Cell Mol Life Sci 58:259-65. 2001
  7. pmc Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns
    P Brown
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Emerg Infect Dis 7:6-16. 2001
  8. ncbi request reprint Iatrogenic Creutzfeldt-Jakob disease at the millennium
    P Brown
    Laboratory of CNS Studies, NINDS, NIH, Bethesda, MD 20892, USA
    Neurology 55:1075-81. 2000
  9. ncbi request reprint Fall-out from a possible transfusion-related transmission of vCJD
    Paul Brown
    National Institutes of Health, Bethesda, Maryland, USA
    Lancet Neurol 3:203. 2004
  10. ncbi request reprint Working with transmissible spongiform encephalopathy agents
    Paul Brown
    National Institutes of Health, Bethesda, Maryland, USA
    ILAR J 46:44-52. 2005

Collaborators

Detail Information

Publications57

  1. pmc New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication
    P Brown
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3418-21. 2000
    ..These results suggest that an inorganic molecular template with a decomposition point near 600 degrees C is capable of nucleating the biological replication of the scrapie agent...
  2. ncbi request reprint Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University Lodz, Czechoslowacka Street 8 10 pl 92 216 Lodz, Poland
    Int J Biochem Cell Biol 36:2473-90. 2004
    ..On a basis of ultrastructural studies, we suggest that autophagy plays a major role in transmissible spongiform encephalopathies (TSEs) and may even participate in a formation of spongiform change...
  3. ncbi request reprint The modern landscape of transfusion-related iatrogenic Creutzfeldt-Jakob disease and blood screening tests
    Paul Brown
    National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Hematol 11:351-6. 2004
    ....
  4. pmc Ultra-high-pressure inactivation of prion infectivity in processed meat: a practical method to prevent human infection
    Paul Brown
    National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:6093-7. 2003
    ....
  5. ncbi request reprint Drug therapy in human and experimental transmissible spongiform encephalopathy
    Paul Brown
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4122, USA
    Neurology 58:1720-5. 2002
    ..Also, very recent work in developing antibodies that can neutralize in vitro infection (and, in conjunction with genetic engineering, in vivo infection) has renewed interest in the strategies of both active and passive immunization...
  6. ncbi request reprint The pathogenesis of transmissible spongiform encephalopathy: routes to the brain and the erection of therapeutic barricades
    P Brown
    Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4122, USA
    Cell Mol Life Sci 58:259-65. 2001
    ..Possible modes and sites of therapeutic intervention are suggested...
  7. pmc Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution, and current concerns
    P Brown
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Emerg Infect Dis 7:6-16. 2001
    ..Government agencies in many countries continue to implement new measures to minimize this risk...
  8. ncbi request reprint Iatrogenic Creutzfeldt-Jakob disease at the millennium
    P Brown
    Laboratory of CNS Studies, NINDS, NIH, Bethesda, MD 20892, USA
    Neurology 55:1075-81. 2000
    ....
  9. ncbi request reprint Fall-out from a possible transfusion-related transmission of vCJD
    Paul Brown
    National Institutes of Health, Bethesda, Maryland, USA
    Lancet Neurol 3:203. 2004
  10. ncbi request reprint Working with transmissible spongiform encephalopathy agents
    Paul Brown
    National Institutes of Health, Bethesda, Maryland, USA
    ILAR J 46:44-52. 2005
    ..In this review, precautions and regulations concerning the handling of TSE agents are discussed in relation to personnel and environmental biosafety...
  11. ncbi request reprint Infectivity studies of both ash and air emissions from simulated incineration of scrapie-contaminated tissues
    Paul Brown
    Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, and Div of Environmental Protection, Office of Research Facilities Development and Operations, NIH, US Dept of HHS, Bethesda, MD 20892, USA
    Environ Sci Technol 38:6155-60. 2004
    ..The extent to which this result can be realized in actual incinerators and other combustion devices will depend on equipment design and operating conditions during the heating process...
  12. ncbi request reprint Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients
    James L Mills
    National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, 6100 Building Room 7B03, Bethesda, MD 20892, USA
    J Pediatr 144:430-6. 2004
    ..We investigated whether they were at increased risk of death from other conditions, particularly preventable conditions...
  13. ncbi request reprint Spontaneous mutations in the prion protein gene causing transmissible spongiform encephalopathy
    Ayush Dagvadorj
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 52:355-9. 2002
    ..We provide evidence that hereditary and apparently sporadic transmissible spongiform encephalopathy cases associated with the D178N mutation result from multiple recurrent mutational events...
