Abee L Boyles

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway
    A L Boyles
    Epidemiology Branch, NIEHS NIH, Durham, NC 27709, USA
    Hum Reprod 26:2232-8. 2011
  2. pmc Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
    Am J Epidemiol 172:924-31. 2010
  3. ncbi request reprint The quest for the elusive causative SNP
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Kidney Int 78:9-10. 2010
  4. pmc Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study
    Abee L Boyles
    Epidemiology Branch, NIEHS NIH, Durham, North Carolina 27709, USA
    Genet Epidemiol 33:247-55. 2009
  5. pmc Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Am J Med Genet A 146:440-9. 2008
  6. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
  7. ncbi request reprint Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Med Genet A 140:2776-85. 2006
  8. ncbi request reprint Apolipoprotein E alleles and sensorineural hearing loss
    Gwen O'Grady
    Department of Surgery Division of Speech Pathology and Audiology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Audiol 46:183-6. 2007
  9. pmc Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 59:220-7. 2005
  10. pmc SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects
    Kristen L Deak
    Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Genet 117:133-42. 2005

Collaborators

Detail Information

Publications11

  1. pmc Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway
    A L Boyles
    Epidemiology Branch, NIEHS NIH, Durham, NC 27709, USA
    Hum Reprod 26:2232-8. 2011
    ..We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor α (FRα), as well as possible effects of parental demographics or prenatal exposures...
  2. pmc Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
    Am J Epidemiol 172:924-31. 2010
    ..9, 95% CI: 0.2, 4.1). The teratogenic effect of alcohol may depend on the genetic capacity of the mother and fetus to metabolize alcohol...
  3. ncbi request reprint The quest for the elusive causative SNP
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Kidney Int 78:9-10. 2010
    ..This may be correct, but only replication of this association, ideally accounting for both the fetal and the maternal genotypes, will provide a better understanding of the biology that underlies the association...
  4. pmc Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study
    Abee L Boyles
    Epidemiology Branch, NIEHS NIH, Durham, North Carolina 27709, USA
    Genet Epidemiol 33:247-55. 2009
    ..Despite strong evidence for genetic causes of oral facial clefts and the protective effects of maternal vitamins, we found no convincing indication that polymorphisms in these vitamin metabolism genes play an etiologic role...
  5. pmc Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Am J Med Genet A 146:440-9. 2008
    ..No associations were found between any of the polymorphisms and CPO. Genetic variations in the nine metabolic genes examined here do not confer a substantial degree of risk for clefts...
  6. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
    ..Most studies addressed these genes individually, often with different populations providing conflicting results...
  7. ncbi request reprint Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Med Genet A 140:2776-85. 2006
    ..5 cM. This linkage evidence supports a genetic role in Chiari malformation and justifies further exploration with fine mapping and investigation of candidate genes in these regions...
  8. ncbi request reprint Apolipoprotein E alleles and sensorineural hearing loss
    Gwen O'Grady
    Department of Surgery Division of Speech Pathology and Audiology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Audiol 46:183-6. 2007
    ..Future studies associating the epsilon 4 allele with SNHL need to be population-based, longitudinal, or done in younger subjects...
  9. pmc Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 59:220-7. 2005
    ..Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies...
  10. pmc SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects
    Kristen L Deak
    Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Genet 117:133-42. 2005
    ..These results suggest variations in NCAM1 may influence risk for human NTDs...
  11. ncbi request reprint Candidate gene analysis in human neural tube defects
    Abee L Boyles
    Duke University Program in Genetics and Genomics, USA
    Am J Med Genet C Semin Med Genet 135:9-23. 2005
    ..New approaches combined with traditional methods and increased sample sizes will help prioritize human NTD candidate genes and clarify the complex etiology of this condition...