I Belfer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
  2. pmc A clinical genetic method to identify mechanisms by which pain causes depression and anxiety
    Mitchell B Max
    Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 2:14. 2006
  3. ncbi request reprint Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20852, USA
    Genes Immun 5:505-12. 2004
  4. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
  5. ncbi request reprint Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Hum Genet 13:341-51. 2005
  6. ncbi request reprint Alcoholism is associated with GALR3 but not two other galanin receptor genes
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Genes Brain Behav 6:473-81. 2007
  7. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005
  8. pmc Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Mol Psychiatry 11:301-11. 2006
  9. ncbi request reprint Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past
    B Buzas
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, 12420 Parklawn Drive, Rockville, MD 20852, USA
    Mol Genet Genomics 272:519-29. 2004
  10. pmc Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen
    Inna Belfer
    National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA
    Int J Stroke 5:145-51. 2010

Collaborators

Detail Information

Publications19

  1. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
    ..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire...
  2. pmc A clinical genetic method to identify mechanisms by which pain causes depression and anxiety
    Mitchell B Max
    Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 2:14. 2006
    ..We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year...
  3. ncbi request reprint Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20852, USA
    Genes Immun 5:505-12. 2004
    ..This study demonstrates the utility of using gene haplotype maps and marker panels as tools for linkage studies on related phenotypes...
  4. ncbi request reprint Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populations
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
    J Hum Genet 49:232-45. 2004
    ..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function...
  5. ncbi request reprint Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African Americans
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Hum Genet 13:341-51. 2005
    ..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function...
  6. ncbi request reprint Alcoholism is associated with GALR3 but not two other galanin receptor genes
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Genes Brain Behav 6:473-81. 2007
    ..6) as compared with the effect of either GAL (2.0) or GALR3 alone (1.6). There was no effect of GALR1 or GALR2 on alcoholism risk. This evidence suggests that GALR3 mediates the alcoholism-related actions of galanin...
  7. ncbi request reprint Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Hum Genet 50:12-20. 2005
    ..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci...
  8. pmc Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations
    I Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Mol Psychiatry 11:301-11. 2006
    ..Our results from two independent populations suggest that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety...
  9. ncbi request reprint Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past
    B Buzas
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, 12420 Parklawn Drive, Rockville, MD 20852, USA
    Mol Genet Genomics 272:519-29. 2004
    ..For both ADRA1A and ADRA1B, haplotype superstructures may represent a novel, higher-level hierarchy in the human genome, which may reduce redundancy of testing by further aggregation of genotype data...
  10. pmc Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screen
    Inna Belfer
    National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA
    Int J Stroke 5:145-51. 2010
    ..The aim of this study was to evaluate the role of single-nucleotide polymorphisms (SNPs) and haplotypes in inflammatory genes as they relate to symptomatic carotid atherosclerosis...
  11. pmc Expansion of the human mu-opioid receptor gene architecture: novel functional variants
    Svetlana A Shabalina
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Hum Mol Genet 18:1037-51. 2009
    ..Our results provide evidence for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses...
  12. ncbi request reprint Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Anesthesiology 100:1562-72. 2004
  13. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  14. pmc Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder
    Luda Diatchenko
    University of North Carolina, Center for Neurosensory Disorders, North Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 141:449-62. 2006
    ....
  15. ncbi request reprint Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
    ..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception...
  16. ncbi request reprint Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Chem 53:1010-5. 2007
    ..A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening method for the pain-protective haplotype...
  17. ncbi request reprint Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    ..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD...
  18. ncbi request reprint Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  19. ncbi request reprint GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    Irmgard Tegeder
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
    Nat Med 12:1269-77. 2006
    ..BH4 is therefore an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits...