Karin Bok

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    Virology 380:328-37. 2008
  2. pmc Evolutionary dynamics of GII.4 noroviruses over a 34-year period
    Karin Bok
    Norovirus Gastroenteritis Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Virol 83:11890-901. 2009
  3. pmc Chimpanzees as an animal model for human norovirus infection and vaccine development
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:325-30. 2011
  4. pmc Development of Norwalk virus-specific monoclonal antibodies with therapeutic potential for the treatment of Norwalk virus gastroenteritis
    Zhaochun Chen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:9547-57. 2013
  5. pmc Multiple antigenic sites are involved in blocking the interaction of GII.4 norovirus capsid with ABH histo-blood group antigens
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    J Virol 86:7414-26. 2012
  6. pmc Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period
    Denali Boon
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Virol 85:8656-66. 2011
  7. pmc The feline calicivirus leader of the capsid protein is associated with cytopathic effect
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    J Virol 87:3003-17. 2013
  8. doi request reprint Genetic characterization of feline calicivirus strains associated with varying disease manifestations during an outbreak season in Missouri (1995-1996)
    Victor G Prikhodko
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC8007, Building 50, Room 6316, Bethesda, MD, 20892 8007, USA
    Virus Genes 48:96-110. 2014
  9. pmc Visualization of feline calicivirus replication in real-time with recombinant viruses engineered to express fluorescent reporter proteins
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Virology 400:18-31. 2010
  10. pmc Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Vaccine 30:3580-6. 2012

Collaborators

Detail Information

Publications16

  1. pmc Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    Virology 380:328-37. 2008
    ..Our data suggest that PPMOs directed against the relatively conserved 5'-end of the norovirus genome may show broad antiviral activity against this genetically diverse group of viruses...
  2. pmc Evolutionary dynamics of GII.4 noroviruses over a 34-year period
    Karin Bok
    Norovirus Gastroenteritis Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Virol 83:11890-901. 2009
    ..Our analysis of archival GII.4 norovirus strains suggests that this genotype has been circulating for more than three decades and provides new ancestral strain sequences for the analysis of GII.4 evolution...
  3. pmc Chimpanzees as an animal model for human norovirus infection and vaccine development
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:325-30. 2011
    ..This study establishes the chimpanzee as a viable animal model for the study of norovirus replication and immunity, and shows that NV VLP vaccines could induce protective homologous immunity even after extended periods of time...
  4. pmc Development of Norwalk virus-specific monoclonal antibodies with therapeutic potential for the treatment of Norwalk virus gastroenteritis
    Zhaochun Chen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:9547-57. 2013
    ..Because chimpanzee immunoglobulins are virtually identical to human immunoglobulins, these chimpanzee anticapsid MAbs may have a clinical application. ..
  5. pmc Multiple antigenic sites are involved in blocking the interaction of GII.4 norovirus capsid with ABH histo-blood group antigens
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, USA
    J Virol 86:7414-26. 2012
    ....
  6. pmc Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period
    Denali Boon
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    J Virol 85:8656-66. 2011
    ..4 noroviruses, as previously proposed. Understanding the evolutionary dynamics of prevalent noroviruses is relevant to the development of effective prevention and control strategies...
  7. pmc The feline calicivirus leader of the capsid protein is associated with cytopathic effect
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    J Virol 87:3003-17. 2013
    ..The host cellular protein annexin A2 was identified as a binding partner of the LC protein, consistent with a role for the LC in mediating host cell interactions that alter the integrity of the cell and enable virus spread...
  8. doi request reprint Genetic characterization of feline calicivirus strains associated with varying disease manifestations during an outbreak season in Missouri (1995-1996)
    Victor G Prikhodko
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC8007, Building 50, Room 6316, Bethesda, MD, 20892 8007, USA
    Virus Genes 48:96-110. 2014
    ..We show that genetically distinct FCV strains were cocirculating in the area, and no apparent correlation could be made between overall sequence and observed disease...
  9. pmc Visualization of feline calicivirus replication in real-time with recombinant viruses engineered to express fluorescent reporter proteins
    Eugenio J Abente
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Virology 400:18-31. 2010
    ....
  10. pmc Immunogenicity and specificity of norovirus Consensus GII.4 virus-like particles in monovalent and bivalent vaccine formulations
    Gabriel I Parra
    Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Vaccine 30:3580-6. 2012
    ....
  11. pmc Diversity of murine norovirus strains isolated from asymptomatic mice of different genetic backgrounds within a single U.S. research institute
    Elyssa L Barron
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21435. 2011
    ..Our study indicates that the murine noroviruses are widespread in these animal facilities, despite rigorous guidelines for animal care and maintenance...
  12. pmc Apoptosis in murine norovirus-infected RAW264.7 cells is associated with downregulation of survivin
    Karin Bok
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bldg 50, Room 6316, Bethesda, MD 20892, USA
    J Virol 83:3647-56. 2009
    ..We observed that MNV-1 replication in RAW264.7 cells activated caspases, resulting in apoptosis through the mitochondrial pathway, possibly as a result of downregulation of survivin...
  13. doi request reprint Norovirus gastroenteritis in immunocompromised patients
    Karin Bok
    From the Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    N Engl J Med 367:2126-32. 2012
    ..Norovirus causes gastroenteritis in immunocompetent and immunocompromised hosts. It is the most common cause of gastroenteritis in U.S. adults seeking emergency department care. Genetic features and emerging treatments are discussed...
  14. ncbi request reprint Prevalence and genetic characterization of caliciviruses among children hospitalized for acute gastroenteritis in the United States
    Carmelann Zintz
    Center for Pediatric Research, Children s Hospital of the King s Daughters, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Infect Genet Evol 5:281-90. 2005
    ..In conclusion, NV and SV were frequent causes of hospitalization for acute gastroenteritis in young children and infecting strains were highly diverse, including newly recognized genogroups and genetic clusters within known genogroups...
  15. ncbi request reprint Rotavirus antigenaemia and viraemia: a common event?
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 362:1445-9. 2003
    ..We assessed whether rotavirus antigen, RNA, or both, were present in serum samples from immunocompetent rotavirus-infected children and animals...
  16. ncbi request reprint Identification of viral agents causing gastroenteritis among children in Buenos Aires, Argentina
    Alesio Bereciartu
    Viral Gastroenteritis Laboratory, National Institute of Infectious Diseases, ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina
    J Clin Virol 25:197-203. 2002
    ..Although the role of rotaviruses as a causal agent of gastroenteritis has been previously established in Argentina, little is known about the frequency of other gastrointestinal viruses...