Jason M Brenchley

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
    N R Klatt
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    Mucosal Immunol 3:387-98. 2010
  2. pmc Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection
    N R Klatt
    Laboratory of Molecular Microbiology and Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    Mucosal Immunol 5:646-57. 2012
  3. doi request reprint Mucosal immunity in human and simian immunodeficiency lentivirus infections
    J M Brenchley
    Program in Tissue Immunity and Repair and Lab of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 6:657-65. 2013
  4. pmc Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    Jason M Brenchley
    Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
    Blood 120:4172-81. 2012
  5. pmc Microbial translocation across the GI tract
    Jason M Brenchley
    Program in Barrier Immunity and Repair and Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    Annu Rev Immunol 30:149-73. 2012
  6. pmc Nonprogressive and progressive primate immunodeficiency lentivirus infections
    Jason M Brenchley
    Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA
    Immunity 32:737-42. 2010
  7. pmc Immunodeficiency lentiviral infections in natural and non-natural hosts
    Jason M Brenchley
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 118:847-54. 2011
  8. pmc Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    Joseph P Casazza
    Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2865-77. 2006
  9. ncbi request reprint The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
  10. pmc T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis
    Jason M Brenchley
    Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:1160-8. 2004

Detail Information

Publications59

  1. pmc Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
    N R Klatt
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    Mucosal Immunol 3:387-98. 2010
    ..Furthermore, these data suggest that PTM may be an ideal model to study therapeutic interventions aimed at decreasing microbial translocation-induced immune activation...
  2. pmc Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection
    N R Klatt
    Laboratory of Molecular Microbiology and Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    Mucosal Immunol 5:646-57. 2012
    ....
  3. doi request reprint Mucosal immunity in human and simian immunodeficiency lentivirus infections
    J M Brenchley
    Program in Tissue Immunity and Repair and Lab of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 6:657-65. 2013
    ..Novel therapeutic interventions aimed at enhancing GI tract anatomy and physiology may improve the prognosis of HIV-infected individuals...
  4. pmc Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    Jason M Brenchley
    Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
    Blood 120:4172-81. 2012
    ..These data provide insights into how natural hosts are able to maintain high levels of plasma viremia while avoiding development of immunodeficiency...
  5. pmc Microbial translocation across the GI tract
    Jason M Brenchley
    Program in Barrier Immunity and Repair and Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    Annu Rev Immunol 30:149-73. 2012
    ..Here, we discuss the mechanisms underlying MT, diseases associated with MT, and therapeutic interventions that aim to decrease it...
  6. pmc Nonprogressive and progressive primate immunodeficiency lentivirus infections
    Jason M Brenchley
    Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA
    Immunity 32:737-42. 2010
    ....
  7. pmc Immunodeficiency lentiviral infections in natural and non-natural hosts
    Jason M Brenchley
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 118:847-54. 2011
    ..Here virologic and immunologic aspects of acute HIV infection of humans and SIV infection of Asian and African nonhuman primates are discussed and compared in relation to how these aspects relate to disease progression...
  8. pmc Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    Joseph P Casazza
    Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2865-77. 2006
    ..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes...
  9. ncbi request reprint The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration
    Michael R Betts
    Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6407-17. 2004
    ..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...
  10. pmc T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis
    Jason M Brenchley
    Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:1160-8. 2004
    ..These data illuminate the underlying mechanisms that distort T-cell homeostasis in HIV infection...
  11. pmc Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
    David A Price
    Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1349-61. 2005
    ..Vaccine strategies that reconstruct these biological processes could generate T cell populations that mediate optimal delivery of antiviral effector function...
  12. pmc High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:9836-44. 2013
    ..Our data suggest that the persistence of PD-1(high) SIV-specific CD8 T cells in chronic infection is maintained in vivo by a mechanism involving high production coupled with a high disappearance rate. ..
  13. pmc The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor
    Phillip Scheinberg
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:5071-80. 2009
    ....
  14. pmc Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques
    Levelle D Harris
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:4148-57. 2010
    ..These findings may lead to novel therapeutic interventions that improve the immune responses against microbial antigens, and thus, decrease microbial translocation-induced immune activation...
  15. pmc Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques
    Lauren A Canary
    Laboratory of Molecular Microbiology, Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:2959-65. 2013
    ..These data suggest that pre-existing levels of microbial translocation and gastrointestinal tract dysfunction may influence the rate of HIV disease progression...
  16. pmc Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection
    Brian Tabb
    AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, SAIC Frederick, Maryland, USA
    J Infect Dis 207:880-92. 2013
    ....
