Lutz Birnbaumer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins
    Meisheng Jiang
    Department of Anesthesiology, School of Medicine, University of California, Los Angeles, California 90095, USA
    Methods Enzymol 344:277-98. 2002
  2. ncbi request reprint Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o)
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:4878-84. 2002
  3. ncbi request reprint A comparison of the genes coding for canonical TRP channels and their M, V and P relatives
    Lutz Birnbaumer
    Laboratory of Signal Transduction, Department of Human Health Services, National Institute of Environmental Health Research, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Calcium 33:419-32. 2003
  4. ncbi request reprint TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit
    Tiffany T Huang
    Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int Immunol 15:1359-67. 2003
  5. pmc Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels
    Brian T Kawasaki
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:335-40. 2006
  6. pmc On the roles of Mg in the activation of G proteins
    Lutz Birnbaumer
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC27709, USA
    J Recept Signal Transduct Res 30:372-5. 2010
  7. doi request reprint The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations
    Lutz Birnbaumer
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Pharmacol Toxicol 49:395-426. 2009
  8. pmc The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding
    Lutz Birnbaumer
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1768:756-71. 2007
  9. pmc Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers
    Lutz Birnbaumer
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1768:772-93. 2007
  10. pmc Orai proteins interact with TRPC channels and confer responsiveness to store depletion
    Yanhong Liao
    Signal Transduction and Neurobiology Laboratories, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 104:4682-7. 2007

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins
    Meisheng Jiang
    Department of Anesthesiology, School of Medicine, University of California, Los Angeles, California 90095, USA
    Methods Enzymol 344:277-98. 2002
  2. ncbi request reprint Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o)
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 22:4878-84. 2002
    ..Thus, the light response of the ON bipolar cell is probably carried by its strongly expressed splice variant, Galpha(o1)...
  3. ncbi request reprint A comparison of the genes coding for canonical TRP channels and their M, V and P relatives
    Lutz Birnbaumer
    Laboratory of Signal Transduction, Department of Human Health Services, National Institute of Environmental Health Research, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Calcium 33:419-32. 2003
    ..The same holds true for TRPV5 and V6. The article presents complication of comparisons including exon-intron boundaries, the amino acid sequence alignments, and the chromosomal organization of each of the presently known TRP channels...
  4. ncbi request reprint TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit
    Tiffany T Huang
    Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Int Immunol 15:1359-67. 2003
    ..These findings indicate that Galphai2(-/-) mice have an intrinsic CD4(+) T cell abnormality in TCR signaling which may be one cause of augmented T cell effector function and Galphai2(-/-) autoimmune susceptibility...
  5. pmc Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels
    Brian T Kawasaki
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:335-40. 2006
    ....
  6. pmc On the roles of Mg in the activation of G proteins
    Lutz Birnbaumer
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC27709, USA
    J Recept Signal Transduct Res 30:372-5. 2010
    ..Disruption of either leads to loss of GTPase activity...
  7. doi request reprint The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations
    Lutz Birnbaumer
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Pharmacol Toxicol 49:395-426. 2009
    ..Both of these questions-mechanism of activation and participation in Ca(2+) entry-are the topics of this review...
  8. pmc The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding
    Lutz Birnbaumer
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1768:756-71. 2007
    ....
  9. pmc Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers
    Lutz Birnbaumer
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1768:772-93. 2007
    ..Emphasis is placed in presenting how the field developed with the hope of conveying why many of the new findings were made...
  10. pmc Orai proteins interact with TRPC channels and confer responsiveness to store depletion
    Yanhong Liao
    Signal Transduction and Neurobiology Laboratories, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 104:4682-7. 2007
    ..We propose that Orai proteins by interacting with TRPCs act as regulatory subunits that confer STIM1-mediated store depletion sensitivity to these channels...
  11. pmc The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits
    Adolfo R Zurita
    Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 105:2363-8. 2008
    ..The data highlight a critical role for the switch 3 region in setting overall properties of signal-transducing GTPases...
