K K Brown

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi Neutrophil-platelet adhesion: relative roles of platelet P-selectin and neutrophil beta2 (DC18) integrins
    K K Brown
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver 80206, USA
    Am J Respir Cell Mol Biol 18:100-10. 1998
  2. ncbi Medical treatment for pulmonary fibrosis: current trends, concepts, and prospects
    Kevin K Brown
    Interstitial Lung Disease Program, National Jewish Medical and Research Center, Denver, CO, USA
    Clin Chest Med 25:759-72, vii. 2004
  3. ncbi Rheumatoid lung disease
    Kevin K Brown
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Proc Am Thorac Soc 4:443-8. 2007
  4. ncbi Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis
    Harold R Collard
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 1400 Jackson Street, Room F107, Denver, CO 80206, USA
    Am J Respir Crit Care Med 168:538-42. 2003
  5. ncbi Chronic cough due to chronic interstitial pulmonary diseases: ACCP evidence-based clinical practice guidelines
    Kevin K Brown
    National Jewish Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:180S-185S. 2006
  6. ncbi Chronic cough due to nonbronchiectatic suppurative airway disease (bronchiolitis): ACCP evidence-based clinical practice guidelines
    Kevin K Brown
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:132S-137S. 2006
  7. ncbi Pulmonary vasculitis
    Kevin K Brown
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:48-57. 2006
  8. ncbi Acute interstitial pneumonitis. Case series and review of the literature
    J S Vourlekis
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, F107, Denver, CO 80206, USA
    Medicine (Baltimore) 79:369-78. 2000
  9. ncbi Respiratory bronchiolitis-interstitial lung disease: long-term outcome
    Joshua Portnoy
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 131:664-71. 2007
  10. ncbi Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation
    J A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 164:2151-9. 2000

Research Grants

  1. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Kevin Brown; Fiscal Year: 2007

Collaborators

Detail Information

Publications90

  1. ncbi Neutrophil-platelet adhesion: relative roles of platelet P-selectin and neutrophil beta2 (DC18) integrins
    K K Brown
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver 80206, USA
    Am J Respir Cell Mol Biol 18:100-10. 1998
    ....
  2. ncbi Medical treatment for pulmonary fibrosis: current trends, concepts, and prospects
    Kevin K Brown
    Interstitial Lung Disease Program, National Jewish Medical and Research Center, Denver, CO, USA
    Clin Chest Med 25:759-72, vii. 2004
    ..The necessary, and desperately needed, next generation of therapies, focused on specific molecular targets thought to play pivotal roles in the development and progression of fibrosis, are under active investigation...
  3. ncbi Rheumatoid lung disease
    Kevin K Brown
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Proc Am Thorac Soc 4:443-8. 2007
    ..The impact of historically available and newer biologic therapies in altering the outcome of RA-ILD is unknown; translational studies focused on the pathobiology and clinical studies focused on the treatment of RA-ILD are needed...
  4. ncbi Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis
    Harold R Collard
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, 1400 Jackson Street, Room F107, Denver, CO 80206, USA
    Am J Respir Crit Care Med 168:538-42. 2003
    ..Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone...
  5. ncbi Chronic cough due to chronic interstitial pulmonary diseases: ACCP evidence-based clinical practice guidelines
    Kevin K Brown
    National Jewish Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:180S-185S. 2006
    ..To review the role of chronic interstitial pulmonary disease in the spectrum of causes of cough and its management...
  6. ncbi Chronic cough due to nonbronchiectatic suppurative airway disease (bronchiolitis): ACCP evidence-based clinical practice guidelines
    Kevin K Brown
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:132S-137S. 2006
    ..To review the role of nonbronchiectatic suppurative airway disease (bronchiolitis) in the spectrum of causes of cough and its management...
  7. ncbi Pulmonary vasculitis
    Kevin K Brown
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Am Thorac Soc 3:48-57. 2006
    ..In this article, we focus on the more common, antineutrophil cytoplasmic antibody-associated disorder, vasculitides...
