Sonja I Berndt

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mismatch repair polymorphisms and the risk of colorectal cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 120:1548-54. 2007
  2. pmc High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays
    Jun Wang
    Fluidigm Corporation, South San Francisco, CA, USA
    BMC Genomics 10:561. 2009
  3. ncbi request reprint Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Res 67:1395-404. 2007
  4. pmc Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 17:2665-72. 2008
  5. ncbi request reprint Disparities in treatment and outcome for renal cell cancer among older black and white patients
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 20892 7240, USA
    J Clin Oncol 25:3589-95. 2007
  6. ncbi request reprint Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:1965-70. 2007
  7. pmc Large-scale fine mapping of the HNF1B locus and prostate cancer risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 20:3322-9. 2011
  8. ncbi request reprint Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
  9. pmc Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8116, MSC 7240, Bethesda, MD 20892 7240, USA
    Cancer Causes Control 20:487-90. 2009
  10. ncbi request reprint A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Urol 175:1613-23. 2006

Detail Information

Publications85

  1. ncbi request reprint Mismatch repair polymorphisms and the risk of colorectal cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 120:1548-54. 2007
    ..No association was observed with the MSH6 and MLH1 polymorphisms overall. This study suggests that common polymorphisms in the mismatch repair gene, MSH3, may increase the risk of colorectal cancer, especially proximal colon cancer...
  2. pmc High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays
    Jun Wang
    Fluidigm Corporation, South San Francisco, CA, USA
    BMC Genomics 10:561. 2009
    ..This is also important for those who work on high throughput genotyping in non-model systems where off-the-shelf assays are not available and a flexible platform is needed...
  3. ncbi request reprint Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Res 67:1395-404. 2007
    ..51; 95% CI, 0.33-0.78, P = 0.002 for PARP1 A284A). This study suggests that polymorphisms in APEX1, XRCC1, and PARP1 may be associated with advanced colorectal adenoma...
  4. pmc Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 17:2665-72. 2008
    ..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...
  5. ncbi request reprint Disparities in treatment and outcome for renal cell cancer among older black and white patients
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 20892 7240, USA
    J Clin Oncol 25:3589-95. 2007
    ..To elucidate reasons for this inequality, we examined differences in treatment and survival between black and white patients...
  6. ncbi request reprint Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:1965-70. 2007
    ..No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma...
  7. pmc Large-scale fine mapping of the HNF1B locus and prostate cancer risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 20:3322-9. 2011
    ..This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. Further studies are needed to investigate the biological basis of the association of variants in 17q12 with prostate cancer...
  8. ncbi request reprint Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
    ..34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility...
  9. pmc Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8116, MSC 7240, Bethesda, MD 20892 7240, USA
    Cancer Causes Control 20:487-90. 2009
    ..To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies...
  10. ncbi request reprint A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Urol 175:1613-23. 2006
    ..However, studies investigating the associations between specific vitamin D receptor polymorphisms and prostate cancer risk have yielded inconsistent results...
  11. ncbi request reprint Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:306-11. 2006
    ....
  12. pmc Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk
    Kathryn Hughes Barry
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892 7240, USA
    Carcinogenesis 33:331-7. 2012
    ..09). In contrast, we did not observe associations among men with other genotypes at these loci. While requiring replication, our findings suggest a role for NER genetic variation in pesticide-associated prostate cancer risk...
  13. ncbi request reprint Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:299-309. 2005
    ..002 and P=0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China...
  14. ncbi request reprint Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Lung Cancer 49:317-23. 2005
    ..However, additional studies in other populations with substantial environmental exposures to PAHs are needed to confirm our findings...
  15. ncbi request reprint Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Immunogenetics 59:839-52. 2007
    ..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted...
  16. pmc Genetic variation in base excision repair pathway genes, pesticide exposure, and prostate cancer risk
    Kathryn Hughes Barry
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7240, USA
    Environ Health Perspect 119:1726-32. 2011
    ..Previous research indicates increased prostate cancer risk for pesticide applicators and pesticide manufacturing workers. Although underlying mechanisms are unknown, evidence suggests a role of oxidative DNA damage...
