Research Topics
Genomes and Genes | Lutz BirnbaumerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteinsMeisheng Jiang
Department of Anesthesiology, School of Medicine, University of California, Los Angeles, California 90095, USA
Methods Enzymol 344:277-98. 2002- Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o)Anuradha Dhingra
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 22:4878-84. 2002..Thus, the light response of the ON bipolar cell is probably carried by its strongly expressed splice variant, Galpha(o1)... - A comparison of the genes coding for canonical TRP channels and their M, V and P relativesLutz Birnbaumer
Laboratory of Signal Transduction, Department of Human Health Services, National Institute of Environmental Health Research, National Institutes of Health, Research Triangle Park, NC 27709, USA
Cell Calcium 33:419-32. 2003..The same holds true for TRPV5 and V6. The article presents complication of comparisons including exon-intron boundaries, the amino acid sequence alignments, and the chromosomal organization of each of the presently known TRP channels... - TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunitTiffany T Huang
Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
Int Immunol 15:1359-67. 2003..These findings indicate that Galphai2(-/-) mice have an intrinsic CD4(+) T cell abnormality in TCR signaling which may be one cause of augmented T cell effector function and Galphai2(-/-) autoimmune susceptibility... 
Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channelsBrian T Kawasaki
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 103:335-40. 2006....
The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrationsLutz Birnbaumer
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Annu Rev Pharmacol Toxicol 49:395-426. 2009..Both of these questions-mechanism of activation and participation in Ca(2+) entry-are the topics of this review...- The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understandingLutz Birnbaumer
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Biochim Biophys Acta 1768:756-71. 2007.... - On the roles of Mg in the activation of G proteinsLutz Birnbaumer
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC27709, USA
J Recept Signal Transduct Res 30:372-5. 2010..Disruption of either leads to loss of GTPase activity... - Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimersLutz Birnbaumer
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
Biochim Biophys Acta 1768:772-93. 2007..Emphasis is placed in presenting how the field developed with the hope of conveying why many of the new findings were made... - Orai proteins interact with TRPC channels and confer responsiveness to store depletionYanhong Liao
Signal Transduction and Neurobiology Laboratories, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 104:4682-7. 2007..We propose that Orai proteins by interacting with TRPCs act as regulatory subunits that confer STIM1-mediated store depletion sensitivity to these channels... - The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunitsAdolfo R Zurita
Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 105:2363-8. 2008..The data highlight a critical role for the switch 3 region in setting overall properties of signal-transducing GTPases... - Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channelsYanhong Liao
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 105:2895-900. 2008..We propose that SOCE/Icrac channels are composed of heteromeric complexes that include TRPCs and Orai proteins... - A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entryYanhong Liao
Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 106:3202-6. 2009..It remains to be determined whether the molecules forming the permeation pathway are the same when Orai:TRPC complexes mediate ROCE or SOCE... - Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPasesAdolfo Zurita
Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 107:9596-601. 2010..Our observations indicate that the Gln and Thr carbonyls play equihierarchical roles in the GTPase process and provide the mechanism that explains why mutating the Thr mimics mutating the Gln and not that of the Ser... - Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombeBrandon J Cuthbertson
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
J Biol Chem 283:2586-94. 2008..zfs1 and its targets in S. pombe represent a useful model system for studies of zinc finger protein/AU-rich element interactions that result in mRNA decay... - Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding modeYanshun Liu
Laboratory of Neurobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 287:43030-41. 2012..We propose a two-step mechanism for CaM-dependent Orai1 inactivation initiated by binding of the C-lobe of CaM to the CMBD of one Orai1 followed by the binding of the N-lobe of CaM to the CMBD of a neighboring Orai1... - XLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion AlexJoel Abramowitz
Transmembrane Signal Transduction Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 101:8366-71. 2004..XXLb proteins are likely to be found as stable dimers with AlexX. The N-terminally longer proteins may play regulatory roles... - Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicityMin Seuk Kim
Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20814, USA