  8. ncbi Acute interstitial pneumonitis. Case series and review of the literature
    J S Vourlekis
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson Street, F107, Denver, CO 80206, USA
    Medicine (Baltimore) 79:369-78. 2000
    ..Likewise, there were no features that predicted the longitudinal course in survivors. Further study to identify causal factors is required in the hope of preventing morbidity and mortality related to this disease...
  9. ncbi Respiratory bronchiolitis-interstitial lung disease: long-term outcome
    Joshua Portnoy
    National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 131:664-71. 2007
    ..In this study, we sought to determine the outcome of RB-ILD patients with and without smoking cessation and with and without corticosteroid therapy...
  10. ncbi Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation
    J A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 164:2151-9. 2000
    ....
  11. ncbi BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
    Talmadge E King
    Department of Medicine, UCSF, 505 Parnassus Avenue, Room M994, San Francisco, CA 94110, USA
    Am J Respir Crit Care Med 177:75-81. 2008
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease lacking effective treatment...
  12. ncbi Interferon-gamma for delayed pulmonary toxicity syndrome resistant to steroids
    B T Suratt
    Department of Medicine, School of Medicine, University of Colorado, Denver, CO 80262, USA
    Bone Marrow Transplant 31:939-41. 2003
    ..We report the symptomatic and physiological improvement of a patient with severe steroid-resistant delayed pulmonary toxicity syndrome, following treatment with interferon-gamma...
  13. ncbi Lung diseases in patients with common variable immunodeficiency: chest radiographic, and computed tomographic findings
    Nobuyuki Tanaka
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO, USA
    J Comput Assist Tomogr 30:828-38. 2006
    ..CONCLUSIONS: Common variable immunodeficiency is associated with 3 major CT patterns: airway disease, nodules, and parenchymal opacification...
  14. ncbi Rheumatoid arthritis-related lung diseases: CT findings
    Nobuyuki Tanaka
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Radiology 232:81-91. 2004
    ..To evaluate computed tomographic (CT) findings of rheumatoid arthritis-related lung disease and categorize findings according to pathologic features...
  15. ncbi Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis
    Gregory P Cosgrove
    Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center and Program in Cell Biology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado CO 80206, USA
    Am J Respir Crit Care Med 170:242-51. 2004
    ..Using 3T3-L1 fibroblasts and human lung fibroblasts, we showed that PEDF was indeed a TGF-beta 1 target gene. Collectively, our findings implicate PEDF as a regulator of pulmonary angiogenesis and an important mediator in IPF...
  16. ncbi Pulmonary fibrosis is associated with an elevated risk of thromboembolic disease
    D B Sprunger
    Interstitial Lung Disease Program and Autoimmune Lung Center, Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO 80220, USA
    Eur Respir J 39:125-32. 2012
    ..Those with VTE and pulmonary fibrosis died at a younger age than those with pulmonary fibrosis alone. These data suggest a link between a pro-fibrotic and a pro-coagulant state...
  17. ncbi High-resolution CT features of severe asthma and bronchiolitis obliterans
    S P Jensen
    National Jewish Medical and Research Center, 1400 Jackson Street, Room A011, Denver, Colorado 80206, USA
    Clin Radiol 57:1078-85. 2002
    ..0006). CONCLUSIONS: Mosaic pattern of attenuation, when present, is highly suggestive of BO, but SA and BO may be indistinguishable...
  18. ncbi Anti-synthetase syndrome in ANA and anti-Jo-1 negative patients presenting with idiopathic interstitial pneumonia
    Aryeh Fischer
    National Jewish Health, Interstitial and Autoimmune Lung Disease Program, Denver, CO 80206, United States
    Respir Med 103:1719-24. 2009
    ..To describe the clinical features of patients presenting with "idiopathic" interstitial pneumonia that were diagnosed with anti-synthetase syndrome based on clinical features and positive anti-PL-7 or PL-12 antibodies...
