Research Topics
Genomes and GenesSpecies | I BelferSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?Bikash K Mishra
Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
Mol Pain 3:20. 2007..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire...- A clinical genetic method to identify mechanisms by which pain causes depression and anxietyMitchell B Max
Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
Mol Pain 2:14. 2006..We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year... - Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African AmericansI Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20852, USA
Genes Immun 5:505-12. 2004..This study demonstrates the utility of using gene haplotype maps and marker panels as tools for linkage studies on related phenotypes... - Haplotype architecture of the norepinephrine transporter gene SLC6A2 in four populationsInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA
J Hum Genet 49:232-45. 2004..The SLC6A2 haplotype map and 25-marker panel (excluding the monomorphic one) is a comprehensive tool for genetic linkage studies on phenotypes related to NET function... - Haplotype structure of the beta adrenergic receptor genes in US Caucasians and African AmericansInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Eur J Hum Genet 13:341-51. 2005..This study demonstrates the utility of using beta-AR gene haplotype maps and marker panels as tools for linkage studies on beta-AR function... - Alcoholism is associated with GALR3 but not two other galanin receptor genesI Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
Genes Brain Behav 6:473-81. 2007..6) as compared with the effect of either GAL (2.0) or GALR3 alone (1.6). There was no effect of GALR1 or GALR2 on alcoholism risk. This evidence suggests that GALR3 mediates the alcoholism-related actions of galanin... - Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each geneInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
J Hum Genet 50:12-20. 2005..The alpha2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknown alpha2-AR functional loci... - Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populationsI Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
Mol Psychiatry 11:301-11. 2006..Our results from two independent populations suggest that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety... - Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal pastB Buzas
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, 12420 Parklawn Drive, Rockville, MD 20852, USA
Mol Genet Genomics 272:519-29. 2004..For both ADRA1A and ADRA1B, haplotype superstructures may represent a novel, higher-level hierarchy in the human genome, which may reduce redundancy of testing by further aggregation of genotype data... - Linkage of large-vessel carotid atherosclerotic stroke to inflammatory genes via a systematic screenInna Belfer
National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, MD, USA
Int J Stroke 5:145-51. 2010..The aim of this study was to evaluate the role of single-nucleotide polymorphisms (SNPs) and haplotypes in inflammatory genes as they relate to symptomatic carotid atherosclerosis... - Expansion of the human mu-opioid receptor gene architecture: novel functional variantsSvetlana A Shabalina
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Hum Mol Genet 18:1037-51. 2009..Our results provide evidence for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses... - Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample sizeInna Belfer
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Anesthesiology 100:1562-72. 2004 - Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humansAlexander Neumeister
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
Pharmacogenet Genomics 15:143-9. 2005..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk... - Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorderLuda Diatchenko
University of North Carolina, Center for Neurosensory Disorders, North Carolina, USA
Am J Med Genet B Neuropsychiatr Genet 141:449-62. 2006.... - Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuliLuda Diatchenko
Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
Pain 125:216-24. 2006..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception... - Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphismsJorn Lotsch
Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Clin Chem 53:1010-5. 2007..A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening method for the pain-protective haplotype... - Genetic basis for individual variations in pain perception and the development of a chronic pain conditionLuda Diatchenko
Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hum Mol Genet 14:135-43. 2005..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD... - Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depressionAlexander Neumeister
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Neuropsychopharmacology 31:1750-6. 2006..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD... - GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistenceIrmgard Tegeder
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
Nat Med 12:1269-77. 2006..BH4 is therefore an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits...