Sasisekhar Bennuru

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000688. 2009
  2. pmc Single molecule sequencing and genome assembly of a clinical specimen of Loa loa, the causative agent of loiasis
    Luke J Tallon
    Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Genomics 15:788. 2014
  3. pmc Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
    Lymphat Res Biol 7:215-9. 2009
  4. pmc Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 83:884-90. 2010
  5. pmc Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:9649-54. 2011
  6. pmc Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Negl Trop Dis 3:e410. 2009
  7. pmc Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 130:248-56.e9. 2012
  8. pmc Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion
    Alexis Boyd
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 81:1420-9. 2013
  9. pmc Structural differences between human proteins and aero- and microbial allergens define allergenicity
    Helton da Costa Santiago
    The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e40552. 2012
  10. pmc Helminth infection alters IgE responses to allergens structurally related to parasite proteins
    Helton da Costa Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 194:93-100. 2015

Collaborators

Detail Information

Publications13

  1. pmc Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000688. 2009
    ..The data suggest that filarial parasites directly induce lymphangiogenesis and lymphatic differentiation and provide insight into the mechanisms underlying the pathology seen in lymphatic filariasis...
  2. pmc Single molecule sequencing and genome assembly of a clinical specimen of Loa loa, the causative agent of loiasis
    Luke J Tallon
    Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Genomics 15:788. 2014
    ..However, the Pacific Biosciences single molecule, real-time sequencing platform holds great promise in reducing input amounts and generating sufficiently long sequences that bypass the need for large insert paired libraries...
  3. pmc Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
    Lymphat Res Biol 7:215-9. 2009
    ....
  4. pmc Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 83:884-90. 2010
    ....
  5. pmc Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:9649-54. 2011
    ..Parasite sex- and stage-specific protein expression identified those pathways related to parasite differentiation and demonstrates stage-specific expression by the Bm endosymbiont Wolbachia as well...
  6. pmc Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling
    Sasisekhar Bennuru
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Negl Trop Dis 3:e410. 2009
    ..This proteomic analysis extends our knowledge of the ES and provides insight into the host-parasite interaction...
  7. pmc Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 130:248-56.e9. 2012
    ..The extensive similarities between helminth proteins and allergens are thought to contribute to helminth-driven allergic sensitization...
  8. pmc Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion
    Alexis Boyd
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 81:1420-9. 2013
    ..Our data suggest that failure by LC to initiate an inflammatory response to the invasive stage of filarial parasites may be a strategy for immune evasion by the filarial parasite...
  9. pmc Structural differences between human proteins and aero- and microbial allergens define allergenicity
    Helton da Costa Santiago
    The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e40552. 2012
    ..Our results suggest that allergenicity may be associated with the relative "uniqueness" of an antigen, i.e. immunogenicity, while similarity would lead to immunological tolerance...
  10. pmc Helminth infection alters IgE responses to allergens structurally related to parasite proteins
    Helton da Costa Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 194:93-100. 2015
    ..These results show that cross-reactivity among allergens and helminth proteins can have practical implications, altering serologic approaches to allergen testing and bringing a new perspective to the "hygiene hypothesis." ..
  11. pmc Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 127:479-86. 2011
    ..The hygiene hypothesis suggests that parasitic infection modulates host immune responses and decreases atopy. Other data suggest parasitic infections may induce allergic responsiveness...
  12. pmc Human monocyte subsets at homeostasis and their perturbation in numbers and function in filarial infection
    Roshanak Tolouei Semnani
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 82:4438-46. 2014
    ..Our data suggest that monocyte subsets have a differential function at homeostasis and in response to helminth parasites...
  13. pmc Repurposed automated handheld counter as a point-of-care tool to identify individuals 'at risk' of serious post-ivermectin encephalopathy
    Sasisekhar Bennuru
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Negl Trop Dis 8:e3180. 2014
    ..Here, we describe a repurposed hand-held automated cell counter (Scepter 2.0; HHAC) as a rapid, point-of-care method for quantifying microfilariae (mf) in the blood of infected individuals...