  19. ncbi Unique characteristics of systemic sclerosis sine scleroderma-associated interstitial lung disease
    Aryeh Fischer
    Division of Rheumatology, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 130:976-81. 2006
    ..To describe the characteristics of systemic sclerosis sine scleroderma (ssSSc)-associated interstitial lung disease (ILD) presenting as idiopathic interstitial pneumonia (IIP)...
  20. ncbi Chronic hypersensitivity pneumonitis: CT features comparison with pathologic evidence of fibrosis and survival
    Hakan Sahin
    Department of Radiology, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Radiology 244:591-8. 2007
    ....
  21. ncbi Anti-th/to-positivity in a cohort of patients with idiopathic pulmonary fibrosis
    Aryeh Fischer
    Division of Rheumatology and the Interstitial Lung Disease Program, National Jewish Medical and Research Center, NJMRC, Denver, Colorado 80206, USA
    J Rheumatol 33:1600-5. 2006
    ..To evaluate the presence and clinical relevance of anti-Th/To-positivity in patients with idiopathic pulmonary fibrosis (IPF)...
  22. ncbi Pericardial abnormalities predict the presence of echocardiographically defined pulmonary arterial hypertension in systemic sclerosis-related interstitial lung disease
    Aryeh Fischer
    Division of Rheumatology, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206
    Chest 131:988-92. 2007
    ..To determine the prevalence and significance of pericardial abnormalities in systemic sclerosis (SSc)-related interstitial lung disease (ILD)...
  23. ncbi Mycophenolate mofetil is safe, well tolerated, and preserves lung function in patients with connective tissue disease-related interstitial lung disease
    Jeffrey J Swigris
    Autoimmune Kung Center, Interstitial Lung Disease Program, National Jewish Medical and Research Center, 1400 Jackson St, Molly Blank J229, Denver, CO 80206, USA
    Chest 130:30-6. 2006
    ..In this study, our objectives were to examine the safety and tolerability of mycophenolate mofetil (MMF) and to determine its impact on lung function in patients with CTD-ILD...
  24. ncbi Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 125:2169-74. 2004
    ....
  25. ncbi Clinically significant interstitial lung disease in limited scleroderma: histopathology, clinical features, and survival
    Aryeh Fischer
    Autoimmune Lung Disease Center, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Chest 134:601-5. 2008
    ..To evaluate the pathologic patterns, clinical features, and survival among subjects with scleroderma (ie, systemic sclerosis [SSc]) and clinically significant interstitial lung disease (ILD) evaluated at an ILD center...
  26. ncbi Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation
    Jai Soung Park
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Comput Assist Tomogr 26:13-20. 2002
    ..These radiologic features, in patients with a history of heavy cigarette smoking, may differentiate RB-ILD from other interstitial lung diseases...
  27. ncbi Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    R William Vandivier
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 109:661-70. 2002
    ..Therefore, defective airway clearance of apoptotic cells in cystic fibrosis and bronchiectasis may be due to elastase-mediated cleavage of phosphatidylserine receptor on phagocytes and may contribute to ongoing airway inflammation...
  28. ncbi Development of the ATAQ-IPF: a tool to assess quality of life in IPF
    Jeffrey J Swigris
    Autoimmune Lung Center and Interstitial Lung Disease Program, National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA
    Health Qual Life Outcomes 8:77. 2010
    ..There is no disease-specific instrument to assess health-related quality of life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF)...
  29. ncbi Overexpression of matrix metalloproteinase-7 in pulmonary fibrosis
    Gregory P Cosgrove
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 121:25S-26S. 2002
  30. ncbi Nonspecific interstitial pneumonitis as the sole histologic expression of hypersensitivity pneumonitis
    Jason S Vourlekis
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Med 112:490-3. 2002
  31. ncbi Evaluation of bosentan for idiopathic pulmonary fibrosis
    Jeffrey J Swigris
    Assistant Professor of Medicine, Interstitial Lung Disease Program, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO, USA
    Expert Rev Respir Med 2:315-21. 2008
    ..Results from this trial are anticipated in 2009...