  14. ncbi request reprint How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:141-7. 2002
    ..Finally, a large area of the cytoplasm was transformed into a collection of autophagic vacuoles of different sizes. Virtually identical alterations, albeit with much lower frequency, were seen in terminally ill CJD-affected hamsters...
  15. ncbi request reprint Pathological prion protein in muscles of hamsters and mice infected with rodent-adapted BSE or vCJD
    Achim Thomzig
    Robert Koch Institut P24 Transmissible Spongiform Encephalopathies, Berlin, Germany
    J Gen Virol 87:251-4. 2006
    ..Our findings emphasize the need for further assessment of possible public-health risks from TSE involvement of skeletal muscle...
  16. ncbi request reprint Advances in screening test development for transmissible spongiform encephalopathies
    Larisa Cervenakova
    American Red Cross Research and Development, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Expert Rev Anti Infect Ther 2:873-80. 2004
    ..However, the quest for a blood test is still in its infancy and requires extensive further research...
  17. ncbi request reprint Inactivation of transmissible spongiform encephalopathy agents in food products by ultra high pressure-temperature treatment
    Franco Cardone
    Degenerative and Inflammatory Neurological Diseases Unit, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochim Biophys Acta 1764:558-62. 2006
    ..These data indicate that the high pressure-temperature treatment is a ready-to-use and feasible strategy to reduce the risk of TSEs transmission via contaminated meat products...
  18. ncbi request reprint Novel methods for disinfection of prion-contaminated medical devices
    Guillaume Fichet
    CEA DSV DRM GIDTIP, Route du Panorama, 92265 Fontenay aux Roses, France
    Lancet 364:521-6. 2004
    ..In view of the widespread tissue distribution of the variant Creutzfeldt-Jakob disease agent in human beings, new practicable decontamination procedures are urgently needed...
  19. ncbi request reprint Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Acta Neurobiol Exp (Wars) 63:309-18. 2003
    ..An analogous network of narrow cisterns was seen to surround whole segments of the myelinated fibers...
  20. doi request reprint Tubulovesicular structures are a consistent (and unexplained) finding in the brains of humans with prion diseases
    Pawel P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, PL 92 216 Lodz, Poland
    Virus Res 132:226-8. 2008
    ..This study confirms the TSE-specificity of TVS, the morphology of which suggests a possible pathogenetic role and relationship to recently described virion-like arrays of 25nm particles in scrapie-infected tissue cultures...
  21. ncbi request reprint Variant CJD transmission through blood: risks to predictors and "predictees"
    Paul Brown
    Transfusion 43:425-7. 2003
  22. ncbi request reprint Transmissible spongiform encephalopathy update and implications for blood safety
    Maura N Ricketts
    World Health Organization, Room L412, Ave Appia, Geneva, Switzerland
    Clin Lab Med 23:129-37. 2003
    ..Surveillance of human TSEs and investigation of the risk of transfusion transmission must continue in order to provide further refinements in blood safety policy...
  23. ncbi request reprint Astrocytes in transmissible spongiform encephalopathies (prion diseases)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:71-88. 2004
    ..An interesting interaction between astrocytes and oligodendrocytes is discussed in detail as well as a particular form of astrocytic reaction in panencephalopathic form of TSEs...
  24. ncbi request reprint Gerstmann-Sträussler-Scheinker disease. II. An effect of GSS mutation on PRP structure
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland
    Folia Neuropathol 42:140-52. 2004
  25. ncbi request reprint Ultrastructural alterations in the optic nerve in transmissible spongiform encephalopathies or prion diseases--a review
    Anna Waliś
    Department of Neurology, Mikolaj Kopernik memorial Regional Multidisciplinary Hospital, Lodz, Poland
    Folia Neuropathol 42:153-60. 2004
    ..It is of special note that in the cytoplasm of several cells as well as the axoplasm numerous autophagic vacuoles were seen...
  26. ncbi request reprint Iatrogenic Creutzfeldt-Jakob disease: the waning of an era
    Paul Brown
    Neurology 67:389-93. 2006
    ..Therefore, at least in those countries in which variant CJD has occurred, precautionary measures must continue for the indefinite future...
  27. ncbi request reprint Infectious agent of sheep scrapie may persist in the environment for at least 16 years
    Gudmundur Georgsson
    Institute for Experimental Pathology, University of Iceland, Keldur v Vesturlandsveg, IS 112 Reykjavik, Iceland
    J Gen Virol 87:3737-40. 2006
    ..Epidemiological investigation established with near certitude that the disease had not been introduced from the outside and it is concluded that the agent may have persisted in the old sheep-house for at least 16 years...
  28. ncbi request reprint Subependymal plaques in scrapie-affected hamster brains--why are they so different from compact kuru plaques?
