Carolyn A Bondy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C
    Daria Grafodatskaya
    Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, ON, Canada
    BMC Med Genomics 6:1. 2013
  2. ncbi request reprint Genomic imprinting and Turner syndrome
    Carolyn A Bondy
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Pediatr Endocrinol Rev 9:728-32. 2012
  3. pmc Co-expression of estrogen receptor-alpha and targets of estrogen receptor action in proliferating monkey mammary epithelial cells
    Constantine Dimitrakakis
    Developmental Endocrinology Branch, NICHD, NIH, Bethesda, MD 20892, USA
    Breast Cancer Res 8:R10. 2006
  4. pmc Androgens and the breast
    Constantine Dimitrakakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103 Bethesda, Maryland 20892 1103, USA
    Breast Cancer Res 11:212. 2009
  5. ncbi request reprint Investigation of cardiac status and bone mineral density in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, CRC 1 3330, 10 Center Dr, National Institutes of Health, Bethesda, MD 20892, USA
    Growth Horm IGF Res 16:S103-8. 2006
  6. ncbi request reprint Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 92:10-25. 2007
  7. ncbi request reprint Heart disease in Turner syndrome
    C A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Minerva Endocrinol 32:245-61. 2007
  8. ncbi request reprint Turner's syndrome and X chromosome-based differences in disease susceptibility
    Carolyn A Bondy
    Gend Med 3:18-30. 2006
  9. ncbi request reprint The physical phenotype of girls and women with Turner syndrome is not X-imprinted
    Carolyn A Bondy
    Chief Developmental Endocrinology Branch, National Institute of Child Health, NIH, Bethesda, MD 20982, USA
    Hum Genet 121:469-74. 2007
  10. ncbi request reprint Prolongation of the cardiac QTc interval in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:75-81. 2006

Collaborators

Detail Information

Publications79

  1. pmc Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C
    Daria Grafodatskaya
    Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, ON, Canada
    BMC Med Genomics 6:1. 2013
    ..Identification of epigenetic alterations occurring in these disorders could shed light on molecular pathways relevant to neurodevelopment...
  2. ncbi request reprint Genomic imprinting and Turner syndrome
    Carolyn A Bondy
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Pediatr Endocrinol Rev 9:728-32. 2012
    ..This may contribute to a high rate of fetal loss in human monosomy via impaired placentation in the most severe cases, and to loss of paternal contribution to growth in the mildest manifestation...
  3. pmc Co-expression of estrogen receptor-alpha and targets of estrogen receptor action in proliferating monkey mammary epithelial cells
    Constantine Dimitrakakis
    Developmental Endocrinology Branch, NICHD, NIH, Bethesda, MD 20892, USA
    Breast Cancer Res 8:R10. 2006
    ..The mitotic index was so low in prior studies, however, that transient co-expression of ERalpha and Ki67 during the cell cycle could have been below detection limits...
  4. pmc Androgens and the breast
    Constantine Dimitrakakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, CRC, Room 1 3330, 10 Center Drive, MSC 1103 Bethesda, Maryland 20892 1103, USA
    Breast Cancer Res 11:212. 2009
    ..Addition of testosterone to the usual hormone therapy regimen may diminish the estrogen/progestin increase in breast cancer risk but the impact of this combined use on mammary gland homeostasis still needs evaluation...
  5. ncbi request reprint Investigation of cardiac status and bone mineral density in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, CRC 1 3330, 10 Center Dr, National Institutes of Health, Bethesda, MD 20892, USA
    Growth Horm IGF Res 16:S103-8. 2006
    ..Therefore, judicious management of estrogen therapy to prevent osteoporosis while minimizing estrogen-associated adverse events is a challenging aspect of care for girls and women with TS...
  6. ncbi request reprint Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 92:10-25. 2007
    ..The objective of this work is to provide updated guidelines for the evaluation and treatment of girls and women with Turner syndrome (TS)...
  7. ncbi request reprint Heart disease in Turner syndrome
    C A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Minerva Endocrinol 32:245-61. 2007
    ..This material is of particular importance because cardiac care for adults with TS appears seriously deficient at present...