  32. ncbi Assessing dyspnea and its impact on patients with connective tissue disease-related interstitial lung disease
    Jeffrey J Swigris
    National Jewish Health, Denver, CO 80206, USA
    Respir Med 104:1350-5. 2010
    ..Dyspnea is the cardinal symptom in patients with any type of interstitial lung disease (ILD); however, there are limited data on dyspnea among patients with connective tissue disease-related ILD (i.e., CTD-ILD)...
  33. ncbi The role of endothelin-1 in the pathogenesis of idiopathic pulmonary fibrosis
    Jeffrey J Swigris
    Interstitial Lung Disease Program, National Jewish Health, Denver, Colorado 80206, USA
    BioDrugs 24:49-54. 2010
    ..Initial results from a trial examining the efficacy of a dual endothelin receptor antagonist suggest that this approach may delay disease progression in a subset of patients with IPF...
  34. ncbi The SF-36 and SGRQ: validity and first look at minimum important differences in IPF
    Jeffrey J Swigris
    Interstitial Lung Disease Program in the Autoimmune Lung Center and Division of Psychosocial Medicine, National Jewish Health, Denver, CO, USA
    Respir Med 104:296-304. 2010
    ..Health-related quality of life (HRQL) is an important outcome in drug trials. Little is known about how the Short Form-36 (SF-36) and Saint George's Respiratory Questionnaire (SGRQ) perform in idiopathic pulmonary fibrosis (IPF)...
  35. ncbi Heart rate recovery after 6-min walk test predicts survival in patients with idiopathic pulmonary fibrosis
    Jeffrey J Swigris
    Interstitial Lung Disease Program and Autoimmune Lung Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 136:841-8. 2009
    ....
  36. ncbi Pulmonary and thrombotic manifestations of systemic lupus erythematosus
    Jeffrey J Swigris
    Autoimmune Lung Disease Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 133:271-80. 2008
    ..This article offers the reader a comprehensive review of the numerous pulmonary and thrombotic manifestations of SLE and suggests approaches to their management...
  37. ncbi Pulmonary rehabilitation in idiopathic pulmonary fibrosis: a call for continued investigation
    Jeffrey J Swigris
    Autoimmune Lung Center, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Respir Med 102:1675-80. 2008
    ..Pulmonary rehabilitation helps to accomplish many of these goals in patients with chronic obstructive pulmonary disease, and emerging data suggest that it may do the same for patients with IPF...
  38. ncbi Exercise peripheral oxygen saturation (SpO2) accurately reflects arterial oxygen saturation (SaO2) and predicts mortality in systemic sclerosis
    J J Swigris
    Interstitial Lung Disease Program and Autoimmune Lung Center, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Thorax 64:626-30. 2009
    ..Measures of oxygenation have not been assessed for prognostic significance in systemic sclerosis-related interstitial lung disease (SSc-ILD)...
  39. ncbi Minor salivary gland biopsy to detect primary Sjogren syndrome in patients with interstitial lung disease
    Aryeh Fischer
    Autoimmune and Interstitial Lung Disease Program, Department of Medicine, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA
    Chest 136:1072-8. 2009
    ..To describe a cohort of patients who presented with interstitial lung disease (ILD) of unknown cause, features of primary Sjögren syndrome (pSS), and a positive minor salivary gland biopsy (MSGB)...
  40. ncbi Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis
    Brent W Kinder
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Chest 133:226-32. 2008
    ..We hypothesized that baseline BAL fluid cell count differential (ie, elevated levels of neutrophils and eosinophils, or reduced levels of lymphocytes) would predict higher mortality among persons with IPF...
