Frances Bosetti

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease
    S Sakura Minami
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Neuroinflammation 7:57. 2010
  2. pmc Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9000 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA
    J Neuroinflammation 5:17. 2008
  3. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
  4. pmc Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Neurochem 102:577-86. 2007
  5. ncbi request reprint Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6N202, Bethesda, MD 20892, USA
    Brain Res Bull 57:205-9. 2002
  6. ncbi request reprint Microarray analysis of rat brain gene expression after chronic administration of sodium valproate
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6N202, Bethesda, MD 20892, USA
    Brain Res Bull 65:331-8. 2005
  7. ncbi request reprint Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 91:1389-97. 2004
  8. ncbi request reprint The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 87:1471-7. 2003
  9. ncbi request reprint Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6N202, Bethesda, MD 20892, USA
    Neurosci Lett 327:71-3. 2002
  10. ncbi request reprint Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 85:690-6. 2003

Collaborators

Detail Information

Publications36

  1. pmc Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease
    S Sakura Minami
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Neuroinflammation 7:57. 2010
    ..This therapeutic strategy is under intense scrutiny in clinical studies, but its application is limited by neuroinflammatory side effects (autoimmune encephalitis and vasogenic edema)...
  2. pmc Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9000 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA
    J Neuroinflammation 5:17. 2008
    ..Recently, we demonstrated that COX-1 deficient mice show decreased neuroinflammatory response and neuronal damage in response to lipopolysaccharide (LPS)...
  3. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
    ....
  4. pmc Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Neurochem 102:577-86. 2007
    ....
  5. ncbi request reprint Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6N202, Bethesda, MD 20892, USA
    Brain Res Bull 57:205-9. 2002
    ..Thus, chronic lithium at a therapeutically relevant concentration reduced expression of a large number of genes involved in multiple signaling and other pathways, without increasing expression at a comparable extent...
  6. ncbi request reprint Microarray analysis of rat brain gene expression after chronic administration of sodium valproate
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6N202, Bethesda, MD 20892, USA
    Brain Res Bull 65:331-8. 2005
    ..Our results suggest that the therapeutic effect of valproate may involve the modulation of multiple signaling pathways...
  7. ncbi request reprint Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 91:1389-97. 2004
    ..Overall, the data suggest that compensatory mechanisms exist in COX-2(-/-) mice and that mPGES-2 is functionally coupled with COX-2...
  8. ncbi request reprint The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 87:1471-7. 2003
    ..This suggests that cPLA2 is critical for COX-2-derived eicosanoid production in mouse brain...
  9. ncbi request reprint Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6N202, Bethesda, MD 20892, USA
    Neurosci Lett 327:71-3. 2002
    ..01) in LiCl-fed rats, 0.86+/-0.06 (SE) compared to 1.2+/-0.07 in control rats. These results suggest that a therapeutic level of lithium may downregulate the synthesis of proteins whose translation depends on eIF-2B...
  10. ncbi request reprint Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 85:690-6. 2003
    ..If targeting this part of the 'AA cascade' accounts for their therapeutic action, non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors might prove effective in bipolar disorder...
  11. ncbi request reprint Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain
    Frances Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 10 Rm 6N202, Bethesda, MD 20892, USA
    Mol Psychiatry 7:845-50. 2002
    ..These and prior results indicate that lithium targets a part of the AA cascade that involves cPLA(2) and COX-2. This effect may contribute to lithium's therapeutic action in bipolar disorder...
  12. pmc Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Brain Res Bull 75:598-609. 2008
    ..Our results suggest that PTGS-2 activity and its specific products may modulate neuronal excitability by affecting GABAergic neurotransmission. Further, inhibition of PTGS-2, but not PTGS-1, may increase the susceptibility to seizures...
  13. pmc Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institute of Health, Bethesda, MD 20892 0947, USA
    Brain Res Bull 73:108-13. 2007
    ..The specific changes in the AA cascade observed in the hippocampus may alter phospholipids homeostasis and possibly increase the susceptibility of the aging brain to neuroinflammation...
  14. ncbi request reprint Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain
    Sandra Ghelardoni
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 56:248-54. 2004
    ....
  15. pmc Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity
    Saba Aid
    Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 30:370-80. 2010
    ..Altogether, these results indicate that COX-2 activity modulates MMP-9 and-3 activities and is necessary to maintain BBB integrity during toll-like receptor 4-dependent innate immune activation...
  16. ncbi request reprint Lithium chloride, administered chronically to rats, does not affect the fractional phosphorylation of brain cytosolic phospholipase A2, while reducing its net protein level
    Gayani R Weerasinghe
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 59:303-6. 2003
    ..Thus, decreased brain PLA(2) enzyme activity caused by chronic lithium is likely a consequence only of lithium's downregulation of cPLA(2) transcription...
  17. ncbi request reprint The effect of chronic lithium on arachidonic acid release and metabolism in rat brain does not involve secretory phospholipase A2 or lipoxygenase/cytochrome P450 pathways
    Gayani R Weerasinghe
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 63:485-9. 2004