  17. ncbi request reprint Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  18. ncbi request reprint Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:2263-9. 2006
    ..00003). Our study suggests that genetic polymorphisms in the NER genes, ERCC6 and XPC, may be associated with an increased risk of colorectal cancer...
  19. pmc A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, MSC 7240, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Int J Hyg Environ Health 211:352-6. 2008
    ..However, in view of our relatively small sample size, this study should be replicated in other populations with substantial exposure to indoor air pollutants such as polycyclic aromatic hydrocarbons (PAH) and particulate matter...
  20. ncbi request reprint Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China
    Kyoung Mu Lee
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:1437-41. 2007
    ..11, 95% CI = 0.03-0.44; P(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population...
  21. pmc Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
    Cancer Res 69:8001-8. 2009
    ..In two large case-control studies, our findings further define a functional region of interest at the APOE locus that increases RCC susceptibility...
  22. pmc Genetic susceptibility loci, pesticide exposure and prostate cancer risk
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58195. 2013
    ..Although additional studies are needed and the exact mechanisms are unknown, this study suggests known genetic susceptibility loci may modify the risk between pesticide use and prostate cancer...
  23. ncbi request reprint Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk
    Mia M Gaudet
    Division of Cancer Epidemiology, National Cancer Institute, 6120 Executive Boulevard, EPS 7055, Rockville, MD 20852, USA
    Cancer Res 66:9781-5. 2006
    ..The suggestion of increased risk associated with a haplotype in the 3' UTR of COMT needs to be confirmed in independent study populations...
  24. ncbi request reprint Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:823-7. 2007
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL...
  25. ncbi request reprint Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer
    Dominique S Michaud
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 66:4525-30. 2006
    ..At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer...
  26. pmc Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Clin Oncol 31:2450-9. 2013
    ..We evaluated the associations of BMI with colorectal adenoma incidence, adenoma recurrence, and cancer in the context of a large screening trial, in which cases and controls had an equal chance for disease detection...
  27. pmc Variation in lung cancer risk by smoky coal subtype in Xuanwei, China
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Int J Cancer 123:2164-9. 2008
    ..2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source...
  28. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs...
  29. pmc Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer
    Bríd M Ryan
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892
    Int J Cancer 134:1399-407. 2014
    ..Additional studies on the functional consequences of rs5995355 in NCF4 may help to clarify the mechanistic link between inflammation and colorectal cancer...
  30. doi request reprint Polymorphisms in pattern-recognition genes in the innate immunity system and risk of non-Hodgkin lymphoma
    Wei Hu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 54:72-7. 2013
    ..39, P-trend = 0.033). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies...
  31. pmc Comprehensive resequence analysis of a 123-kb region of chromosome 11q13 associated with prostate cancer
    Charles C Chung
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Prostate 72:476-86. 2012
    ..This study further annotates common and uncommon variation across this region...
  32. pmc HNF1B and JAZF1 genes, diabetes, and prostate cancer risk
    Victoria L Stevens
    Department of Epidemiology, American Cancer Society, Atlanta, Georgia 30303 1002, USA
    Prostate 70:601-7. 2010
    ..Epidemiologic studies have shown that men with type II diabetes have a lower risk of prostate cancer than non-diabetic men. Recently, common variants in two genes, HNF1B and JAZF1, were found to be associated with both of these diseases...
  33. pmc Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead
    Dana M Van Bemmel
    Cancer Prevention Fellowship Program, Office of the Director, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20432. 2011
    ..Epidemiologic studies are reporting associations between lead exposure and human cancers. A polymorphism in the 5-aminolevulinic acid dehydratase (ALAD) gene affects lead toxicokinetics and may modify the adverse effects of lead...
  34. pmc Variants in blood pressure genes and the risk of renal cell carcinoma
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852 4906, USA
    Carcinogenesis 31:614-20. 2010
    ..003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight...
  35. pmc Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 19:1349-55. 2010
    ..2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7))...
  36. pmc Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Pharmacogenet Genomics 21:615-23. 2011
    ..To explore associations with prostate cancer and farming, it is important to investigate the relationship between pesticide use and single nucleotide polymorphisms (SNPs) in xenobiotic metabolic enzyme (XME) genes...