  41. ncbi Systemic sclerosis-associated interstitial lung disease-proposed recommendations for future randomized clinical trials
    Dinesh Khanna
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Clin Exp Rheumatol 28:S55-62. 2010
    ..Recent investigations into the pathogenesis of SSc-ILD have led to a renewed interest in assessing targeted therapies in SSc-ILD. With this in mind, we propose recommendations for the design of future SSc-ILD studies in this review...
  42. ncbi A 63-year-old man with a persistent pulmonary infiltrate and pleural effusion
    Amy L Olson
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, CO 80262, USA
    Chest 130:1929-34. 2006
  43. ncbi Acute interstitial pneumonia and acute exacerbations of idiopathic pulmonary fibrosis
    Jeffrey J Swigris
    Pulmonary and Critical Care Medicine Division, National Jewish Medical and Research Center, Denver, Colorado 80203, USA
    Semin Respir Crit Care Med 27:659-67. 2006
    ..Survivors of the acute event can recover to their previous baseline; however, most AIP survivors will stabilize with some functional impairment, whereas in those with AEIPF, progressive fibrosis with functional deterioration is the rule...
  44. ncbi Challenges in pulmonary fibrosis. 3: Cystic lung disease
    Gregory P Cosgrove
    National Jewish Medical and Research Center, 1400 Jackson Street, F107, Denver, Colorado 80206, USA
    Thorax 62:820-29. 2007
    ....
  45. ncbi Clinical and pathologic features of familial interstitial pneumonia
    Mark P Steele
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 172:1146-52. 2005
    ..Several lines of evidence suggest that genetic factors and environmental exposures play a role in the development of pulmonary fibrosis...
  46. ncbi High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis
    David A Lynch
    Department of Radiology, and Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box A030, Room 2233 Denver, CO 80262, USA
    Am J Respir Crit Care Med 172:488-93. 2005
    ..High-resolution computed tomography (HRCT) is an integral aspect of the evaluation of patients with suspected idiopathic pulmonary fibrosis (IPF). However, few studies have evaluated its use in a large cohort...
  47. ncbi Organizing pneumonia: prognostic implication of high-resolution computed tomography features
    Jin Seong Lee
    Department of Radiology, Health Sciences Center, University of Colorado School of Medicine, Denver, CO 80262, USA
    J Comput Assist Tomogr 27:260-5. 2003
    ..02). CONCLUSION: In patients with OP, the CT finding of consolidation is associated with partial or complete resolution, whereas reticular opacity is associated with persistent or progressive disease...
  48. ncbi Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex
    R William Vandivier
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine and Pathology, University of Colorado Health Sciences Center, nd Denver, CO, USA
    J Immunol 169:3978-86. 2002
    ....
  49. ncbi Clinical trials and tribulations--lessons from pulmonary fibrosis
    A L Olson
    Department of Medicine, National Jewish Health, 1400 Jackson St, Denver, CO 80401, USA
    QJM 105:1043-7. 2012
    ..Clinically meaningful events such as hospitalization can also provide important efficacy information. The use of non-validated surrogate endpoints as primary outcome measures often leads to uncertainty when interpreting trial results...
  50. ncbi Small vessel vasculitis of the lung
    S K Frankel
    Interstitial Lung Disease Program, National Jewish Medical and Research Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Chron Respir Dis 2:75-84. 2005
    ..The recent completion of a number of randomized, controlled, multicenter clinical trials has greatly improved our knowledge base and ability to care for vasculitis patient. The next decade holds even more promise...
  51. ncbi Organizing pneumonia and lymphoplasmacytic inflammation predict treatment response in idiopathic pulmonary fibrosis
    H R Collard
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Histopathology 50:258-65. 2007
    ..To identify individual histopathological features within usual interstitial pneumonia pattern that predict responsiveness to immunosuppressive therapy...
