G A Boorman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Hepatoblastomas in mice in the US National Toxicology Program (NTP) studies
    Vladimir S Turusov
    NN Blokhin Cancer Research Centre, Moscow, Russian Federation
    Toxicol Pathol 30:580-91. 2002
  2. ncbi Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:899-904. 1999
  3. ncbi Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:185-93. 2005
  4. ncbi Variation in the hepatic gene expression in individual male Fischer rats
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:102-10. 2005
  5. pmc Drinking water disinfection byproducts: review and approach to toxicity evaluation
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 107:207-17. 1999
  6. ncbi Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in F344/N rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:267-78. 1999
  7. ncbi Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group
    G A Boorman
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:202-10. 1997
  8. ncbi High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:657-62. 1999
  9. ncbi Two-year and lifetime toxicity and carcinogenicity studies of ozone in B6C3F1 mice
    R A Herbert
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:539-48. 1996
  10. ncbi Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years
    R C Sills
    Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 135:373-86. 2001

Detail Information

Publications49

  1. ncbi Hepatoblastomas in mice in the US National Toxicology Program (NTP) studies
    Vladimir S Turusov
    NN Blokhin Cancer Research Centre, Moscow, Russian Federation
    Toxicol Pathol 30:580-91. 2002
    ..Therefore, it seems reasonable to combine the incidence of mice with hepatoblastomas and the incidence of mice with hepatocellular carcinomas in hazard identification studies...
  2. ncbi Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:899-904. 1999
    ..This study does not support the hypothesis that magnetic field exposure can promote breast cancer in this rat model...
  3. ncbi Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 86:185-93. 2005
    ..The results of this study demonstrate a prominent circadian rhythm in gene expression in the rat that is a critical factor in planning toxicogenomic experiments...
  4. ncbi Variation in the hepatic gene expression in individual male Fischer rats
    Gary A Boorman
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:102-10. 2005
    ..The level of hepatic gene expression under carefully controlled study conditions is less than 1.5-fold for most genes. The impact of individual animal variability on microarray data can be minimized through experimental design...
  5. pmc Drinking water disinfection byproducts: review and approach to toxicity evaluation
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 107:207-17. 1999
    ..This paper describes the approach developed by these agencies to provide the information needed to make scientifically based regulatory decisions...
  6. ncbi Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in F344/N rats
    G A Boorman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:267-78. 1999
    ..These data, when considered as a whole, are interpreted as indicating that chronic exposure to pure linearly polarized 60 Hz magnetic fields has little or no effect on cancer development in the F344/N rat...
  7. ncbi Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group
    G A Boorman
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:202-10. 1997
    ....
  8. ncbi High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 20:657-62. 1999
    ..The major finding of K-ras A-->T transversions in lung and Harderian gland neoplasms suggests that this mutation may be important for tumor induction by this class of carcinogens...
  9. ncbi Two-year and lifetime toxicity and carcinogenicity studies of ozone in B6C3F1 mice
    R A Herbert
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:539-48. 1996
    ..5 or 1.0 ppm of ozone for 2 yrs, which persist with continued exposure to 30 mo. It is uncertain whether or not the marginal increase (p > 0.05) of alveolar/bronchiolar neoplasms in male B6C3F1 mice resulted from exposure to ozone...
  10. ncbi Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years
    R C Sills
    Laboratory of Experimental Pathology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 135:373-86. 2001
    ....
  11. ncbi The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies
    S L Eustis
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 22:457-72. 1994
    ..For these sex-species groups, there were only two instances, both involving male mice, in which the additional data confirmed an association with kidney neoplasia...
  12. ncbi Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors
    D R Germolec
    Environmental Immunology and Neurobiology Section, NIH, Research Triangle Park, NC 27709, USA
    Mutat Res 386:209-18. 1997
    ..These studies suggest that in vitro studies with human keratinocyte cultures examined in conjunction with TG.AC transgenic mice can provide a useful model for examining the tumor enhancing properties of environmental chemicals...
  13. ncbi Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies
    R C Sills
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:589-99. 1999
    ....
  14. ncbi The effect of short intermittent light exposures on the melatonin circadian rhythm and NMU-induced breast cancer in female F344/N rats
    G S Travlos
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:126-36. 2001
    ..This finding was unexpected and suggests that melatonin can be produced by an organ or tissue other than the pineal gland...