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 46:32-42. 2008
    ..Some microglial cells were observed in close contact with PrP-positive plaques, and secondary lysosomes within these cells were heavily decorated with gold particles...
  29. ncbi request reprint Clinical, neuropathological and immunohistochemical features of sporadic and variant forms of Creutzfeldt-Jakob disease in the squirrel monkey (Saimiri sciureus)
    Lawrence Williams
    Department of Veterinary Sciences, Michale E Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, TX, USA
    J Gen Virol 88:688-95. 2007
    ..Human strains of sCJD and vCJD cause distinguishable clinicopathological features in the squirrel monkey that can provide a baseline for the evaluation of future therapeutic studies...
  30. ncbi request reprint Role of a medical social worker in improving quality of life for patients with advanced cancer with a structured multidisciplinary intervention
    Janis J Miller
    Medial Social Services, Mayo Clinic, Rochester, MN 55905, USA
    J Psychosoc Oncol 25:105-19. 2007
    ..Outlined in this paper is the role of the medical social worker in a clinical trial, how education was provided and strategies for future interventions. doi:10.1300/J077v25n04_07...
  31. ncbi request reprint Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases
    Claire Larramendy-Gozalo
    CEA, IMETI SEPIA, 18 route du Panorama, BP6, 92265 Fontenay aux Roses Cedex, France
    J Gen Virol 88:1062-7. 2007
    ..These results show, once again, that anti-TSE drugs cannot be encouraged for human therapeutic trials solely on the basis of in vitro or ex vivo observations, but must first be subjected to in vivo animal studies...
  32. ncbi request reprint Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies)
    Paweł P Liberski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechosłowacka Str 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 46:1-25. 2008
    ..On the basis of ultrastructural studies, we suggest that autophagy may play a major role in transmissible spongiform encephalopathies and may even participate in the formation of spongiform change...
  33. pmc On the question of sporadic or atypical bovine spongiform encephalopathy and Creutzfeldt-Jakob disease
    Paul Brown
    Emerg Infect Dis 12:1816-21. 2006
    ....
  34. ncbi request reprint Trends in admissions to hospital involving an assault using a knife or other sharp instrument, England, 1997-2005
    Roy Maxwell
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, UK
    J Public Health (Oxf) 29:186-90. 2007
    ..Main outcome measure All completed hospital admissions with a mention of assault by sharp object (International Classification of Diseases, Tenth Revision, code X99) in the relevant diagnosis fields in HES...
  35. doi request reprint Transmissible spongiform encephalopathy in the 21st century: neuroscience for the clinical neurologist
    Paul Brown
    Neurology 70:713-22. 2008
  36. ncbi request reprint Divergent expression of cellular prion protein on blood cells of human and nonhuman primates
    Karel Holada
    Department of Immunology and Microbiology, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Transfusion 47:2223-32. 2007
    ..Nonhuman primates are the most relevant models of human prion diseases...
  37. ncbi request reprint Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc
    Monika Witusik
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, 8 10 Czechoslowacka str, Lodz, Poland
    Brain Res 1186:65-73. 2007
    ..Of note, glial and neuronal cells showed a very large heterogeneity of PrP(c) expression. Our results provide the basis for studying the role of PrP(c) in cell differentiation and neurogenesis from human GFAP-positive progenitor cells...
  38. ncbi request reprint Neuronal autophagy and aggresomes constitute a consistent part of neurodegeneration in experimental scrapie
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
    Folia Neuropathol 45:170-8. 2007
    ..In a few specimens there were round electron-dense structures that we identified as aggresomes. Aggresomes are not membrane-bound and were found in the cytoplasm of a few neurons...
  39. ncbi request reprint Detection of misfolded prion protein in blood with conformationally sensitive peptides
    Tao Pan
    Adlyfe Inc, 9430 Key West Avenue, Rockville, MD 20850, USA
    Transfusion 47:1418-25. 2007
    ....
  40. ncbi request reprint Will improvement in quality of life (QOL) impact fatigue in patients receiving radiation therapy for advanced cancer?
    Paul Brown
    Department of Oncology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Am J Clin Oncol 29:52-8. 2006
    ..In this project, we examined the impact that participation in a randomized controlled trial of a multidisciplinary intervention designed to impact overall QOL had on fatigue for advanced cancer patients actively receiving treatment...
  41. ncbi request reprint Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. I. Alterations of myelinated axons
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:121-9. 2002
    ..In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres...
  42. ncbi request reprint Distribution of codon 129 genotype in human growth hormone-treated CJD patients in France and the UK
    Jean Philippe Brandel
    National Reference Centre of Iatrogenic CJD, Salpetriere Hospital, 75651 Cedex 13, Paris, France
    Lancet 362:128-30. 2003
    ..There is no evident explanation for this different distribution, which might be due to infection with different strains of prion in human growth hormone...
