Louise A Brinton

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
  2. pmc Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA
    Gynecol Oncol 129:277-84. 2013
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  4. pmc Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, hiladelphia, PA 19111, USA
    Breast Cancer Res 12:R98. 2010
  5. pmc Intrauterine environments and breast cancer risk: meta-analysis and systematic review
    Sue Kyung Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Yeongeon Dong, Jongro Gu, Seoul 110 799, Seoul, Republic of Korea
    Breast Cancer Res 10:R8. 2008
  6. pmc Body mass index and risk of ovarian cancer
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cancer 115:812-22. 2009
  7. pmc Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study
    Jasmine Q Lew
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
    Am J Epidemiol 170:308-17. 2009
  8. doi request reprint Genetic variation in CYP17 and endometrial cancer risk
    Mia M Gaudet
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Genet 123:155-62. 2008
  9. ncbi request reprint Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer
    Yawei Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:353-8. 2006
  10. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010

Detail Information

Publications89

  1. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
    ..Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations...
  2. pmc Etiologic heterogeneity in endometrial cancer: evidence from a Gynecologic Oncology Group trial
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA
    Gynecol Oncol 129:277-84. 2013
    ..Within a large Gynecologic Oncology Group trial (GOG-210), which included central pathology review, we investigated the etiologic heterogeneity of endometrial cancers by comparing risk factors for different histologic categories...
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  4. pmc Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk
    Joanne F Dorgan
    Fox Chase Cancer Center, hiladelphia, PA 19111, USA
    Breast Cancer Res 12:R98. 2010
    ..The objective of this study was to determine whether estradiol and testosterone levels in serum collected before menopause are associated with subsequent breast cancer risk...
  5. pmc Intrauterine environments and breast cancer risk: meta-analysis and systematic review
    Sue Kyung Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Yeongeon Dong, Jongro Gu, Seoul 110 799, Seoul, Republic of Korea
    Breast Cancer Res 10:R8. 2008
    ..Despite ample biologic plausibility, epidemiologic studies to date have yielded conflicting results. We investigated the associations between perinatal factors and subsequent breast cancer risk through meta-analyses...
  6. pmc Body mass index and risk of ovarian cancer
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cancer 115:812-22. 2009
    ..However, to the authors' knowledge, data addressing whether the relation between BMI and ovarian cancer differs by MHT use are very sparse...
  7. pmc Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study
    Jasmine Q Lew
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
    Am J Epidemiol 170:308-17. 2009
    ..73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI: 0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breast cancer, specifically hormone receptor-positive tumors...
  8. doi request reprint Genetic variation in CYP17 and endometrial cancer risk
    Mia M Gaudet
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Genet 123:155-62. 2008
    ..Further evaluation in consortia is necessary to confirm potential weak associations between common variation in CYP17 and endometrial cancer risk and to address the concern of publication bias...
  9. ncbi request reprint Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer
    Yawei Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:353-8. 2006
    ..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations...
  10. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  11. ncbi request reprint Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk
    Mia M Gaudet
    Division of Cancer Epidemiology, National Cancer Institute, 6120 Executive Boulevard, EPS 7055, Rockville, MD 20852, USA
    Cancer Res 66:9781-5. 2006
    ..The suggestion of increased risk associated with a haplotype in the 3' UTR of COMT needs to be confirmed in independent study populations...
  12. ncbi request reprint Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Hum Genet 121:483-90. 2007
    ..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP...
  13. pmc Risk factors for specific histopathological types of postmenopausal breast cancer in the NIH-AARP Diet and Health Study
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 7 E236, MSC 9774, Bethesda, MD 20892 9774, USA
    Am J Epidemiol 178:359-71. 2013
    ..82, 95% CI: 1.39, 2.37) and mixed ductal-lobular (HR = 1.87, 95% CI: 1.39, 2.51) tumors. Differing associations for hormonal factors and mucinous and tubular cancers suggest etiologies distinct from those of common breast cancers. ..
  14. doi request reprint Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal women
    Roni T Falk
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA
    Breast Cancer Res Treat 131:287-94. 2012
    ..Measurement of sex hormones in serum and in the microenvironment may help in understanding the hormonal etiology of breast cancer, suggest methods for prevention, and have value in gauging treatment response and prognosis...
  15. pmc HSD17B1 genetic variants and hormone receptor-defined breast cancer
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 17:2766-72. 2008
    ..Associations between HSD17B1 genotypes and risk for ER- breast cancer were inconsistent across studies and should be studied further...
