James C Bonner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City
    J C Bonner
    Airway Inflammation Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Cell Mol Biol 19:672-80. 1998
  2. ncbi request reprint Airway fibrosis in rats induced by vanadium pentoxide
    J C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 278:L209-16. 2000
  3. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
  4. ncbi request reprint IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha
    Jennifer L Ingram
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 18:1132-4. 2004
  5. pmc Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis
    Dianne M Walters
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, NC 27709, USA
    Am J Pathol 167:1221-9. 2005
  6. pmc Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
    James W Voltz
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Cell Mol Biol 39:45-52. 2008
  7. ncbi request reprint Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts
    Jennifer L Ingram
    CIIT Centers for Health Research, Research Triangle Park, Durham, NC 27709, USA
    J Immunol 177:4141-8. 2006
  8. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
  9. ncbi request reprint STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop
    Aurita Antao-Menezes
    Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 180:4200-7. 2008
  10. ncbi request reprint Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase
    Yi Zhe Wang
    Laboratory of Pulmonary Pathobiology, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 35:845-55. 2003

Detail Information

Publications20

  1. ncbi request reprint Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City
    J C Bonner
    Airway Inflammation Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Cell Mol Biol 19:672-80. 1998
    ..These findings suggest that PM10 particles induce expression of the PDGF receptor system through macrophage-dependent and -independent mechanisms involving endotoxin and metals...
  2. ncbi request reprint Airway fibrosis in rats induced by vanadium pentoxide
    J C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 278:L209-16. 2000
    ..These data suggest that myofibroblasts are the principal proliferating cell type that contributes to the progression of airway fibrosis after V(2)O(5) injury...
  3. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  4. ncbi request reprint IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha
    Jennifer L Ingram
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 18:1132-4. 2004
    ..Our findings indicate that IL-13 acts in synergy with IL-1beta to stimulate growth by coordinately up-regulating PDGF-AA and the PDGF-Ralpha, respectively...
  5. pmc Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis
    Dianne M Walters
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, NC 27709, USA
    Am J Pathol 167:1221-9. 2005
    ....
  6. pmc Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
    James W Voltz
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Cell Mol Biol 39:45-52. 2008
    ..Sex differences should be carefully considered when designing and interpreting experimental models of pulmonary fibrosis in mice...
  7. ncbi request reprint Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts
    Jennifer L Ingram
    CIIT Centers for Health Research, Research Triangle Park, Durham, NC 27709, USA
    J Immunol 177:4141-8. 2006
    ..This novel mechanism could aid in identifying molecular targets for the treatment of chronic airway remodeling and fibrosis in asthma...
  8. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
    ..Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se...
  9. ncbi request reprint STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop
    Aurita Antao-Menezes
    Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 180:4200-7. 2008
    ..This mechanism is postulated to counterbalance profibrogenic mechanisms that follow V(2)O(5) injury...
  10. ncbi request reprint Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase
    Yi Zhe Wang
    Laboratory of Pulmonary Pathobiology, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 35:845-55. 2003
    ..Moreover, p38 MAPK and EGF receptor activation are required for V2O5-induced STAT-1 activation...
  11. ncbi request reprint Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases
    Jennifer L Ingram
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 284:L774-82. 2003
    ..The induction of HB-EGF is not related to a burst of H(2)O(2) in V(2)O(5) treated cells, yet the action of V(2)O(5) in upregulating HB-EGF is oxidant dependent and could be due to the reaction of V(2)O(5) with endogenous H(2)O(2)...
  12. pmc Respiratory syncytial virus infection reduces lung inflammation and fibrosis in mice exposed to vanadium pentoxide
    Elizabeth A Turpin
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Respir Res 11:20. 2010
    ..It is unknown whether individuals with pre-existing respiratory viral infection are susceptible to V2O5-induced bronchitis. We hypothesized that respiratory viral infection will exacerbate vanadium-induced lung fibrosis...
  13. ncbi request reprint Regulation of PDGF and its receptors in fibrotic diseases
    James C Bonner
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cytokine Growth Factor Rev 15:255-73. 2004
    ..This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin...
  14. ncbi request reprint Lung fibrotic responses to particle exposure
    James C Bonner
    Respiratory Biology Program, Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 35:148-53. 2007
    ....
  15. pmc Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis
    Jennifer L Ingram
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Respir Res 8:34. 2007
    ....
  16. ncbi request reprint Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma
    Jennifer L Ingram
    Laboratory of Pulmonary Pathobiology Drs Ingram and Bonner, Ms Rice, and Ms Geisenhoffer, National Institute of Environmental Health Science, Research Triangle Park, NC 27709, USA
    Chest 123:422S-4S. 2003
  17. pmc Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages
    Jong Kwon Lee
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA
    Part Fibre Toxicol 9:14. 2012
    ....
  18. ncbi request reprint EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases
    Jennifer L Ingram
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27709, USA
    Curr Mol Med 6:409-21. 2006
    ..A full understanding of the complex mechanisms involving these receptors and ligands should lead to therapeutic strategies for the treatment of a wide range of fibroproliferative lung diseases...
  19. ncbi request reprint p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts
    Annette B Rice
    Airway Inflammation Group, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Am J Respir Cell Mol Biol 27:759-65. 2002
    ..Collectively, these data demonstrate that p38 MAP kinase activation negatively regulates PDGF- and EGF-mediated growth responses by directly interacting with ERK1/2 and suppressing its phosphorylation...
  20. pmc Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences NIEHS National Institute of Health NIH, Research Triangle Park, Durham, NC, USA
    Part Fibre Toxicol 11:28. 2014
    ..However, the mechanism leading to remodeling is poorly understood. Particularly, there is limited insight about the role of airway epithelial injury in these changes...