  37. pmc Common genetic variants in prostate cancer risk prediction--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 21:437-44. 2012
    ..In this study, we evaluated the discriminative and predictive ability for prostate cancer risk models incorporating 25 common prostate cancer genetic markers, family history of prostate cancer, and age...
  38. pmc Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry
    Zhaoming Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Genet 131:1173-85. 2012
    ....
  39. pmc A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    BMC Cancer 11:209. 2011
    ..We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways...
  40. pmc Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
    Fangyi Gu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:2877-87. 2010
    ..Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins...
  41. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  42. pmc Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20877, USA
    Hum Genet 129:675-85. 2011
    ..12 ng/ml, 95% CI = 0.96-1.28) (P = 9.70 × 10(-5)). Together our results suggest that germline KLK3 variants could influence the diagnosis of nonaggressive prostate cancer by influencing the likelihood of biopsy...
  43. pmc DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Carcinogenesis 32:882-7. 2011
    ....
  44. pmc Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 70:2389-96. 2010
    ..In conclusion, we observed a significant association between PIK3C2B and prostate cancer risk, especially for familial, early-onset disease, which may be attributable to IGF-dependent PI3K signaling...
  45. pmc Genetic contributions to the association between adult height and testicular germ cell tumors
    Michael B Cook
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, US
    Int J Epidemiol 40:731-9. 2011
    ..Recently, a number of single nucleotide polymorphisms (SNPs) have been found to be related to height. We examined whether these SNPs were associated with TGCT and whether they explained the relationship between height and TGCT...
  46. ncbi request reprint Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China
    Min Shen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7240, USA
    Anticancer Res 25:537-42. 2005
    ..34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China...
  47. pmc Hematopoietic malignancies associated with viral and alcoholic hepatitis
    Lesley A Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076 Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:3069-75. 2008
    ..In summary, HCV, but not other causes of hepatitis, was associated with the elevated risk of non-Hodgkin lymphoma and acute myeloid leukemia. HCV may induce lymphoproliferative malignancies through chronic immune stimulation...
  48. pmc Nitric oxide synthase gene polymorphisms and prostate cancer risk
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 30:621-5. 2009
    ..61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer...
  49. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  50. pmc Genetic variants reflecting higher vitamin e status in men are associated with reduced risk of prostate cancer
    Jacqueline M Major
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, NIH, Bethesda, MD
    J Nutr 144:729-33. 2014
    ..This study suggests that polymorphisms near BUD13/ZNF259/APOA5, involved in vitamin E transport and metabolism, may be associated with lower risk of prostate cancer. This trial was registered at clinicaltrials.gov as NCT00002540. ..
  51. ncbi request reprint Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005
    ..Consistent findings from three case-control studies suggest that selected DNA repair enzymes may play a role in head and neck carcinogenesis...
  52. ncbi request reprint Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:152-7. 2005
    ..02). In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers...
  53. pmc Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer Res 69:1877-84. 2009
    ..The observed effect provides evidence to support the hypothesis that HCAs may act as promoters of malignant transformation by altering mitogenic signaling...
  54. pmc Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
    Charles C Chung
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute NIH, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    Hum Mol Genet 20:2869-78. 2011
    ..We estimate that at least 63 common variants should be considered in future studies designed to investigate the biological basis of the multiple association signals...
  55. pmc Genetic variation in cell cycle and apoptosis related genes and multiple myeloma risk
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
    Leuk Res 33:1609-14. 2009
    ..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies...
  56. pmc Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Bethesda, Maryland, USA
    Nat Genet 45:868-76. 2013
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism...
  57. pmc Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Nat Genet 44:1330-5. 2012
    ..3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking...
  58. pmc Replication of five prostate cancer loci identified in an Asian population--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)
    Sara Lindstrom
    Department of Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 21:212-6. 2012
    ..In this study, we attempt to replicate these five loci in a series of nested prostate cancer case-control studies of European ancestry...
  59. pmc Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma
    Bryan A Bassig
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 53:145-51. 2012
    ..Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings...
  60. ncbi request reprint Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Pharmacogenet Genomics 16:547-53. 2006
    ..The present study provides strong evidence against the existence of a substantial overall association between common genetic variation in CYP1B1 and breast cancer risk...
