Marc R Blackman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial
    Marc R Blackman
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 288:2282-92. 2002
  2. pmc Growth hormone and sex steroid effects on serum glucose, insulin, and lipid concentrations in healthy older women and men
    Thomas Münzer
    Endocrine Section, Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 94:3833-41. 2009
  3. ncbi request reprint Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men
    Thomas Münzer
    Endocrine Section, Laboratory of Clinical Investigations, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Am J Physiol Endocrinol Metab 290:E1006-13. 2006
  4. ncbi request reprint Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men
    Colleen Christmas
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 57:M12-8. 2002
  5. ncbi request reprint The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men
    S Mitchell Harman
    National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Horm Res 60:121-4. 2003
  6. ncbi request reprint Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
    Annabelle Rodriguez
    Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 92:3568-72. 2007
  7. ncbi request reprint Effects of growth hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and men
    Xin Huang
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2179, USA
    Metabolism 54:1162-7. 2005
  8. ncbi request reprint Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men
    Tracey Ann Roy
    Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Endocrinol Metab 283:E284-94. 2002
  9. ncbi request reprint Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Clin Endocrinol Metab 87:5001-7. 2002
  10. ncbi request reprint Mitochondria as key components of the stress response
    Irini Manoli
    Human Biochemical Genetics Section, MGB, NHGRI, NIH, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 18:190-8. 2007

Detail Information

Publications38

  1. ncbi request reprint Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial
    Marc R Blackman
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 288:2282-92. 2002
    ..Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown...
  2. pmc Growth hormone and sex steroid effects on serum glucose, insulin, and lipid concentrations in healthy older women and men
    Thomas Münzer
    Endocrine Section, Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 94:3833-41. 2009
    ..With aging, GH, IGF-I, and sex steroid concentrations and glucose tolerance decrease, and body fat and serum lipids increase...
  3. ncbi request reprint Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men
    Thomas Münzer
    Endocrine Section, Laboratory of Clinical Investigations, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Am J Physiol Endocrinol Metab 290:E1006-13. 2006
    ..Whether GH and/or sex steroid administration alters local tissue production of IGFBPs and whether the latter influence autocrine or paracrine actions of IGF-I remain to be determined...
  4. ncbi request reprint Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men
    Colleen Christmas
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 57:M12-8. 2002
    ..Long-term estrogen replacement slows bone loss and prevents fractures in postmenopausal women, whereas the effects of supplementation of GH or testosterone on bone metabolism and BMD in aged individuals remains uncertain...
  5. ncbi request reprint The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men
    S Mitchell Harman
    National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Horm Res 60:121-4. 2003
    ....
  6. ncbi request reprint Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
    Annabelle Rodriguez
    Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 92:3568-72. 2007
    ..The aim of this study was to evaluate the relationship between the MS and circulating androgen levels in a cohort of men in the Baltimore Longitudinal Study of Aging...
  7. ncbi request reprint Effects of growth hormone and/or sex steroid administration on whole-body protein turnover in healthy aged women and men
    Xin Huang
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2179, USA
    Metabolism 54:1162-7. 2005
    ..2 g protein.kg-1.d-1; P<.01). These data suggest that low-dose GH administration increases protein synthesis in healthy aged women and men, and that the coadministration of testosterone plus GH enhances this effect in elderly men...
  8. ncbi request reprint Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men
    Tracey Ann Roy
    Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Endocrinol Metab 283:E284-94. 2002
    ..FTI is a better predictor of arm and leg strength than T in aging men...
  9. ncbi request reprint Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Clin Endocrinol Metab 87:5001-7. 2002
    ..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men...
  10. ncbi request reprint Mitochondria as key components of the stress response
    Irini Manoli
    Human Biochemical Genetics Section, MGB, NHGRI, NIH, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 18:190-8. 2007
    ..Understanding the often reciprocal interplay between stress mediators and mitochondrial function is likely to help identify potential therapeutic targets for many stress and mitochondria-related pathologies...
