Research Topics
Species | Jason M BrenchleySummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infectionsJason M Brenchley
Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
Blood 120:4172-81. 2012..These data provide insights into how natural hosts are able to maintain high levels of plasma viremia while avoiding development of immunodeficiency...- Microbial translocation across the GI tractJason M Brenchley
Program in Barrier Immunity and Repair and Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
Annu Rev Immunol 30:149-73. 2012..Here, we discuss the mechanisms underlying MT, diseases associated with MT, and therapeutic interventions that aim to decrease it... - Immunodeficiency lentiviral infections in natural and non-natural hostsJason M Brenchley
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Blood 118:847-54. 2011..Here virologic and immunologic aspects of acute HIV infection of humans and SIV infection of Asian and African nonhuman primates are discussed and compared in relation to how these aspects relate to disease progression... - Nonprogressive and progressive primate immunodeficiency lentivirus infectionsJason M Brenchley
Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA
Immunity 32:737-42. 2010.... - Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturationJoseph P Casazza
Immunology Laboratory, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID, National Institutes of Health (NIH, Bethesda, MD 20892, USA
J Exp Med 203:2865-77. 2006..Thus, mature CMV-specific CD4+ T cells exhibit distinct functional properties reminiscent of antiviral CD8+ T lymphocytes... 
The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentrationMichael R Betts
Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:6407-17. 2004..The inherent ability of viruses to induce high or low Ag states may be the primary determinant of the cytokine vs cytolytic nature of the virus-specific CD8(+) T cell response...- T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesisJason M Brenchley
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 78:1160-8. 2004..These data illuminate the underlying mechanisms that distort T-cell homeostasis in HIV infection... - Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA virusesDavid A Price
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:1349-61. 2005..Vaccine strategies that reconstruct these biological processes could generate T cell populations that mediate optimal delivery of antiviral effector function... - The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donorPhillip Scheinberg
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Blood 114:5071-80. 2009.... - Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaquesLevelle D Harris
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Blood 116:4148-57. 2010..These findings may lead to novel therapeutic interventions that improve the immune responses against microbial antigens, and thus, decrease microbial translocation-induced immune activation... - Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infectionBrian Tabb
AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, SAIC Frederick, Maryland, USA
J Infect Dis 207:880-92. 2013.... - Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaquesLevelle D Harris
Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA
J Virol 84:7886-91. 2010..In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques... - Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infectionJoseph P Casazza
Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA
PLoS Pathog 5:e1000646. 2009..These data suggest that CD4+ T cells which produce MIP-1alpha and MIP-1beta bind these chemokines in an autocrine fashion which decreases the risk of in vivo HIV infection... - T cell receptor recognition motifs govern immune escape patterns in acute SIV infectionDavid A Price
Human Immunology Section, Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA
Immunity 21:793-803. 2004..These findings have profound implications for the development of vaccines that elicit T cell immunity to combat pathogens with unstable genomes... - SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccinationNichole R Klatt
Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 118:5803-12. 2011.... - Microbial translocation is a cause of systemic immune activation in chronic HIV infectionJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:1365-71. 2006..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection... - Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivoJason M Brenchley
Human Virology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
J Virol 80:6801-9. 2006.... - Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infectionDavid A Price
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 206:923-36. 2009..Thus, the pattern of antigen-specific clonotype recruitment within a protective CD8(+) T cell population is a prognostic indicator of vaccine efficacy and biological outcome in an AIDS virus infection... - Recombination-mediated changes in coreceptor usage confer an augmented pathogenic phenotype in a nonhuman primate model of HIV-1-induced AIDSYoshiaki Nishimura
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 85:10617-26. 2011..These results indicate that the effects of retrovirus recombination in vivo can be functionally profound and may even occur when one of the recombination participants is undetectable in the circulation as cell-free virus... - HIV preferentially infects HIV-specific CD4+ T cellsDaniel C Douek
Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
Nature 417:95-8. 2002..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption... - Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cellsMarybeth Daucher
National Institute of Allergy and Infectious Diseases, Bldg 10 Rm 11B13, Bethesda, MD 20892, USA
J Virol 82:4102-14. 2008.... - Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infectionsJason M Brenchley
Human Immunology Section, Vaccine Research Center VRC, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
Blood 112:2826-35. 2008..Finally, these data may help account for the nonprogressive nature of nonpathogenic SIV infection in sooty mangabeys... - Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulationMichael R Betts
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
J Immunol Methods 281:65-78. 2003.... - PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionConstantinos Petrovas
Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:2281-92. 2006.... - T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterizationKatayoun Rezvani
Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung Blood Institute and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 11:8799-807. 2005..Four HLA-A*0201-restricted WT1-derived epitopes have been identified: WT37, WT126, WT187, and WT235. We determined the natural immunogenecity of these antigens in patients with hematologic malignancies and healthy donor... - Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapyJoseph P Casazza