  8. ncbi request reprint Turner's syndrome and X chromosome-based differences in disease susceptibility
    Carolyn A Bondy
    Gend Med 3:18-30. 2006
  9. ncbi request reprint The physical phenotype of girls and women with Turner syndrome is not X-imprinted
    Carolyn A Bondy
    Chief Developmental Endocrinology Branch, National Institute of Child Health, NIH, Bethesda, MD 20982, USA
    Hum Genet 121:469-74. 2007
    ..We did demonstrate a selective maternal effect on final stature that was independent of X-chromosome origin, suggesting potential autosomal imprinting effects on growth revealed by X monosomy...
  10. ncbi request reprint Prolongation of the cardiac QTc interval in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:75-81. 2006
    ....
  11. ncbi request reprint Growth hormone treatment and aortic dimensions in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:1785-8. 2006
    ..In recent years many girls with Turner syndrome (TS) have been treated with supraphysiological doses of GH to increase adult height. In addition to promoting statural growth, GH may have direct effects on the cardiovascular system...
  12. ncbi request reprint Prolonged rate-corrected QT interval and other electrocardiogram abnormalities in girls with Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Building 10 CRC, Room 1 3330, Bethesda, MD 20892 1103, USA
    Pediatrics 118:e1220-5. 2006
    ..We recently reported that electrocardiographic abnormalities are common in adults with monosomy X (Turner syndrome), but this issue has not been investigated in girls with Turner syndrome...
  13. ncbi request reprint New issues in the diagnosis and management of Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Rev Endocr Metab Disord 6:269-80. 2005
    ....
  14. doi request reprint Congenital cardiovascular disease in Turner syndrome
    Carolyn A Bondy
    National Institute of Child Health and Human Development, National Institutes of Health Developmental Endocrinology Branch, Bethesda, MD 20892, USA
    Congenit Heart Dis 3:2-15. 2008
    ..X-chromosome genetic pathways implicated in Turner cardiovascular disease, including premature coronary artery disease, are discussed. Recent guidelines for diagnosis and treatment of girls and women with TS are reviewed...
  15. doi request reprint Monosomy for the X chromosome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Chromosome Res 17:649-58. 2009
    ..This article reviews observations and arguments attempting to explain the phenotypic effects of X monosomy in humans and other mammals in terms of X chromosome gene dosage...
  16. doi request reprint Turner syndrome 2008
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Horm Res 71:52-6. 2009
    ..Fetuses with incidental diagnoses of mosaicism for 45,X associated with normal ultrasounds have a high survival rate and may have no or only mild features of TS...
  17. pmc Aortic dissection in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Cardiol 23:519-26. 2008
    ..This review focuses on emerging knowledge of the characteristics of aortic disease in Turner syndrome in comparison with Marfan-like syndromes and isolated aortic valve disease...
  18. ncbi request reprint Growth hormone therapy and bone mineral density in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:4886-9. 2004
    ..Furthermore, regression analysis in a linear model including independent variables of age, age at diagnosis, body mass index, presence of spontaneous puberty, and GH use confirmed that GH use did not contribute to variation in BMD...
  19. pmc Growth hormone treatment and left ventricular dimensions in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Pediatr 150:587-91. 2007
    ..To determine whether cardiac dimensions were different in girls with Turner syndrome (TS) who received growth hormone (GH) compared with those who did not receive GH...
  20. ncbi request reprint Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women
    Emily C Corrigan
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Menopause 13:911-6. 2006
    ..It remains unclear whether these changes are due primarily to ovarian failure or aging. The aim of this study was to clarify the impact of ovarian failure on body composition and insulin sensitivity in young women...
  21. ncbi request reprint Aortic dilatation and dissection in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 116:1663-70. 2007
    ..It is unknown whether aortic dilatation precedes acute aortic dissection in TS and, if so, what specific diameter predicts impending deterioration...
