Catharine M Bosio

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The subversion of the immune system by francisella tularensis
    Catharine M Bosio
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health Hamilton, MT, USA
    Front Microbiol 2:9. 2011
  2. ncbi request reprint Active suppression of the pulmonary immune response by Francisella tularensis Schu4
    Catharine M Bosio
    Department of Microbiology, Immunology and Pathology, Colorado State University, Ft Collins, CO 80523, USA
    J Immunol 178:4538-47. 2007
  3. pmc Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs
    Rebecca V Anderson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S, 4th Street, Hamilton, MT 59840, USA
    Vaccine 28:6562-72. 2010
  4. pmc Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination
    Dedeke Rockx-Brouwer
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 7:e37752. 2012
  5. pmc The presence of CD14 overcomes evasion of innate immune responses by virulent Francisella tularensis in human dendritic cells in vitro and pulmonary cells in vivo
    Jennifer C Chase
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Infect Immun 78:154-67. 2010
  6. pmc Lipids derived from virulent Francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor α
    Deborah D Crane
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA
    Clin Vaccine Immunol 20:1531-40. 2013
  7. pmc Lung environment determines unique phenotype of alveolar macrophages
    Amanda M Guth
    Departments of Clinical Sciences, Colorado State University, Ft Collins, USA
    Am J Physiol Lung Cell Mol Physiol 296:L936-46. 2009
  8. pmc Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens
    Robin Ireland
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000921. 2010
  9. pmc IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis
    Timothy J Bauler
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites Rocky Mountain Laboratories National Institute of Allergy and Infectious Disease National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 187:1845-55. 2011
  10. pmc B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses
    Deborah D Crane
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 190:2756-66. 2013

Collaborators

  • Rong Wang
  • William J Janssen
  • B Joseph Hinnebusch
  • Vinod Nair
  • E Crouch
  • Peter Henson
  • Mansour Mohamadzadeh
  • Jean Celli
  • Claudette L Fuller
  • Siobhán C Cowley
  • K L Elkins
  • Deborah D Crane
  • Tara D Wehrly
  • Jennifer C Chase
  • Amanda J Griffin
  • Robin Ireland
  • Timothy J Bauler
  • Rebecca V Anderson
  • Jeffrey C Chandler
  • Pamela Small
  • Joshua B Alinger
  • Dana P Scott
  • John T Belisle
  • Dedeke Rockx-Brouwer
  • Robert Child
  • Audrey Chong
  • Amanda M Guth
  • Kelly L Warfield
  • Marisa R Harton
  • Marjorie D Sutherland
  • Darragh G Heaslip
  • Claudia R Molins
  • Norma Olivares-Zavaleta
  • Clayton Jarrett
  • Jeffery Fairman
  • Frank C Gherardini
  • Jonathan M Warawa
  • Luke Wicke
  • Elizabeth R Fischer
  • Dan E Sturdevant
  • John J Kupko
  • Shayna L Warner
  • Craig Martens
  • Alissa J Curda
  • Kimmo Virtaneva
  • Jessica A Edwards
  • Dedeke Brouwer
  • Stephen F Porcella
  • Steven W Dow
  • Emily M Deal
  • Alan Schmaljohn
  • Sina Bavari
  • Brent C Welcher
  • M Javad Aman

