Michel Bernier

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
    Michel Bernier
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 286:19270-9. 2011
  2. pmc Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells
    Jennifer L Fiori
    Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Endocrinology 150:2551-60. 2009
  3. pmc S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling
    Yi Xie
    Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Endocrinology 150:1122-31. 2009
  4. doi request reprint (R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility
    Rajib K Paul
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health NIH, Baltimore, MD 21224, USA Electronic address
    Biochem Pharmacol 87:547-61. 2014
  5. pmc Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
    Yong Kook Kwon
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institute of Health, Baltimore, MD 21224 6825, USA
    J Cell Biol 163:375-84. 2003
  6. ncbi request reprint In vivo biological activity of exendin (1-30)
    Maire E Doyle
    Diabetes Section National Institute on Aging, National Institutes of Health Diabetes Section, National Institute on Aging, National Institutes of Health, Baltimore MD 21224, USA
    Endocrine 27:1-9. 2005
  7. pmc Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Diabetes 58:318-28. 2009
  8. ncbi request reprint Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells
    Tie Nian Zhu
    Diabetes Section, Laboratory of Clinical Investigation, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 282:14816-26. 2007
  9. pmc Wnt5A activates the calpain-mediated cleavage of filamin A
    Michael P O'Connell
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Invest Dermatol 129:1782-9. 2009
  10. pmc Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells
    Prateek Bhatia
    Laboratory of Clinical Investigation, National Institute on Aging NIA NIH, Baltimore, MD, USA
    Xenobiotica 42:748-55. 2012