  22. ncbi request reprint The importance of estrogen replacement in young women with Turner syndrome
    Lori Hanton
    Developmental Endocrinology Branch, National Institute of Child Health, National Institutes of Health, Bethesda, Maryland20892, USA
    J Womens Health (Larchmt) 12:971-7. 2003
    ..We aimed to determine the level of ERT use in women with TS living in the United States and assess the effects of ERT adherence vs. nonadherence on bone mineral density (BMD)...
  23. doi request reprint Aortic valve disease in Turner syndrome
    Vandana Sachdev
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Am Coll Cardiol 51:1904-9. 2008
    ..Our goal was to determine the prevalence and characteristics of aortic valve disease in girls and women with monosomy for the X chromosome, or Turner syndrome (TS)...
  24. pmc Reduced abdominal adiposity and improved glucose tolerance in growth hormone-treated girls with Turner syndrome
    Nicole Wooten
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:2109-14. 2008
    ..Individuals with Turner syndrome (TS) are at increased risk for impaired glucose tolerance and diabetes mellitus. It is unknown whether pharmacological GH treatment commonly used to treat short stature in TS alters this risk...
  25. ncbi request reprint Selective reduction in cortical bone mineral density in turner syndrome independent of ovarian hormone deficiency
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:5717-22. 2003
    ..We conclude that there is a selective deficiency in forearm cortical bone in TS that appears independent of ovarian hormone exposure and is probably related to X-chromosome gene(s) haploinsufficiency...
  26. ncbi request reprint The effects of growth hormone treatment on bone mineral density and body composition in girls with turner syndrome
    Mim Ari
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4302-5. 2006
    ..Many girls with Turner syndrome (TS) are treated with GH to increase adult height. In addition to promoting longitudinal bone growth, GH has effects on bone and body composition...
  27. ncbi request reprint Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic features
    Vincent B Ho
    Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Circulation 110:1694-700. 2004
    ..To better understand the prevalence and pathogenesis of cardiovascular defects in TS, we prospectively evaluated a group of asymptomatic adult volunteers with TS using magnetic resonance (MR) angiography...
  28. doi request reprint Spectrum of aortic valve abnormalities associated with aortic dilation across age groups in Turner syndrome
    Laura J Olivieri
    National Institute of Child Health and Human Development and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
    Circ Cardiovasc Imaging 6:1018-23. 2013
    ..Our objective was to characterize aortic valve structure in subjects with Turner syndrome and to determine the prevalence of aortic dilation and valve dysfunction associated with different types of aortic valves...
  29. pmc N-terminal pro-brain natriuretic peptide levels and aortic diameters
    Liat S Gutin
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am Heart J 164:419-24. 2012
    ..To better understand the pathology and develop tools to monitor the risk of aortic disease, we investigated N-terminal pro-brain natriuretic peptide (BNP) (NT-proBNP) levels in women with TS and healthy female controls...
  30. pmc Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency
    Vladimir K Bakalov
    Section on Epigenetics and Development, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, 10 Center Dr CRC 1 3330 Bethesda, MD 20892 1103, USA
    J Autoimmun 38:315-21. 2012
    ..The absence of a normal second X-chromosome further contributes to increased autoimmunity in TS...
  31. pmc X-chromosome gene dosage and the risk of diabetes in Turner syndrome
    Vladimir K Bakalov
    National Institute of Child Health and Human Development, Clinical Research Center, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:3289-96. 2009
    ..Turner syndrome (TS) is caused by the absence or fragmentation of the second sex chromosome. An increased risk of diabetes mellitus (DM) has consistently been noted, but the specific phenotype and genetic etiology of this trait are unknown...
  32. pmc Uterine development in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Pediatr 151:528-31, 531.e1. 2007
    ..To evaluate uterine development of women with Turner syndrome (TS) receiving conventional medical care...
  33. ncbi request reprint Impaired insulin secretion in the Turner metabolic syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10 10N262, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 89:3516-20. 2004
    ....
  34. ncbi request reprint Truth-telling and Turner Syndrome: the importance of diagnostic disclosure
    Erica J Sutton
    National Human Genome Research Institute and the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1852, USA
    J Pediatr 148:102-7. 2006
    ..A targeted analysis with transcript data from previous research was designed to study the perceived effects of secret-keeping on individuals with Turner syndrome (TS)...