  15. ncbi Toxicology and carcinogenesis studies of ozone and ozone 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone in Fischer-344/N rats
    G A Boorman
    Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 22:545-54. 1994
    ....
  16. ncbi Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years
    H H Hong
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:646-50. 1998
    ..The ras mutation frequency and spectrum were similar to those of the structurally related chemical tetrachloroethylene...
  17. ncbi Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice
    V R Torti
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709-2137, USA
    Toxicol Sci 64:269-80. 2001
    ..Resolution of the kidney lesions indicates that periods of very high regenerative cell proliferation, potentially important in the carcinogenic process, may not be observed if measurements are taken only at 3 weeks of exposure or later...
  18. doi Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning
    Scott S Auerbach
    National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC 27709, USA
    Toxicol Appl Pharmacol 243:300-14. 2010
    ..Furthermore, we find that exposure duration is a critical variable in the success or failure of such an approach, particularly when evaluating chemicals with unknown carcinogenic potency...
  19. ncbi Renal lesions induced by ochratoxin A exposure in the F344 rat
    G A Boorman
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 20:236-45. 1992
    ..This study demonstrates that ochratoxin A is a potent renal carcinogen in the F344 rat and suggests that contamination of feedstuff by this mycotoxin may pose a potential hazard to domestic animals and man...
  20. ncbi Proliferative exocrine pancreatic lesions in rats. The effect of sample size on the incidence of lesions
    G A Boorman
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 15:451-6. 1987
    ..In addition, examination of a larger tissue sample identified a similar but smaller effect of the corn oil vehicle in female F344 rats that had not been detected by routine sampling of the pancreas...
  21. ncbi Gene interaction network analysis suggests differences between high and low doses of acetaminophen
    Hiroyoshi Toyoshiba
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 215:306-16. 2006
    ..The approaches shown here could provide predictive information to understand high- versus low-dose mechanisms of toxicity...
  22. ncbi Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations
    Alexandra N Heinloth
    National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:276-83. 2007
    ....
  23. ncbi Pancreatic hepatocytes associated with chronic 2,6-dichloro-p-phenylenediamine administration in Fischer 344 rats
    M M McDonald
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 17:1-6. 1989
    ..A statistically significant increase (p less than 0.01) in pancreatic acinar atrophy and fibrosis was also seen in treated female rats, but the relationship of these lesions to the PH is unclear...
  24. ncbi Primary cardiac hemangiosarcomas induced by 1,3-butadiene in B6C3F1 hybrid mice
    H A Solleveld
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 16:46-52. 1988
    ..Metastatic lesions were observed in liver, lung and kidney. To date, 1,3-butadiene is the only carcinogen reported that induces proliferative vascular lesions in the heart of mice...
  25. ncbi Use of historical control data in carcinogenicity studies in rodents
    J K Haseman
    Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 12:126-35. 1984
    ..All studies in the database are of two years duration, and all neoplasms occurring with a frequency of 0.5% or more are reported...
  26. ncbi Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years
    H H Hong
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:529-34. 2000
    ....
  27. pmc Optimal sampling of rat liver tissue for toxicogenomic studies
    Julie F Foley
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:795-801. 2006
    ..Additionally, a powdered sample provided the advantages of a homogenous sample pool and the ability to use sample aliquots for other analyses to include proteomics, metabonomics, and other molecular techniques...
  28. ncbi Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen
    Richard D Irwin
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:111-7. 2005
    ....
  29. ncbi Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data
    Richard D Irwin
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:72-83. 2004
    ..Most studies will require the input from the disciplines of toxicology, pathology, molecular biology, bioinformatics, biochemistry, and others depending on the types of questions being asked...
  30. ncbi Gene expression profiling of rat livers reveals indicators of potential adverse effects
    Alexandra N Heinloth
    National Center for Toxicogenomics, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 80:193-202. 2004
    ..In conclusion, this study provides evidence that supports the hypothesis that gene expression profiling may be a sensitive means of identifying indicators of potential adverse effects in the absence of the occurrence of overt toxicity...
  31. pmc Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice
    Grace E Kissling
    Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 107:19-26. 2009
    ..AC mice appear less sensitive to hepatocarcinogenesis than standard rodent models. These results suggest caution for the use of Tg.AC and p53 mice to screen unknown chemicals in drinking water for potential carcinogenicity...
