Remy Bosselut

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals
    Remy Bosselut
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 4:529-40. 2004
  2. pmc The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, NIH, Bethesda, MD 20892 4259, USA
    Eur J Immunol 40:2385-90. 2010
  3. pmc Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Immunol 9:1122-30. 2008
  4. pmc The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 29:876-87. 2008
  5. doi request reprint Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus
    Yumei Xiong
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892 4259, MD, USA
    Eur J Immunol 43:918-28. 2013
  6. ncbi request reprint Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes
    Xiaolong Liu
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:4465-74. 2005
  7. pmc Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation
    S Rhiannon Jenkinson
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:267-72. 2007
  8. pmc The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus
    Monica Zamisch
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:2685-99. 2009
  9. pmc CD4-CD8 lineage differentiation: Thpok-ing into the nucleus
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4259, USA
    J Immunol 183:2903-10. 2009
  10. pmc Themis, a T cell-specific protein important for late thymocyte development
    Renaud Lesourne
    Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Immunol 10:840-7. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals
    Remy Bosselut
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 4:529-40. 2004
  2. pmc The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, NIH, Bethesda, MD 20892 4259, USA
    Eur J Immunol 40:2385-90. 2010
    ..These findings identify the sequential activity of Gata3 and Thpok as a hallmark of CD4(+) T-cell differentiation, regardless of MHC restriction...
  3. pmc Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Immunol 9:1122-30. 2008
    ..We propose that GATA-3 acts as a specification factor for the CD4(+) lineage 'upstream' of the ThPOK-controlled CD4(+) commitment checkpoint...
  4. pmc The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 29:876-87. 2008
    ..We conclude that a key function of Zbtb7b in the mature CD4+ T cell compartment is to repress CD8-lineage gene expression...
  5. doi request reprint Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus
    Yumei Xiong
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892 4259, MD, USA
    Eur J Immunol 43:918-28. 2013
    ..Thus, in addition to its previously documented role in promoting CD4-lineage gene-expression, Gata3 represses CD8-lineage gene expression. These findings identify Gata3 as a critical pivot of CD4-CD8 lineage differentiation...
  6. ncbi request reprint Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes
    Xiaolong Liu
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:4465-74. 2005
    ..We conclude from these findings that MHC-II-signaled thymocytes remain competent to initiate CD8-specific gene expression even after CD8 down-regulation and that CD4 lineage differentiation is not fixed before the CD4 SP stage...
  7. pmc Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation
    S Rhiannon Jenkinson
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:267-72. 2007
    ..These observations reveal a persistent degree of plasticity in CD4-CD8 differentiation in mature T cells...
  8. pmc The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus
    Monica Zamisch
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:2685-99. 2009
    ..These findings identify Ets1 as a key player during CD8 lineage differentiation and indicate that it acts, at least in part, by promoting Runx3 expression...
  9. pmc CD4-CD8 lineage differentiation: Thpok-ing into the nucleus
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4259, USA
    J Immunol 183:2903-10. 2009
    ..We also discuss how the "circuitry" connecting these factors could operate to match the expression of the lineage-committing factors Thpok and Runx3, and therefore lineage differentiation, to MHC specificity...
  10. pmc Themis, a T cell-specific protein important for late thymocyte development
    Renaud Lesourne
    Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Immunol 10:840-7. 2009
    ..Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation...
  11. pmc Coreceptor gene imprinting governs thymocyte lineage fate
    Stanley Adoro
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    EMBO J 31:366-77. 2012
    ..This study identifies coreceptor gene imprinting as a critical determinant of lineage fate determination in the thymus...
  12. ncbi request reprint The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer
    Kathryn F Wildt
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:4405-14. 2007
    ..These findings demonstrate that the transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated CD4 repression...
  13. ncbi request reprint The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection
    Guangping Sun
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 6:373-81. 2005
    ..CD4 lineage differentiation mediated by cKrox required its N-terminal BTB (bric-a-brac, tramtrack, broad complex) domain. These findings identify cKrox as a chief CD4 differentiation factor during positive selection...
  14. pmc Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection
    Xiaolong Liu
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:363-73. 2003
    ..These observations identify a TCR-dependent proofreading mechanism that verifies thymocyte TCR specificity and differentiation choices before the completion of positive selection...
  15. doi request reprint The Transcription Factors Thpok and LRF Are Necessary and Partly Redundant for T Helper Cell Differentiation
    Andrea C Carpenter
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:622-33. 2012
    ..These findings identify the Thpok-LRF pair as a core node of Th cell differentiation and function...
  16. ncbi request reprint 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1049-59. 2007
    ..This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity...
  17. ncbi request reprint Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
    Xiaolong Liu
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 5:280-8. 2004
    ..These findings support the hypothesis that distinct kinetics of MHC class I- and MHC class II-induced TCR signals direct intrathymic developmental decisions...
  18. ncbi request reprint CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision
    Alfred Singer
    Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Adv Immunol 83:91-131. 2004
  19. pmc Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4259, USA
    Semin Immunol 22:294-302. 2010
    ..In a second part, we evaluate current observations and hypotheses on the connections between sensing transcription factors and effector circuitries...
  20. pmc Decision checkpoints in the thymus
    Andrea C Carpenter
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 11:666-73. 2010
    ..We focus on the divergence of alphabeta and gammadelta lineage cells and the elaboration of the alphabeta T cell repertoire, with special emphasis on the emergence of transcriptional programs that direct lineage decisions...
  21. pmc Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β
    Joanne E Konkel
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:312-9. 2011
    ..Our data demonstrate a previously unrecognized role for TGF-β in the development of TCRαβ+CD8αα+ IELs and the expression of CD8α in T cells...
  22. pmc Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells
    Remy Bosselut
    Laboratory of Immune Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 197:1709-19. 2003
    ..These results challenge classical concepts of lineage commitment but fulfill predictions of the kinetic signaling model...
  23. pmc CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
    Ling Zhao
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Blood 109:3432-40. 2007
    ..Our data suggest that Cbfb-MYH11 suppressed Cbfb in several stages of T-cell development and provide a mechanism for CBFB-MYH11 association with myeloid but not lymphoid leukemia...
  24. pmc Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, NIH, Bethesda, MD 20892 4259, USA
    Semin Immunol 23:360-7. 2011
    ....
  25. pmc CD4-CD8 differentiation in the thymus: connecting circuits and building memories
    Yumei Xiong
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Curr Opin Immunol 24:139-45. 2012
    ..The present review attempts to integrate these findings and discusses the still elusive mechanisms that match CD4-CD8 lineage differentiation to MHC specificity...
  26. pmc The enigma of CD4-lineage specification
    Yumei Xiong
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, NIH, Bethesda, MD 20892 4259, USA
    Eur J Immunol 41:568-74. 2011
    ....
  27. pmc GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice
    Elizabeth A Wohlfert
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 121:4503-15. 2011
    ..Overall, our work reveals what we believe to be a new facet in the complex role of GATA3 in T cells and highlights what may be a fundamental role in controlling Treg physiology during inflammation...
  28. pmc Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2
    Cyril Berthet
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute Frederick, Bldg 560 22 56, 1050 Boyles Street, Frederick, MD 21702 1201, USA
    Mol Cell Biol 27:5079-89. 2007
    ....