  52. ncbi Fibroblast foci are not discrete sites of lung injury or repair: the fibroblast reticulum
    Carlyne D Cool
    Departments of Medicine and Pathology, University of Colorado Health Sciences Center; and Interstitial Lung Disease Program, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 174:654-8. 2006
    ..CONCLUSIONS: The fibroblast foci of UIP are the leading edge of a complex reticulum that is highly interconnected and extends from the pleura into the underlying parenchyma. It is a reactive, rather than a malignant, process...
  53. ncbi Nonspecific interstitial pneumonia: radiologic, clinical, and pathologic considerations
    Seth J Kligerman
    Department of Radiology, National Jewish Medical and Research Center, 1400 S Jackson St, Denver, CO 80206, USA
    Radiographics 29:73-87. 2009
    ....
  54. ncbi Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis
    Talmadge E King
    Department of Medicine, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA 94110, USA
    Chest 127:171-7. 2005
    ..Idiopathic pulmonary fibrosis (IPF) is a devastating disease, yet validated, reliable criteria for evaluating patient response to therapies in clinical trials are lacking...
  55. ncbi Acute exacerbations of fibrotic hypersensitivity pneumonitis: a case series
    Amy L Olson
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, CO 80262, USA
    Chest 134:844-50. 2008
    ..While best described in patients with IPF, they have also been reported in patients with other forms of interstitial lung disease. We sought to determine if this same phenomenon occurs in patients with hypersensitivity pneumonitis (HP)...
  56. ncbi A detailed evaluation of acute respiratory decline in patients with fibrotic lung disease: aetiology and outcomes
    Tristan J Huie
    University of Colorado Denver, Division of Pulmonary Sciences and Critical Care Medicine, Aurora, Colorado 80045, USA
    Respirology 15:909-17. 2010
    ..A comprehensive diagnostic evaluation is recommended for all patients with fibrotic lung disease and acute respiratory decompensation. However, the effect on clinical outcomes of this evaluation remains unknown...
  57. ncbi The 6 minute walk in idiopathic pulmonary fibrosis: longitudinal changes and minimum important difference
    Jeffrey J Swigris
    Interstitial Lung Disease Program and Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Thorax 65:173-7. 2010
    ....
  58. ncbi Update in the diagnosis and management of pulmonary vasculitis
    Stephen K Frankel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Chest 129:452-65. 2006
    ..However, for the purpose of this review, we will focus on the ANCA-associated vasculitides...
  59. ncbi Diffuse pulmonary neuroendocrine cell hyperplasia: radiologic and clinical features
    Jin Seong Lee
    Department of Radiology, Health Sciences Center, University of Colorado School of Medicine, Denver, CO, USA
    J Comput Assist Tomogr 26:180-4. 2002
    ..The purpose of this study was to define the radiologic features of pulmonary neuroendocrine cell hyperplasia and correlate them with clinical findings...
  60. ncbi Obliterative bronchiolitis: varying presentations and clinicopathological correlation
    K D Markopoulo
    Dept of Pathology, University of Colorado Health Sciences Center, Denver, USA
    Eur Respir J 19:20-30. 2002
    ..No correlation was observed between the degree of bronchiolar fibrosis and the degree of airflow limitation...
  61. ncbi Seasonal variation: mortality from pulmonary fibrosis is greatest in the winter
    Amy L Olson
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 136:16-22. 2009
    ..Our objective was to determine if mortality rates from IPF and/or PF of any cause exhibit seasonal variation...
  62. ncbi Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly
    Michael B Fessler
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Respirology 9:274-7. 2004
    ..To our knowledge, this is the first report of acromegaly associated with IDHPNC, and supports the possibility that IDHPNC may fall at one extreme of the spectrum of disorders encountered in multiple endocrine neoplasia type 1...
  63. ncbi Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis
    Seung Ick Cha
    Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 42:140-8. 2010
    ....
