K G Becker

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Autism, asthma, inflammation, and the hygiene hypothesis
    Kevin G Becker
    Gene Expression and Genomics Unit, RRB, TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Med Hypotheses 69:731-40. 2007
  2. pmc Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster
    Supriyo De
    Gene Expression and Genomics Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    BMC Genomics 14:580. 2013
  3. pmc Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    BMC Genomics 14:545. 2013
  4. pmc IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme
    Andrea L Wurster
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, USA
    BMC Immunol 13:9. 2012
  5. doi request reprint Male gender bias in autism and pediatric autoimmunity
    Kevin G Becker
    Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Autism Res 5:77-83. 2012
  6. pmc Aging-kb: a knowledge base for the study of the aging process
    Kevin G Becker
    Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States
    Mech Ageing Dev 132:592-4. 2011
  7. pmc Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin
    Cheryl A Sherman-Baust
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore MD 21224, USA
    J Ovarian Res 4:21. 2011
  8. pmc Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Genome Biol 8:R234. 2007
  9. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
  10. pmc Genetic and environmental pathways to complex diseases
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 3:46. 2009

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Autism, asthma, inflammation, and the hygiene hypothesis
    Kevin G Becker
    Gene Expression and Genomics Unit, RRB, TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Med Hypotheses 69:731-40. 2007
    ..This hypothesis is meant to address the apparent rise in the prevalence of autism in the population...
  2. pmc Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster
    Supriyo De
    Gene Expression and Genomics Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    BMC Genomics 14:580. 2013
    ..Many model systems lack species specific organized phenotype based gene sets to enable high throughput analysis of large molecular datasets...
  3. pmc Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    BMC Genomics 14:545. 2013
    ..METH is an illicit drug of abuse that influences gene expression in the rat striatum. Histone modifications regulate gene transcription...
  4. pmc IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme
    Andrea L Wurster
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, USA
    BMC Immunol 13:9. 2012
    ..Different versions of SWI/SNF complexes, including BAF and PBAF, have been described based on unique subunit composition. However, the relative role of BAF and PBAF in Th cell function and cytokine expression has not been reported...
  5. doi request reprint Male gender bias in autism and pediatric autoimmunity
    Kevin G Becker
    Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Autism Res 5:77-83. 2012
    ..It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease...
  6. pmc Aging-kb: a knowledge base for the study of the aging process
    Kevin G Becker
    Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States
    Mech Ageing Dev 132:592-4. 2011
    ..The Aging Wiki allows community participation in describing and defining concepts and terms in the Wiki format. This aging knowledge base provides a simple intuitive interface to the complexities of aging...
  7. pmc Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin
    Cheryl A Sherman-Baust
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore MD 21224, USA
    J Ovarian Res 4:21. 2011
    ..abstract:..
  8. pmc Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Genome Biol 8:R234. 2007
    ..The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly understood...
  9. pmc Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain
    Christopher D Toscano
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 8:R14. 2007
    ....
  10. pmc Genetic and environmental pathways to complex diseases
    Julia M Gohlke
    Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Syst Biol 3:46. 2009
    ....
  11. pmc Cortical gene transcription response patterns to water maze training in aged mice
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    BMC Neurosci 12:63. 2011
    ..We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training...
  12. pmc Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information
    Yonqing Zhang
    Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genomics 3:1. 2010
    ..Likewise, mouse genetic models of disease often have pleiotropic and overlapping phenotypes. Moreover, phenotypic descriptions in the literature in both human and mouse are often poorly characterized and difficult to compare directly...
  13. pmc Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability
    Chris Cheadle
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    BMC Genomics 6:75. 2005
    ..One reason for this difficulty may result from the intricate convergence of both transcriptional and mRNA turnover events which, together, directly influence steady-state mRNA levels...
  14. pmc Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary
    Alexei A Sharov
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Biol 6:24. 2008
    ..In addition, we compared a group of mice on ad libitum (AL) feeding with a group on lifespan-extending 40% calorie restriction (CR)...