  17. pmc Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection
    Joseph P Casazza
    Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000646. 2009
    ..These data suggest that CD4+ T cells which produce MIP-1alpha and MIP-1beta bind these chemokines in an autocrine fashion which decreases the risk of in vivo HIV infection...
  18. pmc Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques
    Levelle D Harris
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 84:7886-91. 2010
    ..In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques...
  19. pmc Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center VRC, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 112:2826-35. 2008
    ..Finally, these data may help account for the nonprogressive nature of nonpathogenic SIV infection in sooty mangabeys...
  20. pmc Superior T memory stem cell persistence supports long-lived T cell memory
    Enrico Lugli
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, 40, Convent Dr, Bethesda, Maryland 20892, USA
    J Clin Invest 123:594-9. 2013
    ..Thus, one mechanism for maintenance of long-term T cell memory derives from the unique homeostatic properties of TSCM cells. Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells...
  21. ncbi request reprint T cell receptor recognition motifs govern immune escape patterns in acute SIV infection
    David A Price
    Human Immunology Section, Vaccine Research Center, NIAID NIH, Bethesda, MD 20892, USA
    Immunity 21:793-803. 2004
    ..These findings have profound implications for the development of vaccines that elicit T cell immunity to combat pathogens with unstable genomes...
  22. pmc SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination
    Nichole R Klatt
    Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 118:5803-12. 2011
    ....
  23. pmc Recombination-mediated changes in coreceptor usage confer an augmented pathogenic phenotype in a nonhuman primate model of HIV-1-induced AIDS
    Yoshiaki Nishimura
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:10617-26. 2011
    ..These results indicate that the effects of retrovirus recombination in vivo can be functionally profound and may even occur when one of the recombination participants is undetectable in the circulation as cell-free virus...
  24. pmc Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo
    Jason M Brenchley
    Human Virology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    J Virol 80:6801-9. 2006
    ....
  25. pmc Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection
    David A Price
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:923-36. 2009
    ..Thus, the pattern of antigen-specific clonotype recruitment within a protective CD8(+) T cell population is a prognostic indicator of vaccine efficacy and biological outcome in an AIDS virus infection...
  26. ncbi request reprint Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses
    Karin Lore
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3022, USA
    J Immunol 171:4320-8. 2003
    ....
  27. ncbi request reprint Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  28. pmc Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
    Nichole R Klatt
    National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    J Clin Invest 123:903-7. 2013
    ..Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis...
  29. pmc Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells
    Marybeth Daucher
    National Institute of Allergy and Infectious Diseases, Bldg 10 Rm 11B13, Bethesda, MD 20892, USA
    J Virol 82:4102-14. 2008
    ....
  30. ncbi request reprint HIV preferentially infects HIV-specific CD4+ T cells
    Daniel C Douek
    Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
    Nature 417:95-8. 2002
    ..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption...
  31. ncbi request reprint Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    Michael R Betts
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    J Immunol Methods 281:65-78. 2003
    ....
  32. pmc Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy
    Joseph P Casazza
    Immunology Laboratory, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 79:3653-63. 2005
    ....
  33. pmc PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    Constantinos Petrovas
    Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2281-92. 2006
    ....
  34. ncbi request reprint T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization
    Katayoun Rezvani
    Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung Blood Institute and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:8799-807. 2005
    ..Four HLA-A*0201-restricted WT1-derived epitopes have been identified: WT37, WT126, WT187, and WT235. We determined the natural immunogenecity of these antigens in patients with hematologic malignancies and healthy donor...
  35. ncbi request reprint Flow cytometric analysis of human antigen-specific T-cell proliferation
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20874, USA
    Methods Cell Biol 75:481-96. 2004
  36. pmc Reduction of immune activation with chloroquine therapy during chronic HIV infection
    Shannon M Murray
    Human Immunology Section, NIH Vaccine Research Center, Bethesda, MD 20892 3005, USA
    J Virol 84:12082-6. 2010
    ..Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals...
  37. pmc Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    Jacob D Estes
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    PLoS Pathog 6:e1001052. 2010
    ..Novel therapeutic approaches to inhibit microbial translocation and/or attenuate chronic immune activation in HIV-infected individuals may complement treatments aimed at direct suppression of viral replication...
  38. ncbi request reprint Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    Jason M Brenchley
    Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:2711-20. 2003
    ..Thus, our studies define a phenotype associated with replicative senescence in HIV-specific CD8(+) T cells, which may have broad implications to other conditions associated with chronic antigenic stimulation...