  12. pmc Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels
    Yanhong Liao
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 105:2895-900. 2008
    ..We propose that SOCE/Icrac channels are composed of heteromeric complexes that include TRPCs and Orai proteins...
  13. pmc A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry
    Yanhong Liao
    Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 106:3202-6. 2009
    ..It remains to be determined whether the molecules forming the permeation pathway are the same when Orai:TRPC complexes mediate ROCE or SOCE...
  14. pmc Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe
    Brandon J Cuthbertson
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Biol Chem 283:2586-94. 2008
    ..zfs1 and its targets in S. pombe represent a useful model system for studies of zinc finger protein/AU-rich element interactions that result in mRNA decay...
  15. pmc Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases
    Adolfo Zurita
    Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 107:9596-601. 2010
    ..Our observations indicate that the Gln and Thr carbonyls play equihierarchical roles in the GTPase process and provide the mechanism that explains why mutating the Thr mimics mutating the Gln and not that of the Ser...
  16. pmc Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode
    Yanshun Liu
    Laboratory of Neurobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 287:43030-41. 2012
    ..We propose a two-step mechanism for CaM-dependent Orai1 inactivation initiated by binding of the C-lobe of CaM to the CMBD of one Orai1 followed by the binding of the N-lobe of CaM to the CMBD of a neighboring Orai1...
  17. pmc XLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex
    Joel Abramowitz
    Transmembrane Signal Transduction Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 101:8366-71. 2004
    ..XXLb proteins are likely to be found as stable dimers with AlexX. The N-terminally longer proteins may play regulatory roles...
  18. pmc Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production
    Nevenka Medic
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive MSC 1881, Bethesda, MD 20892 1881, USA
    Cell Calcium 53:315-26. 2013
    ..These data thus provide evidence that, in this model, TRPC1 promotes recovery from the anaphylactic response by repressing antigen-mediated TNF-α release from MCs...
  19. pmc Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity
    Min Seuk Kim
    Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20814, USA
    Gastroenterology 140:2107-15, 2115.e1-4. 2011
    ..We investigated whether genetic or pharmacologic inhibition of TRPC3 protects pancreas and salivary glands from Ca2+-dependent damage...
  20. pmc Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins
    Nicholas W Plummer
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Durham, NC 27709, USA
    Proc Natl Acad Sci U S A 109:21366-71. 2012
    ..These phenotypes reveal a previously unknown role for G protein-coupled signaling pathways in development of the axial skeleton...
  21. pmc Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel
    Eda Yildirim
    Transmembrane Signaling Group, Laboratory of Signal Transduction, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 102:3307-11. 2005
    ....
  22. pmc Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice
    Eda Yildirim
    Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 303:L539-49. 2012
    ..Thus we propose that TRPC1 signaling is necessary in lymphocyte biology and in regulation of allergen-induced lung hyperresponsiveness, making TRPC1 a potential target for treatment of immune diseases and asthma...
  23. ncbi request reprint Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels
    Mohamed Trebak
    Laboratory of Signal Transduction, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 278:16244-52. 2003
    ..We conclude that receptor-mediated activation of phospholipase C in intact cells activates TRPC3 via diacylglycerol production, independently of G proteins, protein kinase C, or inositol 1,4,5-trisphosphate...
  24. pmc The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus
    Eda Yildirim
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 100:2220-5. 2003
    ..We conclude that the human TRPC2 gene may never have been an active gene because of incomplete ancestral duplication or, if it was complete at one point, that it became inactive upon loss of chromosomal sequences...
  25. pmc Physiology and pathophysiology of canonical transient receptor potential channels
    Joel Abramowitz
    Transmembrane Signaling Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FASEB J 23:297-328. 2009
    ..TRPCs emerge as targets for a thus far nonexistent field of pharmacological intervention that may ameliorate complex diseases...
  26. doi request reprint Do canonical transient receptor potential channels mediate cholinergic excitation of cortical pyramidal neurons?
