M L Block

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 20:251-8. 2006
  2. ncbi request reprint Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 18:1618-20. 2004
  3. ncbi request reprint Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    Michelle L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Neurosci 8:57-69. 2007
  4. ncbi request reprint Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    Michelle L Block
    Neuropharmacology Section, MD F1 01, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Prog Neurobiol 76:77-98. 2005
  5. ncbi request reprint Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Glia 52:78-84. 2005
  6. ncbi request reprint MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity
    Zhong Pei
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Glia 55:1362-73. 2007
  7. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
  8. ncbi request reprint Chronic microglial activation and progressive dopaminergic neurotoxicity
    M L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U S A
    Biochem Soc Trans 35:1127-32. 2007
  9. ncbi request reprint Morphinan neuroprotection: new insight into the therapy of neurodegeneration
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Crit Rev Neurobiol 16:271-302. 2004
  10. ncbi request reprint Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:550-7. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 20:251-8. 2006
    ..Here we demonstrate a tightly regulated mechanism governing microglia-derived oxidative stress, where the neuropeptide balance of dynorphin and substance P is critical to DA neuron survival...
  2. ncbi request reprint Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 18:1618-20. 2004
    ..Together, these in vitro data indicate that DEP selectively damages DA neurons through the phagocytic activation of microglial NADPH oxidase and consequent oxidative insult...
  3. ncbi request reprint Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    Michelle L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Neurosci 8:57-69. 2007
    ....
  4. ncbi request reprint Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    Michelle L Block
    Neuropharmacology Section, MD F1 01, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Prog Neurobiol 76:77-98. 2005
    ....
  5. ncbi request reprint Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Glia 52:78-84. 2005
    ....
  6. ncbi request reprint MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity
    Zhong Pei
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Glia 55:1362-73. 2007
    ..Together, these data demonstrate that MAC1 is essential for LPS-induced superoxide from microglia, implicating MAC1 as a critical trigger of microglial-derived oxidative stress during inflammation-mediated neurodegeneration...
  7. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
    ....
  8. ncbi request reprint Chronic microglial activation and progressive dopaminergic neurotoxicity
    M L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U S A
    Biochem Soc Trans 35:1127-32. 2007
    ..Here, we review proposed mechanisms responsible for chronic neuroinflammation and explain the interconnected relationship between deleterious microglial activation, DA neuron damage and neurodegenerative disease...
  9. ncbi request reprint Morphinan neuroprotection: new insight into the therapy of neurodegeneration
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Crit Rev Neurobiol 16:271-302. 2004
    ..The following review will describe novel neuroprotective effects of several morphinans in multiple inflammatory disease models. The potential therapeutic utility and underlying mechanisms of morphinan neuroprotection are discussed...
  10. ncbi request reprint Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:550-7. 2005
    ....
  11. ncbi request reprint Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 125:560-6. 2005
    ....
  12. ncbi request reprint Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 1053:107-20. 2005
    ....
  13. ncbi request reprint Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  14. pmc Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier
    Anika M S Hartz
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FASEB J 22:2723-33. 2008
    ..These experiments disclose a novel blood-brain barrier signaling pathway, with clear implications for environmental toxicology, CNS pathology, and the pharmacotherapy of CNS disorders...
  15. ncbi request reprint Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage
    Guorong Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:489-96. 2005
    ..These findings suggest a novel therapeutic concept of using "ultra-low" drug concentrations for the intervention of inflammation-related neurodegenerative diseases...
  16. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD F1 01, P O Box 12233, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 319:595-603. 2006
    ....
  17. ncbi request reprint The role of microglia in paraquat-induced dopaminergic neurotoxicity
    Xue Fei Wu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Antioxid Redox Signal 7:654-61. 2005
    ..Here we report a novel mechanism of PQinduced oxidative stress, where at lower doses, the indirect insult generated from microglial NADPH oxidase is the essential factor mediating DA neurotoxicity...
  18. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
    ....
  19. pmc Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
    Xuefei Wu
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Int J Neuropsychopharmacol 11:1123-34. 2008
    ..This study indicates that astrocytes may be a critical neuroprotective mechanism of HDAC inhibitors, revealing a novel target for the treatment of psychiatric and neurodegenerative diseases...
  20. ncbi request reprint Protective effect of dextromethorphan against endotoxic shock in mice
    Guorong Li
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NCI, National Institute of Environmental Health Sciences, National Institutes of Health Sciences, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 69:233-40. 2005
    ..This study not only extends neuroprotective effect of DM, but also suggests that DM may be a novel compound for the therapeutic intervention for sepsis...
  21. ncbi request reprint A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation
    Yoon Seong Kim
    Burke Medical Research Institute, and Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    FASEB J 21:179-87. 2007
    ..Our results could lead to a novel therapeutic approach to PD...
  22. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
    ..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
  23. ncbi request reprint Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase
    Li Qian
    The Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Pharmacol Exp Ther 319:44-52. 2006
    ..Together, our results suggest that IL-10 inhibits LPS-induced DA neurotoxicity through the inhibition of PHOX activity in a JAK1-dependent mechanism...
  24. ncbi request reprint In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS
    Vadim S Polikov
    Department of Biomedical Engineering, Duke University, Durham NC 27708 0281, USA
    Biomaterials 27:5368-76. 2006
    ..The time course and relative positions of the glia in response to the different injury paradigms correlated well with stereotypical in vivo responses and warrant further work in the development of a functional in vitro test bed...