  43. ncbi request reprint Temozolomide: too early for definitive conclusions
    Paul Brown
    J Clin Oncol 21:3710. 2003
  44. ncbi request reprint Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy
    Larisa Cervenakova
    Jerome H Holland Laboratory for the Biomedical Sciences, Red Cross, Rockville, MD 20855, USA
    Transfusion 43:1687-94. 2003
    ....
  45. ncbi request reprint Partitioning of human and sheep forms of the pathogenic prion protein during the purification of therapeutic proteins from human plasma
    Christopher J Stenland
    Department of Pathogen Safety Research, Bayer Biological Products, Research Triangle Park, North Carolina 27709, USA
    Transfusion 42:1497-500. 2002
    ..Sheep scrapie (PrP(Sc)) was similarly evaluated...
  46. ncbi request reprint Qualifications to the report of a new case of Creutzfeldt-Jakob disease in the recipient of a corneal transplant
    R Nick Hogan
    Dallas, Tex
    Arch Neurol 60:293-4; author reply 294. 2003
  47. ncbi request reprint Fate of myelinated fibres in the optic nerves in experimental Creutzfeldt-Jakob disease in rodents: an ultrastructural study
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland
    Folia Neuropathol 42:101-5. 2004
    ..This finding suggests that myelin lamellae participate in the formation of vacuoles...
  48. ncbi request reprint Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study
    Beata Sikorska
    Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland
    Int J Biochem Cell Biol 36:2563-73. 2004
    ..Autophagic vacuoles are formed in many synapses in all categories of human transmissible encephalopathies. We conclude that synaptic autophagy contributes to overall synaptic loss in brains affected in prion diseases...
  49. ncbi request reprint Prion diseases: from transmission experiments to structural biology--still searching for the cause
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Chair of Oncology, Medical University of Lodz
    Folia Neuropathol 42:15-32. 2004
  50. ncbi request reprint Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. II. Astrocytic and macrophage reaction towards axonal destruction
    Paweł P Liberski
    Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Medical Academy Łódź, Poland
    Acta Neurobiol Exp (Wars) 62:131-9. 2002
    ..Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae...
  51. ncbi request reprint A prion lexicon (out of control)
    Paul Brown
    Lancet 365:122. 2005
  52. ncbi request reprint BSE infection of the small short-lived primate Microcebus murinus
    Noëlle Bons
    Laboratoire de Neuromorphologie Fonctionnelle, EPHE, Universite Montpellier II, 34095 Montpellier, France
    C R Biol 325:67-74. 2002
    ....
  53. ncbi request reprint Risk of oral infection with bovine spongiform encephalopathy agent in primates
    Corinne Ida Lasmezas
    Commissariat à l Energie Atomique Direction des Sciences du Vivant Départment de Recherche Médicale, 18 route du Panorama, 92265 Fontenay aux Roses, France
    Lancet 365:781-3. 2005
    ....
  54. ncbi request reprint Effect of protease treatment on plasma infectivity in variant Creutzfeldt-Jakob disease mice
    Oksana Yakovleva
    Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    Transfusion 44:1700-5. 2004
    ..This study was initiated to explain why attempts to identify protease-resistant prion protein (PrPres) following treatment with proteinase K (PK) in blood or blood components have so far failed...
  55. ncbi request reprint Removal of exogenous (spiked) and endogenous prion infectivity from red cells with a new prototype of leukoreduction filter
    Samuel Sowemimo-Coker
    Pall Medical, Pall Corp, Port Washington, New York 11050, USA
    Transfusion 45:1839-44. 2005
    ..In the absence of a preclinical screening test, removal of the infectious agent by processing is the only means by which risk to recipients of blood from donors with inapparent vCJD infections can be eliminated...
  56. ncbi request reprint Impacting quality of life for patients with advanced cancer with a structured multidisciplinary intervention: a randomized controlled trial
    Teresa A Rummans
    Department of Psychiatry and Psychology, Mayo Clinic Cancer Center, and Medical Social Services, Mayo Clinic, Rochester MN 55905, USA
    J Clin Oncol 24:635-42. 2006
    ....
  57. ncbi request reprint Failure of immunocompetitive capillary electrophoresis assay to detect disease-specific prion protein in buffy coat from humans and chimpanzees with Creutzfeldt-Jakob disease
    Larisa Cervenakova
    Plasma Derivatives Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
    Electrophoresis 24:853-9. 2003
    ..Thus, the ICCE assay as presently performed is not suitable for use as a screening test in human transmissible spongiform encephalopathies (TSEs)...