  15. ncbi request reprint The common genetic hypothesis of autoimmune/inflammatory disease
    K G Becker
    DNA Array Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Curr Opin Allergy Clin Immunol 1:399-405. 2001
    ....
  16. ncbi request reprint Assembly and use of a broadly applicable neural cDNA microarray
    T Barrett
    Transgenic and Knockout Facility Section, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Restor Neurol Neurosci 18:127-35. 2001
    ..This selected set of brain-relevant cDNAs should be widely useful in the analysis of gene expression patterns from brain tissues as well as neural cell lines...
  17. pmc PubMatrix: a tool for multiplex literature mining
    Kevin G Becker
    Gene Expression and Genomics Unit, National Institutes of Health, Baltimore, MD, USA
    BMC Bioinformatics 4:61. 2003
    ..PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence...
  18. ncbi request reprint Deciphering the gene expression profile of long-lived snell mice
    Kevin G Becker
    DNA Array Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Sci Aging Knowledge Environ 2002:pe4. 2002
    ..In this Perspective, the author argues that although the authors have developed a solid analytical approach, further refinements are needed to produce robust conclusions...
  19. ncbi request reprint The common variants/multiple disease hypothesis of common complex genetic disorders
    Kevin G Becker
    Gene Expression and Genomics Unit, TRIAD Technology Center, National Institute on Aging, National Institutes on Health, Room 208, 333 Cassell Drive, Baltimore, MD 21224, USA
    Med Hypotheses 62:309-17. 2004
    ..Common deleterious alleles, found at a relatively high frequency in the population may play a role in related clinical phenotypes in the context of different genetic backgrounds and under different environmental conditions...
  20. ncbi request reprint Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?
    K G Becker
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Diabetes 48:1353-8. 1999
    ..This supports a hypothesis that the underlying genetic susceptibility to type 1 diabetes may be shared with other clinically distinct autoimmune diseases such as systemic lupus erythemastosus, multiple sclerosis, and Crohn's Disease...
  21. ncbi request reprint The sharing of cDNA microarray data
    K G Becker
    Gerontology Research Center, Room 4 D16, 5600 Nathan Shock Drive, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Nat Rev Neurosci 2:438-40. 2001
    ..There is great interest in the sharing of cDNA microarray data, but several issues related to format, quality and validation will need to be resolved before microarray data can be meaningfully integrated into other molecular databases...
  22. ncbi request reprint BBID: the biological biochemical image database
    K G Becker
    DNA Array Unit, RRB NCTS, National Institutes on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Bioinformatics 16:745-6. 2000
    ..Pathway information is annotated and can be queried in the study of complex gene expression. In this way, complex regulatory pathways can be tested empirically in an efficient manner in the context of large-scale gene-expression systems...
  23. ncbi request reprint Application of cDNA microarrays to examine gene expression differences in schizophrenia
    M P Vawter
    Section on Plasticity and Development, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Brain Res Bull 55:641-50. 2001
    ..Identification of patterns of changes in gene expression may lead to a better understanding of the pathophysiology of schizophrenia disorders...
  24. ncbi request reprint C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain
    K G Becker
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Dev Neurosci 15:891-9. 1997
    ..These data suggest that C2H2-171 may play an important role in vertebrate brain development and function...
  25. pmc Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases
    K G Becker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:9979-84. 1998
    ..This nonrandom clustering supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes...
  26. pmc Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    J Neurochem 114:323-34. 2010
    ..The data further suggest that modification of dietary energy intake could provide a novel potential approach to addiction treatments...
  27. ncbi request reprint Gene expression profile in early stage of retinoic acid-induced differentiation of human SH-SY5Y neuroblastoma cells
    M E Truckenmiller
    Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Restor Neurol Neurosci 18:67-80. 2001
    ..We employed a broad human 15K microarray (15,000 genes) and focused Neuroarray (1152 genes) to examine changes in gene expression early in the process of differentiation (6 hr), before morphology or growth changes are observed...
