Adriano Boasso

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:11593-603. 2007
  2. pmc HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815, USA
    Blood 109:3351-9. 2007
  3. pmc Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Immunol 126:235-42. 2008
  4. ncbi request reprint How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Curr Drug Metab 8:217-23. 2007
  5. pmc Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13974-9. 2005
  6. ncbi request reprint Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
  7. pmc CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    Blood 106:3524-31. 2005
  8. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
  9. doi request reprint HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques
    Jean Philippe Herbeuval
    Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    AIDS 23:35-40. 2009
  10. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006

Collaborators

Detail Information

Publications29

  1. pmc Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Virol 81:11593-603. 2007
    ..Increased T(reg) and IDO in LT of SIV-infected macaques may be the consequence of increased tissue inflammation and/or may favor virus replication during the chronic phase of SIV infection...
  2. pmc HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20815, USA
    Blood 109:3351-9. 2007
    ..Thus, induction of IDO in pDCs by HIV may contribute to the T-cell functional impairment observed in HIV/AIDS by a non-interferon-dependent mechanism...
  3. pmc Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Immunol 126:235-42. 2008
    ..Subsequent production of type I interferon and indoleamine 2,3-dioxygenase may exert suppressive and cytotoxic effects on T cells...
  4. ncbi request reprint How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Curr Drug Metab 8:217-23. 2007
    ..Therapeutic approaches aimed at manipulating this powerful immune suppressive mechanism might be considered in the setting of HIV infection...
  5. pmc Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:13974-9. 2005
    ..Our findings suggest a potential unique role of pDCs in the immunopathogenesis of HIV-1 infection by inducing the death molecule TRAIL...
  6. ncbi request reprint Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4313-20. 2009
    ..Further studies are required to elucidate the immunologic or virologic mechanism by which d-1mT inhibited SIV replication in vivo...
  7. pmc CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA
    Blood 106:3524-31. 2005
    ..We propose a novel model in which a type 1 IFN-regulated TRAIL /DR5 mechanism induces apoptosis of HIV-1-exposed CD4(+) T cells...
  8. pmc Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    Valentina Cecchinato
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 180:5439-47. 2008
    ..These data provide the first direct evidence that immune activation drives viral replication, and suggest caution in the use of therapeutic approaches for HIV infection in vivo that increase CD4(+) T cell proliferation...
  9. doi request reprint HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques
    Jean Philippe Herbeuval
    Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, USA
    AIDS 23:35-40. 2009
    ..To determine how antiretroviral therapy (ART) or HAART affects the expression of apoptotic ligands and their death receptors in the blood and lymphoid tissues of HIV-infected patients and simian immunodeficiency virus-infected macaques...
  10. pmc CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques
    Anna Hryniewicz
    NCI, Bldg 41 Rm D 804, Bethesda, MD 20892 5065, USA
    Blood 108:3834-42. 2006
    ..Therefore, blunting T(reg) function in macaques infected with SIV did not have detrimental virologic effects and may provide a valuable approach to complement ART and therapeutic vaccination in the treatment of HIV-1 infection...
  11. ncbi request reprint Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques
    Anna Hryniewicz
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Building 41, Bethesda, MD 20892, USA
    J Immunol 178:3492-504. 2007
    ..These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals...
  12. pmc Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20092, USA
    Proc Natl Acad Sci U S A 103:7000-5. 2006
    ..TRAIL mRNA levels in LT correlated with plasma viral load. We show that HIV-1 induces IFN-alpha and the TRAIL/DR5 apoptotic pathway in LT, suggesting a role for these cytokines in HIV-1 immunopathogenesis...
  13. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
    ..Finally, T cell proliferation was improved by PDL-1 blockade in HIV-treated PBMC. In the setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1...
  14. ncbi request reprint TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells
    Jean Philippe Herbeuval
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, 9000 Rockville Pike, Bethesda, MD, USA
    Blood 105:2458-64. 2005
    ..The high production of TRAIL by antigen-presenting cells may contribute to the death of CD4+ T cells during progression to AIDS...
  15. pmc HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2961. 2008
    ....
  16. pmc Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD, USA
    J Virol 87:3526-37. 2013
    ....
  17. pmc Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, Maryland, USA
    J Virol 86:108-13. 2012
    ..Thus, caution should be used when considering approaches aimed at targeting immune activation during ART...
  18. ncbi request reprint Do regulatory T-cells play a role in AIDS pathogenesis?
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    AIDS Rev 8:141-7. 2006
    ....
  19. ncbi request reprint Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells
    Adriano Boasso
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1574-81. 2005
    ....
  20. doi request reprint Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells
    Oscar D Cano
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 438:22-5. 2008
    ..Thus type I and type II IFN stimulate astrocyte-derived cells to produce neopterin and exert differential effects on amino acid metabolism...
  21. ncbi request reprint B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression
    Daria Trabattoni
    Chair of Immunolgy, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate DISP LITA Vialba, University of Milano, Milano, Italy
    Blood 101:2514-20. 2003
    ..B7-H1 is a surrogate marker potentially involved in AIDS disease progression...
  22. ncbi request reprint Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals
    Daria Trabattoni
    Department of Immunology, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    AIDS 18:859-69. 2004
    ..CTL are stimulated by type 1 cytokines and can kill targets via granule-dependent (perforin and granzymes) and -independent (tumour necrosis factor-alpha, CD95) mechanisms...
  23. ncbi request reprint The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients
    Jan Andersson
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 174:3143-7. 2005
    ..Our data could provide a new basis for immune-based therapies that counteract in vivo Treg and thereby reinforce appropriate antiviral immunity...
  24. pmc HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS
    Jakob Nilsson
    Division of Molecular Immunology ML 7021, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 108:3808-17. 2006
    ..Considered together, our findings imply that therapeutic manipulation of Treg-cell number and/or function could improve immune control of HIV infection...
  25. ncbi request reprint Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression
    Victoria I Bedoya
    Immunovirology Group, Universidad de Antioquia, Medelin, Colombia
    AIDS Res Hum Retroviruses 22:897-907. 2006
    ..These findings raise the possibilities that multiple naturally occurring RNases may contribute to protection against HIV-1 infection and could be considered for utilization in HIV-1 therapy...
  26. doi request reprint The hunt for an HIV vaccine: time to rethink recent failures
    Adriano Boasso
    Department of Immunology, Chelsea and Westminster Hospital, Imperial College, London, UK
    Lancet 371:1897-8. 2008
  27. ncbi request reprint Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters
    Giuliana Magri
    Laboratory of Immunology, DSP LITA Vialba, Universita degli Studi di Milano, Via G B Grassi 74, 20157 Milano, Italy
    Vaccine 23:2862-8. 2005
    ..Vaccination could be an effective therapeutic approach to postpone disease onset...
  28. ncbi request reprint IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai
    Mara Biasin
    Department of Immunology, Universita di Milano, 20157 Milan, Italy
    AIDS 17:1563-5. 2003
    ..Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism...
  29. ncbi request reprint AIDS in Africa
    Mario Clerici
    Lancet 360:1424. 2002