Kristin L Bigos

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Acute 5-HT reuptake blockade potentiates human amygdala reactivity
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
    Neuropsychopharmacology 33:3221-5. 2008
  2. doi request reprint Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: an updated review
    Kristin L Bigos
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gend Med 6:522-43. 2009
  3. ncbi request reprint Decreasing pain and anxiety associated with patient-activated atrial shock: a placebo-controlled study of adjunctive sedation with oral triazolam
    Tanya J Fabian
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    J Cardiovasc Electrophysiol 17:391-5. 2006
  4. ncbi request reprint Genetic variation in KCNH2 associated with expression in the brain of a unique hERG isoform modulates treatment response in patients with schizophrenia
    Jose A Apud
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, NIMH, Bethesda, MD 20877, USA
    Am J Psychiatry 169:725-34. 2012
  5. ncbi request reprint Gender differences in the pharmacokinetics and pharmacodynamics of antidepressants
    Robert R Bies
    Department of Pharmaceutical Sciences, 805 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gend Specif Med 6:12-20. 2003
  6. doi request reprint Sex, race, and smoking impact olanzapine exposure
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, 805 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
    J Clin Pharmacol 48:157-65. 2008
  7. ncbi request reprint Pharmacokinetics in geriatric psychiatry
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, 3501 Terrace Street, 805 Salk Hall, Pittsburgh, PA 15261, USA
    Curr Psychiatry Rep 10:30-6. 2008
  8. ncbi request reprint Population pharmacokinetics in geriatric psychiatry
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 14:993-1003. 2006
  9. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
  10. ncbi request reprint Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals
    Dwight Dickinson
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    JAMA Psychiatry 71:647-56. 2014

Research Grants

Detail Information

Publications13

  1. pmc Acute 5-HT reuptake blockade potentiates human amygdala reactivity
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
    Neuropsychopharmacology 33:3221-5. 2008
    ....
  2. doi request reprint Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: an updated review
    Kristin L Bigos
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gend Med 6:522-43. 2009
    ..An increasing number of studies have reported differences in the pharmacokinetics and/or pharmacodynamics of antidepressants between women and men...
  3. ncbi request reprint Decreasing pain and anxiety associated with patient-activated atrial shock: a placebo-controlled study of adjunctive sedation with oral triazolam
    Tanya J Fabian
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    J Cardiovasc Electrophysiol 17:391-5. 2006
    ..The main objective of the present study was to determine whether triazolam improved patient perception of the shock experience or altered patient memory of shock discomfort relative to placebo...
  4. ncbi request reprint Genetic variation in KCNH2 associated with expression in the brain of a unique hERG isoform modulates treatment response in patients with schizophrenia
    Jose A Apud
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, NIMH, Bethesda, MD 20877, USA
    Am J Psychiatry 169:725-34. 2012
    ..1, that has unique physiological properties. The authors assessed whether genetic variation associated with KCNH2 3.1 expression influences the therapeutic effects of antipsychotic drugs...
  5. ncbi request reprint Gender differences in the pharmacokinetics and pharmacodynamics of antidepressants
    Robert R Bies
    Department of Pharmaceutical Sciences, 805 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gend Specif Med 6:12-20. 2003
    ..Given the evidence of distinct gender-specific differences, it is critical that these differences be addressed more widely in research evaluating the administration of antidepressants in women...
  6. doi request reprint Sex, race, and smoking impact olanzapine exposure
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, 805 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
    J Clin Pharmacol 48:157-65. 2008
    ..0001). Differences in olanzapine exposure due to sex, race, and smoking may account for some of the variability in response to olanzapine...
  7. ncbi request reprint Pharmacokinetics in geriatric psychiatry
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, 3501 Terrace Street, 805 Salk Hall, Pittsburgh, PA 15261, USA
    Curr Psychiatry Rep 10:30-6. 2008
    ....
  8. ncbi request reprint Population pharmacokinetics in geriatric psychiatry
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA 15261, USA
    Am J Geriatr Psychiatry 14:993-1003. 2006
    ..This article reviews the methods used in pharmacokinetic modeling, as well as providing examples of population pharmacokinetic modeling, highlighting its application to geriatric psychiatry...
  9. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  10. ncbi request reprint Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals
    Dwight Dickinson
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    JAMA Psychiatry 71:647-56. 2014
    ..CONCLUSIONS AND RELEVANCE The findings implicate SCN2A and sodium channel biology in cognitive impairment in schizophrenia cases and unaffected relatives and may facilitate development of cognition-enhancing treatments. ..
  11. doi request reprint Imaging genetics--days of future past
    Kristin L Bigos
    Genes Cognition and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, MSC 1379, Bethesda, MD 20892, USA
    Neuroimage 53:804-9. 2010
    ..The future of imaging genetics holds great promise for brain research and for biologic validation of genetic validation in CNS disorders, but a disciplined application of the basic principles outlined in this review is critical...
  12. pmc Neuroimaging: technologies at the interface of genes, brain, and behavior
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 17:459-67, viii. 2007
    ....
  13. ncbi request reprint Influence of DHEA administration on 24-hour cortisol concentrations
    Patricia D Kroboth
    Pharmacodynamic Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Psychopharmacol 23:96-9. 2003
    ..0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation...

Research Grants1

  1. Pharmacodynamics of IV Citalopram Using Functional MRI
    KRISTIN BIGOS; Fiscal Year: 2006
    ..The purpose of this award is to provide the applicant with two years of support during her doctoral training, while she completes this research for her thesis. ..