Linda S Birnbaum

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint When environmental chemicals act like uncontrolled medicine
    Linda S Birnbaum
    National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27709, USA
    Trends Endocrinol Metab 24:321-3. 2013
  2. pmc Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A
    Linda S Birnbaum
    National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1640-4. 2012
  3. pmc Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009
    Olivier Humblet
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health 10:62. 2011
  4. doi request reprint From endocrine disruptors to nanomaterials: advancing our understanding of environmental health to protect public health
    Linda S Birnbaum
    National Institute of Environmental Health Sciences and National Toxicology Program in Research Triangle Park, North Carolina, USA
    Health Aff (Millwood) 30:814-22. 2011
  5. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4, 414e1-5. 2013
  6. doi request reprint Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, route, repeated exposure, and metabolism
    David Taylor Szabo
    United States Environmental Protection Agency, Office of Research and Development, National Health Effects and Exposure Research Laboratory, Integrated Systems Toxicology Division, Mail Drop B143 01, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 121:234-44. 2011
  7. ncbi request reprint Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice
    Daniele F Staskal
    UNC Curriculum in Toxicology, US EPA, MD B143 01, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:28-37. 2006
  8. doi request reprint Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice
    David T Szabo
    University of North Carolina Chapel Hill Curriculum in Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:256-63. 2011
  9. pmc Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice
    Michele La Merrill
    Department of Genetics, Center for Environmental and Health Susceptibility, Lineberger Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 118:596-601. 2010
  10. pmc An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology
    Sally S White
    National Center for Environmental Assessment, U S Environmental Protection Agency, North Carolina, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:197-211. 2009

Collaborators

Detail Information

Publications35

  1. doi request reprint When environmental chemicals act like uncontrolled medicine
    Linda S Birnbaum
    National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27709, USA
    Trends Endocrinol Metab 24:321-3. 2013
    ..These effects on endocrine and other physiological systems can have significant population-level impacts and thus require public health approaches to disease control. ..
  2. pmc Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A
    Linda S Birnbaum
    National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1640-4. 2012
    ..However, research gaps have precluded a full understanding of the effects of BPA in humans and engendered controversies surrounding the chemical's potential toxicity...
  3. pmc Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009
    Olivier Humblet
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health 10:62. 2011
    ....
  4. doi request reprint From endocrine disruptors to nanomaterials: advancing our understanding of environmental health to protect public health
    Linda S Birnbaum
    National Institute of Environmental Health Sciences and National Toxicology Program in Research Triangle Park, North Carolina, USA
    Health Aff (Millwood) 30:814-22. 2011
    ..We review the important implications for public health policy and recommend a broad environmental health research strategy aimed at protecting and improving human health...
  5. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4, 414e1-5. 2013
    ..Currently, little is known about the health effects of human exposure to these materials...
  6. doi request reprint Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, route, repeated exposure, and metabolism
    David Taylor Szabo
    United States Environmental Protection Agency, Office of Research and Development, National Health Effects and Exposure Research Laboratory, Integrated Systems Toxicology Division, Mail Drop B143 01, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 121:234-44. 2011
    ....
  7. ncbi request reprint Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice
    Daniele F Staskal
    UNC Curriculum in Toxicology, US EPA, MD B143 01, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:28-37. 2006
    ....
  8. doi request reprint Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice
    David T Szabo
    University of North Carolina Chapel Hill Curriculum in Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:256-63. 2011
    ..This study suggests that developmental stage may be a risk factor for the harmful effects of α-HBCD and γ-HBCD, when developing animals may be more sensitive to effects and have increased body burden...
  9. pmc Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice
    Michele La Merrill
    Department of Genetics, Center for Environmental and Health Susceptibility, Lineberger Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 118:596-601. 2010
    ....
  10. pmc An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology
    Sally S White
    National Center for Environmental Assessment, U S Environmental Protection Agency, North Carolina, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:197-211. 2009
    ..Given these concerns, prudent public health policy should include the continued reduction of exposures...
  11. pmc Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis
    Rajendrakumar A Gosavi
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, North Carolina, USA
    Environ Health Perspect 121:1194-9. 2013
    ..g., 3-OH-BDE-47) have been suggested to inhibit estrogen sulfotransferase, potentially affecting estrogen metabolism...
  12. doi request reprint Toxicokinetics of the flame retardant hexabromocyclododecane gamma: effect of dose, timing, route, repeated exposure, and metabolism
    David T Szabo
    University of North Carolina Curriculum in Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 117:282-93. 2010
    ..The toxicokinetic behavior reported here has important implications for the extrapolation of toxicological studies of the commercial HBCD mixture to the assessment of risk...
  13. pmc Cancer and developmental exposure to endocrine disruptors
    Linda S Birnbaum
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:389-94. 2003
    ..Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection...
  14. pmc Brominated flame retardants: cause for concern?
    Linda S Birnbaum
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:9-17. 2004
    ..Overall, the toxicology database is very limited; the current literature is incomplete and often conflicting. Available data, however, raise concern over the use of certain classes of brominated flame retardants...
  15. ncbi request reprint Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 116:297-312. 2010
    ..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation...
  16. ncbi request reprint Elevated PBDE levels in pet cats: sentinels for humans?
    Janice A Dye
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 41:6350-6. 2007
    ..S. adults. Our results support the hypothesis that cats are highly exposed to PBDEs; hence, pet cats may serve as sentinels to better assess human exposure and adverse health outcomes related to low-level but chronic PBDE exposure...
  17. ncbi request reprint Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)
    Linda S Birnbaum
    Experimental Toxicology Division MD B 143 01, Office of Research and Development, United States Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Environ Int 29:855-60. 2003
    ....
  18. pmc Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups
    David T Szabo
    University of North Carolina Curriculum in Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 107:27-39. 2009
    ..In conclusion, deiodination, active transport, and sulfation, in addition to glucuronidation, may be involved in disruption of TH homeostasis due to perinatal exposure to DE-71 in male rat offspring...
  19. ncbi request reprint Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology and Experimental Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 88:181-92. 2005
    ....
  20. pmc Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review
    Kyla W Taylor
    Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:774-83. 2013
    ..Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health...
  21. doi request reprint The effect of environmental chemicals on human health
    Linda S Birnbaum
    Experimental Toxicology Division, US EPA NHEERL, Research Triangle Park, North Carolina 27709, USA
    Fertil Steril 89:e31. 2008
  22. pmc The fate of β-hexabromocyclododecane in female C57BL/6 mice
    J Michael Sanders
    Toxicology and Toxicokinetics Group, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 134:251-7. 2013
    ..The extent of metabolism and excretion of β-HBCD in female C57BL/6 mice was similar to that for γ-HBCD. The potential for accumulation of β-HBCD-derived material in most tissues appeared to be less than for α-HBCD. ..
  23. doi request reprint The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource
    Mark F Cesta
    1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, North Carolina, USA
    Toxicol Pathol 42:458-60. 2014
    ..The atlas is also a useful training tool for pathology residents and can be used to bolster any organization's own lesion databases. Researchers have free access to this online resource at www.ntp.niehs.nih.gov/nonneoplastic. ..
  24. ncbi request reprint Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Suzanne E Fenton
    Division of Reproductive Toxicology, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 67:63-74. 2002
    ..Our data suggest that exposure to TCDD prior to migration of the mammary bud into the fat pad permanently alters mammary epithelial development in female rat offspring...
  25. pmc Dioxins and endometriosis: a plausible hypothesis
    Linda S Birnbaum
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 110:15-21. 2002
    ..In this article, we review the literature related to endometriosis and dioxins and attempt to integrate the various sources of information that bolster the hypothesis connecting dioxins and endometriosis...