Piotr J Bilski

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Photochemical reactions involved in the phototoxicity of the anticonvulsant and antidepressant drug lamotrigine (Lamictal)
    Piotr J Bilski
    Laboratory of Pharmacology, NIEHS, RTP, NC, USA
    Photochem Photobiol 85:1327-35. 2009
  2. ncbi request reprint Merocyanine 540 solubilized as an ion pair with cationic surfactant in nonpolar solvents: spectral and photochemical properties
    P Bilski
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Photochem Photobiol 69:671-6. 1999
  3. ncbi request reprint Photosensitization by norfloxacin is a function of pH
    P Bilski
    Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 64:496-500. 1996
  4. pmc Photocytotoxicity of the fluorescent nonsteroidal androgen receptor ligand TDPQ
    Piotr J Bilski
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 85:1225-32. 2009
  5. ncbi request reprint Photochemical characterization of water samples from Minnesota and Vermont sites with malformed frogs: potential influence of photosensitization by singlet molecular oxygen (1O(2)) and free radicals on aquatic toxicity
    P Bilski
    Laboratory of Pharmacology and Chemistry and Laboratory of Toxicology, ETP, NIEHS, Research Triangle Park, NC 27709, USA
    Aquat Toxicol 65:229-41. 2003
  6. ncbi request reprint Interaction of singlet molecular oxygen with double fluorescent and spin sensors
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Free Radic Biol Med 34:489-95. 2003
  7. ncbi request reprint Photosensitized oxidation of 2',7'-dichlorofluorescin: singlet oxygen does not contribute to the formation of fluorescent oxidation product 2',7'-dichlorofluorescein
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 33:938-46. 2002
  8. ncbi request reprint Optimization of a pulse laser spectrometer for the measurement of the kinetics of singlet oxygen O2(delta 1g) decay in solution
    P Bilski
    Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Biochem Biophys Methods 33:73-80. 1996
  9. ncbi request reprint Influence of solvent polarity and proticity on the photochemical properties of norfloxacin
    P Bilski
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 68:20-4. 1998
  10. ncbi request reprint Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 71:129-34. 2000