Detail Information

Publications27

  1. pmc The subversion of the immune system by francisella tularensis
    Catharine M Bosio
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health Hamilton, MT, USA
    Front Microbiol 2:9. 2011
    ..Compilation of this work will undoubtedly aid in enhancing our understanding of the myriad of mechanisms utilized by virulent F. tularensis for successful infection, colonization, and pathogenesis in the mammalian host...
  2. ncbi request reprint Active suppression of the pulmonary immune response by Francisella tularensis Schu4
    Catharine M Bosio
    Department of Microbiology, Immunology and Pathology, Colorado State University, Ft Collins, CO 80523, USA
    J Immunol 178:4538-47. 2007
    ..tularensis, Schu4 induced broad immunosuppression within the first few days after aerosol infection. This difference may explain the increased virulence of type A strains compared with their more attenuated counterparts...
  3. pmc Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs
    Rebecca V Anderson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 S, 4th Street, Hamilton, MT 59840, USA
    Vaccine 28:6562-72. 2010
    ..tularensis infection. Instead, survival of SchuS4 infection at extended time points after immunization was only associated with production of IFN-γ and activation of T cells in peripheral organs...
  4. pmc Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccination
    Dedeke Rockx-Brouwer
    Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 7:e37752. 2012
    ..Together our data provides proof of principle that low dose attenuated vaccines may be a viable goal in development of novel vaccines directed against tularemia...
  5. pmc The presence of CD14 overcomes evasion of innate immune responses by virulent Francisella tularensis in human dendritic cells in vitro and pulmonary cells in vivo
    Jennifer C Chase
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA
    Infect Immun 78:154-67. 2010
    ..Thus, the presence of this receptor may aid in control of virulent F. tularensis infections at early, but not late, stages of infection...
  6. pmc Lipids derived from virulent Francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor α
    Deborah D Crane
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA
    Clin Vaccine Immunol 20:1531-40. 2013
    ..tularensis to efficiently evade host immune responses. ..
  7. pmc Lung environment determines unique phenotype of alveolar macrophages
    Amanda M Guth
    Departments of Clinical Sciences, Colorado State University, Ft Collins, USA
    Am J Physiol Lung Cell Mol Physiol 296:L936-46. 2009
    ....
  8. pmc Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens
    Robin Ireland
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America
    PLoS Pathog 6:e1000921. 2010
    ..Lastly, CLDC+MPF was also effective at controlling infections with Yersinia pestis, Burkholderia pseudomallei and Brucella abortus. Thus, CLDC+MPF represents a novel prophylaxis to protect against multiple, highly virulent pathogens...
  9. pmc IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis
    Timothy J Bauler
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites Rocky Mountain Laboratories National Institute of Allergy and Infectious Disease National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 187:1845-55. 2011
    ..Together, these data demonstrated a novel mechanism by which virulent bacteria, in contrast to attenuated strains, modulate human cells to cause disease...
  10. pmc B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses
    Deborah D Crane
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 190:2756-66. 2013
    ..Similarly, depletion of NK/NKT cells also increased bacterial burdens in XID mice. Together, our data suggest B cell-NK/NKT cell cross-talk is a critical pivot controlling survival of infection with virulent F. tularensis...
  11. pmc Generation of a convalescent model of virulent Francisella tularensis infection for assessment of host requirements for survival of tularemia
    Deborah D Crane
    Immunity to Pulmonary Pathogens, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 7:e33349. 2012
    ..tularensis and provides evidence that this model will be a useful tool for better understanding the dynamics of tularemia infection...
  12. ncbi request reprint Francisella tularensis induces aberrant activation of pulmonary dendritic cells
    Catharine M Bosio
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
    J Immunol 175:6792-801. 2005
    ....
  13. pmc Alternative activation of macrophages and induction of arginase are not components of pathogenesis mediated by Francisella species
    Amanda J Griffin
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 8:e82096. 2013
    ..Together our data establish that neither induction of alternative activation nor expression of arginase1 are critical features of disease mediated by attenuated or virulent Francisella species. ..
  14. pmc Francisella tularensis SchuS4 and SchuS4 lipids inhibit IL-12p40 in primary human dendritic cells by inhibition of IRF1 and IRF8
    Robin Ireland
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 191:1276-86. 2013
