Research Topics
Species | Melissa A BrotmanSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in childrenMelissa A Brotman
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 60:991-7. 2006..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorderMelissa A Brotman
Emotion and Development Branch, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Psychiatry 167:61-9. 2010..The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison youths...- Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family membersMelissa A Brotman
National Institute of Mental Health, Mood and Anxiety Program, 15K North Drive, Room 208, Bethesda, MD 20892, USA
J Am Acad Child Adolesc Psychiatry 48:628-35. 2009..We tested the hypothesis that, compared with controls, both youths with BD and those at familial risk for the disorder would have increased ISV-RT... - Risk for bipolar disorder is associated with face-processing deficits across emotionsMelissa A Brotman
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Am Acad Child Adolesc Psychiatry 47:1455-61. 2008..It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest... 
Facial emotion labeling deficits in children and adolescents at risk for bipolar disorderMelissa A Brotman
Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, MD 20892, USA
Am J Psychiatry 165:385-9. 2008....- Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulationMelissa A Brotman
Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Psychiatry 164:1238-41. 2007..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation... - Attention bias to threat faces in children with bipolar disorder and comorbid lifetime anxiety disordersMelissa A Brotman
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Biol Psychiatry 61:819-21. 2007..Although comorbid anxiety disorders are common in children with bipolar disorder (BD), it is unclear how this comorbidity impacts the pathophysiology of the illness... - Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorderChristen M Deveney
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
Prog Neuropsychopharmacol Biol Psychiatry 38:127-33. 2012..This study examined the neural correlates of motor inhibition in a sample of symptom-free youths at familial risk for BD... - Neural correlates of cognitive flexibility in children at risk for bipolar disorderPilyoung Kim
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 2670, USA
J Psychiatr Res 46:22-30. 2012..Youth with bipolar disorder (BD) show behavioral and neural deficits in cognitive flexibility; however, whether such deficits exist among youths at risk for BD has not been explored... - Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorderAviva K Olsavsky
Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, Maryland, USA
J Am Acad Child Adolesc Psychiatry 51:294-303. 2012..e., those with a first-degree BD relative) will demonstrate amygdala hyperactivation when viewing fearful and happy faces. The at-risk youth were unaffected, in that they had no history of mood disorder... - Affective prosody labeling in youths with bipolar disorder or severe mood dysregulationChristen M Deveney
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
J Child Psychol Psychiatry 53:262-70. 2012..Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations... - Brain systems underlying response flexibility in healthy and bipolar adolescents: an event-related fMRI studyEric E Nelson
Mood and Anxiety Disorders Program, National Institute of Mental Health, Building 106 C, 5413 W Cedar Lane, Bethesda, MD 20892, USA
Bipolar Disord 9:810-9. 2007..The present study was undertaken to determine if neuronal responses differed between BD and control subjects on a simple motor response flexibility task... - Specificity of facial expression labeling deficits in childhood psychopathologyAmanda E Guyer
Mood and Anxiety Program MAP, National Institute of Mental Health NIMH, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
J Child Psychol Psychiatry 48:863-71. 2007..We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation... - Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuitBrendan A Rich
Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda 20892 2670, MD, USA
J Child Psychol Psychiatry 49:88-96. 2008.... - Cognitive flexibility in phenotypes of pediatric bipolar disorderDaniel P Dickstein
National Institute of Mental Health, Pediatrics and Developmental Neuropsychiatry Branch, 9000 Rockville Pike, MSC 2670 Building 15K Room 204, Bethesda MD 20892 2670, USA
J Am Acad Child Adolesc Psychiatry 46:341-55. 2007..6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression)... - A developmental study of the neural circuitry mediating motor inhibition in bipolar disorderJudah D Weathers
Section on Bipolar Spectrum Disorders, Emotion and Development Branch, NIMH, Bethesda, MD, USA
Am J Psychiatry 169:633-41. 2012..The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers... - A genome-wide association study of amygdala activation in youths with and without bipolar disorderXinmin Liu
National Institute of Mental Health, Bethesda, MD 20892, USA
J Am Acad Child Adolesc Psychiatry 49:33-41. 2010..We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype... - Differing amygdala responses to facial expressions in children and adults with bipolar disorderPilyoung Kim
NIMH, Bethesda, MD, USA
Am J Psychiatry 169:642-9. 2012..The authors used functional MRI to compare amygdala activity during a face processing task in children and adults with bipolar disorder and in healthy comparison subjects... - Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorderNancy E Adleman
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Child Psychol Psychiatry 53:1149-56. 2012..Furthermore, the developmental trajectories of structural abnormalities in BD or SMD are unknown. This study provides such data in BD, SMD, and HV... - The Affective Reactivity Index: a concise irritability scale for clinical and research settingsArgyris Stringaris
King s College London, Institute of Psychiatry, Denmark Hill, London, UK
J Child Psychol Psychiatry 53:1109-17. 2012....