Collaborators

Detail Information

Publications23

  1. doi request reprint Photochemical reactions involved in the phototoxicity of the anticonvulsant and antidepressant drug lamotrigine (Lamictal)
    Piotr J Bilski
    Laboratory of Pharmacology, NIEHS, RTP, NC, USA
    Photochem Photobiol 85:1327-35. 2009
    ..Our results demonstrate that LTG is a moderate generator of 1O2 prone to photodechlorination, especially in a reducing environment, which can contribute to the reported phototoxicity of LTG...
  2. ncbi request reprint Merocyanine 540 solubilized as an ion pair with cationic surfactant in nonpolar solvents: spectral and photochemical properties
    P Bilski
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Photochem Photobiol 69:671-6. 1999
    ..In contrast, any cytotoxic products from photodecomposition may be important in hydrophilic cell compartments. Our data show the spectral and photochemical properties of MC in a pure hydrophobic environment...
  3. ncbi request reprint Photosensitization by norfloxacin is a function of pH
    P Bilski
    Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 64:496-500. 1996
    ..The relatively high, unquenched 1O2 production at physiological pH 7.4 (phi s0 approximately 0.08) suggests that 1O2 reactions may play an important role in the cutaneous phototoxicity of norfloxacin and other FQ antibiotics...
  4. pmc Photocytotoxicity of the fluorescent nonsteroidal androgen receptor ligand TDPQ
    Piotr J Bilski
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 85:1225-32. 2009
    ..The combination of AR selectivity with photocytotoxicity makes TDPQ a promising candidate for selective targeting of AR-positive cells during photodynamic therapy...
  5. ncbi request reprint Photochemical characterization of water samples from Minnesota and Vermont sites with malformed frogs: potential influence of photosensitization by singlet molecular oxygen (1O(2)) and free radicals on aquatic toxicity
    P Bilski
    Laboratory of Pharmacology and Chemistry and Laboratory of Toxicology, ETP, NIEHS, Research Triangle Park, NC 27709, USA
    Aquat Toxicol 65:229-41. 2003
    ..The observation of 1O(2) emission directly from natural water may also provide new opportunities to investigate the involvement of 1O(2) in other complex environmental processes...
  6. ncbi request reprint Interaction of singlet molecular oxygen with double fluorescent and spin sensors
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Free Radic Biol Med 34:489-95. 2003
    ..This result shows that care must be taken when the dansyl-based sensors are used in experiments requiring UV irradiation. We hope that our results will contribute to a better characterization and wider use of these novel double sensors...
  7. ncbi request reprint Photosensitized oxidation of 2',7'-dichlorofluorescin: singlet oxygen does not contribute to the formation of fluorescent oxidation product 2',7'-dichlorofluorescein
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 33:938-46. 2002
    ..These findings suggest that DCFH should not be regarded as a probe sensitive to singlet molecular oxygen, and that care must be taken when using DCFH to measure oxidative stress in cells as a result of both visible and UV light exposure...
  8. ncbi request reprint Optimization of a pulse laser spectrometer for the measurement of the kinetics of singlet oxygen O2(delta 1g) decay in solution
    P Bilski
    Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Biochem Biophys Methods 33:73-80. 1996
    ..The small sample volume (0.1 ml) prepared in quartz tubes permits fast and inexpensive data acquisition for the determination of 1O2 quenching rate constants in most solvents...
  9. ncbi request reprint Influence of solvent polarity and proticity on the photochemical properties of norfloxacin
    P Bilski
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 68:20-4. 1998
    ..The phototoxicity of NF and other fluoroquinolone antibiotics may strongly depend on their localization in hydrophilic or hydrophobic cell/tissue regions...
  10. ncbi request reprint Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 71:129-34. 2000
    ....
  11. doi request reprint Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008
    ..In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism)...
  12. pmc Real-time visualization of photochemically induced fluorescence of 8-halogenated quinolones: lomefloxacin, clinafloxacin and Bay3118 in live human HaCaT keratinocytes
    Edmond B Koker
    Department of Chemistry and Physics, Elizabeth City State University, Elizabeth City, NC, USA
    Photochem Photobiol 86:792-7. 2010
    ..Our images not only help to localize these phototoxic agents in the cell, but also provide means for dynamic monitoring of their phototransformations in the cellular environment...
  13. pmc Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 21:1056-63. 2008
    ..Our results clearly show that the phototoxicity induced by (gamma-CyD) 2/C 60 is mainly mediated by singlet oxygen with a minor contribution from superoxide, while C 60(OH) 24 phototoxicity is mainly due to superoxide...
  14. pmc Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 241:163-72. 2009
    ..We expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future...
  15. doi request reprint The photosensitizing potential of compact fluorescent vs incandescent light bulbs
    Colin F Chignell
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1291-3. 2008
    ..These results suggest that substitution of a compact fluorescent bulb for an incandescent bulb of the same luminous flux should not increase the phototoxicity of skin porphyrins or lens riboflavin...
  16. ncbi request reprint Ultraviolet A sensitivity in Smith-Lemli-Opitz syndrome: Possible involvement of cholesta-5,7,9(11)-trien-3 beta-ol
    Colin F Chignell
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 41:339-46. 2006
    ..Finally, we have previously detected 9-DDHC in skin lipids from normal subjects, so this sterol may also be the skin chromophore responsible for skin photoaging and UV-induced skin cancer...
  17. pmc Oxidation of flame retardant tetrabromobisphenol A by singlet oxygen
    S K Han
    Department of Marine Environmental Engineering, Mokpo National Maritime University, 571 2 Chukkyo dong, Mokpo 530 729, South Korea
    Environ Sci Technol 42:166-72. 2008
    ....
  18. ncbi request reprint Interaction of singlet molecular oxygen with melatonin and related indoles
    Z Matuszak
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 78:449-55. 2003
    ....
  19. ncbi request reprint Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine
    J J Inbaraj
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 14:1529-34. 2001
    ..These findings suggest that exposure to sunlight or artificial light sources emitting UVA should be avoided when topical preparations derived from Goldenseal or containing berberine are used...
  20. ncbi request reprint Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine
    J J Inbaraj
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 19:739-44. 2006
    ..Although palmatine is photoactive, it is present in such small amounts in Goldenseal root powder that the phototoxicity of the herb is most likely due to berberine, the major constituent alkaloid...
  21. ncbi request reprint TL emission spectra from differently doped LiF:Mg detectors
    E Mandowska
    Institute of Physics Pedagogical University, Armi Krajowej, Czestochowa, Poland
    Radiat Prot Dosimetry 100:451-4. 2002
    ..Preliminary results indicate that emission of the LiF:Mg,Cu,Ti sample is similar to that of LiF:Mg,Cu,P rather than to LiF:Mg,Ti, showing a maximum for wavelengths well below 400 nm...
  22. ncbi request reprint Characterisation of thermoluminescent LiF:Mg,Ti (MTS-N) detectors in the 85-550 K temperature range
    D Briand
    LPES CRESA, EA1174, Universite de Nice Sophia Antipolis, France
    Radiat Prot Dosimetry 100:297-300. 2002
    ..TSEE glow curves above 300 K similar to those of TL were observed. The behaviour of TSEE and TL peak 5 following an X ray exposure from 33 to 500 Gy was studied: its intensity is a linear function of air kerma in both cases...
  23. ncbi request reprint Microdosimetric interpretation of the photon energy response of LiF:Mg,Ti detectors
    P Olko
    Institute of Nuclear Physics, Krakow, Poland
    Radiat Prot Dosimetry 100:119-22. 2002
    ..The calculation procedure can be applied to predict the photon energy response of LiF:Mg,Ti detectors in an arbitrary photon field...