  32. ncbi The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity
    Grace E Kissling
    Environmental Medicine and Diseases Program and Environmental Toxicology Program, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Sci 92:143-56. 2006
    ..These results suggest that fish models are of limited utility in screening unknown chemicals for potential carcinogenicity...
  33. ncbi Rodent carcinogenicity bioassay: past, present, and future
    G A Boorman
    Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 22:105-11. 1994
    ....
  34. ncbi Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia
    M J Hooth
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 29:250-9. 2001
    ..Follicular cell hyperplasia was not present in male or female B6C3F1 mice. These data can be used to estimate the human health risk that would be associated with using ClO2, rather than chlorine, to disinfect drinking water...
  35. ncbi The contribution of the mouse in hazard identification studies
    R R Maronpot
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:726-31. 1996
    ..To utilize only one species for this important means of protecting human health is premature at this time...
  36. ncbi Toxicogenomics, drug discovery, and the pathologist
    Gary A Boorman
    Laboratory for Experimental Pathology, Environmental Toxicology Program, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 30:15-27. 2002
    ..In return, you will gain a greater depth of understanding of cell and tissue function, both in health and disease...
  37. pmc Blood gene expression signatures predict exposure levels
    P R Bushel
    Biostatistics Branch, Environmental Stress and Cancer Group, Environmental Toxicology Program, Microarray Group, Cancer Biology Group, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 104:18211-6. 2007
    ..It also supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage...
  38. pmc Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors
    D R Germolec
    Environmental Immunology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 153:1775-85. 1998
    ....
  39. ncbi o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis
    R C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA
    Carcinogenesis 25:605-12. 2004
    ..These alterations, which are hallmarks of human colon cancer, probably contributed to the pathogenesis of the large intestinal carcinomas in mice following o-nitrotoluene exposure...
  40. pmc Gene set enrichment analysis for non-monotone association and multiple experimental categories
    Rongheng Lin
    Biostatistics Branch, National Institute of Environmental Health Science, Research Triangle Park, NC 27713, USA
    BMC Bioinformatics 9:481. 2008
    ..Methods applicable to continuous non-monotone relationships are needed. Furthermore, for multiple experimental categories, methods that combine multiple GSEA/SAFE analyses are needed...
  41. ncbi Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age
    Kazuhiko Mori
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27701, USA
    Toxicol Pathol 35:242-51. 2007
    ..Alterations that are considered crucial to the interpretation of long-term study results could then be confirmed by subsequent metabolic studies...
  42. ncbi Documenting foci of hepatocellular alteration in two-year carcinogenicity studies: current practices of the National Toxicology Program
    R R Maronpot
    National Toxicology Program, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 17:675-83; discussion 683-4. 1989
    ..However, such data may form part of weight-of-evidence considerations used by regulatory bodies when accompanied by a concomitant liver tumor response...
  43. pmc Heat map visualization of high-density clinical chemistry data
    J Todd Auman
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Physiol Genomics 31:352-6. 2007
    ..The value of this clinical chemistry data transformation and visualization will manifest itself through integration with other high-density data, such as genomics data, to study physiology at the systems level...
  44. ncbi Quality review procedures necessary for rodent pathology databases and toxicogenomic studies: the National Toxicology Program experience
    Gary A Boorman
    Laboratory for Experimental Pathology, Environmental Toxicology Program, National Center for Toxicogenomics, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 30:88-92. 2002
    ..The lessons learned in assuring data quality in standard rodent studies also applies to the emerging field of toxicogenomics...
  45. pmc Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
    ..The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data...
  46. ncbi The hepatic transcriptome as a window on whole-body physiology and pathophysiology
    Kevin T Morgan
    Aventis Inc, Bridgewater, New Jersey 08876, USA
    Toxicol Pathol 33:136-45. 2005
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through (www.toxpath.org)...
  47. ncbi Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Morrisville, North Carolina 27560, USA
    Toxicol Pathol 34:921-8. 2006
    ....
  48. pmc Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver
    Christine L Powell
    Curriculum in Toxicology and Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 93:213-22. 2006
    ....
  49. ncbi Standardizing global gene expression analysis between laboratories and across platforms
    Theodore Bammler
    Nat Methods 2:351-6. 2005
    ..These findings indicate that microarray results can be comparable across multiple laboratories, especially when a common platform and set of procedures are used...