Research Topics
Genomes and Genes
| Yasmine BelkaidSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Regulatory T cells and infection: a dangerous necessityYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, Maryland 20892, USA
Nat Rev Immunol 7:875-88. 2007..In this Review, I discuss current hypotheses and points of polemic associated with the origin, mode of action and antigen specificity of the various populations of regulatory T cells that arise during infection...
Arming Treg cells at the inflammatory siteYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 30:322-3. 2009..In this issue of Immunity, Zhang et al. (2009) propose that Treg cells, in order to efficiently control alloimmune response, need to be educated first in the target tissue before entering the draining lymph node...- Role of Foxp3-positive regulatory T cells during infectionYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Eur J Immunol 38:918-21. 2008..In this review, I discuss current hypotheses and points of polemic associated with the origin, mode of action and antigen specificity of Foxp3+ Treg during infection... - Regulatory T cells in the control of host-microorganism interactions (*)Yasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Immunol 27:551-89. 2009.... - Parasites and immunoregulatory T cellsYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Curr Opin Immunol 18:406-12. 2006..Recent findings implicate various populations of regulatory T cells in this homeostatic regulation... - Natural regulatory T cells and parasites: a common quest for host homeostasisYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
Immunol Rev 212:287-300. 2006..We discuss the hypothesis that parasites have evolved means to manipulate the host's natural Treg population, thereby generating conditions that secure survival in their vertebrate host for an extended period of time... - Natural regulatory T cells in infectious diseaseYasmine Belkaid
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Nat Immunol 6:353-60. 2005..We describe here various situations in which the balance between natural T(reg) cells and effector immune functions influences the outcome of infection and discuss how manipulating this equilibrium might be exploited therapeutically... - Regulatory ripplesYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 11:1077-8. 2010..Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iTR35 cells', which may have an important role in the phenomenon of infectious tolerance... - Inhibition of TLR-4/MD-2 signaling by RP105/MD-1Senad Divanovic
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Endotoxin Res 11:363-8. 2005.... 
Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunitySusana Mendez
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 200:201-10. 2004....- Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responsesJason A Hall
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 29:637-49. 2008..Together, these data point to gfDNA as a natural adjuvant for priming intestinal responses via modulation of Treg/Teff cell equilibrium... - IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 miceCharles F Anderson
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
J Immunol 180:4090-7. 2008..Thus, chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies... - Optimization of DNA vaccination against cutaneous leishmaniasisSusana Mendez
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 126, Building 4, Center Dr MSC 0425, Bethesda, MD 20892 0425, USA
Vaccine 20:3702-8. 2002..These results establish intradermal vaccination using DNA encoding multiple Leishmania antigens as a way to optimize priming of CD4+ and CD8+ T cells necessary for potent and durable protection against cutaneous leishmaniasis... - Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cellsAngela M Thornton
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 184:3433-41. 2010..Collectively, these results demonstrate that Helios is potentially a specific marker of thymic-derived Treg cells and raises the possibility that a significant percentage of Foxp3(+) Treg cells are generated extrathymically... - A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infectionIsabelle Suffia
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
J Immunol 174:5444-55. 2005..Thus, CD103, by controlling T(reg) retention, can contribute to the outcome of chronic infection by Leishmania... - Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunityStacie Reckling
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
Infect Immun 76:1179-85. 2008..Taken together, these data suggest that Bim limits protective immunity and that the absence of Bim allows the host to bypass antigen persistence for maintenance of immunity against reinfection... - Acute gastrointestinal infection induces long-lived microbiota-specific T cell responsesTimothy W Hand
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
Science 337:1553-6. 2012.... - GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in miceElizabeth A Wohlfert
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
J Clin Invest 121:4503-15. 2011..Overall, our work reveals what we believe to be a new facet in the complex role of GATA3 in T cells and highlights what may be a fundamental role in controlling Treg physiology during inflammation... - Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durabilitySusana Mendez
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Infect Immun 71:5121-9. 2003..Our results suggest that immune modulation using CpG ODNs might be a practical approach to improving the safety of a highly effective live vaccine that has already been widely applied... - The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cellsMatthias Hesse
Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:3157-66. 2004..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis... - Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cellsSylvie Bertholet
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Infect Immun 73:6620-8. 2005..The ability of L. major transgenic parasites to activate OT-I CD8(+) T cells in vivo will permit the analysis of parasite-driven T-cell expansion, differentiation, and recruitment at the clonal level... 
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigensIsabelle J Suffia
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID, National Institutes of Health (NIH, Bethesda, MD 20892, USA
J Exp Med 203:777-88. 2006..Further, we showed that parasite-specific natural T reg cells are restricted to sites of infection and that their survival is strictly dependent on parasite persistence...- Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infectionKhaled S Tabbara
NIAID, Laboratory of Parasitic Diseases, Bldg. 4, Rm. 126, Center Dr. MSC 0425, Bethesda, MD 20892-0425, USA
Infect Immun 73:4714-22. 2005..A delicate balance of effector and regulatory T cells may be required to optimize the potency and durability of vaccines against Leishmaniasis and other intracellular pathogens... - Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingKamran Ghoreschi
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 467:967-71. 2010..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications... - Microbe-dendritic cell dialog controls regulatory T-cell fateJohn R Grainger
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20894, USA
Immunol Rev 234:305-16. 2010..In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes... - T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune toleranceMarko Pesu
Molecular Immunology and Inflammation Branch, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 455:246-50. 2008..Targeting furin has emerged as a strategy in malignant and infectious disease. Our results suggest that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance... - Compartmentalized control of skin immunity by resident commensalsShruti Naik
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
Science 337:1115-9. 2012..These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease... - Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infectionGuillaume Oldenhove
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 31:772-86. 2009..These data reveal a mechanism for Th1 cell pathogenicity that extends beyond their proinflammatory program to limit Treg cell survival... - Tuning microenvironments: induction of regulatory T cells by dendritic cellsYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20894, USA
Immunity 29:362-71. 2008..Various populations of dendritic cells (DCs) are central to the orchestration of this control. In this review, we will discuss some new findings associating DCs from defined compartments with the induction of antigen-specific Treg cells... - Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidCheng Ming Sun
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:1775-85. 2007..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion... - CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityYasmine Belkaid
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 420:502-7. 2002.... - The Transcription Factors Thpok and LRF Are Necessary and Partly Redundant for T Helper Cell DifferentiationAndrea C Carpenter
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 37:622-33. 2012..These findings identify the Thpok-LRF pair as a core node of Th cell differentiation and function... - The role of retinoic acid in tolerance and immunityJason A Hall
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 35:13-22. 2011.... - The role of CD4(+)CD25(+) regulatory T cells in Leishmania infectionYasmine Belkaid
Children s Hospital Research Foundation, Molecular Immunology, MLC 7021, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Expert Opin Biol Ther 3:875-85. 2003..The mechanisms and consequences of such control in both susceptible or resistant mouse strains are discussed... - Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105Senad Divanovic
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Leukoc Biol 82:265-71. 2007..This overview outlines current knowledge and controversies about the immunobiology of the RP105/MD-1 complex, a modulator of the most robustly signaling TLR, TLR4... - Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105Senad Divanovic
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 6:571-8. 2005..Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo. Thus, our results identify RP105 as a physiological negative regulator of TLR4 responses... - Association of CTLA4 polymorphism with regulatory T cell frequencySowsan F Atabani
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Eur J Immunol 35:2157-62. 2005..These data implicate CTLA4 in regulatory T cell development, and provide a mechanism to account for the link between polymorphisms at this locus and the biological outcome of adaptive immune responses to self and to pathogens... - Stromal-derived IL-6 alters the balance of myeloerythroid progenitors during Toxoplasma gondii infectionDavid B Chou
Mucosal Immunology, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Leukoc Biol 92:123-31. 2012..Finally, direct ex vivo sorting revealed that VCAM(+)CD146(lo) BM stromal fibroblasts significantly increase IL-6 secretion after infection. These data suggest that BMSCs regulate the hematopoietic changes during inflammation via IL-6... - Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alphaJason A Hall
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 34:435-47. 2011.... - Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restrictionWolfgang Kastenmuller
Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 187:3186-97. 2011.... - Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopeniaCarl G Feng
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 6148, Building 50, 50 South Drive, Bethesda, MD 20892, USA
J Immunol 172:1163-8. 2004..These findings establish a role for LRG-47 in host control of mycobacteria and demonstrate that in the context of the IFN-gamma response to persistent infection, LRG-47 can have downstream regulatory effects on lymphocyte survival... - Role of endogenous and induced regulatory T cells during infectionsElizabeth Wohlfert
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892, USA
J Clin Immunol 28:707-15. 2008..OBJECTIVE: In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections... - CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and functionIan P Lewkowich
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 202:1549-61. 2005..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility... - Microbial control of regulatory and effector T cell responses in the gutTimothy Hand
NIAID, National Institutes of Health, Laboratory of Parasitic Diseases, 4 Center Drive, Bethesda, MD 20892, USA
Curr Opin Immunol 22:63-72. 2010..In this review we will focus on recent findings associating microbes that colonize or invade the gut, specialized mucosal DCs, and induction of effector or regulatory response in the GI tract... - Intestinal microbiota: shaping local and systemic immune responsesMichael J Molloy
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 243, Bethesda, MD 20892, USA
Semin Immunol 24:58-66. 2012.... - Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary locationTakashi Kakinuma
Dermatology Branch, Center for Cancer Research, NCI, Bldg 10 Rm12N246, 10 Center Dr, Bethesda, MD 20892 1908, USA
Cancer Immunol Immunother 56:1119-31. 2007..These studies suggest that small numbers of tumor cells (possibly regulated by CD4(+)CD25(+) regulatory T cells expressing Foxp3) are required for effective host anti-tumor responses at alternate inoculation sites... - Dietary and commensal derived nutrients: shaping mucosal and systemic immunitySean P Spencer
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD 20892, USA
Curr Opin Immunol 24:379-84. 2012..In addition, dietary derived AHR ligands and commensal derived metabolites are now emerging as important players in mucosal immunity. Thus nutrition, commensal microflora and the mucosal immune system are all intimately connected... - Distinct requirements for T-bet in gut innate lymphoid cellsGiuseppe Sciumè
Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
J Exp Med 209:2331-8. 2012..Thus, T-bet has a general importance for ILC in the gut and plays a selective and critical role in the generation of NKp46(+) ILC22... - CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania majorYasmine Belkaid
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:3992-4000. 2002..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin... - Paradoxical roles of Foxp3+ T cells during infection: from regulators to regulatorsYasmine Belkaid
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892, USA
Cell Host Microbe 3:341-3. 2008..In a recent issue of Science, Lund et al. support the idea that these cells can also coordinate the early entrance of innate cells at the effector site and therefore positively contribute to protective immunity... - Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airwayChristopher L Karp
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 5:388-92. 2004..These findings suggest that there is a pathophysiologically important defect in lipoxin-mediated anti-inflammatory activity in the cystic fibrosis lung and that lipoxins have therapeutic potential in this lethal autosomal disease... - A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismJanine L Coombes
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
J Exp Med 204:1757-64. 2007..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine... - Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected miceKevin N Couper
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, U K
J Immunol 178:4136-46. 2007.... - Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivationMichael H Shaw
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02906, USA
J Immunol 176:7263-71. 2006..Thus, Tyk2 can be viewed as a dual-function Jak, mediating both pro and anti-inflammatory cytokine responses... - CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cellsAna P Campanelli
Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
J Infect Dis 193:1313-22. 2006..These findings suggest that functional Treg cells accumulate at sites of Leishmania infection in humans and possibly contribute to the local control of effector T cell functions... - IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infectionKevin N Couper
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Pathog 4:e1000004. 2008..In summary, we have identified a population of induced Foxp3- regulatory (Tr1) T cells, characterised by production of IL-10 and down regulation of IL-7Ralpha, that modulates the inflammatory response to malaria... - Systemic immune responses induced by mucosal administration of lipopeptides without adjuvantLbachir BenMohamed
Biomedical Parasitology Unit, Pasteur Institute, Paris, France
Eur J Immunol 32:2274-81. 2002.... - Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infectionMark R Schleiss
Department of Pediatrics, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN, 55455, USA
J Infect Dis 195:789-98. 2007..These results indicate that cell-mediated immune responses directed against a CMV matrix protein can protect against congenital CMV infection and disease... - Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNAEsther von Stebut
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Invest Dermatol 119:621-8. 2002..In addition, CpG-containing immunostimulatory oligodeoxynucleotides may also act locally on skin macrophages to facilitate Leishmania clearance by inducing nitric oxide production... - Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c miceEsther von Stebut
Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
J Exp Med 198:191-9. 2003..Differential production of IL-1 by C57BL/6 and BALB/c mice may provide a partial explanation for the disparate outcomes of infection in these mouse strains... - Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotidesWenhui Wu
Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington DC, USA
Eur J Immunol 36:3238-47. 2006..Transfer of vaccine-primed dendritic cells into IL-6-deficient mice mitigated lesion development, indicating that IL-6 reconstitution limited pathology in the vaccination site... - CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistenceEkaterina Yurchenko
Department of Microbiology and Immunology, McGill University, Montreal, H3A 2B4, Canada
J Exp Med 203:2451-60. 2006..Thus, this study shows that CCR5 directs the homing of CD4+CD25+ nTreg cells to L. major-infected dermal sites where they promote the establishment of infection and long-term survival of the parasite in the immune host... - Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunityFlorian Woelbing
Department of Dermatology and 2Section for Pathophysiology, First Department of Internal Medicine, Johannes Gutenberg University, Mainz 55131, Germany
J Exp Med 203:177-88. 2006..major with different outcomes, and indicate that B cell-derived, parasite-reactive IgG and DC FcgammaRI and FcgammaRIII are essential for optimal development of protective immunity...
Research Grants
- Role of Regulatory T cells in Leishmania major infectionYasmine Belkaid; Fiscal Year: 2004..major; and (2) Determine the mechanisms underlying Treg-mediated modulation of immune responses to L. major both in vitro and in vivo. ..