  28. pmc A genomic-scale view of the cAMP response element-enhancer decoy: a tumor target-based genetic tool
    Yee Sook Cho
    Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:15626-31. 2002
    ..The CRE-decoy ODN, therefore, may serve as a target-based genetic tool to treat cancer and other diseases in which CRE-directed transcription is abnormally used...
  29. pmc Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
    Ana Lustig
    Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Med Sci 6:51-64. 2009
    ..These studies provide valuable insight into the cellular and molecular mechanisms associated with thymic aging...
  30. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  31. ncbi request reprint Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cells
    J Li
    Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
    Oncogene 26:2860-72. 2007
    ..The pathways important in cisplatin response, as well as the genes found differentially expressed between cisplatin-resistant and -sensitive cells, may represent targets for therapy aimed at reversing drug resistance...
  32. ncbi request reprint The use of microarrays to characterize neuropsychiatric disorders: postmortem studies of substance abuse and schizophrenia
    E Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Curr Mol Med 3:437-46. 2003
    ....
  33. ncbi request reprint Radioactive 33-P probes in hybridization to glass cDNA microarrays using neural tissues
    L W Whitney
    Molecular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurosci Methods 106:9-13. 2001
    ....
  34. pmc The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice
    R H Bonow
    Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
    Pharmacogenomics J 9:116-26. 2009
    ..Overall, altered expression of these genes may underlie some of the inflammatory and behavioral effects of neuroinflammation...
  35. ncbi request reprint A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicity
    T Barrett
    Research Resources Branch, Laboratory of Genetics, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA
    Neurobiol Dis 8:822-33. 2001
    ..This is the first work to describe a gene expression profile for a neuronal subtype and to identify gene expression changes during methamphetamine neurotoxicity...
  36. ncbi request reprint Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex
    I N Krasnova
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Genes Brain Behav 7:193-202. 2008
    ..Differences in the transcriptional responses in the hippocampus and cortex suggest the primary importance of the hippocampus for recent memory processing associated with cocaine-induced CPP...
  37. ncbi request reprint Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells
    K Liu
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 166:7335-44. 2001
    ....
  38. pmc Antisense DNAs as multisite genomic modulators identified by DNA microarray
    Y S Cho
    Cellular Biochemistry Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA
    Proc Natl Acad Sci U S A 98:9819-23. 2001
    ....
  39. ncbi request reprint Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurosci 24:7043-50. 2004
    ..The present findings may have therapeutic implications for neuropathological conditions involving DA neurons...
  40. ncbi request reprint Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity
    Isabel Lopez de Silanes
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Gene Expr 12:49-59. 2004
    ....
  41. pmc Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1957-70. 2008
    ..The primary objective of this study was to identify the non-MHC genes involved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their protein products for immunotherapy...
  42. ncbi request reprint The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells
    Kasper J Kyng
    Laboratory of Molecular Gerontology, National Institute on Aging, 5600 Nathan Schock Drive, National Institute of Health, Baltimore, MD 21224, USA
    Oncogene 22:1135-49. 2003
    ..Some major defects are in the transcription of genes involved in DNA repair, signal transduction, and ribosomal functions...
  43. pmc Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach
    Krystyna Mazan-Mamczarz
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Cancer Res 68:7730-5. 2008
    ..These findings further support the feasibility of using a ribonomics approach for the identification of cancer-related pathways...
  44. pmc Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype
    K Mazan-Mamczarz
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 27:6151-63. 2008
    ....
  45. pmc Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues
    Ashani T Weeraratna
    Laboratory of Immunology, National Institutes of Health, Baltimore, MD 21224, USA
    Exp Cell Res 313:450-61. 2007
    ..Together, these findings open up new avenues of investigation and possible therapeutic strategies targeting inflammation and amyloid clearance in AD patients...