  39. pmc Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques
    Yoshiaki Nishimura
    Laboratory of Molecular Microbiology, National Institutes of Health, Bethesda, MD 20892 0460, USA
    J Virol 84:4769-81. 2010
    ..The sustained viremia, associated depletion of CD4(+) T lymphocytes, and induction of AIDS make the SHIV(AD8) lineage of viruses a potentially valuable reagent for vaccine studies...
  40. pmc CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus
    Carol Vinton
    Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA
    J Virol 85:8702-8. 2011
    ..Understanding the genetic factors that lead to downregulation of these receptors may lead to therapeutic interventions that mimic this modulation in progressive infections...
  41. pmc CD4 T follicular helper cell dynamics during SIV infection
    Constantinos Petrovas
    Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    J Clin Invest 122:3281-94. 2012
    ..Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins...
  42. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
    ....
  43. pmc CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection
    Coreen M Beaumier
    Lab of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 15:879-85. 2009
    ....
  44. pmc Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    Joshua D Milner
    Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 452:773-6. 2008
    ..Thus, our data suggest that the inability to produce T(H)17 cells is a mechanism underlying the susceptibility to the recurrent infections commonly seen in HIES...
  45. ncbi request reprint Flow cytometric analysis of vaccine responses: how many colors are enough?
    Mario Roederer
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    Clin Immunol 110:199-205. 2004
    ..In this manuscript, we discuss these technologies, with a focus on assisting in the design and implementation of immunogenicity trials for future vaccine efforts...
  46. ncbi request reprint HIV disease: fallout from a mucosal catastrophe?
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 7:235-9. 2006
    ....
  47. pmc Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopenia
    Philip I Lee
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 199:1664-70. 2009
    ..These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection...
  48. pmc T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy
    Elaine M Sloand
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 117:2691-9. 2011
    ..Thus, our results suggest that WT1 is one of the antigens that triggers T cell-mediated myelosuppression in MDS...
  49. pmc Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques
    Que Dang
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:13795-9. 2012
    ..Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease...
  50. pmc Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques
    Nichole R Klatt
    Laboratory of Molecular Microbiology and Program in Barrier Immunity and Repair, NIAID, NIH, Bethesda, Maryland, USA
    J Virol 86:1203-13. 2012
    ..These data evaluate the kinetics of SIVmac239-induced disease progression and highlight PTM as a model for HIV infection and the importance of immune activation in SIV disease progression...
  51. pmc Th17 cell dynamics in HIV infection
    Nichole R Klatt
    Immunopathogenesis Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin HIV AIDS 5:135-40. 2010
    ..Here we examine the relationship between Th17 cells and HIV disease pathogenesis...
  52. ncbi request reprint Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation
    Katayoun Rezvani
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:2892-900. 2003
    ..The increased response in patients after SCT suggests a quantitative explanation for the greater effect of allogeneic SCT...
  53. pmc Microbial translocation, immune activation, and HIV disease
    Nichole R Klatt
    Laboratory of Molecular Microbiology, Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD, USA
    Trends Microbiol 21:6-13. 2013
    ..Here we review the mechanisms underlying microbial translocation and its role in contributing to immune activation and disease progression in HIV infection...
  54. pmc A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
    Andrea M Siegel
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:806-18. 2011
    ..These data point to a specific role for STAT3 in human central memory T cell formation and in control of certain chronic viruses...
  55. pmc Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection
    John R Grainger
    Program in Barrier Immunity and Repair, Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 19:713-21. 2013
    ..Collectively, our results place inflammatory monocyte-derived PGE2 at the center of a commensal-driven regulatory loop required to control host-commensal dialog during pathogen-induced inflammation...
  56. pmc Decreased interleukin 7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopenia
    Camille E Puronen
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 205:1382-90. 2012
    ....
  57. ncbi request reprint A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape
    Daniel C Douek
    Department of Experimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3099-104. 2002
    ..Thus, CD8(+) T cells comprising multiple TCR clonotypes may expand in vivo in response to individual epitopes, and may increase the ability of the response to recognize virus escape mutants...
  58. ncbi request reprint Beyond six colors: a new era in flow cytometry
    Stephen C De Rosa
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 9:112-7. 2003
  59. pmc The mucosal barrier and immune activation in HIV pathogenesis
    Jason M Brenchley
    aViral Pathogenesis and Vaccine Section, Laboratory of Molecular Microbiology, USA bHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin HIV AIDS 3:356-61. 2008
    ....