Research Topics
Genomes and GenesSpecies | Brian W BoothSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Estrogen receptor-alpha and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strandsBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA
Breast Cancer Res 8:R49. 2006..Mouse mammary epithelium contains label-retaining epithelial cells that divide asymmetrically and retain their template DNA...- IL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17Brian W Booth
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, USA
Respir Res 8:51. 2007..TGFalpha exists as an integral membrane protein and requires proteolytic processing to its mature form, with a disintegrin and metalloproteinase (ADAM)17 responsible for this processing in a variety of tissues... - The mammary microenvironment alters the differentiation repertoire of neural stem cellsBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:14891-6. 2008..This result supports the conclusion that tissue-specific signals emanating from the stroma and from the differentiated somatic cells of the mouse mammary gland can redirect the NSCs to produce cellular progeny committed to MEC fates... - Selective segregation of DNA strands persists in long-label-retaining mammary cells during pregnancyBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
Breast Cancer Res 10:R90. 2008..Mouse mammary epithelium in nonpregnant mice contains long label-retaining epithelial cells (LREC) that divide asymmetrically and retain their template DNA strands. The role of LREC during alveogenesis has not been determined... - Stem cells and the mammary microenvironmentBrian W Booth
Section for Mammary Stem Cell Biology, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Breast Dis 29:57-67. 2008..This suggests the ascendancy of the microenvironment over the intrinsic nature of somatic stem cells... 
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary glandLuigi Strizzi
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA
J Cell Physiol 216:824-34. 2008..These results suggest that Netrin-1 may facilitate functional differentiation of mammary epithelial cells and possibly affect the expression of Nanog and/or Cripto-1 in multipotent cells that may reside in the mammary gland...
Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactationBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Physiol 212:729-36. 2007....- Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristicsBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Exp Cell Res 316:422-32. 2010..AREG knockdown inhibits mammosphere formation by duct-limited mammary progenitor cells but not lobule-limited mammary progenitor cells. These data demonstrate AREG mediates the function of a subset of mammary progenitor cells in vitro... - Reprogramming human cancer cells in the mouse mammary glandKaren M Bussard
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 70:6336-43. 2010..This is the first demonstration that human cells are capable of recognizing the signals generated by the mouse mammary gland microenvironment present during gland regeneration in vivo... - Roles of transforming growth factor-alpha in mammary development and diseaseBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Growth Factors 25:227-35. 2007..TGFalpha has also been implicated in numerous disease states including forms of breast cancer. This minireview summarizes the basic biology of TGFalpha and its actions during normal and pathogenic development of the mammary epithelium... - Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivoCorinne A Boulanger
Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:3871-6. 2007..Our results provide evidence for the ascendancy of the tissue microenvironment over the intrinsic nature of cells from an alternative adult tissue... - TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epitheliumBrian W Booth
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
Int J Cancer 120:493-9. 2007....