  16. pmc Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP Diet and Health Study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Cancer 124:2139-47. 2009
    ..02). Associations with vigorous activities, which may interact with body mass index, suggest directions for future research to clarify underlying biologic mechanisms, including those relating to hormonal alterations...
  17. ncbi request reprint Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 320, Executive Plaza South, MSC7232, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 16:723-30. 2007
    ..We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy...
  18. pmc Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort
    Britton Trabert
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland Electronic address
    Fertil Steril 100:1660-6. 2013
    ..To examine the relationship of ovulation-inducing drugs and ovarian cancer...
  19. pmc Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20952 7234, USA
    BMC Cancer 7:60. 2007
    ..We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer...
  20. ncbi request reprint Endometrial cancer and menopausal hormone therapy in the National Institutes of Health-AARP Diet and Health Study cohort
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Cancer 109:1303-11. 2007
    ....
  21. pmc Is estrogen plus progestin menopausal hormone therapy safe with respect to endometrial cancer risk?
    Britton Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Int J Cancer 132:417-26. 2013
    ..Risks were highest among thin-to-normal weight women, presumably reflecting their lower endogenous estrogen levels, suggesting that menopausal hormones and obesity increase endometrial cancer through common etiologic pathways...
  22. pmc Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD 20852 7234, USA
    Breast Cancer Res 10:R38. 2008
    ..Epidemiologic evidence for a protective role of NSAIDs in breast cancer, however, is equivocal...
  23. pmc Recent trends in breast cancer among younger women in the United States
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, MD 20852 7234, USA
    J Natl Cancer Inst 100:1643-8. 2008
    ..Continued surveillance of trends is needed, particularly for molecular subtypes that preferentially occur among young women...
  24. ncbi request reprint Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions
    William F Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Executive Plaza South 8070, 6120 Executive Plaza Blvd, Rockville, MD 20892 7242, USA
    Cancer Causes Control 18:439-47. 2007
    ..Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues...
  25. pmc Menopausal hormone therapy and breast cancer risk in the NIH-AARP Diet and Health Study Cohort
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA
    Cancer Epidemiol Biomarkers Prev 17:3150-60. 2008
    ..Results from the Women's Health Initiative trial raise new questions regarding the effects of estrogen therapy (ET) and estrogen plus progestin therapy (EPT) on breast cancer risk...
  26. pmc Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 31:827-33. 2010
    ..Associations with variants in other genes have been suggested, but findings have been inconsistent...
  27. pmc Prospective study of physical activity and risk of postmenopausal breast cancer
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Breast Cancer Res 10:R92. 2008
    ..To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk...
  28. pmc Genetic variation in the androgen receptor gene and endometrial cancer risk
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 18:585-9. 2009
    ..Results from our study, taken together with previously published studies, provide little evidence of a consistent association between common genetic variation in AR and endometrial cancer risk...
  29. ncbi request reprint Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Cancer Res 67:10608-17. 2007
    ....
  30. pmc Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients
    Hannah Arem
    MHS, 6120 Executive Blvd, EPS 3029, Rockville, MD 20852, USA
    J Natl Cancer Inst 105:342-9. 2013
    ..Intervention studies of the effect of these modifiable lifestyle factors on mortality are needed...
  31. pmc Endometrial cancer risk factors by 2 main histologic subtypes: the NIH-AARP Diet and Health Study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, NIH, Department of Human Services, Bethesda, USA
    Am J Epidemiol 177:142-51. 2013
    ..Because of the limited number of Type II cancers, additional evaluation of risk factors will benefit from consortial efforts...
  32. ncbi request reprint Causes of infertility as predictors of subsequent cancer risk
    Louise A Brinton
    National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Epidemiology 16:500-7. 2005
    ..Although studies have found elevated risks of certain cancers linked to infertility, the underlying reasons remain unclear...
  33. pmc Body mass index and risk of lung cancer among never, former, and current smokers
    Llewellyn Smith
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:778-89. 2012
    ..These studies are difficult to interpret because of potential confounding by cigarette smoking, a major risk factor for lung cancer that is associated with lower BMI...
  34. pmc Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH-AARP Diet and Health Study Cohort
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    Cancer Causes Control 23:487-96. 2012
    ..Previous studies have reported that lung cancer risk may be decreased, increased, or unaffected by prior use of menopausal hormone therapy (MHT)...
  35. pmc Coffee intake and breast cancer risk in the NIH-AARP diet and health study cohort
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Suite 550, Rockville, MD, USA
    Int J Cancer 131:452-60. 2012
    ..Null findings persisted for risk of both HR-positive and -negative breast cancers. These findings from a large prospective cohort do not support a role of coffee intake in breast carcinogenesis...
  36. pmc Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Breast Cancer Res 13:R42. 2011
    ..Thus, we examined the relationship between single nucleotide polymorphisms (SNPs) in PRL and PRLR, serum prolactin levels and breast cancer risk in a population-based case-control study...
  37. pmc Anthropometric measures and physical activity and the risk of lung cancer in never-smokers: a prospective cohort study
    Tram Kim Lam
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 8:e70672. 2013
    ..If anything, we observed some evidence for positive associations with a larger BMI or waist circumference...
  38. pmc Recent changes in endometrial cancer trends among menopausal-age U.S. women
    Paige Wartko
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Cancer Epidemiol 37:374-7. 2013
    ..Changes in endometrial cancer incidence rates after the precipitous decline in menopausal hormone therapy (MHT) use in 2002 have not been evaluated...
  39. ncbi request reprint Melanoma, thyroid, cervical, and colon cancer risk after use of fertility drugs
    Michelle D Althuis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Obstet Gynecol 193:668-74. 2005
    ..This study was undertaken to evaluate melanoma, thyroid, colon, and cervical cancer risks after clomiphene or gonadotropins...
  40. ncbi request reprint Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 121:1079-85. 2007
    ..07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers...
  41. pmc Non-steroidal anti-inflammatory drug use and ovarian cancer risk: findings from the NIH-AARP Diet and Health Study and systematic review
    Megan A Murphy
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 23:1839-52. 2012
    ..Chronic inflammation has been proposed as a risk factor for ovarian cancer. Some data suggest that anti-inflammatory medications may be protective against ovarian cancer; however, results have been inconsistent...
  42. ncbi request reprint Risks of cancer among a cohort of 23,935 men and women with osteoporosis
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Int J Cancer 122:1879-84. 2008
    ..Conversely, factors associated with later onset osteoporosis may be related to a decreased risk of cancer...
  43. pmc Alcohol and endometrial cancer risk in the NIH-AARP diet and health study
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Int J Cancer 128:2953-61. 2011
    ..Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics...
  44. pmc Ovarian cancer risk factors by histologic subtypes in the NIH-AARP Diet and Health Study
    Hannah P Yang
    Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 131:938-48. 2012
    ..83 (serous). Obesity was a significant risk factor only for endometrioid cancers (RR = 1.64; 95% CI: 1.00, 2.70). Our findings support a link between etiological factors and histological heterogeneity in ovarian carcinoma...
  45. pmc Relationships of uterine and ovarian tumors to pre-existing chronic conditions
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Gynecol Oncol 107:487-94. 2007
    ..Several chronic diseases have been hypothesized to affect the risk of subsequent gynecologic malignancies, possibly through shared hormonal mechanisms...
  46. pmc Circulating adipokine levels and endometrial cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    Patricia Luhn
    Division of Cancer Epidemiology and Genetics, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:1304-12. 2013
    ..Circulating adipokine levels may be associated with endometrial cancer risk, yet few studies have evaluated these markers prospectively...
  47. pmc Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium
    Gretchen L Gierach
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Natl Cancer Inst 104:1218-27. 2012
    ..Women with elevated mammographic density have an increased risk of developing breast cancer. However, among women diagnosed with breast cancer, it is unclear whether higher density portends reduced survival, independent of other factors...
  48. pmc Active and passive cigarette smoking and the risk of endometrial cancer in Poland
    Hannah P Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, Suite 520, Rockville, MD 20852, USA
    Eur J Cancer 46:690-6. 2010
    ..However, dose-response relationships with quantitative measures of active smoking or passive smoking remain less clear...
  49. pmc Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome)
    Louise A Brinton
    National Cancer Institute, Rockville, Maryland, USA
    Fertil Steril 94:1787-92. 2010
    ..To define relationships of androgen excesses to cancer risk...
  50. pmc Ovarian volumes among women with endometrial carcinoma: associations with risk factors and serum hormones
    Mark E Sherman
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Gynecol Oncol 107:431-5. 2007
    ..Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case-control study...
  51. pmc Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health-AARP Diet and Health Study
    Yikyung Park
    Divisions of Cancer Epidemiology and Genetics and Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA
    Am J Clin Nutr 90:664-71. 2009
    ..Although dietary fiber has been hypothesized to lower risk of breast cancer by modulating estrogen metabolism, the association between dietary fiber intake and risk of breast cancer by hormone receptor status is unclear...