    Sameera Dasari
    Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756 0001, USA
    Neuroreport 24:550-4. 2013
    ....
  27. pmc Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice
    Xibao Liu
    Secretory Physiology Section, Gene Therapy and Therapeutic Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:17542-7. 2007
    ..Thus, TRPC1 is a critical component of the SOC channel in salivary gland acinar cells and is essential for neurotransmitter-regulation of fluid secretion...
  28. pmc Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices
    Christian Erxleben
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:3932-7. 2006
    ..We propose that aberrant phosphorylation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associated with Timothy syndrome and with chronic cyclosporin treatment of transplant patients...
  29. pmc Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop
    Christian Erxleben
    Laboratory of Signal Transduction and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 100:2929-34. 2003
    ....
  30. ncbi request reprint A unified nomenclature for the superfamily of TRP cation channels
    Craig Montell
    Mol Cell 9:229-31. 2002
  31. pmc Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors
    Katharina Foerster
    Department of Pharmacology, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 100:14475-80. 2003
    ..This result indicates that subtype-specific signaling of beta 2-adrenoreceptor functionally bifurcates at the level of Gi, leading to different effects depending on the G alpha isoform...
  32. ncbi request reprint Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation
    Victor V Pineda
    Department of Pharmacology, The University of Washington, Seattle, 98195, USA
    Neuron 41:153-63. 2004
    ..We hypothesize that loss of G(ialpha1) amplifies the responsiveness of CA1 postsynaptic neurons to stimuli that strengthen synaptic efficacy, thereby diminishing synapse-specific plasticity required for new memory formation...
  33. pmc Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system
    Irene Brunk
    Institute for Integrative Neuroanatomy, Center for Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    FASEB J 22:3736-46. 2008
    ..We conclude that Go2alpha optimizes vesicular filling which is instrumental for normal dopamine functioning and for the development of drug-induced behavioral sensitization...
  34. pmc Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice
    Robert A Edwards
    Department of Pathology, University of California, Irvine, Irvine, California 92697 4800, USA
    Inflamm Bowel Dis 14:898-907. 2008
    ..They are predominantly right-sided, multifocal, mucinous, and arise from areas of flat dysplasia...
  35. pmc Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation
    Alejandra Young
    Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Invest Ophthalmol Vis Sci 49:3245-52. 2008
    ..This study was undertaken to test whether one of the G alpha i proteins, G alpha i3, signals in the same pathway as OA1 to regulate melanosome biogenesis and axonal growth through the optic chiasm...
  36. pmc Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease
    Yong Zhu Jin
    Wellman Center of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 38:1988-98. 2008
    ..These observations underscore interplay between Galphai2 and Galphai3 and potentially provide a novel strategy to prevent GVHD by blocking T cell homing at early stages and T effector cell trafficking at later time points...
  37. ncbi request reprint B cell developmental requirement for the G alpha i2 gene
    Harnisha Dalwadi
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1732, USA
    J Immunol 170:1707-15. 2003
    ..Collectively, these results reveal a selective role for Galphai2 in MZ and B-1 B cell development. Disorders of this Galphai2-dependent process in B cell development may represent a mechanism for IBD susceptibility...
  38. pmc Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung
    Anna G Taranova
    Department of Biochemistry and Molecular Biology, Divisions of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Cancer Res 68:8582-9. 2008
    ....
  39. pmc Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins
    Hongkuan Fan
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    Immunology 122:116-23. 2007
    ..These data suggest that G(i2) and G(i1/3) proteins are both involved and differentially regulate murine inflammatory cytokine and chemokine production in response to both LPS and Gram-positive microbial stimuli...