    ..Together these data provide novel insight into how highly virulent bacteria selectively modulate the host to interfere with innate immune responses required for survival of infection. ..
  15. pmc Successful protection against tularemia in C57BL/6 mice is correlated with expansion of Francisella tularensis-specific effector T cells
    Amanda J Griffin
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA
    Clin Vaccine Immunol 22:119-28. 2015
    ..Together, our data provide a unique model to compare efficacious vaccines to nonefficacious vaccines, which will enable comprehensive identification of host and bacterial components required for immunization against tularemia. ..
  16. pmc Virulent Francisella tularensis destabilize host mRNA to rapidly suppress inflammation
    Timothy J Bauler
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Mont, USA
    J Innate Immun 6:793-805. 2014
    ..Thus, our findings represent a novel strategy by which a highly virulent pathogen modulates host inflammatory responses critical to the evasion of innate immunity...
  17. pmc Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4
    Jennifer C Chase
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 303 S 4th St Hamilton, MT 59840, USA
    Infect Immun 77:180-95. 2009
    ..This suggests that immune dysregulation by F. tularensis operates on a broader and more comprehensive scale than previously appreciated...
  18. pmc Francisella tularensis LVS surface and membrane proteins as targets of effective post-exposure immunization for tularemia
    Jeffrey C Chandler
    Rocky Mountain Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Department of Microbiology, Immunology, and Pathology, Colorado State University, Campus Delivery 0922, Fort Collins 80523, Colorado, United States
    J Proteome Res 14:664-75. 2015
    ..Collectively, this use of orthogonal proteomic approaches reduced the complexity of potential immunogens in MPF by 96% and allowed for prioritization of target immunogens for antibody-based immunotherapies against tularemia. ..
  19. pmc A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis
    Deborah D Crane
    Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 183:4593-600. 2009
    ..tularensis. This mechanism may also represent a more common hereto unrecognized strategy by which virulent bacteria evade detection and clearance by Ig...
  20. pmc Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages
    Tara D Wehrly
    Tularemia Pathogenesis Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Cell Microbiol 11:1128-50. 2009
    ....
  21. ncbi request reprint Early interaction of Yersinia pestis with APCs in the lung
    Catharine M Bosio
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Immunol 175:6750-6. 2005
    ..pestis. Depletion of these airway cells by Y. pestis may therefore be one strategy the organism uses to overcome pulmonary defenses following inhalation of the organism...
  22. ncbi request reprint Innate and adaptive immunity to Francisella
    Karen L Elkins
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER U S FDA, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1105:284-324. 2007
    ..Thus a number of known proinflammatory and Th-1 T cell related components of the immune system combat this virulent bacterium; no doubt others remain to be discovered...
  23. ncbi request reprint Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain
    Karen L Elkins
    Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA
    Microbes Infect 5:135-42. 2003
    ..Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens...
  24. ncbi request reprint NKp30-dependent cytolysis of filovirus-infected human dendritic cells
    Claudette L Fuller
    United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Cell Microbiol 9:962-76. 2007
    ..Further elucidation of the biology of NK cell activation, specifically natural cytotoxicity receptors like NKp30 and NKp46, promises to aid our understanding of microbial pathology...
  25. ncbi request reprint Ebola and Marburg virus-like particles activate human myeloid dendritic cells
    Catharine M Bosio
    Clinical Research Management, Frederick, MD 21702, USA
    Virology 326:280-7. 2004
    ..Thus, our findings suggest that unlike EBOV and MARV, VLPs are effective stimulators of DCs and have potential in enhancing innate and adaptive immune responses...
  26. pmc Ebola virus-like particles protect from lethal Ebola virus infection
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 100:15889-94. 2003
    ..Together, our data suggest that eVLPs represent a promising vaccine candidate for protection against Ebola virus infections and a much needed tool to examine the genesis and nature of immune responses to Ebola virus...
  27. ncbi request reprint Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation
    Catharine M Bosio
    United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702 5011, USA
    J Infect Dis 188:1630-8. 2003
    ..These findings may explain the profound virulence of EBOV and MARV--DCs are disabled, and an effective early host response is delayed by the necessary reliance on less-efficient secondary mechanisms...