Omer Bonne

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
  2. ncbi Cerebral blood flow in chronic symptomatic mild traumatic brain injury
    Omer Bonne
    Departments of Psychiatry, Hadassah University Hospital, Kiryat Hadassah P O Box 12000, 91120 Jerusalem, Israel
    Psychiatry Res 124:141-52. 2003
  3. ncbi Parent-daughter discrepancies in perception of family function in bulimia nervosa
    Omer Bonne
    Outpatient Clinic, Department of Psychiatry, Hadassah University Hospital, Jerusalem
    Psychiatry 66:244-54. 2003
  4. ncbi Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder
    Omer Bonne
    The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
    Psychiatry Res 119:171-5. 2003
  5. ncbi Does short-term diet restriction in mice precipitate the development of anorexia?
    Omer Bonne
    Department of Psychiatry, Hebrew University Hadassah Medical School, PO Box 12000, Jerusalem 91120, Israel
    Nutr Neurosci 6:197-9. 2003
  6. ncbi A randomized, double-blind, placebo-controlled study of classical homeopathy in generalized anxiety disorder
    Omer Bonne
    Department of Psychiatry, Hadassah University Medical School and the Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    J Clin Psychiatry 64:282-7. 2003
  7. ncbi Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analyses
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Hospital, Kiryat Hadassah, PO Box 12000, Jerusalem 91120, Israel
    Psychiatry Res 122:49-57. 2003
  8. ncbi No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
  9. ncbi Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
    Omer Bonne
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Neurosci Biobehav Rev 28:65-94. 2004
  10. ncbi Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006

Detail Information

Publications42

  1. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  2. ncbi Cerebral blood flow in chronic symptomatic mild traumatic brain injury
    Omer Bonne
    Departments of Psychiatry, Hadassah University Hospital, Kiryat Hadassah P O Box 12000, 91120 Jerusalem, Israel
    Psychiatry Res 124:141-52. 2003
    ..Such competence is still to be attained...
  3. ncbi Parent-daughter discrepancies in perception of family function in bulimia nervosa
    Omer Bonne
    Outpatient Clinic, Department of Psychiatry, Hadassah University Hospital, Jerusalem
    Psychiatry 66:244-54. 2003
    ..Future research should aim to replicate these findings, incorporate them into treatment paradigms, and employ them to monitor treatment outcome...
  4. ncbi Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder
    Omer Bonne
    The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
    Psychiatry Res 119:171-5. 2003
    ..Survivors with and without PTSD had similar mean levels of cortisol at both time points. Cortisol levels at 6 months negatively correlated with self-reported PTSD symptoms within PTSD subjects...
  5. ncbi Does short-term diet restriction in mice precipitate the development of anorexia?
    Omer Bonne
    Department of Psychiatry, Hebrew University Hadassah Medical School, PO Box 12000, Jerusalem 91120, Israel
    Nutr Neurosci 6:197-9. 2003
    ..All mice regained appetite and weight. Our conclusions are that diet restriction does not precipitate anorexia in mice. Our findings do not support a role for diet restriction per se in triggering AN...
  6. ncbi A randomized, double-blind, placebo-controlled study of classical homeopathy in generalized anxiety disorder
    Omer Bonne
    Department of Psychiatry, Hadassah University Medical School and the Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    J Clin Psychiatry 64:282-7. 2003
    ..This study evaluates the effect of homeopathic treatment in generalized anxiety disorder, a prevalent mental disorder characterized by an enduring pattern of excessive apprehension and distress and by mental and bodily complaints...
  7. ncbi Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analyses
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Hospital, Kiryat Hadassah, PO Box 12000, Jerusalem 91120, Israel
    Psychiatry Res 122:49-57. 2003
    ..Given the advantages and drawbacks of each procedure, the choice of methodology should be determined in accordance with the study design, and complementary use of both methods may be considered...
  8. ncbi No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  9. ncbi Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
    Omer Bonne
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Neurosci Biobehav Rev 28:65-94. 2004
    ..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed...
  10. ncbi Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  11. ncbi Brain SPECT study of common ground between hypothyroidism and depression
    Yodphat Krausz
    Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Int J Neuropsychopharmacol 10:99-106. 2007
    ..Following treatment, rCBF in depressed patients increased and normalized, but remained unchanged in hypothyroidism. Affective symptoms in hypothyroidism may be mediated by neurocircuitry different from that of major depression...
  12. ncbi Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  13. ncbi Resting regional cerebral perfusion in recent posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Biol Psychiatry 54:1077-86. 2003
    ..Additionally, virtually only activation brain imaging paradigms have been done in posttraumatic stress disorder, whereas in other mental disorders both resting and activation studies have been performed...
  14. doi Cerebral perfusion after a 2-year remission in major depression
    Yoav Kohn
    Department of Psychiatry and Medical Biophysics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:837-43. 2008
    ..These findings suggest that perfusion increases in parieto/cerebellar regions may be involved in acute response to treatment whereas increases in frontal regions may be related to its consolidation...
  15. ncbi Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine Technion IIT, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:807-13. 2007
    ..These results suggest that the correlation between peripheral complex I activity and rCGM in regions implicated in schizophrenia, could be a pathological factor that is differentially expressed in subgroups of schizophrenic patients...
  16. ncbi Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  17. ncbi Depressive tendencies and lower levels of self-sacrifice in mothers, and selflessness in their anorexic daughters
    Eytan Bachar
    Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel
    Eur Eat Disord Rev 16:184-90. 2008
    ..The results support the clinical literature that depicts the anorexic daughters' readiness to sacrifice themselves for the family's needs. Clinical implications are drawn...
  18. ncbi 99mTc-HMPAO SPECT study of cerebral perfusion after treatment with medication and electroconvulsive therapy in major depression
    Yoav Kohn
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Nucl Med 48:1273-8. 2007
    ..However, it is not known if the reversal of rCBF compromise is dependent on the mode of antidepressant treatment. The current study aimed to address this question...
  19. doi Hyperintensities on T2-weighted images in the basal ganglia of patients with major depression: cerebral perfusion and clinical implications
    Noa Vardi
    Department of Psychiatry, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel
    Psychiatry Res 192:125-30. 2011
    ..Clinical symptoms are largely reversible even in depressed patients with WMH T2-WI in basal ganglia...
  20. ncbi PTSD symptoms and cognitive performance in recent trauma survivors
    Dalia Brandes
    Center for Traumatic Stress, Department of Psychiatry, Hadassah University Hospital, P O Box 12000, Jerusalem, Israel
    Psychiatry Res 110:231-8. 2002
    ..It disappeared, however, when the effect of depressive symptoms was controlled for. Lower IQ and impaired attention are associated with early PTSD and depressive symptoms. Poorer attention may have a role in shaping traumatic memories...
  21. ncbi Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects
    Alexander Neumeister
    NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
    Am J Psychiatry 162:805-7. 2005
    ....
  22. ncbi Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  23. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD, USA Electronic address
    Eur Neuropsychopharmacol 23:822-9. 2013
    ..These findings suggest that 5-HT1A receptor binding is abnormally reduced in BD, and this abnormality may particularly involve the postsynaptic 5-HT1A receptor system of individuals with a tendency toward cortisol hypersecretion. ..
  24. ncbi Regional cerebral blood flow in patients with mild hypothyroidism
    Yodphat Krausz
    Department of Medical Biophysics and Nuclear Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Nucl Med 45:1712-5. 2004
    ..The aims of this study were to compare regional cerebral blood flow (rCBF) between hypothyroid patients and healthy subjects and assess flow during the euthyroid state after treatment...
  25. ncbi Evidence for continuing neuropsychological impairments in depression
    Petra Weiland-Fiedler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, North Drive, Building 15K, Room 200, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:253-8. 2004
    ..The purpose of the present study was to describe the neuropsychological functioning of fully remitted, unmedicated patients with a history of MDD by focusing on tasks related to prefrontal cortex functioning...
  26. ncbi Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  27. doi Brain activation and heart rate during script-driven traumatic imagery in PTSD: preliminary findings
    Gavriel Barkay
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, Israel
    Psychiatry Res 204:155-60. 2012
    ..These preliminary results indicate that "top down" central nervous system regulation of autonomic stress response in PTSD may involve associative, sensory and motor areas in addition to regions commonly implicated in fear conditioning...
  28. ncbi Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Neuropsychopharmacology 31:182-8. 2006
    ..Patients with PTSD had increased glucocorticoid sensitivity in the focal brain regions mediating trace eyeblink conditioning...
  29. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  30. pmc Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 66:47-53. 2009
    ..This study tested the hypothesis that elevated anxious reactivity, specifically for unpredictable aversive events, is a psychophysiological correlate of PTSD...
  31. doi Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel 91120
    J Clin Psychiatry 72:1124-8. 2011
    ..Furthermore, no study to date has evaluated the effects of successful antidepressant treatment on cerebrospinal fluid (CSF) abnormalities in PTSD...
  32. doi Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A
    Philip W Gold
    Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 520:1-5. 2012
    ..In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state...
  33. ncbi Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernible
    Gavriel Barkai
    Department of Psychiatry, Tel Aviv Sourasky Medical Center and Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St, Tel Aviv 64239, Israel
    Psychiatry Res 132:279-83. 2004
    ..Valproate treatment was associated with increased prefrontal perfusion concomitant with clinical improvement and abolished response to acetazolamide challenge...
  34. ncbi Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  35. pmc Habenula volume in post-traumatic stress disorder measured with high-resolution MRI
    Jonathan B Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 1:7. 2011
    ..abstract:..
  36. ncbi T2-weighted image hyperintensities in major depression: focus on the basal ganglia
    Ronit Agid
    Department of Radiology, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel
    Int J Neuropsychopharmacol 6:215-24. 2003
    ..Depressed patients with T2-WIH in basal ganglia were clearly the most severely depressed and cognitively impaired subjects, and may constitute a clinically distinct subgroup within major depression...
  37. ncbi Rejection of life in anorexic and bulimic patients
    Eytan Bachar
    Department of Psychiatry, Hadassah University Medical Center, Jerusalem, Israel
    Int J Eat Disord 31:43-8. 2002
    ..To investigate eating- disordered (ED) patients' attraction to life and death...
  38. ncbi [Emotional distress in Israeli medical students]
    Omer Bonne
    Department of Psychiatry, Hadassah University Hospital, Hadassah Hebrew University Medical Faculty, Jerusalem, Israel
    Harefuah 142:588-91, 647. 2003
    ..However, causal relationship between putative, nh stress factors and emotional state has not yet been determined. Moreover, most data concerning mental health of medical students has been acquired in the USA...
  39. ncbi Neuropathology of stress: prospects and caveats
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Psychiatry 67:407-11. 2004
  40. doi Exposure and susceptibility: schizophrenia in a young man following prolonged high exposures to organic solvents
    Yael Stein
    Unit of Occupational and Environmental Medicine, Hebrew University Hadassah School of Medicine, Jerusalem, Israel
    Neurotoxicology 31:603-7. 2010
    ..In the meantime, policies to prevent such exposures at the source can be expected to contribute to the prevention of a non-trivial proportion of neurotoxic diseases, including, possibly, schizophrenia in worker populations...
  41. ncbi Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder
    Asaf Gilboa
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Biol Psychiatry 55:263-72. 2004
    ..e., extinction) over a hyperresponsive amygdala, based primarily on animal research of fear conditioning and the finding of cingulate hypoperfusion in PTSD...
  42. ncbi The cognitive-orientation theory of anorexia nervosa
    Shulamith Kreitler
    Tel Aviv University and Tel Aviv Medical Center, Tel Aviv, Israel
    J Clin Psychol 59:651-71. 2003
    ..A brief CO questionnaire was developed. Discussion centered on the similarity of the identified themes to some of those discussed by others, on the pathogeneity of the CO of anorexia, and on outlining a blueprint of a theory of anorexia...