Immunology Laboratory, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 79:3653-63. 2005.... - Flow cytometric analysis of human antigen-specific T-cell proliferationJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20874, USA
Methods Cell Biol 75:481-96. 2004 - Reduction of immune activation with chloroquine therapy during chronic HIV infectionShannon M Murray
Human Immunology Section, NIH Vaccine Research Center, Bethesda, MD 20892 3005, USA
J Virol 84:12082-6. 2010..Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals... - Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infectionsJacob D Estes
AIDS and Cancer Virus Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
PLoS Pathog 6:e1001052. 2010..Novel therapeutic approaches to inhibit microbial translocation and/or attenuate chronic immune activation in HIV-infected individuals may complement treatments aimed at direct suppression of viral replication... - Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaquesYoshiaki Nishimura
Laboratory of Molecular Microbiology, National Institutes of Health, Bethesda, MD 20892 0460, USA
J Virol 84:4769-81. 2010..The sustained viremia, associated depletion of CD4(+) T lymphocytes, and induction of AIDS make the SHIV(AD8) lineage of viruses a potentially valuable reagent for vaccine studies... - CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virusCarol Vinton
Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA
J Virol 85:8702-8. 2011..Understanding the genetic factors that lead to downregulation of these receptors may lead to therapeutic interventions that mimic this modulation in progressive infections... - Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responsesKarin Lore
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3022, USA
J Immunol 171:4320-8. 2003.... - Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cellsJason M Brenchley
Vaccine Research Center and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:2711-20. 2003..Thus, our studies define a phenotype associated with replicative senescence in HIV-specific CD8(+) T cells, which may have broad implications to other conditions associated with chronic antigenic stimulation... - CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
J Exp Med 200:749-59. 2004.... - CD4 T follicular helper cell dynamics during SIV infectionConstantinos Petrovas
Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
J Clin Invest 122:3281-94. 2012..Therefore, chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins... - CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infectionCoreen M Beaumier
Lab of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
Nat Med 15:879-85. 2009.... - Flow cytometric analysis of vaccine responses: how many colors are enough?Mario Roederer
Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
Clin Immunol 110:199-205. 2004..In this manuscript, we discuss these technologies, with a focus on assisting in the design and implementation of immunogenicity trials for future vaccine efforts... - HIV disease: fallout from a mucosal catastrophe?Jason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 7:235-9. 2006.... - Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndromeJoshua D Milner
Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 452:773-6. 2008..Thus, our data suggest that the inability to produce T(H)17 cells is a mechanism underlying the susceptibility to the recurrent infections commonly seen in HIES... - Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopeniaPhilip I Lee
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 199:1664-70. 2009..These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection... 
Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaquesLauren A Canary
Laboratory of Molecular Microbiology, Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 190:2959-65. 2013..These data suggest that pre-existing levels of microbial translocation and gastrointestinal tract dysfunction may influence the rate of HIV disease progression...- Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaquesQue Dang
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:13795-9. 2012..Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease... - Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaquesNichole R Klatt
Laboratory of Molecular Microbiology and Program in Barrier Immunity and Repair, NIAID, NIH, Bethesda, Maryland, USA
J Virol 86:1203-13. 2012..These data evaluate the kinetics of SIVmac239-induced disease progression and highlight PTM as a model for HIV infection and the importance of immune activation in SIV disease progression... - Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantationKatayoun Rezvani
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 102:2892-900. 2003..The increased response in patients after SCT suggests a quantitative explanation for the greater effect of allogeneic SCT... - Th17 cell dynamics in HIV infectionNichole R Klatt
Immunopathogenesis Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
Curr Opin HIV AIDS 5:135-40. 2010..Here we examine the relationship between Th17 cells and HIV disease pathogenesis... - T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapyElaine M Sloand
Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 117:2691-9. 2011..Thus, our results suggest that WT1 is one of the antigens that triggers T cell-mediated myelosuppression in MDS... - A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memoryAndrea M Siegel
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 35:806-18. 2011..These data point to a specific role for STAT3 in human central memory T cell formation and in control of certain chronic viruses... - Decreased interleukin 7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopeniaCamille E Puronen
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 205:1382-90. 2012.... - Microbial translocation, immune activation, and HIV diseaseNichole R Klatt
Laboratory of Molecular Microbiology, Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD, USA
Trends Microbiol 21:6-13. 2013..Here we review the mechanisms underlying microbial translocation and its role in contributing to immune activation and disease progression in HIV infection... - The mucosal barrier and immune activation in HIV pathogenesisJason M Brenchley
aViral Pathogenesis and Vaccine Section, Laboratory of Molecular Microbiology, USA bHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Curr Opin HIV AIDS 3:356-61. 2008.... - Beyond six colors: a new era in flow cytometryStephen C De Rosa
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nat Med 9:112-7. 2003 - A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escapeDaniel C Douek
Department of Experimental Transplantation and Immunology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:3099-104. 2002..Thus, CD8(+) T cells comprising multiple TCR clonotypes may expand in vivo in response to individual epitopes, and may increase the ability of the response to recognize virus escape mutants...