Melissa A Brotman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
  2. pmc Risk for bipolar disorder is associated with face-processing deficits across emotions
    Melissa A Brotman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008
  3. doi request reprint Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
  4. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
  5. pmc Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members
    Melissa A Brotman
    National Institute of Mental Health, Mood and Anxiety Program, 15K North Drive, Room 208, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 48:628-35. 2009
  6. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
  7. ncbi request reprint Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:819-21. 2007
  8. pmc Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Prog Neuropsychopharmacol Biol Psychiatry 38:127-33. 2012
  9. pmc Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging
    Nancy E Adleman
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Psychiatry Res 212:161-3. 2013
  10. pmc Neural correlates of cognitive flexibility in children at risk for bipolar disorder
    Pilyoung Kim
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    J Psychiatr Res 46:22-30. 2012

Detail Information

Publications24

  1. ncbi request reprint Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
    ..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
  2. pmc Risk for bipolar disorder is associated with face-processing deficits across emotions
    Melissa A Brotman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008
    ..It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest...
  3. doi request reprint Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder
    Melissa A Brotman
    Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
    Am J Psychiatry 165:385-9. 2008
    ....
  4. pmc Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder
    Melissa A Brotman
    Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 167:61-9. 2010
    ..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...
  5. pmc Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members
    Melissa A Brotman
    National Institute of Mental Health, Mood and Anxiety Program, 15K North Drive, Room 208, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 48:628-35. 2009
    ..We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT...
  6. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  7. ncbi request reprint Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disorders
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:819-21. 2007
    ..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness...
  8. pmc Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    Prog Neuropsychopharmacol Biol Psychiatry 38:127-33. 2012
    ..This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD...
  9. pmc Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging
    Nancy E Adleman
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Psychiatry Res 212:161-3. 2013
    ..Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker...
  10. pmc Neural correlates of cognitive flexibility in children at risk for bipolar disorder
    Pilyoung Kim
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
    J Psychiatr Res 46:22-30. 2012
    ..Youth with bipolar disorder (BD) show behavioral and neural deficits in cognitive flexibility; however, whether such deficits exist among youths at risk for BD has not been explored...
  11. pmc Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder
    Aviva K Olsavsky
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, Maryland, USA
    J Am Acad Child Adolesc Psychiatry 51:294-303. 2012
    ..e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder...
  12. doi request reprint Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation
    Christen M Deveney
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    J Child Psychol Psychiatry 53:262-70. 2012
    ..Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations...
  13. pmc Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit
    Brendan A Rich
    Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
    J Child Psychol Psychiatry 49:88-96. 2008
    ....
  14. ncbi request reprint Specificity of facial expression labeling deficits in childhood psychopathology
    Amanda E Guyer
    Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Child Psychol Psychiatry 48:863-71. 2007
    ..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation...
  15. ncbi request reprint Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI study
    Eric E Nelson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
    Bipolar Disord 9:810-9. 2007
    ..The present study was undertaken to determine if neuronal responses differed between BD and control subjects on a simple motor response flexibility task...
  16. ncbi request reprint Cognitive flexibility in phenotypes of pediatric bipolar disorder
    Daniel P Dickstein
    National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670 Building 15K Room 204, Bethesda MD 20892 2670, USA
    J Am Acad Child Adolesc Psychiatry 46:341-55. 2007
    ..6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression)...
  17. pmc Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder
    Nancy E Adleman
    National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Child Psychol Psychiatry 53:1149-56. 2012
    ..Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV...
  18. pmc A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder
    Judah D Weathers
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:633-41. 2012
    ..The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers...
  19. pmc A genome-wide association study of amygdala activation in youths with and without bipolar disorder
    Xinmin Liu
    National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 49:33-41. 2010
    ..We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype...
  20. pmc Differing amygdala responses to facial expressions in children and adults with bipolar disorder
    Pilyoung Kim
    NIMH, Bethesda, MD, USA
    Am J Psychiatry 169:642-9. 2012
    ..The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects...
  21. pmc Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation
    Pilyoung Kim
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, and Department of Psychology, University of Denver, Denver, Colo, USA
    J Psychiatry Neurosci 38:407-16. 2013
    ..In those with other psychiatric disorders, such deficits have been associated with reduced attention to eye regions while looking at faces...
  22. doi request reprint Neural circuitry of masked emotional face processing in youth with bipolar disorder, severe mood dysregulation, and healthy volunteers
    LAURA A THOMAS
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States Office of the Director, National Institute on Drug Abuse, Bethesda, MD, United States Electronic address
    Dev Cogn Neurosci 8:110-20. 2014
    ..Regardless of awareness, BD and SMD differ in activation patterns from HV and each other in multiple brain regions, suggesting that BD and SMD are distinct developmental mood disorders. ..
  23. pmc A developmental study on the neural circuitry mediating response flexibility in bipolar disorder
    Judah Weathers
    Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
    Psychiatry Res 214:56-65. 2013
    ..Future studies should use longitudinal fMRI to examine the developmental trajectory of the neural circuitry mediating response flexibility in BD...
  24. pmc The Affective Reactivity Index: a concise irritability scale for clinical and research settings
    Argyris Stringaris
    King s College London, Institute of Psychiatry, Denmark Hill, London, UK
    J Child Psychol Psychiatry 53:1109-17. 2012
    ....