Diane L Bolton

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques
    Diane L Bolton
    Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:303-14. 2010
  2. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010
  3. pmc 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr
    Diane L Bolton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD 20892, USA
    Biol Direct 3:17. 2008
  4. doi request reprint Flow cytometry and the future of vaccine development
    Diane L Bolton
    Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    Expert Rev Vaccines 8:779-89. 2009
  5. pmc Vpr cytopathicity independent of G2/M cell cycle arrest in human immunodeficiency virus type 1-infected CD4+ T cells
    Diane L Bolton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 11N311, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 81:8878-90. 2007
  6. pmc Priming T-cell responses with recombinant measles vaccine vector in a heterologous prime-boost setting in non-human primates
    Diane L Bolton
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, United States
    Vaccine 30:5991-8. 2012
  7. pmc Superior T memory stem cell persistence supports long-lived T cell memory
    Enrico Lugli
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, 40, Convent Dr, Bethesda, Maryland 20892, USA
    J Clin Invest 123:594-9. 2013
  8. pmc Death of CD4(+) T-cell lines caused by human immunodeficiency virus type 1 does not depend on caspases or apoptosis
    Diane L Bolton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Virol 76:5094-107. 2002
  9. pmc Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env
    Michael J Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Virol 76:5082-93. 2002
  10. pmc Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24924. 2011

Collaborators

Detail Information

Publications11

  1. pmc Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques
    Diane L Bolton
    Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:303-14. 2010
    ..The lack of impact following transfer of such a large number of functional Ag-specific CD8(+) T cells on SIV replication may reflect the magnitude of the immune response required to contain the virus...
  2. pmc Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 84:6410-24. 2010
    ..Inhibition of PKA activity during HIV-1 infection abrogates Vpr cell cycle arrest. These findings provide new insight into the signaling event that activates Vpr cell cycle arrest, ultimately leading to the death of infected T cells...
  3. pmc 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr
    Diane L Bolton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD 20892, USA
    Biol Direct 3:17. 2008
    ..The HIV-1 Vpr accessory protein causes cell death, likely through a mechanism related to its ability to arrest cells in the G2,M phase. Recent evidence implicated the scaffold protein, 14-3-3, in Vpr cell cycle blockade...
  4. doi request reprint Flow cytometry and the future of vaccine development
    Diane L Bolton
    Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    Expert Rev Vaccines 8:779-89. 2009
    ..Finally, flow cytometry can also be used to analyze the contribution of innate immunity to vaccine efficacy and disease pathogenesis...
  5. pmc Vpr cytopathicity independent of G2/M cell cycle arrest in human immunodeficiency virus type 1-infected CD4+ T cells
    Diane L Bolton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 11N311, 10 Center Dr, Bethesda, MD 20892 1892, USA
    J Virol 81:8878-90. 2007
    ....
  6. pmc Priming T-cell responses with recombinant measles vaccine vector in a heterologous prime-boost setting in non-human primates
    Diane L Bolton
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, United States
    Vaccine 30:5991-8. 2012
    ..These data demonstrate feasibility of using rMV as a priming component of heterologous prime-boost vaccine regimens for pathogens requiring strong cellular responses...
  7. pmc Superior T memory stem cell persistence supports long-lived T cell memory
    Enrico Lugli
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, 40, Convent Dr, Bethesda, Maryland 20892, USA
    J Clin Invest 123:594-9. 2013
    ..Thus, one mechanism for maintenance of long-term T cell memory derives from the unique homeostatic properties of TSCM cells. Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells...
  8. pmc Death of CD4(+) T-cell lines caused by human immunodeficiency virus type 1 does not depend on caspases or apoptosis
    Diane L Bolton
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Virol 76:5094-107. 2002
    ..Rather, cell death occurs most likely via a necrotic or lytic form of death independent of caspase activation in directly infected cells...
  9. pmc Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env
    Michael J Lenardo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Virol 76:5082-93. 2002
    ..Thus, env can accelerate cell death chiefly as an entry function, but one or more viral functions other than env or nef is essential for necrosis of CD4(+) T cells induced by HIV-1...
  10. pmc Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death
    R Anthony Barnitz
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24924. 2011
    ..The levels of toxicity during virion delivery of Vpr correlated with G2/M arrest. Thus, the exposed hydrophobic amino acids in the amino-terminal helix-1 are important for the cell cycle arrest and cytopathicity functions of Vpr...
  11. pmc Genetic immunization in the lung induces potent local and systemic immune responses
    Kaimei Song
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:22213-8. 2010
    ..Thus, genetic immunization in the lung offers a powerful platform approach to generating protective immune responses against respiratory pathogens...