Gastroenterology 140:2107-15, 2115.e1-4. 2011..We investigated whether genetic or pharmacologic inhibition of TRPC3 protects pancreas and salivary glands from Ca2+-dependent damage... - Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteinsNicholas W Plummer
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Durham, NC 27709, USA
Proc Natl Acad Sci U S A 109:21366-71. 2012..These phenotypes reveal a previously unknown role for G protein-coupled signaling pathways in development of the axial skeleton... - Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channelEda Yildirim
Transmembrane Signaling Group, Laboratory of Signal Transduction, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 102:3307-11. 2005.... - Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient miceEda Yildirim
Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Am J Physiol Lung Cell Mol Physiol 303:L539-49. 2012..Thus we propose that TRPC1 signaling is necessary in lymphocyte biology and in regulation of allergen-induced lung hyperresponsiveness, making TRPC1 a potential target for treatment of immune diseases and asthma... - Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channelsMohamed Trebak
Laboratory of Signal Transduction, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
J Biol Chem 278:16244-52. 2003..We conclude that receptor-mediated activation of phospholipase C in intact cells activates TRPC3 via diacylglycerol production, independently of G proteins, protein kinase C, or inositol 1,4,5-trisphosphate... - The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminusEda Yildirim
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 100:2220-5. 2003..We conclude that the human TRPC2 gene may never have been an active gene because of incomplete ancestral duplication or, if it was complete at one point, that it became inactive upon loss of chromosomal sequences... - Physiology and pathophysiology of canonical transient receptor potential channelsJoel Abramowitz
Transmembrane Signaling Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
FASEB J 23:297-328. 2009..TRPCs emerge as targets for a thus far nonexistent field of pharmacological intervention that may ameliorate complex diseases... - Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) miceXibao Liu
Secretory Physiology Section, Gene Therapy and Therapeutic Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:17542-7. 2007..Thus, TRPC1 is a critical component of the SOC channel in salivary gland acinar cells and is essential for neurotransmitter-regulation of fluid secretion... - Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helicesChristian Erxleben
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 103:3932-7. 2006..We propose that aberrant phosphorylation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associated with Timothy syndrome and with chronic cyclosporin treatment of transplant patients... - Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loopChristian Erxleben
Laboratory of Signal Transduction and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 100:2929-34. 2003.... - A unified nomenclature for the superfamily of TRP cation channelsCraig Montell
Mol Cell 9:229-31. 2002 - Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formationVictor V Pineda
Department of Pharmacology, The University of Washington, Seattle, 98195, USA
Neuron 41:153-63. 2004..We hypothesize that loss of G(ialpha1) amplifies the responsiveness of CA1 postsynaptic neurons to stimuli that strengthen synaptic efficacy, thereby diminishing synapse-specific plasticity required for new memory formation... - Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptorsKatharina Foerster
Department of Pharmacology, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany
Proc Natl Acad Sci U S A 100:14475-80. 2003..This result indicates that subtype-specific signaling of beta 2-adrenoreceptor functionally bifurcates at the level of Gi, leading to different effects depending on the G alpha isoform... - Modulation of the N-type calcium channel gene expression by the alpha subunit of GoBum Jun Kim
Department of Anatomy, School of Medicine, Ajou University, San 5, Wonchon dong, Paldal Gu, Suwon, 442 749, South Korea
Brain Res Mol Brain Res 112:95-102. 2003..2 in the brain. These results suggest that Go may regulate neuronal differentiation through modulation of gene expression of target genes such as N-type calcium channels... - Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine systemIrene Brunk
Institute for Integrative Neuroanatomy, Center for Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
FASEB J 22:3736-46. 2008..We conclude that Go2alpha optimizes vesicular filling which is instrumental for normal dopamine functioning and for the development of drug-induced behavioral sensitization... - Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lungAnna G Taranova
Department of Biochemistry and Molecular Biology, Divisions of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
Cancer Res 68:8582-9. 2008.... - Galphao2 regulates vesicular glutamate transporter activity by changing its chloride dependenceSandra Winter
AG Funktionelle Zellbiologie, Centrum für Anatomie, Charite Universitatsmedizin Berlin, D 10115 Berlin, Germany
J Neurosci 25:4672-80. 2005..Thus, Galpha(o2) acts on a putative regulatory chloride binding domain that appears to modulate transport activity of vesicular glutamate transporters... - TRPC4 knockout mice: the coming of age of TRP channels as gates of calcium entry responsible for cellular responsesLutz Birnbaumer
