Karin Bok

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Chimpanzees as an animal model for human norovirus infection and vaccine development
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:325-30. 2011
  2. ncbi Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    Virology 380:328-37. 2008
  3. ncbi Evolutionary dynamics of GII.4 noroviruses over a 34-year period
    Karin Bok
    Norovirus Gastroenteritis Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Virol 83:11890-901. 2009
  4. ncbi Multiple antigenic sites are involved in blocking the interaction of GII.4 norovirus capsid with ABH histo-blood group antigens
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    J Virol 86:7414-26. 2012
  5. ncbi Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period
    Denali Boon
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Virol 85:8656-66. 2011
  6. ncbi Visualization of feline calicivirus replication in real-time with recombinant viruses engineered to express fluorescent reporter proteins
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Virology 400:18-31. 2010
  7. ncbi The feline calicivirus leader of the capsid protein is associated with cytopathic effect
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    J Virol 87:3003-17. 2013
  8. ncbi Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Vaccine 30:3580-6. 2012
  9. ncbi Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute
    Elyssa L Barron
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21435. 2011
  10. ncbi Apoptosis in murine norovirus-infected RAW264.7 cells is associated with downregulation of survivin
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    J Virol 83:3647-56. 2009

Collaborators

  • K Y Green
  • David O Matson
  • Jerrold M Ward
  • Claro Yu
  • Carl D Kirkwood
  • Kyeong Ok Chang
  • R H Purcell
  • Mary K Estes
  • Xi Jiang
  • Eugenio J Abente
  • Gabriel I Parra
  • Stanislav V Sosnovtsev
  • Carlos Sandoval-Jaime
  • Denali Boon
  • Elyssa L Barron
  • Carmelann Zintz
  • Sarah E Blutt
  • Alesio Bereciartu
  • Joel R Haynes
  • Charles Richardson
  • Ross Taylor
  • Kim Hasenkrug
  • Jackie E Mahar
  • Victor Prikhodko
  • Crystal R Rhodes
  • Kathy Perdue
  • Aaron B Carmody
  • Albert Z Kapikian
  • Mary A Staat
  • Myra Barnes-Eley
  • Tamas Berke
  • Ester Parada
  • Parvin Azimi
  • Ruth F Bishop
  • Viviana Parreño
  • Max Ciarlet
  • Margaret E Conner
  • Kelly L Warfield

Detail Information

Publications14

  1. ncbi Chimpanzees as an animal model for human norovirus infection and vaccine development
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:325-30. 2011
    ..This study establishes the chimpanzee as a viable animal model for the study of norovirus replication and immunity, and shows that NV VLP vaccines could induce protective homologous immunity even after extended periods of time...
  2. ncbi Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    Virology 380:328-37. 2008
    ..Our data suggest that PPMOs directed against the relatively conserved 5'-end of the norovirus genome may show broad antiviral activity against this genetically diverse group of viruses...
  3. ncbi Evolutionary dynamics of GII.4 noroviruses over a 34-year period
    Karin Bok
    Norovirus Gastroenteritis Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Virol 83:11890-901. 2009
    ..Our analysis of archival GII.4 norovirus strains suggests that this genotype has been circulating for more than three decades and provides new ancestral strain sequences for the analysis of GII.4 evolution...
  4. ncbi Multiple antigenic sites are involved in blocking the interaction of GII.4 norovirus capsid with ABH histo-blood group antigens
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    J Virol 86:7414-26. 2012
    ....
  5. ncbi Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period
    Denali Boon
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Virol 85:8656-66. 2011
    ..4 noroviruses, as previously proposed. Understanding the evolutionary dynamics of prevalent noroviruses is relevant to the development of effective prevention and control strategies...
  6. ncbi Visualization of feline calicivirus replication in real-time with recombinant viruses engineered to express fluorescent reporter proteins
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Virology 400:18-31. 2010
    ....
  7. ncbi The feline calicivirus leader of the capsid protein is associated with cytopathic effect
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    J Virol 87:3003-17. 2013
    ..The host cellular protein annexin A2 was identified as a binding partner of the LC protein, consistent with a role for the LC in mediating host cell interactions that alter the integrity of the cell and enable virus spread...
  8. ncbi Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Vaccine 30:3580-6. 2012
    ....
  9. ncbi Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute
    Elyssa L Barron
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21435. 2011
    ..Our study indicates that the murine noroviruses are widespread in these animal facilities, despite rigorous guidelines for animal care and maintenance...
  10. ncbi Apoptosis in murine norovirus-infected RAW264.7 cells is associated with downregulation of survivin
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    J Virol 83:3647-56. 2009
    ..We observed that MNV-1 replication in RAW264.7 cells activated caspases, resulting in apoptosis through the mitochondrial pathway, possibly as a result of downregulation of survivin...
  11. ncbi Norovirus gastroenteritis in immunocompromised patients
    Karin Bok
    From the Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    N Engl J Med 367:2126-32. 2012
    ..Norovirus causes gastroenteritis in immunocompetent and immunocompromised hosts. It is the most common cause of gastroenteritis in U.S. adults seeking emergency department care. Genetic features and emerging treatments are discussed...
  12. ncbi Prevalence and genetic characterization of caliciviruses among children hospitalized for acute gastroenteritis in the United States
    Carmelann Zintz
    Center for Pediatric Research, Children's Hospital of The King's Daughters, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Infect Genet Evol 5:281-90. 2005
    ..In conclusion, NV and SV were frequent causes of hospitalization for acute gastroenteritis in young children and infecting strains were highly diverse, including newly recognized genogroups and genetic clusters within known genogroups...
  13. ncbi Rotavirus antigenaemia and viraemia: a common event?
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 362:1445-9. 2003
    ..We assessed whether rotavirus antigen, RNA, or both, were present in serum samples from immunocompetent rotavirus-infected children and animals...
  14. ncbi Identification of viral agents causing gastroenteritis among children in Buenos Aires, Argentina
    Alesio Bereciartu
    Viral Gastroenteritis Laboratory, National Institute of Infectious Diseases, , Buenos Aires, Argentina
    J Clin Virol 25:197-203. 2002
    ..The introduction of affordable viral diagnosis in our pediatric hospitals will improve patient care by reducing the unnecessary use of antibiotics...