E A Berger

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc sCD4-17b bifunctional protein: extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates
    Laurel A Lagenaur
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Retrovirology 7:11. 2010
  2. pmc Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer
    Karl Salzwedel
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Retrovirology 6:75. 2009
  3. pmc Targeted cytotoxic therapy: adapting a rapidly progressing anticancer paradigm for depletion of persistent HIV-infected cell reservoirs
    Edward A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin HIV AIDS 6:80-5. 2011
  4. ncbi request reprint Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 17:657-700. 1999
  5. pmc Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120
    K Salzwedel
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:326-33. 2000
  6. pmc STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1
    F Liao
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Exp Med 185:2015-23. 1997
  7. ncbi request reprint Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1
    C Combadiere
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:23799-804. 1998
  8. pmc CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion
    C C Broder
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:913-26. 1993
  9. ncbi request reprint HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
  10. pmc Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11511-3. 1998

Collaborators

Detail Information

Publications18

  1. pmc sCD4-17b bifunctional protein: extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates
    Laurel A Lagenaur
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Retrovirology 7:11. 2010
    ..We also examined the sCD4-17b sensitivities of isogenic viruses generated from different producer cell types...
  2. pmc Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer
    Karl Salzwedel
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Retrovirology 6:75. 2009
    ..An emerging question concerns cooperative interactions between the protomers in the trimer, and possible implications for Env function...
  3. pmc Targeted cytotoxic therapy: adapting a rapidly progressing anticancer paradigm for depletion of persistent HIV-infected cell reservoirs
    Edward A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin HIV AIDS 6:80-5. 2011
    ..Complementary strategies aimed at selective killing of infected cells are described...
  4. ncbi request reprint Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 17:657-700. 1999
    ..Beyond providing new perspectives on fundamental aspects of HIV-1 transmission and pathogenesis, the coreceptors suggest new avenues for developing novel therapeutic and preventative strategies to combat the AIDS epidemic...
  5. pmc Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120
    K Salzwedel
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:326-33. 2000
    ..Thus, the sCD4-activated system reveals conserved Env-blocking epitopes that are masked in native Env and hence not readily detected by conventional systems...
  6. pmc STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1
    F Liao
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Exp Med 185:2015-23. 1997
    ..Based on the pattern of tissue expression of the STRL33 mRNA, and given the ability of STRL33 to function with Envs of differing tropisms, STRL33 may play a role in the establishment and/or progression of HIV-1 infection...
  7. ncbi request reprint Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1
    C Combadiere
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:23799-804. 1998
    ..Thus CMKBRL1/V28 is a specific receptor for fractalkine, and we propose to rename it CX3CR1 (CX3C chemokine receptor 1), according to an accepted nomenclature system...
  8. pmc CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion
    C C Broder
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:913-26. 1993
    ..abstract truncated at 400 words)..
  9. ncbi request reprint HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
    ..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
  10. pmc Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11511-3. 1998
    ..We suggest experimental approaches in vitro and in animal models to test various issues related to safety and efficacy of this concept...
  11. pmc Calcium ions are required for cell fusion mediated by the CD4-human immunodeficiency virus type 1 envelope glycoprotein interaction
    D S Dimitrov
    Section on Membrane Structure and Function, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 67:1647-52. 1993
    ..Binding of soluble CD4 to gp120-gp41-expressing cells was not affected by Ca2+ and Mg2+. We conclude that Ca2+ is involved in postbinding steps in cell fusion mediated by the CD4-HIV-1 envelope glycoprotein interaction...
  12. ncbi request reprint Determinants of HIV-1 coreceptor function on CC chemokine receptor 3. Importance of both extracellular and transmembrane/cytoplasmic regions
    G Alkhatib
    Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:20420-6. 1997
    ....
  13. pmc Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells
    P A Ashorn
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 64:2149-56. 1990
    ....
  14. pmc Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis
    T Mizukami
    Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:9273-7. 1988
    ..Moderate impairment of gp120 binding resulted from the insertion after amino acid residues 164 in the second immunoglobulin-like domain, where the epitopes for monoclonal antibodies MT151 and OKT4B were also mapped...
  15. ncbi request reprint A human immunodeficiency virus-transgenic mouse model for assessing interventions that block microbial-induced proviral expression
    M L Schito
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Infect Dis 183:1592-600. 2001
    ..Because HIV-1 expression cannot be induced in T lymphocytes from line 166 mice, this model may be of particular advantage for testing interventions that target virus production by non-T cell virus reservoirs...
  16. pmc Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in m
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 88:8082-6. 1991
    ....
  17. pmc Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 66:6208-12. 1992
    ..We demonstrate herein that envelope glycoprotein molecules rendered fusion defective by mutations in conserved residues within the V3 region nevertheless undergo efficient soluble CD4-induced gp120 release...