  11. ncbi request reprint Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells
    Julia T Arnold
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 0933, USA
    Prostate 67:1152-62. 2007
    ..LNCaP and LAPC-4 prostate cancer cells were used to determine whether DHEA-modulated proliferation and prostate specific antigen (PSA) production were mediated via the androgen receptor (AR) and/or ERbeta...
  12. ncbi request reprint Low intensity permanent magnets in the treatment of chronic lumbar radicular pain
    Suzan Khoromi
    National Center for Complementary and Alternative Medicine, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20814, USA
    J Pain Symptom Manage 34:434-45. 2007
    ..Although these data cannot rule out a chance effect, the positive trends suggest that larger, longer-duration, sham-controlled trials with 200G magnets be considered in patients with chronic lumbar radicular pain...
  13. pmc Health behaviors and risk factors in those who use complementary and alternative medicine
    Richard L Nahin
    National Center for Complementary and Alternative Medicine, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 2182, USA
    BMC Public Health 7:217. 2007
    ..In the present study we sought to determine whether the use of complementary and alternative medicine is associated with health behaviors or risk factors known to impact on health status...
  14. pmc Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells
    Julia T Arnold
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    J Steroid Biochem Mol Biol 111:240-6. 2008
    ....
  15. pmc Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5
    Tomoshige Kino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 2:ra5. 2009
    ..Our results indicate that Brx integrates the responses of immune cells to osmotic stress and inflammation by elevating intracellular osmolarity and stimulating the production of cytokines...
  16. pmc Plasma CRP levels in premenopausal women with major depression: a 12-month controlled study
    G Cizza
    Clinical Endocrine Section, Clinical Endocrinology Branch, NIDDK, NIH, DHHS, Bethesda, MD 20892 1613, USA
    Horm Metab Res 41:641-8. 2009
    ..Depression was associated with increased plasma CRP in women with MDD. The clinical significance of abnormal plasma CRP for cardiovascular risk needs to be assessed in large prospective studies of women with depression...
  17. pmc Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells
    Xunxian Liu
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 151:1428-40. 2010
    ..Although DHEA may enhance PrCa cell growth via androgenic or estrogenic pathways, the effects of DHEA administration on clinical prostate function remain to be determined...
  18. pmc Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study
    Giovanni Cizza
    Clinical Endocrine Section, Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1613, USA
    J Clin Psychiatry 71:1079-87. 2010
    ....
  19. ncbi request reprint Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells
    Vernon E Steele
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Anticancer Res 26:3205-15. 2006
    ..Because DHEA can be converted to androgens or estrogens, such use may promote prostate cancer. In this study, the effects of DHEA were compared with those of DHT using gene expression array profiles in human LNCaP prostate cancer cells...
  20. ncbi request reprint Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells
    Julia T Arnold
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, NCCAM, NIH, 9 Memorial Dr, Rm 1N105, Bethesda, MD 20892 0933, USA
    Am J Physiol Endocrinol Metab 288:E573-84. 2005
    ..Further studies of the mechanisms of DHEA effects on prostate cancer epithelial cells of varying AR status, as well as on prostate stromal cells, will be required to discern the implications of DHEA supplementation on prostatic health...
  21. ncbi request reprint Mistletoe and gemcitabine in patients with advanced cancer: a model for the phase I study of botanicals and botanical-drug interactions in cancer therapy
    Patrick J Mansky
    National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892 2669, USA
    Integr Cancer Ther 2:345-52. 2003
    ....
  22. ncbi request reprint Effects of chronic osteoarthritis pain on neuroendocrine function in men
    Suzan Khoromi
    Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 1302, USA
    J Clin Endocrinol Metab 91:4313-8. 2006
    ..Most endocrine studies have been conducted in patients in whom the potentially confounding effects of depression, inflammatory disease, or coexistent medication use have not been controlled...
  23. ncbi request reprint Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells
    Irini Manoli
    Endocrine Section, Laboratory of Clinical Investigation, NCCAM, NIH, Bethesda, Maryland 20892, USA
    FASEB J 19:1359-61. 2005
    ..We suggest that MAO-A-mediated oxidative stress can lead to cell damage, representing a novel pathogenetic mechanism for glucocorticoid-induced myopathy and a potential target for therapeutic intervention...