Collaborators

Detail Information

Publications38

  1. pmc Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
    Michel Bernier
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 286:19270-9. 2011
    ..These results have implications for understanding the interplay between STAT3 and SIRT1 in pro-inflammatory conditions...
  2. pmc Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells
    Jennifer L Fiori
    Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Endocrinology 150:2551-60. 2009
    ..These results suggest the requirement of FLNa for efficient EGFR kinase activation and the sorting of endocytosed receptors into the degradation pathway...
  3. pmc S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling
    Yi Xie
    Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Endocrinology 150:1122-31. 2009
    ..These results are the first to show S-glutathionylation of STAT3, a modification that may exert regulatory function in STAT3 signaling...
  4. doi request reprint (R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility
    Rajib K Paul
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health NIH, Baltimore, MD 21224, USA Electronic address
    Biochem Pharmacol 87:547-61. 2014
    ..This study shows for the first time that MNF impairs GPR55-mediated signaling and, therefore, may have therapeutic potential in the management of cancer. ..
  5. pmc Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
    Yong Kook Kwon
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institute of Health, Baltimore, MD 21224 6825, USA
    J Cell Biol 163:375-84. 2003
    ..Our results show that PLCgamma1 is a thiol-reactive protein whose association with the IR could contribute to the activation of MAPK signaling by insulin...
  6. ncbi request reprint In vivo biological activity of exendin (1-30)
    Maire E Doyle
    Diabetes Section National Institute on Aging, National Institutes of Health Diabetes Section, National Institute on Aging, National Institutes of Health, Baltimore MD 21224, USA
    Endocrine 27:1-9. 2005
    ..We observed no change in beta-cell area, but did see a change in the number of islets with nuclei positive for BrdU [10.7 +/- 1.8% exendin (1-30) vs 6.5 +/- 0.5% control]...
  7. pmc Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Diabetes 58:318-28. 2009
    ..Similarly to Huntington's disease patients, mice expressing the mutated human huntingtin protein also exhibit neurodegenerative changes, motor dysfunction, perturbed energy metabolism, and elevated blood glucose levels...
  8. ncbi request reprint Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells
    Tie Nian Zhu
    Diabetes Section, Laboratory of Clinical Investigation, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 282:14816-26. 2007
    ..Our results indicate that expression of FLNa regulates constitutive activation of the Ras/ERK pathway partly through a Ras-GRF1 mechanism to modulate the production of MMP-9...
  9. pmc Wnt5A activates the calpain-mediated cleavage of filamin A
    Michael P O'Connell
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Invest Dermatol 129:1782-9. 2009
    ..Our results indicate that Wnt5A activates calpain-1, leading to the cleavage of filamin A, which results in a remodeling of the cytoskeleton and an increase in melanoma cell motility...
  10. pmc Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells
    Prateek Bhatia
    Laboratory of Clinical Investigation, National Institute on Aging NIA NIH, Baltimore, MD, USA
    Xenobiotica 42:748-55. 2012
    ..In conclusion, BCRP is expressed in the nuclear extracts of select GBM and astrocytoma cell lines and in a human GBM tumour biopsy. Its presence in the nucleus of cancer cells suggests new role for BCRP in MDR...
  11. pmc Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3
    Shaoming Song
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Biochem Cell Biol 42:1856-63. 2010
    ..These results unravel a previously unrecognized mechanism by which PDTC and related compounds could confer cellular protection against inflammation through HSF1-induced expression of heat shock response genes...
  12. ncbi request reprint Binding of manumycin A inhibits IkappaB kinase beta activity
    Michel Bernier
    Diabetes Section, Bioanalytical Chemistry and Drug Discovery Section, Laboratory of Clinical Investigation, and Laboratory of Experimental Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 281:2551-61. 2006
    ..Thus, manumycin A with its epoxyquinoid moieties plays an important regulatory function in IKK signaling through pathways distinct from its role as a protein farnesylation inhibitor...
  13. pmc Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets
    Jie Zhou
    Diabetes Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Endocrinol Metab 293:E538-47. 2007
    ..These results suggest that the GIP-R is ubiquitated, resulting in downregulation of the actions of GIP...
  14. pmc Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction
    Min Zhu
    Laboratory of Experimental Gerontology, National Institute on Aging, 6200 Seaforth Street, Baltimore, MD 21224, USA
    Exp Gerontol 42:733-44. 2007
    ..Overall these results suggest that CR increased the expression of adipogenic factors, and maintained the differentiated state of adipocytes, which is critically important for adiponectin biosynthesis and insulin sensitivity...
  15. ncbi request reprint Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogen-activated protein kinase pathway
    Hua Jun He
    Diabetes Section, Laboratory of Clinical Investigation, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 278:27096-104. 2003
    ..Taken together, these results indicate that FLNa interacts constitutively with the IR to exert an inhibitory tone along the MAPK activation pathway...
  16. pmc Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation
    Shaoming Song
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 339:905-13. 2011
    ..These results demonstrate a critical effect of PDTC on mTOR complex 1 function and provide evidence that PDTC can reverse IL-6-related signaling via induction of DDIT4...
  17. pmc Determination of free and protein-bound glutathione in HepG2 cells using capillary electrophoresis with laser-induced fluorescence detection
    Yan Wang
    Laboratory of Clinical Investigation, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    J Chromatogr A 1216:3533-7. 2009
    ....
  18. ncbi request reprint The roles of phospholipase C-gamma 1 and actin-binding protein filamin A in signal transduction of the insulin receptor
    Michel Bernier
    Diabetes Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Vitam Horm 69:221-47. 2004
  19. pmc Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    Hyeung Jin Jang
    National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:15069-74. 2007
    ..Modulating GLP-1 secretion in gut "taste cells" may provide an important treatment for obesity, diabetes and abnormal gut motility...