  40. ncbi request reprint TRPC4 knockout mice: the coming of age of TRP channels as gates of calcium entry responsible for cellular responses
    Lutz Birnbaumer
    Circ Res 91:1-3. 2002
  41. ncbi request reprint Erythropoietin modulates calcium influx through TRPC2
    Xin Chu
    Henry Hood Research Program, The Sigfried and Janet Weis Center for Research, Geisinger Clinic, 100 N Academy Avenue, Danville, PA 17822, USA
    J Biol Chem 277:34375-82. 2002
    ..This rise in [Ca](i) required Epo and extracellular calcium. These results identify a calcium-permeable channel, TRPC2, in erythroid cells and demonstrate modulation of calcium influx through this channel by erythropoietin...
  42. ncbi request reprint Modulation of the N-type calcium channel gene expression by the alpha subunit of Go
    Bum Jun Kim
    Department of Anatomy, School of Medicine, Ajou University, San 5, Wonchon dong, Paldal Gu, Suwon, 442 749, South Korea
    Brain Res Mol Brain Res 112:95-102. 2003
    ..2 in the brain. These results suggest that Go may regulate neuronal differentiation through modulation of gene expression of target genes such as N-type calcium channels...
  43. pmc Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets
    Bo Wei
    Department of Pathology and Laboratory Medicine and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:2010-5. 2005
    ....
  44. ncbi request reprint Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation
    Julia Skokowa
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Immunol 174:3041-50. 2005
    ....
  45. ncbi request reprint Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB Rm 403, Charleston, SC 29425, USA
    Am J Physiol Cell Physiol 289:C293-301. 2005
    ..These data suggest that G(i) proteins differentially regulate murine TLR-mediated inflammatory cytokine production in a cell-specific manner in response to both LPS and gram-positive microbial stimuli...
  46. ncbi request reprint Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependence
    Sandra Winter
    AG Funktionelle Zellbiologie, Centrum für Anatomie, Charite Universitatsmedizin Berlin, D 10115 Berlin, Germany
    J Neurosci 25:4672-80. 2005
    ..Thus, Galpha(o2) acts on a putative regulatory chloride binding domain that appears to modulate transport activity of vesicular glutamate transporters...
  47. pmc Increased vascular smooth muscle contractility in TRPC6-/- mice
    Alexander Dietrich
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Germany
    Mol Cell Biol 25:6980-9. 2005
    ..Thus, TRPC6 has distinct nonredundant roles in the control of vascular smooth muscle tone...
  48. ncbi request reprint Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins
    Hongkuan Fan
    Department of Neuroscience, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
    Biochim Biophys Acta 1763:1051-8. 2006
    ....
  49. pmc Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go
    Sungho Ghil
    Department of Biology, Kyonggi University, Suwon 442 760, South Korea
    Proc Natl Acad Sci U S A 103:19158-63. 2006
    ..This regulatory mechanism by which G(o) bifurcates PKA signaling may provide insights into how G(o) regulates complex processes such as neuritogenesis, synaptic plasticity, and cell transformation...
  50. pmc Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling
    Brian D Thompson
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 282:9547-55. 2007
    ..This interplay has heretofore been masked by the use of pertussis toxin, a broad inhibitor of the G alpha(i/o) protein family...
  51. pmc An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver
    Antje Gohla
    Institut für Biochemie und Molekularbiologie II and Klinik für Gastroenterologie, Hepatologie, und Infektiologie, Klinikum der Heinrich Heine Universität, D 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 104:3003-8. 2007
    ..These data indicate that Galpha(i3) is crucial for the antiautophagic action of insulin and suggest an as-yet-unrecognized function for Galpha(i3) on autophagosomal membranes...
  52. pmc Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation
    Ralph S Pero
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Proc Natl Acad Sci U S A 104:4371-6. 2007
    ..Collectively, these data suggest that specific Galpha(i2)-mediated signaling between endothelial cells and leukocytes is required for the extravasation of leukocytes and for tissue-specific accumulation...
  53. ncbi request reprint The TRP channels, a remarkably functional family
    Craig Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 108:595-8. 2002
    ..Moreover, the biological roles of TRP channels appear to be equally diverse and range from roles in pain perception to male aggression...