  35. ncbi request reprint Analysis of auditory phenotype and karyotype in 200 females with Turner syndrome
    Kelly A King
    Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ear Hear 28:831-41. 2007
    ..The purpose of this study was to describe the auditory phenotype in a large group of individuals with Turner Syndrome, with analysis focusing on hearing loss and age, as well as the phenotypic relationship to karyotype variation...
  36. pmc Outcomes of spontaneous and assisted pregnancies in Turner syndrome: the U.S. National Institutes of Health experience
    Tracy N Hadnott
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 95:2251-6. 2011
    ..To assess fetal and maternal outcomes of pregnancies in women with Turner syndrome (TS)...
  37. pmc Insulin-like growth factor 1 regulates developing brain glucose metabolism
    C M Cheng
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:10236-41. 2000
    ..These data support the hypothesis that endogenous brain Igf1 serves an anabolic, insulin-like role in developing brain metabolism...
  38. ncbi request reprint Perturbation of the transforming growth factor β system in Turner syndrome
    Jian Zhou
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Beijing Da Xue Xue Bao 44:720-4. 2012
    ..To measure components of the circulating transforming growth factor β (TGFβ) system in patients with Turner syndrome (TS) compared to relevant controls and to ascertain correlation with endocrine and cardiovascular parameters...
  39. ncbi request reprint Monosomy for the X-chromosome is associated with an atherogenic lipid profile
    Phillip L Van
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 91:2867-70. 2006
    ..To determine whether X-chromosomal gene dosage affects lipid metabolism independent of sex steroid effects, we compared lipid profiles in age- and body mass-matched young women with ovarian failure, differing only in X-chromosome dosage...
  40. ncbi request reprint Current and lifetime psychiatric illness in women with Turner syndrome
    Graca Cardoso
    Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1276, USA
    Gynecol Endocrinol 19:313-9. 2004
    ..Women with TS reported a higher rate of lifetime depression compared with rates observed in community-based studies but similar to those obtained from gynecologic clinic samples...
  41. ncbi request reprint Bone mineral density and fractures in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland 20892, USA
    Am J Med 115:259-64. 2003
    ..To determine whether women with Turner syndrome who were treated with estrogen were more likely to have osteoporosis and fractures...
  42. doi request reprint Fracture risk and bone mineral density in Turner syndrome
    Vladimir K Bakalov
    National Institute of Child Health and Human Development, Bethesda, MD, USA
    Rev Endocr Metab Disord 9:145-51. 2008
    ..In addition, other measures to prevent fall and trauma should be considered, including optimizing hearing and vision, avoiding contact sports and exercise to improve coordination...
  43. ncbi request reprint A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development
    Zhi Bin Tong
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Reprod 17:903-11. 2002
    ..Mater is a maternal effect gene required for early embryonic development in mice, and its protein serves as an autoantigen in a mouse model of autoimmune premature ovarian failure...
  44. ncbi request reprint Insulin-like growth factor binding protein 4 expression parallels luteinizing hormone receptor expression and follicular luteinization in the primate ovary
    Jian Zhou
    Developmental Endocrinology Branch, NICHD, NIH, Bethesda, Maryland 20892, USA
    Biol Reprod 69:22-9. 2003
    ..These observations suggest that IGFBP4 or an IGFBP4 proteolytic product may be involved with LH-induced steroidogenesis and/or luteinization rather than with inhibition of follicular growth...
  45. ncbi request reprint Developmental expression and subcellular localization of mouse MATER, an oocyte-specific protein essential for early development
    Zhi Bin Tong
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Endocrinology 145:1427-34. 2004
    ..The presence of MATER protein in mitochondria and nucleoli suggests that it may participate in both cytoplasmic and nuclear events during early development...
  46. ncbi request reprint Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus
    C M Cheng
    Developmental Endocrinology Branch, NICHD, NIH, Bethesda, Maryland 20892, USA
    J Neurosci Res 64:341-7. 2001
    ..J. Neurosci. Res. 64:341-347, 2001. Published 2001 Wiley-Liss, Inc...
