M R Boyd

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases
    M R Boyd
    Laboratory of Natural Products, Division of Basic Sciences, National Cancer Institute, Bldg 1052, Rm 121, Frederick, MD 21702 1201, USA
    J Pharmacol Exp Ther 297:114-20. 2001
  2. ncbi request reprint A new isoquinoline alkaloid from the marine sponge Haliclona species
    M A Rashid
    Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:1249-50. 2001
  3. ncbi request reprint New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii
    T C McKee
    Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, NCI FCRDC, Frederick, Maryland 21702 1201, USA
    J Nat Prod 59:754-8. 1996
  4. ncbi request reprint Structure-activity modifications of the HIV-1 inhibitors (+)-calanolide A and (-)-calanolide B
    D L Galinis
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Med Chem 39:4507-10. 1996
  5. ncbi request reprint Microspinosamide, a new HIV-inhibitory cyclic depsipeptide from the marine sponge Sidonops microspinosa
    M A Rashid
    Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:117-21. 2001
  6. ncbi request reprint Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor
    J B McMahon
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland, USA
    J Pharmacol Exp Ther 276:298-305. 1996
  7. ncbi request reprint New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species
    K M Meragelman
    Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-FCRDC, Frederick, MD 21702, USA
    J Nat Prod 64:389-92. 2001
  8. ncbi request reprint Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A
    M J Currens
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland, USA
    J Pharmacol Exp Ther 279:652-61. 1996
  9. ncbi request reprint Chondropsin D, a new 37-membered-ring macrolide lactam from the marine sponge Chondropsis species
    M A Rashid
    Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Building 1052, Room 121, Frederick, MD 21702-1201, USA
    J Nat Prod 64:1341-4. 2001
  10. ncbi request reprint Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species
    R D Charan
    Laboratory of Drug Discovery Research and Development, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:661-3. 2001

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases
    M R Boyd
    Laboratory of Natural Products, Division of Basic Sciences, National Cancer Institute, Bldg 1052, Rm 121, Frederick, MD 21702 1201, USA
    J Pharmacol Exp Ther 297:114-20. 2001
    ....
  2. ncbi request reprint A new isoquinoline alkaloid from the marine sponge Haliclona species
    M A Rashid
    Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:1249-50. 2001
    ..Mimosamycin (2) was the principal cytotoxin with an IC(50) of approximately 10 microg/mL against melanoma and ovarian human tumor cell lines...
  3. ncbi request reprint New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii
    T C McKee
    Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, NCI FCRDC, Frederick, Maryland 21702 1201, USA
    J Nat Prod 59:754-8. 1996
    ..F. Stevens (Clusiaceae). The structure elucidation and anti-HIV activity of calanolide E2 (4), cordatolide E (5), pseudocordatolide C (6), and calanolide F (9), along with a simple prenylated coumarin precursor (11), are described here...
  4. ncbi request reprint Structure-activity modifications of the HIV-1 inhibitors (+)-calanolide A and (-)-calanolide B
    D L Galinis
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Med Chem 39:4507-10. 1996
    ..While none of the compounds showed activity superior to the two unmodified leads, some structure-activity requirements were apparent from the relative anti-HIV potencies of the various analogs...
  5. ncbi request reprint Microspinosamide, a new HIV-inhibitory cyclic depsipeptide from the marine sponge Sidonops microspinosa
    M A Rashid
    Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:117-21. 2001
    ..Microspinosamide (1) inhibited the cytopathic effect of HIV-1 infection in an XTT-based in vitro assay with an EC(50) value of approximately 0.2 microg/mL...
  6. ncbi request reprint Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor
    J B McMahon
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland, USA
    J Pharmacol Exp Ther 276:298-305. 1996
    ..The favorable physical characteristics, lack of toxicity, potency and bioavailability of UC 38 may make it a candidate for combination chemotherapy of acquired immune deficiency syndrome...
  7. ncbi request reprint New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species
    K M Meragelman
    Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-FCRDC, Frederick, MD 21702, USA
    J Nat Prod 64:389-92. 2001
    ..collected in the South Pacific. All the compounds isolated showed antiproliferative activity against melanoma cells (MALME-3M)...
  8. ncbi request reprint Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A
    M J Currens
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland, USA
    J Pharmacol Exp Ther 279:652-61. 1996
    ....
  9. ncbi request reprint Chondropsin D, a new 37-membered-ring macrolide lactam from the marine sponge Chondropsis species
    M A Rashid
    Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Building 1052, Room 121, Frederick, MD 21702-1201, USA
    J Nat Prod 64:1341-4. 2001
    ..Rearrangement of the methylated derivative of chondropsin A (3) to the corresponding methylated analogue of chondropsin D (4) confirmed the structure of 2...
  10. ncbi request reprint Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species
    R D Charan
    Laboratory of Drug Discovery Research and Development, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:661-3. 2001
    ..Both compounds 1 and 2 inhibited the growth of MALME-3M (melanoma) and MCF-7 (breast) cancer cell lines in the range 30-40 microg/mL. The known compound palauolol (3) was isolated as well and was also cytotoxic...
  11. ncbi request reprint Cytotoxic quassinoids from Cedronia granatensis
    M Tischler
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702 1201
    J Nat Prod 55:667-71. 1992
    ..These and related quassinoids may, therefore, be of interest for in vivo evaluation in appropriate xenograft tumor models...
  12. pmc Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development
    M R Boyd
    Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Antimicrob Agents Chemother 41:1521-30. 1997
    ..The biological activity of CV-N is highly resistant to physicochemical denaturation, further enhancing its potential as an anti-HIV microbicide...
  13. ncbi request reprint Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1
    M J Currens
    Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Cancer Research and Development Center, Maryland 21702 1201, USA
    J Pharmacol Exp Ther 279:645-51. 1996
    ..The study substantially supports the conclusion that calanolide A represents a novel subclass of nonnucleoside RT inhibitor which merits consideration for anti-HIV drug development...
  14. ncbi request reprint Anti-HIV prenylated flavonoids from Monotes africanus
    K M Meragelman
    Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:546-8. 2001
    ..In addition, several (13)C NMR assignments of lonchocarpol A (6) were corrected...
  15. ncbi request reprint Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins
    S R Shenoy
    Laboratory of Drug Discovery Research and Development, NCI Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    J Pharmacol Exp Ther 297:704-10. 2001
    ..488 microM), several hundredfold greater than observed for oligosaccharides and their protein lectins (K(d) = 1 microM--1 mM), further establishing a critical role of high-mannose oligosaccharides in CV-N binding to glycoproteins...
  16. ncbi request reprint A novel anti-HIV macrocyclic peptide from Palicourea condensata
    H R Bokesch
    Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, NCI-Frederick, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:249-50. 2001
    ..Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM...
  17. ncbi request reprint Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea
    M A Rashid
    Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI-FCRDC, Building 1052, Room 121, Frederick, MD 21702-1201, USA
    Nat Prod Lett 15:21-6. 2001
    ..In an in vitro XTT-based anti-HIV assay, 2-5 micrograms/mL of minquartynoic acid (1) effectively inhibited human lymphoblastoid cell killing by HIV-1...
  18. ncbi request reprint 10-Demethoxystegane, a new lignan from Steganotaenia araliacea
    K M Meragelman
    Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA
    J Nat Prod 64:1480-2. 2001
    ..Steganone (2) showed antiproliferative activity against an ovarian cancer cell line (OVCAR-3)...