Aaron Bestor

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Competitive advantage of Borrelia burgdorferi with outer surface protein BBA03 during tick-mediated infection of the mammalian host
    Aaron Bestor
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    Infect Immun 80:3501-11. 2012
  2. pmc Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of Borrelia burgdorferi
    Aaron Bestor
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 78:2397-407. 2010
  3. pmc Borrelia burgdorferi linear plasmid 38 is dispensable for completion of the mouse-tick infectious cycle
    Daniel P Dulebohn
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Infect Immun 79:3510-7. 2011
  4. pmc GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 191:6231-41. 2009
  5. pmc Rapid clearance of Lyme disease spirochetes lacking OspC from skin
    Kit Tilly
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 75:1517-9. 2007
  6. pmc A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle
    Philip E Stewart
    Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th St, Hamilton, MT 59840, USA
    Infect Immun 76:1970-8. 2008
  7. pmc Genetic basis for retention of a critical virulence plasmid of Borrelia burgdorferi
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 66:975-90. 2007
  8. pmc OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi
    Kit Tilly
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 77:2672-82. 2009
  9. pmc Borrelia burgdorferi linear plasmid 28-3 confers a selective advantage in an experimental mouse-tick infection model
    Daniel P Dulebohn
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:2986-96. 2013
  10. pmc Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content
    Amit Sarkar
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 53:4490-4. 2009

Detail Information

Publications13

  1. pmc Competitive advantage of Borrelia burgdorferi with outer surface protein BBA03 during tick-mediated infection of the mammalian host
    Aaron Bestor
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA
    Infect Immun 80:3501-11. 2012
    ..burgdorferi. These results suggest that BBA03 provides a competitive advantage to spirochetes carrying this protein during tick transmission to a mammalian host in the natural infectious cycle...
  2. pmc Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of Borrelia burgdorferi
    Aaron Bestor
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 78:2397-407. 2010
    ..burgdorferi and surprisingly revealed that a large number of the highly conserved proteins encoded on lp54 are not required to complete the infectious cycle...
  3. pmc Borrelia burgdorferi linear plasmid 38 is dispensable for completion of the mouse-tick infectious cycle
    Daniel P Dulebohn
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Infect Immun 79:3510-7. 2011
    ....
  4. pmc GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 191:6231-41. 2009
    ..burgdorferi in the infection cycle and highlight a potential difference in the requirements for purine salvage in the disparate mammalian and tick environments...
  5. pmc Rapid clearance of Lyme disease spirochetes lacking OspC from skin
    Kit Tilly
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 75:1517-9. 2007
    ..To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission...
  6. pmc A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle
    Philip E Stewart
    Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th St, Hamilton, MT 59840, USA
    Infect Immun 76:1970-8. 2008
    ..Although OspD is nonessential to the infectious cycle of B. burgdorferi, the tight regulation of expression suggests a beneficial contribution of OspD to the spirochete during bacterial replication within the tick midgut...
  7. pmc Genetic basis for retention of a critical virulence plasmid of Borrelia burgdorferi
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 66:975-90. 2007
    ..We conclude that the genetic linkage of critical physiological and virulence functions on cp26 is pertinent to its stable maintenance throughout the evolution of B. burgdorferi...
  8. pmc OspC-independent infection and dissemination by host-adapted Borrelia burgdorferi
    Kit Tilly
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 77:2672-82. 2009
    ..The strict temporal control of B. burgdorferi outer surface protein gene expression may reflect immunological constraints rather than distinct functions...
  9. pmc Borrelia burgdorferi linear plasmid 28-3 confers a selective advantage in an experimental mouse-tick infection model
    Daniel P Dulebohn
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:2986-96. 2013
    ..Our data demonstrate that genes carried by lp28-3, although not essential, contribute to the fitness of B. burgdorferi during infection. ..
  10. pmc Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content
    Amit Sarkar
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    Antimicrob Agents Chemother 53:4490-4. 2009
    ..We conclude that the essential role of OspC is unrelated to resistance to this component of innate immunity...
  11. pmc Defining the plasmid-borne restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi
    Ryan O M Rego
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Bacteriol 193:1161-71. 2011
    ..burgdorferi strains with distinct plasmid contents. Further characterization and identification of the nucleotide sequences recognized by BBE02 and BBQ67 will facilitate efficient genetic manipulation of this pathogenic spirochete...
  12. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
    ..We conclude that OspC is indispensable for establishing infection by B. burgdorferi in mammals but is not required at any other point of the mouse-tick infection cycle...
  13. pmc Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Mol Microbiol 89:216-27. 2013
    ..burgdorferi...