Circ Res 91:1-3. 2002 - B cell developmental requirement for the G alpha i2 geneHarnisha Dalwadi
Department of Pathology and Laboratory Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1732, USA
J Immunol 170:1707-15. 2003..Collectively, these results reveal a selective role for Galphai2 in MZ and B-1 B cell development. Disorders of this Galphai2-dependent process in B cell development may represent a mechanism for IBD susceptibility... - The TRP channels, a remarkably functional familyCraig Montell
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 108:595-8. 2002..Moreover, the biological roles of TRP channels appear to be equally diverse and range from roles in pain perception to male aggression... - Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperationJulia Skokowa
Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
J Immunol 174:3041-50. 2005.... - Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsetsBo Wei
Department of Pathology and Laboratory Medicine and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 102:2010-5. 2005.... - Reciprocal function of Galphai2 and Galphai3 in graft-versus-host diseaseYong Zhu Jin
Wellman Center of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School, Boston, MA, USA
Eur J Immunol 38:1988-98. 2008..These observations underscore interplay between Galphai2 and Galphai3 and potentially provide a novel strategy to prevent GVHD by blocking T cell homing at early stages and T effector cell trafficking at later time points... - Erythropoietin modulates calcium influx through TRPC2Xin Chu
Henry Hood Research Program, The Sigfried and Janet Weis Center for Research, Geisinger Clinic, 100 N Academy Avenue, Danville, PA 17822, USA
J Biol Chem 277:34375-82. 2002..This rise in [Ca](i) required Epo and extracellular calcium. These results identify a calcium-permeable channel, TRPC2, in erythroid cells and demonstrate modulation of calcium influx through this channel by erythropoietin... - Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signalingBrian D Thompson
Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 282:9547-55. 2007..This interplay has heretofore been masked by the use of pertussis toxin, a broad inhibitor of the G alpha(i/o) protein family... - An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liverAntje Gohla
Institut für Biochemie und Molekularbiologie II and Klinik für Gastroenterologie, Hepatologie, und Infektiologie, Klinikum der Heinrich Heine Universität, D 40225 Dusseldorf, Germany
Proc Natl Acad Sci U S A 104:3003-8. 2007..These data indicate that Galpha(i3) is crucial for the antiautophagic action of insulin and suggest an as-yet-unrecognized function for Galpha(i3) on autophagosomal membranes... - Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasationRalph S Pero
Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Proc Natl Acad Sci U S A 104:4371-6. 2007..Collectively, these data suggest that specific Galpha(i2)-mediated signaling between endothelial cells and leukocytes is required for the extravasation of leukocytes and for tissue-specific accumulation... - Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteinsHongkuan Fan
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB Rm 403, Charleston, SC 29425, USA
Am J Physiol Cell Physiol 289:C293-301. 2005..These data suggest that G(i) proteins differentially regulate murine TLR-mediated inflammatory cytokine production in a cell-specific manner in response to both LPS and gram-positive microbial stimuli... - Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteinsHongkuan Fan
Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
Immunology 122:116-23. 2007..These data suggest that G(i2) and G(i1/3) proteins are both involved and differentially regulate murine inflammatory cytokine and chemokine production in response to both LPS and Gram-positive microbial stimuli... - Compartmentalization of protein kinase A signaling by the heterotrimeric G protein GoSungho Ghil
Department of Biology, Kyonggi University, Suwon 442-760, South Korea
Proc Natl Acad Sci U S A 103:19158-63. 2006..This regulatory mechanism by which G(o) bifurcates PKA signaling may provide insights into how G(o) regulates complex processes such as neuritogenesis, synaptic plasticity, and cell transformation... - Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteinsHongkuan Fan
Department of Neuroscience, 173 Ashley Ave, BSB Room 403, Charleston, SC 29425, USA
Biochim Biophys Acta 1763:1051-8. 2006.... - Increased vascular smooth muscle contractility in TRPC6-/- miceAlexander Dietrich
Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Germany
Mol Cell Biol 25:6980-9. 2005..Thus, TRPC6 has distinct nonredundant roles in the control of vascular smooth muscle tone... - Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- miceRobert A Edwards
Department of Pathology, University of California, Irvine, Irvine, California 92697 4800, USA
Inflamm Bowel Dis 14:898-907. 2008..They are predominantly right-sided, multifocal, mucinous, and arise from areas of flat dysplasia... - Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formationAlejandra Young
Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
Invest Ophthalmol Vis Sci 49:3245-52. 2008..This study was undertaken to test whether one of the G alpha i proteins, G alpha i3, signals in the same pathway as OA1 to regulate melanosome biogenesis and axonal growth through the optic chiasm...