  61. pmc Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour
    Christian P Kratz
    Division of CancerEpidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Med Genet 48:473-6. 2011
    ..Familial testicular germ cell tumours (TGCTs) and bilateral TGCTs comprise 1-2% and 5% of all TGCTs, respectively, but their genetic basis remains largely unknown...
  62. pmc Occupational sunlight exposure and risk of renal cell carcinoma
    Sara Karami
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer 116:2001-10. 2010
    ....
  63. pmc Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium
    Mitchell J Machiela
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 176:1121-9. 2012
    ..These data suggest a shared genetic component between T2D and PCa and add to the evidence for an interrelation between these diseases...
  64. pmc Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer
    Anne M J Gilsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, USA
    Carcinogenesis 33:1332-9. 2012
    ..This large and comprehensive study of XME genes, meat mutagens and the risk of colorectal tumours found that a NAT1 polymorphism modified the association between MeIQx intake and colorectal adenoma risk...
  65. doi request reprint Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake
    Summer S Han
    1Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:417-27. 2012
    ..Low dietary and circulating folate and polymorphic variation in this pathway are associated with increased risk of colorectal adenoma and cancer...
  66. ncbi request reprint Prediagnostic plasma vitamin C levels and the subsequent risk of prostate cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Nutrition 21:686-90. 2005
    ..We assessed whether higher prediagnostic plasma concentrations of vitamin C were associated with a lower risk of prostate cancer in a well-nourished cohort of men...
  67. pmc Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Mol Genet 18:3749-57. 2009
    ..8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones...
  68. pmc Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer Res 70:9224-33. 2010
    ..This is the first report of effect modification between 8q24 and an environmental exposure on prostate cancer risk...
  69. pmc GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: a meta-analysis
    H Dean Hosgood
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, Bethesda, MD 20892 7240, USA
    Mutat Res 636:134-43. 2007
    ..Our results suggest that the GSTM1 null genotype may be associated with a more substantial risk of lung cancer in populations with coal exposure...
  70. pmc Genetic variation at chromosome 8q24 in osteosarcoma cases and controls
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Carcinogenesis 31:1400-4. 2010
    ..Future large studies of osteosarcoma genetic risk factors are warranted to improve our understanding of the genetic contribution to this cancer of adolescents and young adults...
  71. pmc An analysis of growth, differentiation and apoptosis genes with risk of renal cancer
    Linda M Dong
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4895. 2009
    ..In conclusion, our evaluation has identified common genetic variants in CASP1, CASP5, EGFR, and IGFBP3 that could be associated with renal cancer risk...
  72. pmc A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33
    Hemang Parikh
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20877, USA
    Hum Genet 127:91-9. 2010
    ....
  73. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  74. pmc Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer
    Kala Visvanathan
    Department of Epidemiology, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 31:467-76. 2007
    ..Because alcohol is a known risk factor for breast cancer, we evaluated the joint association of genetic variants in ADH and alcohol consumption in relation to breast cancer...
  75. pmc Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease
    Lisa Gallicchio
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Cancer 6:173. 2006
    ....
  76. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
  77. pmc Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 30:50-8. 2009
    ..Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity...
  78. ncbi request reprint Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Urology 60:1118-23. 2002
    ..To investigate the association between prostate cancer and calcium and other nutrients thought to influence the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D]...
  79. pmc Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer
    Meredith Yeager
    Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Hum Genet 126:743-50. 2009
    ..No sites were observed to be polymorphic within the exons of MSMB...
  80. doi request reprint Complications after prostate biopsy: data from SEER-Medicare
    Stacy Loeb
    Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 186:1830-4. 2011
    ..We determined the risk of serious complications requiring hospitalization. We hypothesized that with emerging multidrug resistant organisms there may be an increasing risk of infectious complications...
  81. pmc Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies
    Lesley A Anderson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 125:398-405. 2009
    ..These results support a mechanism whereby chronic antigenic stimulation leads to lymphoid malignancy...
  82. ncbi request reprint Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trial
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1303-5. 2007
  83. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  84. ncbi request reprint Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007
    ..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E...
  85. pmc Identification of ten loci associated with height highlights new biological pathways in human growth
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:584-91. 2008
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait...