Marcelo G Bonini

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation
    Marcelo G Bonini
    Laboratories of Pharmacology and Chemistry and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 105:8569-74. 2008
  2. pmc Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle
    Marcelo G Bonini
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    J Biol Chem 284:14618-27. 2009
  3. pmc Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD, USA
    Free Radic Biol Med 42:985-92. 2007
  4. pmc Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:530-40. 2007
  5. ncbi request reprint The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy?
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, Ntional Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 40:968-75. 2006
  6. pmc Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice
    Saurabh Chatterjee
    Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Free Radic Biol Med 46:454-61. 2009
  7. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
  8. pmc Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis
    Saurabh Chatterjee
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:988-99. 2011
  9. pmc Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis
    Saurabh Chatterjee
    Free Radical Metabolism Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 183:4055-66. 2009
  10. pmc Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate
    Kalina Ranguelova
    Laboratory of Pharmacology and Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:589-94. 2012

Collaborators

Detail Information

Publications27

  1. pmc Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation
    Marcelo G Bonini
    Laboratories of Pharmacology and Chemistry and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 105:8569-74. 2008
    ..Our studies in cell cultures, isolated vessels, and whole animals identified endothelial NOS activation as a fundamental requirement for nitroglycerin action at pharmacologically relevant concentrations in WT animals...
  2. pmc Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle
    Marcelo G Bonini
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    J Biol Chem 284:14618-27. 2009
    ..The results gathered herein indicate that peroxymonocarbonate (HOOCO(2)(-)) is a key intermediate in the SOD1 peroxidase cycle and identify this species as the precursor of carbonate radical anions...
  3. pmc Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD, USA
    Free Radic Biol Med 42:985-92. 2007
    ....
  4. pmc Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:530-40. 2007
    ....
  5. ncbi request reprint The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy?
    Marcelo G Bonini
    Laboratory of Pharmacology and Chemistry, Ntional Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 40:968-75. 2006
    ..Our findings demonstrate that this assay is subject to a serious artifact in that it produces what it is purported to measure; therefore, its use in biological systems should be approached with caution...
  6. pmc Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice
    Saurabh Chatterjee
    Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Free Radic Biol Med 46:454-61. 2009
    ..This suggests the presence of a possible mechanism for CPB1 activity loss with compensatory protein production...
  7. pmc Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 21:1143-53. 2008
    ..We propose that drug-induced free radical formation on MPO may play a role in the origin of agranulocytosis...
  8. pmc Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis
    Saurabh Chatterjee
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 50:988-99. 2011
    ..In one such mechanism, radical formation initiated by xanthine oxidase formed protein and DNA radicals, which may lead to cell death of germinal center FDCs...
  9. pmc Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis
    Saurabh Chatterjee
    Free Radical Metabolism Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 183:4055-66. 2009
    ..These results open up new avenues for the investigation of several enzymes involved in inflammation and their site-specific oxidative modifications by protein-protein interactions as well as their role in sepsis...
  10. pmc Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate
    Kalina Ranguelova
    Laboratory of Pharmacology and Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:589-94. 2012
    ..It is proposed that the dissociation of His61 from the active site Cu(I) in SOD-Cu(I) contributes to this chemistry by facilitating the binding of larger anions, such as peroxymonocarbonate...
  11. pmc (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation
    Kalina Ranguelova
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:970-5. 2010
    ..This free radical further reacts with oxygen to form the peroxymonosulfate anion radical (-O(3)SOO*) and sulfate anion radical (SO(4)*-)...
  12. pmc Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation
    Maria B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Diabetes 61:586-96. 2012
    ..Our results suggest that hepatic iNOS expression may underlie the accumulation of lipid end products and that reducing the accumulation of toxic lipid metabolites contributes to a better redox status in insulin-sensitive tissues...
  13. pmc Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis
    Arno G Siraki
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 20:1038-45. 2007
    ..We propose that drug-dependent free radical formation on MPO may play a role in the origin of agranulocytosis...
  14. pmc Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233 MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:866-74. 2008
    ..Taken together, our studies support inducible nitric oxide synthase as a significant source of EPR-detectable reactive intermediates, which leads to lipid peroxidation and may contribute to disease progression as well...
  15. pmc Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Endocrinol Metab 295:E456-62. 2008
    ..Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression...
  16. ncbi request reprint Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis
    Suchandra Bhattacharjee
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Am Chem Soc 129:13493-501. 2007
    ..This complex phenomenon of electron transfer from one radical to another has been investigated in proteins by IST, ESR, and MS...
  17. doi request reprint NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses
    Danielle Duma
    Laboratory of Signal Transduction, Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC, USA
    Eur J Pharmacol 668:285-92. 2011
    ....
  18. pmc Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes
    Marilyn Ehrenshaft
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Photochem Photobiol 86:752-6. 2010
    ..These experiments demonstrate that we have developed a tool for the specific detection of oxidized tryptophan residues in cells and suggest that this tool could be useful in tracking the fate of these oxidized proteins...
  19. pmc Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment
    Shannon Dallas
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    J Neuroinflammation 10:58. 2013
    ..HIV/AIDS patients frequently suffer bacterial and viral co-infections, leading to deregulation of glial cell function and release of pro-inflammatory mediators including cytokines, chemokines, and nitric oxide...
  20. pmc Spatial distribution of protein damage by singlet oxygen in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Photochem Photobiol 84:69-74. 2008
    ..The subcellular localization of the protein DMPO adducts was coincident with that of RB. This approach may provide information on the spatial distribution of singlet oxygen generated in cells...
  21. ncbi request reprint Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation
    Emersom S Lima
    Clinical and Toxicological Analysis Department, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Free Radic Biol Med 39:532-9. 2005
    ..In addition to provide a mechanism to explain nitric oxide production from nitrated lipids, the results support their role as endogenous sources of nitric oxide that may play a role in endothelium-independent vasorelaxation...
  22. ncbi request reprint Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate
    Marcelo G Bonini
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, São Paulo CEP 05513 970, Brazil
    J Biol Chem 279:51836-43. 2004
    ....
  23. ncbi request reprint Spin trapping of glutathiyl and protein radicals produced from nitric oxide-derived oxidants
    Ohara Augusto
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, CEP 05599 970, Sao Paulo, SP, Brazil
    Free Radic Biol Med 36:1224-32. 2004
    ..The possible intermediacy of these species in the biological formation of mediators of protein-cysteine redox signaling, such as S-nitrosothiols and sulfenic acids, is also discussed...
  24. ncbi request reprint Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals
    Marcelo G Bonini
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, CEP 05513 970, Sao Paulo, SP, Brazil
    Biochemistry 43:344-51. 2004
    ..Overall, the results prove the diffusible and radical nature of the oxidants produced during the peroxidase activity of Cu,Zn-SOD in the presence of bicarbonate or nitrite...
  25. ncbi request reprint Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology
    Ohara Augusto
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    Free Radic Biol Med 32:841-59. 2002
    ..In this review, we provide a framework for this hypothesis and discuss the potential sources and properties of these radicals that are likely to become increasingly recognized as important mediators of biological processes...
  26. ncbi request reprint The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species
    Marcelo G Bonini
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brazil
    Chem Res Toxicol 15:506-11. 2002
    ..Overall, the results support a role for peroxynitrite and its derived radicals in the tissue pathology associated with inflammatory conditions...
  27. ncbi request reprint Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases
    Kimberly W Raines
    Department of Biochemistry and Biophysics, University of North Carolina, 530 Mary Ellen Jones Building, Chapel Hill, NC 27599 7260, USA
    Cardiovasc Res 75:229-39. 2007
    ..This article reviews the mechanism of free radical-mediated GTPase regulation and shows nitric oxide can serve as important regulator of small GTPase proteins (i.e. Ras and RhoA) through protein modifications such as S-nitrosation...