    ..These results indicate that the effect of lithium selectively involves the cPLA2/COX-2 pathway, which might be responsible for the therapeutic effect in bipolar disorder...
  18. pmc Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation
    Saba Aid
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    Neurosci Lett 478:113-8. 2010
    ..This is likely due to the direct effect of LPS on glial rather than neuronal cells...
  19. pmc Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    FASEB J 22:1491-501. 2008
    ..These findings suggest that COX-1 plays a previously unrecognized role in neuroinflammatory damage...
  20. pmc Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis
    Sang Ho Choi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 98:801-11. 2006
    ..Additionally, COX-1 deficiency can affect the expression of reciprocal and coupled enzymes, COX-2, Ca2+ -dependent PLA2, and terminal mPGES-2, to overcome defects in brain AA cascade...
  21. ncbi request reprint Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, Bldg 10, Room 6N202, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:592-6. 2002
    ..Lithium and certain anticonvulsants, including carbamazepine and valproic acid, are effective antimanic drugs for treating bipolar disorder, but their mechanisms of action remain uncertain...
  22. ncbi request reprint Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells
    Elisabetta A Tendi
    Brain Physiology and Metabolism Section, National Institute on Aging National Institutes of Health Bethesda, MD 20892, USA
    Neurochem Res 27:319-23. 2002
    ....
  23. ncbi request reprint Down-regulation of brain nuclear factor-kappa B pathway in the cyclooxygenase-2 knockout mouse
    Jagadeesh S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 9, Room 1S 128, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 139:217-24. 2005
    ..Overall, our data indicate that constitutive brain NF-kappaB activity is decreased in COX-2 deficient mice and suggest a reciprocal coupling between NF-kappaB and COX-2...
  24. ncbi request reprint Topiramate does not alter expression in rat brain of enzymes of arachidonic acid metabolism
    Sandra Ghelardoni
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm 6N202, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 180:523-9. 2005
    ..Phase II clinical trials with the anticonvulsant topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] suggest that this drug may also be effective for bipolar disorder...
  25. ncbi request reprint Modulatory role of cyclooxygenase-2 in cerebrovascular coupling
    Bojana Stefanovic
    Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke NIH, 10 Center Drive, Building 10, Room B1D109, Bethesda, MD 20892 1065, USA
    Neuroimage 32:23-32. 2006
    ..These findings suggest a modulatory role of COX-2 products in the cerebrovascular coupling and provide evidence for existence of a functional metabolic buffer...
  26. ncbi request reprint Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat
    Ho Joo Lee
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA
    Neurochem Res 30:677-83. 2005
    ..The results of our study indicate that topiramate does not possess a pharmacological property that three drugs with proven efficacy in treating bipolar disorder have in common...
  27. ncbi request reprint Co-localization of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey cerebellum
    Sibile Pardue
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6N202, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 116:106-14. 2003
    ....
  28. ncbi request reprint Decrease in the AP-2 DNA-binding activity and in the protein expression of AP-2 alpha and AP-2 beta in frontal cortex of rats treated with lithium for 6 weeks
    Jagadeesh S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:2006-13. 2005
    ....
  29. ncbi request reprint Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide
    Thad A Rosenberger
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1582, USA
    J Neurochem 88:1168-78. 2004
    ..These observations suggest that selective alterations in brain arachidonic acid metabolism involving cytosolic and secretory PLA2 contribute to early pathology in neuroinflammation...
  30. pmc Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    Sang Ho Choi
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Aging (Albany NY) 1:234-44. 2009
    ..These results indicate that inhibition of COX-1 activity may be valid therapeutic strategy to reduce brain inflammatory response and neurodegeneration...
  31. pmc Regional protein levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age
    Gayani R Weerasinghe
    Brain Physiology and Metabolism Section, National Institute on Aging NIH, 9 Memorial Drive, Bldg 9, Rm 1S126, Bethesda, MD 20892 0947, USA
    Brain Res Bull 69:614-21. 2006
    ....
  32. pmc NMDA-induced seizure intensity is enhanced in COX-2 deficient mice
    Christopher D Toscano
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurotoxicology 29:1114-20. 2008
    ..Furthermore, increased levels of prostaglandins after seizures are associated with consistent manifestation of neuronal damage...
  33. pmc The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research
    Sang Ho Choi
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Pharmacol Sci 30:174-81. 2009
    ....
  34. ncbi request reprint Quenching of intracellular ROS generation as a mechanism for oleate-induced reduction of endothelial activation and early atherogenesis
    Marika Massaro
    Laboratory for Thrombosis and Vascular Research, C N R Institute of Clinical Physiology, Pisa, Italy
    Thromb Haemost 88:335-44. 2002
    ..These results indicate that oleate may exert direct vascular atheroprotective effects by inhibiting endothelial activation through a quenching of stimuli-induced increase in ROS...
  35. pmc Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania
    M Elizabeth Sublette
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Bipolar Disord 9:759-65. 2007
    ....
  36. ncbi request reprint Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease
    Michelangelo Mancuso
    Department of Neurosciences, Neurological Clinics, University of Pisa, Via Roma 67, 56126, Pisa, Italy
    Exp Neurol 182:421-6. 2003
    ..These results support the hypothesis of a systemic impairment of the mitochondrial function in AD and indicate that decreased COX activity could have functional consequences on metabolism...