  64. ncbi Collagen vascular disease-related lung disease: high-resolution computed tomography findings based on the pathologic classification
    Nobuyuki Tanaka
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO, USA
    J Comput Assist Tomogr 28:351-60. 2004
    ..Although high-resolution computed tomography (HRCT) findings of lung disease are often nonspecific, there are some characteristic HRCT findings for some lung diseases based on pathologic findings...
  65. ncbi Computed tomographic features of idiopathic fibrosing interstitial pneumonia: comparison with pulmonary fibrosis related to collagen vascular disease
    Jeong Hwa Hwang
    Department of Radiology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Comput Assist Tomogr 33:410-5. 2009
    ..To compare the computed tomographic (CT) features of idiopathic fibrosing interstitial pneumonia with those of pulmonary fibrosis related to collagen vascular disease (CVD)...
  66. ncbi Connective tissue disease-associated interstitial lung disease: a call for clarification
    Aryeh Fischer
    Division of Rheumatology, National Jewish Health and University of Colorado, Denver, CO 80206, USA
    Chest 138:251-6. 2010
    ....
  67. ncbi Expression of human herpesvirus 8 in primary pulmonary hypertension
    Carlyne D Cool
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 349:1113-22. 2003
    ..Our data suggest that infection with the vasculotropic virus HHV-8 may have a pathogenetic role in primary pulmonary hypertension...
  68. ncbi Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity
    Stephen K Frankel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Chest 126:2007-13. 2004
    ..In this report, we characterize the clinical, radiographic, physiologic, and pathologic findings of this entity, which we term idiopathic pleuroparenchymal fibroelastosis...
  69. ncbi Human lung project: evaluating variance of gene expression in the human lung
    Michael P Gruber
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 35:65-71. 2006
    ..The generation of this robust dataset has important implications for the design and implementation of future comparative expression analysis with pulmonary disease states...
  70. ncbi Idiopathic pulmonary fibrosis: a decade of progress
    Jeffrey J Swigris
    Interstitial Lung Disease Program, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Bras Pneumol 32:249-60. 2006
    ..This article offers the reader a view of the recent advances in idiopathic pulmonary fibrosis research, with a focus on natural history, pathogenesis and treatment...
  71. ncbi Possible role of human herpesvirus 8 in the lymphoproliferative disorders in common variable immunodeficiency
    William H Wheat
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Exp Med 202:479-84. 2005
    ..HHV8 infection may be an important factor in the pathogenesis of the interstitial lung disease and lymphoproliferative disorders in patients with CVID...
  72. ncbi Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway
    Ramarao Vepachedu
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 179:682-90. 2007
    ..Taken together, our results suggest that Unc119 plays an important role in fibrotic processes through myofibroblast differentiation...
  73. ncbi Acute exacerbations of idiopathic pulmonary fibrosis
    Harold R Collard
    Department of Medicine, San Francisco General Hospital, University of California, USA
    Am J Respir Crit Care Med 176:636-43. 2007
    ..The potential pathobiological roles of infection, disordered cell biology, coagulation, and genetics are discussed, and future research directions are proposed...
  74. ncbi Prognosis in idiopathic pulmonary fibrosis
    Gabriel Thabut
    Am J Respir Crit Care Med 169:1075-6; author reply 1076. 2004
  75. ncbi Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT
    C Isabela S Silva
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 3350 950 W 10th Ave, Vancouver, BC, Canada V5Z 4E3
    Radiology 246:288-97. 2008
    ....
  76. ncbi Gene expression profiling of familial and sporadic interstitial pneumonia
    Ivana V Yang
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, P O Box 12233, MD B3 08, Research Triangle Park, NC 27909, USA
    Am J Respir Crit Care Med 175:45-54. 2007
    ..Both the genetics and the histologic type of IIP play a role in the etiology and pathogenesis of interstitial lung disease, but transcriptional signatures of these subtypes are unknown...