  24. ncbi request reprint Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements
    Hidetaka Hougaku
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 290:E234-42. 2006
    ..05). Thus the adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function...
  25. ncbi request reprint Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
    Sean X Leng
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Aging Clin Exp Res 16:153-7. 2004
    ..In the present study, our aim is to evaluate the possible role of endocrine dysregulation and its relationship with serum IL-6 in the pathogenesis of this syndrome...
  26. ncbi request reprint Low bone mass in premenopausal women with depression
    Farideh Eskandari
    Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, Cleveland, Ohio, USA
    Arch Intern Med 167:2329-36. 2007
    ..An increased prevalence of low bone mineral density (BMD) has been reported in patients with major depressive disorder (MDD), mostly women...
  27. doi request reprint Complementary and alternative medicine (CAM)
    Barbara Moquin
    National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD, USA
    Geriatr Nurs 30:196-203. 2009
    ..This article describes the state of the science regarding the efficacy and safety of CAM modalities and actions that ALC nurses might undertake to collaborate with residents to address their CAM interest and use respectfully...
  28. ncbi request reprint Determinants of serum total and free testosterone levels in women over the age of 65 years
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Clin Endocrinol Metab 92:509-16. 2007
    ..Little is known about testosterone (T) levels and their determinants in women of late postmenopausal age...
  29. doi request reprint Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells
    Xunxian Liu
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 29:816-23. 2008
    ..This study expands the understanding of the preventive mechanisms of lycopene in prostate cancer...
  30. ncbi request reprint Third-generation human mitochondria-focused cDNA microarray and its bioinformatic tools for analysis of gene expression
    Xueyan Bai
    The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    Biotechniques 42:365-75. 2007
    ..Thus, hMitChip3 and its bioinformatics software provide an integrated tool for profiling mitochondria-focused gene expression...
  31. pmc Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study
    Marc R Blackman
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 9:R73. 2007
    ..Whether these changes contribute to rheumatoid cachexia remains to be determined. Trial registration number: NCT00034060...
  32. ncbi request reprint Does DHEA exert direct effects on androgen and estrogen receptors, and does it promote or prevent prostate cancer?
    Julia T Arnold
    Endocrinology 146:4565-7. 2005
  33. ncbi request reprint DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells
    Hanh Le
    Endocrine Section, LCI, DIR, NCCAM, 9 Memorial Dr, Bethesda, MD 20892 0933, USA
    Am J Physiol Endocrinol Metab 290:E952-60. 2006
    ..These data suggest that DHT and T promote prostate growth partly via modulation of the stromal cell IGF axis, with potential paracrine effects on prostate epithelial cells...
  34. ncbi request reprint Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Endocrinol Metab 293:E769-75. 2007
    ..02), with no significant change in IGFBP-3 levels after T vs. placebo. We conclude that low-dose T supplementation for 26 wk increases spontaneous nocturnal GH secretion and morning serum IGF-I concentrations in healthy older men...
  35. ncbi request reprint Dehydroepiandrosterone secretion in healthy older men and women: effects of testosterone and growth hormone administration in older men
    Ranganath Muniyappa
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4445-52. 2006
    ....
  36. ncbi request reprint Use of growth hormone secretagogues to prevent or treat the effects of aging: not yet ready for prime time
    Marc R Blackman
    Ann Intern Med 149:677-9. 2008
  37. ncbi request reprint Use of growth hormone for prevention or treatment of effects of aging
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Suite 220, Phoenix, AZ 85016, USA
    J Gerontol A Biol Sci Med Sci 59:652-8. 2004
    ..Until more research has better defined the risk/benefit relationships, treatment of elderly individuals with rhGH should be confined to controlled research studies...
  38. ncbi request reprint Manipulation of the growth hormone axis in patients with HIV infection
    Marc R Blackman
    N Engl J Med 357:2397-9. 2007