  47. ncbi request reprint Reduced GLUT1 expression in Igf1-/- null oocytes and follicles
    J Zhou
    Developmental Endocrinology Branch, NICHD NIH, Bethesda, MD, 20892, USA
    Growth Horm IGF Res 10:111-7. 2000
    ....
  48. pmc High levels of education and employment among women with Turner syndrome
    Harley N Gould
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Womens Health (Larchmt) 22:230-5. 2013
    ..In this study we evaluated the influence of adult height and parental origin of the single X chromosome on education, employment, and marital outcomes among women with TS...
  49. ncbi request reprint Tau is hyperphosphorylated in the insulin-like growth factor-I null brain
    Clara M Cheng
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 146:5086-91. 2005
    ..These observations indicate that IGF-I has a major role in regulating tau phosphorylation in the aging brain, whereas its role in promoting or preventing oxidative stress remains uncertain...
  50. pmc Aneurysmal dilatation of medium caliber arteries in Turner syndrome
    Pritam R Polkampally
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Congenit Heart Dis 6:382-3. 2011
    ..We report aneurysmal dilation of medium caliber arteries involving the celiac axis and coronary vessels in two women with Turner syndrome...
  51. doi request reprint Sexual function in women with Turner syndrome
    Alexis T Sheaffer
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Womens Health (Larchmt) 17:27-33. 2008
    ..The present study aimed to determine the level of sexual activity in adult women with TS participating as volunteers in the NIH natural history study...
  52. ncbi request reprint Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy
    Constantine Dimitrakakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Menopause 11:531-5. 2004
    ....
  53. ncbi request reprint A ketogenic diet increases brain insulin-like growth factor receptor and glucose transporter gene expression
    Clara M Cheng
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 144:2676-82. 2003
    ..In addition, the data may be consistent with a role for enhanced IGF1R and GLUT expression in ketogenic diet-induced seizure suppression...
  54. ncbi request reprint Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy
    J Wang
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 13:1985-90. 1999
    ..These data suggest that Igf1 promotes longitudinal bone growth by 'insulin-like' anabolic actions which augment chondrocyte hypertrophy...
  55. ncbi request reprint Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex
    C M Cheng
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:907-15. 2001
    ..Tamoxifen, an antiestrogen at the breast, is shown to have estrogen-like effects on higher brain centers in the monkey, suggesting that some SERMs may share estrogen's neuroprotective potential for menopausal women...
  56. ncbi request reprint Growth hormone, insulin-like growth factors and the female reproductive system
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Adv Exp Med Biol 567:91-115. 2005
  57. pmc Turner syndrome: four challenges across the lifespan
    Erica J Sutton
    National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1852, USA
    Am J Med Genet A 139:57-66. 2005
    ..Enhanced awareness of the evolving physical and psychological challenges faced by girls and women with TS may help health care providers (HCPs) improve the quality of life for these individuals...
  58. ncbi request reprint Insulin-like growth factor 1 is essential for normal dendritic growth
    Clara M Cheng
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    J Neurosci Res 73:1-9. 2003
    ..01) in Igf1 null mice. Evidence is presented that Igf1 deletion causes disruptions in lipid and microtubule metabolism, leading to impaired neuronal somatic and dendritic growth. Published 2003 Wiley-Liss, Inc...
  59. ncbi request reprint Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth
    J Wang
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    J Endocrinol 180:247-55. 2004
    ..The question of whether GH has direct effects on chondrocyte generation is still not settled, however, since it now appears that IGF-II may medicate some of these effects on the growth plate...
  60. pmc Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle
    O O Adesanya
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA
    Proc Natl Acad Sci U S A 96:3287-91. 1999
    ..These data show that Igf1 is an essential mediator of E2's mitogenic effects, with a critical role not in G1 progression but in G2 progression...
  61. ncbi request reprint Caloric restriction augments brain glutamic acid decarboxylase-65 and -67 expression
    Clara M Cheng
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Neurosci Res 77:270-6. 2004
    ....