  77. ncbi Classifying interstitial lung disease: remembrance of things past
    Kevin K Brown
    Chest 130:1289-91. 2006
  78. ncbi Interstitial lung disease: clinical evaluation and keys to an accurate diagnosis
    Ganesh Raghu
    Departments of Medicine and Laboratory Medicine, University of Washington Medical Center, 1959 East Pacific, Campus Box 356522, Seattle, WA 91895 6522, USA
    Clin Chest Med 25:409-19, v. 2004
    ..This article discusses the importance and essentials of clinical evaluation and keys to an accurate diagnosis of interstitial lung disease...
  79. ncbi Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project
    William D Travis
    Attending Thoracic Pathologist, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Respir Crit Care Med 177:1338-47. 2008
    ..Concern was expressed that NSIP was a "wastebasket" category, difficult to distinguish from other idiopathic interstitial pneumonias...
  80. ncbi High-resolution computed tomography features of nonspecific interstitial pneumonia and usual interstitial pneumonia
    Tracy L Elliot
    Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada
    J Comput Assist Tomogr 29:339-45. 2005
    ..The presence of predominant ground-glass and reticular opacity is highly characteristic of NSIP, but there is a subset of patients with UIP who have this pattern and may require biopsy for differentiation from NSIP...
  81. ncbi The effect of pulmonary fibrosis on survival in patients with hypersensitivity pneumonitis
    Jason S Vourlekis
    Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Med 116:662-8. 2004
    ..01; 95% confidence interval: 1.68 to 21.45; P = 0.006). CONCLUSION: Pulmonary fibrosis is associated with diminished survival in patients with hypersensitivity pneumonitis...
  82. ncbi Radiologic and pathologic features of bronchiolitis
    Sudhakar J Pipavath
    Department of Radiology, University of Washington, Seattle, WA, USA
    AJR Am J Roentgenol 185:354-63. 2005
    ..When high-resolution CT features overlap, clinical details will usually help to narrow the differential diagnosis...
  83. ncbi A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Ganesh Raghu
    Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
    N Engl J Med 350:125-33. 2004
    ..Idiopathic pulmonary fibrosis is a progressive, fatal disease with no known efficacious therapy...
  84. ncbi The clinical course of patients with idiopathic pulmonary fibrosis
    Fernando J Martinez
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann Intern Med 142:963-7. 2005
    ..Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse...
  85. ncbi Familial pulmonary fibrosis in the United States
    Momen M Wahidi
    Duke University Medical Center, Durham, NC 27710, USA
    Chest 121:30S. 2002
  86. ncbi The spectrum of scleroderma lung disease
    Kristin B Highland
    Division of Pulmonary Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Semin Respir Crit Care Med 28:418-29. 2007
    ..For each manifestation we outline the current knowledge of etiology, risk factors, diagnosis, treatment, and prognosis. We also discuss the current state of lung transplantation in this population...
  87. ncbi TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis
    Stephen K Frankel
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 34:293-304. 2006
    ....
  88. ncbi Genetic predisposition to respiratory diseases: infiltrative lung diseases
    Mark P Steele
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Respiration 74:601-8. 2007
    ..Further insight into these areas may lead to new therapeutic interventions...
  89. ncbi The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment
    Jay H Ryu
    Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 173:105-11. 2006
    ..Previous descriptions of clinical characteristics of subjects with lymphangioleiomyomatosis have been based on a limited number of patients...
  90. ncbi Human pulmonary chimerism after hematopoietic stem cell transplantation
    Benjamin T Suratt
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Crit Care Med 168:318-22. 2003
    ..These results suggest that significant chimerism of the human lung may follow hematopoietic stem cell transplantation and that adult human stem cells could potentially play a therapeutic role in treatment of the damaged lung...

Research Grants3

  1. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Kevin Brown; Fiscal Year: 2007
    ..Our hypothesis is that active TGF-beta in BAL fluid is responsible for this activity and can be favorably altered by PG12 therapy. (End of Abstract) ..