Catharine M Bosio
Affiliation: National Institutes of Health
- Active suppression of the pulmonary immune response by Francisella tularensis Schu4Catharine M Bosio
Department of Microbiology, Immunology and Pathology, Colorado State University, Ft Collins, CO 80523, USA
J Immunol 178:4538-47. 2007..tularensis, Schu4 induced broad immunosuppression within the first few days after aerosol infection. This difference may explain the increased virulence of type A strains compared with their more attenuated counterparts...
- Lung environment determines unique phenotype of alveolar macrophagesAmanda M Guth
Departments of Clinical Sciences, Colorado State University, Ft Collins, USA
Am J Physiol Lung Cell Mol Physiol 296:L936-46. 2009....
- Francisella tularensis induces aberrant activation of pulmonary dendritic cellsCatharine M Bosio
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
J Immunol 175:6792-801. 2005....
- Early interaction of Yersinia pestis with APCs in the lungCatharine M Bosio
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
J Immunol 175:6750-6. 2005..pestis. Depletion of these airway cells by Y. pestis may therefore be one strategy the organism uses to overcome pulmonary defenses following inhalation of the organism...
- The presence of CD14 overcomes evasion of innate immune responses by virulent Francisella tularensis in human dendritic cells in vitro and pulmonary cells in vivoJennifer C Chase
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
Infect Immun 78:154-67. 2010..Thus, the presence of this receptor may aid in control of virulent F. tularensis infections at early, but not late, stages of infection...
- Innate and adaptive immunity to FrancisellaKaren L Elkins
Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER U S FDA, Bethesda, Maryland, USA
Ann N Y Acad Sci 1105:284-324. 2007..Thus a number of known proinflammatory and Th-1 T cell related components of the immune system combat this virulent bacterium; no doubt others remain to be discovered...
- Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strainKaren L Elkins
Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
Microbes Infect 5:135-42. 2003..Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens...
- Ebola and Marburg virus-like particles activate human myeloid dendritic cellsCatharine M Bosio
Clinical Research Management, Frederick, MD 21702, USA
Virology 326:280-7. 2004..Thus, our findings suggest that unlike EBOV and MARV, VLPs are effective stimulators of DCs and have potential in enhancing innate and adaptive immune responses...
- Ebola virus-like particles protect from lethal Ebola virus infectionKelly L Warfield
US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 100:15889-94. 2003..Together, our data suggest that eVLPs represent a promising vaccine candidate for protection against Ebola virus infections and a much needed tool to examine the genesis and nature of immune responses to Ebola virus...
- NKp30-dependent cytolysis of filovirus-infected human dendritic cellsClaudette L Fuller
United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
Cell Microbiol 9:962-76. 2007..Further elucidation of the biology of NK cell activation, specifically natural cytotoxicity receptors like NKp30 and NKp46, promises to aid our understanding of microbial pathology...
- Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturationCatharine M Bosio
United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702 5011, USA
J Infect Dis 188:1630-8. 2003..These findings may explain the profound virulence of EBOV and MARV--DCs are disabled, and an effective early host response is delayed by the necessary reliance on less-efficient secondary mechanisms...