Research Topics
Species | M L BlockSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphinM L Block
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
FASEB J 20:251-8. 2006..Here we demonstrate a tightly regulated mechanism governing microglia-derived oxidative stress, where the neuropeptide balance of dynorphin and substance P is critical to DA neuron survival...- Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidaseM L Block
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
FASEB J 18:1618-20. 2004..Together, these in vitro data indicate that DEP selectively damages DA neurons through the phagocytic activation of microglial NADPH oxidase and consequent oxidative insult... - Microglia-mediated neurotoxicity: uncovering the molecular mechanismsMichelle L Block
Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Nat Rev Neurosci 8:57-69. 2007.... - Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanismMichelle L Block
Neuropharmacology Section, MD F1 01, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
Prog Neurobiol 76:77-98. 2005.... - Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activationLiya Qin
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Glia 52:78-84. 2005.... - MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicityZhong Pei
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Glia 55:1362-73. 2007..Together, these data demonstrate that MAC1 is essential for LPS-induced superoxide from microglia, implicating MAC1 as a critical trigger of microglial-derived oxidative stress during inflammation-mediated neurodegeneration... - NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microgliaLiya Qin
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
J Biol Chem 279:1415-21. 2004.... - Chronic microglial activation and progressive dopaminergic neurotoxicityM L Block
Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U S A
Biochem Soc Trans 35:1127-32. 2007..Here, we review proposed mechanisms responsible for chronic neuroinflammation and explain the interconnected relationship between deleterious microglial activation, DA neuron damage and neurodegenerative disease... - Morphinan neuroprotection: new insight into the therapy of neurodegenerationWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Crit Rev Neurobiol 16:271-302. 2004..The following review will describe novel neuroprotective effects of several morphinans in multiple inflammatory disease models. The potential therapeutic utility and underlying mechanisms of morphinan neuroprotection are discussed... - Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stressLiya Qin
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
FASEB J 19:550-7. 2005.... - Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytesYu Ying He
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
J Invest Dermatol 125:560-6. 2005.... - Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotectionLiya Qin
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Ann N Y Acad Sci 1053:107-20. 2005.... - Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's diseaseWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 19:533-42. 2005..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity... 
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrierAnika M S Hartz
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
FASEB J 22:2723-33. 2008..These experiments disclose a novel blood-brain barrier signaling pathway, with clear implications for environmental toxicology, CNS pathology, and the pharmacotherapy of CNS disorders...- Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damageGuorong Li
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
FASEB J 19:489-96. 2005..These findings suggest a novel therapeutic concept of using "ultra-low" drug concentrations for the intervention of inflammation-related neurodegenerative diseases... - Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stressSufen Yang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD F1-01, P.O. Box 12233, Research Triangle Park, NC 27709, USA
J Pharmacol Exp Ther 319:595-603. 2006.... - The role of microglia in paraquat-induced dopaminergic neurotoxicityXue-Fei Wu
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Antioxid Redox Signal 7:654-61. 2005..Here we report a novel mechanism of PQinduced oxidative stress, where at lower doses, the indirect insult generated from microglial NADPH oxidase is the essential factor mediating DA neurotoxicity... - Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's diseaseXiaoming Hu
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Immunol 181:7194-204. 2008.... - Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neuronsXuefei Wu
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
Int J Neuropsychopharmacol 11:1123-34. 2008..This study indicates that astrocytes may be a critical neuroprotective mechanism of HDAC inhibitors, revealing a novel target for the treatment of psychiatric and neurodegenerative diseases... - Protective effect of dextromethorphan against endotoxic shock in miceGuorong Li
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NCI, National Institute of Environmental Health Sciences, National Institutes of Health Sciences, Research Triangle Park, NC 27709, USA
Biochem Pharmacol 69:233-40. 2005..This study not only extends neuroprotective effect of DM, but also suggests that DM may be a novel compound for the therapeutic intervention for sepsis... - A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activationYoon Seong Kim
Burke Medical Research Institute, and Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
FASEB J 21:179-87. 2007..Our results could lead to a novel therapeutic approach to PD... - Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease... - Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidaseLi Qian
The Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599-7455, USA
J Pharmacol Exp Ther 319:44-52. 2006..Together, our results suggest that IL-10 inhibits LPS-induced DA neurotoxicity through the inhibition of PHOX activity in a JAK1-dependent mechanism... - In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNSVadim S Polikov
Department of Biomedical Engineering, Duke University, Durham NC 27708-0281, USA
Biomaterials 27:5368-76. 2006..The time course and relative positions of the glia in response to the different injury paradigms correlated well with stereotypical in vivo responses and warrant further work in the development of a functional in vitro test bed...