  62. ncbi request reprint Signaling by insulin-like growth factor 1 in brain
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Bldg 10 10N262, 10 Center Drive, Bethesda, MD 20892, USA
    Eur J Pharmacol 490:25-31. 2004
    ....
  63. ncbi request reprint Insulin-like growth factor-1 promotes neuronal glucose utilization during brain development and repair processes
    Carolyn A Bondy
    Developmental Endocrinology Branch, NICHD, NIH Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 51:189-217. 2002
  64. ncbi request reprint Estradiol alters transcription factor gene expression in primate prefrontal cortex
    J Wang
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland, USA
    J Neurosci Res 76:306-14. 2004
    ..These data indicate that estrogen may have direct as well as indirect effects on neuronal gene expression in the primate prefrontal cortex...
  65. ncbi request reprint Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition
    C M Cheng
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 18:5673-81. 1998
    ..These data make a strong case for the primacy of axonal factors, not including IGF1, in determining oligodendrocyte survival and myelination...
  66. ncbi request reprint Mater, a maternal effect gene required for early embryonic development in mice
    Z B Tong
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 26:267-8. 2000
    ..We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage. Females lacking the maternal effect gene Mater are sterile. Null males are fertile...
  67. ncbi request reprint Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis
    E Wang
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 136:2741-51. 1995
    ....
  68. ncbi request reprint High-level expression of Dok-1 in neurons of the primate prefrontal cortex and hippocampus
    A Smith
    Developmental Endocrinology Branch, National Institute of Child Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci Res 75:218-24. 2004
    ..These expression patterns are very similar to those of the IGF-1 receptor and suggest that Dok-1 could be among the downstream targets of IGF signaling in areas of the primate brain involved in learning and memory...
  69. ncbi request reprint Androgens and mammary growth and neoplasia
    Constantine Dimitrakakis
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Fertil Steril 77:S26-33. 2002
    ..Evaluation of current clinical, experimental, genetic, and epidemiological data pertaining to the role of androgens in mammary growth and neoplasia...
  70. ncbi request reprint Adrenal antibodies detect asymptomatic auto-immune adrenal insufficiency in young women with spontaneous premature ovarian failure
    V K Bakalov
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20829 1862, USA
    Hum Reprod 17:2096-100. 2002
    ..Auto-immune adrenal insufficiency is a potentially fatal disorder. Young women with spontaneous premature ovarian failure (POF) are at increased risk of developing this condition...
  71. ncbi request reprint H1FOO is coupled to the initiation of oocytic growth
    Mamoru Tanaka
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 0082, Japan
    Biol Reprod 72:135-42. 2005
    ....
  72. ncbi request reprint Lipid profiles in women with 45,X vs 46,XX primary ovarian failure
    Margaret Cooley
    JAMA 290:2127-8. 2003
  73. ncbi request reprint The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family
    Michiharu Horikawa
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    Biol Reprod 72:879-89. 2005
    ..The structural attributes, expression pattern, and cellular localization of MATER and RNH2 largely conformed to those reported for NALP14...
  74. ncbi request reprint Maternal X chromosome, visceral adiposity, and lipid profile
    Phillip L Van
    JAMA 295:1373-4. 2006
  75. ncbi request reprint The prevalence of diabetes mellitus in the parents of women with Turner's syndrome
    Vladimir K Bakalov
    Clin Endocrinol (Oxf) 60:272. 2004
  76. ncbi request reprint Association between fetal lymphedema and congenital cardiovascular defects in Turner syndrome
    Melissa L Loscalzo
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 115:732-5. 2005
    ..The objective of this study was to determine whether there is a specific association between a history of fetal lymphedema and CCVDs in monosomy X, or TS, independent of karyotype or general severity of the phenotype...
  77. ncbi request reprint Endogenous sex hormones and type 2 diabetes risk
    Carolyn A Bondy
    JAMA 296:169; author reply 169-70. 2006
  78. ncbi request reprint Declining estrogen use in young women with Turner syndrome
    Carolyn A Bondy
    Arch Intern Med 166:1322. 2006
  79. ncbi request reprint Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failure
    Peter J Schmidt
    JAMA 295:1374-6. 2006