  20. pmc Metformin improves healthspan and lifespan in mice
    Alejandro Martín-Montalvo
    Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA
    Nat Commun 4:2192. 2013
    ..These findings are in agreement with current epidemiological data and raise the possibility of metformin-based interventions to promote healthy aging. ..
  21. doi request reprint The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
    Sarah J Mitchell
    Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia
    Cell Rep 6:836-43. 2014
    ..Combined with our previous work, the current study further supports the beneficial effects of SRT1720 on health across the lifespan in mice. ..
  22. pmc The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRα
    Susan M Krzysik-Walker
    Laboratory of Clinical Investigation, National Institute on Aging, NIH, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224, USA
    Mol Pharmacol 83:157-66. 2013
    ..These results reveal a novel molecular mechanism by which AM251 and related compounds alter mitochondrial physiology through destabilization of ERRα...
  23. pmc Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells
    Nagendra S Singh
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Signal 25:2634-45. 2013
    ....
  24. pmc Capillary electrophoresis-laser-induced fluorescence (CE-LIF) assay for measurement of intracellular D-serine and serine racemase activity
    Nagendra S Singh
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Anal Biochem 421:460-6. 2012
    ..Although the SR dimer has been identified as the active form of the enzyme, all four of the tested cell lines expressed enzymatically active SR...
  25. ncbi request reprint Protein tyrosine phosphatases: potential role in beta-cell insulin signal transduction
    Michel Bernier
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Cell Biochem Biophys 40:209-18. 2004
    ..Hence, the development of tissue-specific gene inactivation strategies should facilitate the study of the potential role of PTPases in beta-cell insulin signaling transduction...
  26. ncbi request reprint Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes
    Hua Jun He
    Diabetes Section, Laboratory of Clinical Investigation, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 281:31369-79. 2006
    ..These studies are consistent with the ability of PDTC to down-regulate IL-6-induced STAT3 activation by altering the stability of STAT3-Hsp90 complex...
  27. pmc Triplex targeted genomic crosslinks enter separable deletion and base substitution pathways
    Sally Richards
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Nucleic Acids Res 33:5382-93. 2005
    ..We conclude that targeted pso-TFO crosslinks can enter genetically distinct mutational routes that resolve to base substitutions or deletions...
  28. ncbi request reprint Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization
    Min Zhu
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 39:1049-59. 2004
    ..Taken together, our findings suggest an important role for adiponectin in the beneficial effects of long-term CR...
  29. pmc Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytes
    Valeria de Mello Coelho
    Laboratories of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Med Sci 7:1-14. 2009
    ..Moreover, we found that adipocyte differentiation appear to be influenced by the proinflammatory chemokines, CCL3, CCL4 and CCL5...
  30. ncbi request reprint Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type
    Ruin Moaddel
    Gerontology Research Center, National Institutes on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Anal Chem 80:48-54. 2008
    ..The results are also consistent with the observation that the alpha7 nAChR is localized in lipid rafts in both of these cell lines and that the cholate detergent removed cholesterol from these microdomains...
  31. pmc Cannabinoid receptor activation correlates with the proapoptotic action of the β2-adrenergic agonist (R,R')-4-methoxy-1-naphthylfenoterol in HepG2 hepatocarcinoma cells
    Rajib K Paul
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    J Pharmacol Exp Ther 343:157-66. 2012
    ..The data indicate that the presence of the naphthyl moiety in MNF results in functional coupling to the CBR pathway, providing one of the first examples of a dually acting β(2)-AR-CBR ligand...
  32. pmc Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells
    Mukesh K Gandhari
    Laboratory of Clinical Investigation, Biomedical Research Center, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    Mol Cell Endocrinol 315:314-8. 2010
    ..These results indicate that ERRalpha and ERRgamma are differentially expressed in these tumor cell lines and likely contribute to agonist-dependent ERR transcriptional activity...
  33. pmc S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity
    Yun Jeong Kim
    Laboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Mol Biol 414:313-26. 2011
    ..This modification is reversible by reducing agents, which restore APE1 incision function. Our studies describe a novel posttranslational modification of APE1 that regulates the DNA repair function of the protein...
  34. pmc Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction
    Evi M Mercken
    Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Aging (Albany NY) 5:692-703. 2013
    ..Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. ..
  35. pmc Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet
    Yolanda Jimenez-Gomez
    Translational Gerontology Branch, Intramural Research Program, National Institute on Aging NIA, National Institutes of Health NIH, Baltimore, MD 21224, USA
    Cell Metab 18:533-45. 2013
    ..In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys...
  36. ncbi request reprint Wortmannin-sensitive pathway is required for insulin-stimulated phosphorylation of inhibitor kappaBalpha
    Sanjay K Pandey
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, Maryland 21224 6825, USA
    Endocrinology 143:375-85. 2002
    ..These data demonstrate that insulin regulates IkappaBalpha function through a distinct low-affinity wortmannin-sensitive pathway...
  37. pmc Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities
    Michał P Marszałł
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Anal Biochem 373:313-21. 2008
    ..80+/-0.18 microM, and the relative IC(50) values were 17-AAG>GM>RAD, in agreement with previously reported values and indicating that immobilization had not affected ATPase activity or sensitivity to inhibition...
  38. ncbi request reprint The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity
    Maire E Doyle
    Diabetes Section, 23, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Regul Pept 114:153-8. 2003
    ..Observations of the cAMP response in an insulinoma cell line show a similar trend for biological activity...