  52. ncbi request reprint Uterine cancer after use of clomiphene citrate to induce ovulation
    Michelle D Althuis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    Am J Epidemiol 161:607-15. 2005
    ..52, 95% CI: 1.5, 108.0). Clomiphene may increase uterine cancer risk, with higher doses leading to higher risk. Long-term follow-up of infertility cohorts is necessary to clarify the association between clomiphene use and uterine cancer...
  53. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  54. pmc Fertility drugs and endometrial cancer risk: results from an extended follow-up of a large infertility cohort
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Reprod 28:2813-21. 2013
    ..Do fertility drugs influence the subsequent risk of endometrial cancer in a manner that is independent of other risk predictors, such as parity?..
  55. pmc Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Gynecol Oncol 120:167-73. 2011
    ..We assessed whether common genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2-genes that reportedly are frequently altered in endometrial cancer-was associated with risk of endometrial cancer...
  56. ncbi request reprint Differences in risk factors for breast cancer molecular subtypes in a population-based study
    Xiaohong R Yang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7014, 6120 Executive Boulevard, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 16:439-43. 2007
    ..Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer...
  57. ncbi request reprint Menopausal hormone therapy and ovarian cancer risk in the National Institutes of Health-AARP Diet and Health Study Cohort
    James V Lacey
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MDUSA
    J Natl Cancer Inst 98:1397-405. 2006
    ....
  58. doi request reprint Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 121:727-35. 2010
    ..These results warrant analysis in studies of clinical outcomes accounting for age, ER status and treatment...
  59. pmc The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer
    Denise L Stredrick
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5060, USA
    Hum Mutat 27:538-44. 2006
    ..S49C, may be breast cancer susceptibility alleles. Because of their low frequency, even larger sample sizes are required to more firmly establish these associations...
  60. pmc Association of serum sex steroid hormone hemodilution and body mass index among healthy postmenopausal women
    Hannah P Yang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Ann Epidemiol 21:466-71. 2011
    ..Assessing the relationship of hormone concentration to total mass varies by body mass index (BMI) is etiologically important because obesity is related to hormone metabolism and cancer risk...
  61. pmc Prospective evaluation of risk factors for male breast cancer
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 100:1477-81. 2008
    ..Differences in risk factors may reflect unique mechanisms associated with androgens and their ratio to bioavailable estrogens...
  62. ncbi request reprint Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Pharmacogenet Genomics 16:547-53. 2006
    ..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk...
  63. ncbi request reprint Breast cancer risk in older women: results from the NIH-AARP Diet and Health Study
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA
    Cancer Causes Control 25:843-57. 2014
    ..Divergent risk factors exist for premenopausal and postmenopausal breast cancers, but it is unclear whether differences by age exist among postmenopausal women...
  64. pmc Prolactin receptor expression and breast cancer: relationships with tumor characteristics among pre- and post-menopausal women in a population-based case-control study from Poland
    Jessica M Faupel-Badger
    Cancer Prevention Fellowship Program, National Cancer Institute, 9609 Medical Center Drive, 2W 172, Bethesda, MD, 20892, USA
    Horm Cancer 5:42-50. 2014
    ..These data provide new avenues from which to explore the associations of the prolactin/prolactin receptor signaling network with breast tumorigenesis. ..
  65. pmc Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 124:1716-20. 2009
    ..02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival...
  66. pmc Nonsteroidal anti-inflammatory drug use and endometrial cancer risk in the NIH-AARP Diet and Health Study
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Prev Res (Phila) 2:466-72. 2009
    ..Overall, our data do not support an association between aspirin or NA-NSAID use and endometrial cancer risk...
  67. ncbi request reprint Intrauterine environment and breast cancer risk in a population-based case-control study in Poland
    Sue Kyung Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 119:2136-41. 2006
    ..Our results add support to the growing evidence that some perinatal exposures may relate to breast cancer risk. Additional studies are needed to confirm associations and clarify the biologic mechanisms underlying these associations...
  68. pmc Prospective study of physical activity and the risk of ovarian cancer
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Rockville, MD 20892, USA
    Cancer Causes Control 20:765-73. 2009
    ..Available studies on physical activity and ovarian cancer have produced inconsistent findings, with some previous studies reporting a positive association between vigorous physical activity and ovarian cancer risk...
  69. ncbi request reprint Endometrial carcinoma risks among menopausal estrogen plus progestin and unopposed estrogen users in a cohort of postmenopausal women
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 14:1724-31. 2005
    ..However, endometrial carcinoma risks among estrogen plus progestin users and among former unopposed estrogen users are not firmly established...
  70. ncbi request reprint Ovarian cancer risk associated with varying causes of infertility
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852, USA
    Fertil Steril 82:405-14. 2004
    ..To evaluate the risk of ovarian cancer as related to underlying causes of infertility...
  71. pmc Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study
    Barbara J Fuhrman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:1582-91. 2012
    ..We investigated the cross-sectional associations of urinary estrogens, and their 2-, 4-, and 16-hydroxylated metabolites with MD...
  72. pmc Obesity-related hormones and endometrial cancer among postmenopausal women: a nested case-control study within the B~FIT cohort
    Cher M Dallal
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20852, USA
    Endocr Relat Cancer 20:151-60. 2013
    ..Continued exploration of these pathways in larger prospective studies may help elucidate mechanisms underlying observed obesity-endometrial cancer associations...
  73. pmc Etiologic factors for male breast cancer in the U.S. Veterans Affairs medical care system database
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 5018, Rockville, MD 20852, USA
    Breast Cancer Res Treat 119:185-92. 2010
    ..21-8.03), obesity (1.91, 1.50-2.44), and orchitis/epididymitis (1.80, 1.08-3.01). These results support previous speculations that male breast cancer is influenced not only by tissue at risk, but also by hormonal and inflammatory factors...
  74. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  75. pmc Reproductive and hormonal factors and lung cancer risk in the NIH-AARP Diet and Health Study cohort
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 20:900-11. 2011
    ..Inconsistent findings about hormonal factors on risk may reflect incomplete control for confounding, misclassification of exposures, or insufficient attention to variation by histology...
  76. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  77. pmc Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA
    Cancer Causes Control 21:77-82. 2010
    ..Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer...
  78. ncbi request reprint Weight, height, and body mass index and risk for ovarian cancer in a cohort study
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville 20852 7234, MD
    Ann Epidemiol 16:869-76. 2006
    ..Reported associations between ovarian cancer and body size are inconsistent. We assessed ovarian cancer and anthropometry in the Breast Cancer Detection Demonstration Project Follow-Up Study...
  79. pmc Measurement of sex steroid hormones in breast adipocytes: methods and implications
    Roni T Falk
    Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard S, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:1891-5. 2008
    ....
  80. pmc In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Fertil Steril 99:1189-96. 2013
    ..To assess long-term cancer risks associated with in vitro fertilization (IVF)...
  81. pmc Accelerometer-based measures of active and sedentary behavior in relation to breast cancer risk
    Cher M Dallal
    Cancer Prevention Fellowship Program, Center for Cancer Training, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Breast Cancer Res Treat 134:1279-90. 2012
    ..Our findings support an inverse association between accelerometer-based measures of moderate-to-vigorous physical activity and breast cancer while also suggesting potential increases in risk with sedentary time...
  82. pmc Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Hum Mol Genet 20:4693-706. 2011
    ..Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer...
  83. ncbi request reprint Interrelationships between serum leptin, IGF-1, IGFBP3, C-peptide and prolactin and breast cancer risk in young women
    Roni T Falk
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Breast Cancer Res Treat 98:157-65. 2006
    ..With the possible exception of leptin, our findings do not suggest that these markers explain the breast cancer protection provided by obesity in premenopausal women...
  84. ncbi request reprint Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors
    Louise A Brinton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7068, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:2929-35. 2005
    ..Although endometriosis and uterine leiomyomas are common conditions, the extent to which either is associated with certain types of malignancies remains uncertain...
  85. ncbi request reprint Fertility drugs and the risk of breast and gynecologic cancers
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, MD 20852 7234, USA
    Semin Reprod Med 30:131-45. 2012
    ....
  86. ncbi request reprint Global trends in breast cancer incidence and mortality 1973-1997
    Michelle D Althuis
    Hormone and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Rockville, MD 20852, USA
    Int J Epidemiol 34:405-12. 2005
    ..Worldwide, breast cancer is the most common cancer and is the leading cause of cancer death among women...
  87. ncbi request reprint Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
    Hum Genet 119:376-88. 2006
    ..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes...
  88. ncbi request reprint A case-control study of risk factors for invasive cervical cancer among U.S. women exposed to oncogenic types of human papillomavirus
    Tammy S Shields
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:1574-82. 2004
    ..It is particularly worth considering further why studies of different designs are inconsistent regarding the effect of oral contraceptive use...
  89. ncbi request reprint Etiology of hormone receptor-defined breast cancer: a systematic review of the literature
    Michelle D Althuis
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7084, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:1558-68. 2004
    ..Large population-based studies of determinants of hormone receptor-defined breast cancers defined using state-of-the-art quantitative immunostaining methods are needed to clarify the role of ER/PR expression in breast cancer etiology...