  46. pmc Analysis of microarray data using Z score transformation
    Chris Cheadle
    DNA Array Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21221, USA
    J Mol Diagn 5:73-81. 2003
    ..The results provided by these methods can be as rigorous and are no more arbitrary than other test methods, and, in addition, they have the advantage that they can be easily adapted to standard spreadsheet programs...
  47. ncbi request reprint AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression
    M E Truckenmiller
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Exp Neurol 175:318-37. 2002
    ..These data suggest that the AF5 cell line may be useful as an in vitro model system for studies of neural differentiation...
  48. ncbi request reprint Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancer
    G Peter Sawiris
    Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cancer Res 62:2923-8. 2002
    ....
  49. ncbi request reprint Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity
    Tao Xie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurosci 22:274-83. 2002
    ..The precise role of COX1 and other genes in METH neurotoxicity remains to be elucidated...
  50. pmc CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis
    X F Liu
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Oncogene 31:1673-82. 2012
    ..CAPC expressing tumors showed a decrease in the number of proliferating cells and a large increase in ECM. The role of CAPC in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment...
  51. pmc Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse
    E Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Pharmacogenomics J 3:27-40. 2003
    ..These data suggest that cocaine abuse targets a distinct subset of genes in the dlPFC, resulting in either a state of acute activation in which increased gene expression predominates, or a relatively destimulated, refractory phase...
  52. ncbi request reprint Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
    L W Whitney
    Molecular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1400, USA
    Ann Neurol 46:425-8. 1999
    ..Thus, cDNA microarray technology represents a powerful new tool for the identification of genes not previously associated with the MS disease process...
  53. ncbi request reprint CCG repeats in cDNAs from human brain
    J J Kleiderlein
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 103:666-73. 1998
    ..This list of cDNAs should expedite the search for expansion mutations associated with diseases of the central nervous system...
  54. pmc Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse
    Elin Lehrmann
    Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 1:e114. 2006
    ..These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers...
  55. ncbi request reprint Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Pediatr Res 53:762-9. 2003
    ..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS...
  56. pmc Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Endocrinology 148:4318-33. 2007
    ....
  57. ncbi request reprint Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study
    Marquis P Vawter
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Schizophr Res 58:11-20. 2002
    ..These results are subject to limitations based on variations inherent to human subjects and tissue samples, possible effects of neuroleptic treatment, and the requirement for verification using independent techniques...
  58. ncbi request reprint Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy
    Yoon S Cho-Chung
    Cellular Biochemistry Section, BRL, CCR, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1750, USA
    Ann N Y Acad Sci 968:22-36. 2002
    ..Thus, a complex circuitry of cAMP signaling comprises cAMP growth regulatory function, and deregulation of the effector molecule by this circuitry may underlie cancer genesis and tumor progression...
  59. pmc Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells
    Jia Chen
    Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Neurosci Res 85:1724-33. 2007
    ..These data suggest that increases in 14-3-3 proteins mediate THC-induced neuroprotection under conditions of NMDA-induced cellular stress...
  60. pmc A mechanism for the inhibition of neural progenitor cell proliferation by cocaine
    Chun Ting Lee
    Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS Med 5:e117. 2008
    ..To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation...
  61. pmc Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2398. 2008
    ....
  62. pmc Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements
    Supriyo De
    Research Resources Branch, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    Mol Cell Biol 31:1512-27. 2011
    ..Our findings suggest that BRG1 binding is a useful marker for identifying active cis-regulatory regions in protein-coding and miRNA genes...
  63. ncbi request reprint Methamphetamine-induced gene expression profiles in the striatum of male rat pups exposed to the drug in utero
    Pierre Antoine H Noailles
    Molecular Neuropsychiatry Branch, NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Dev Brain Res 147:153-62. 2003
    ..Thus, during development, METH exposure in utero might cause significant long-term changes in gene expression that might constitute, in part, some of the substrates for the behavioral and cognitive anomalies reported in the literature...
  64. ncbi request reprint Kinetic assessment of general gene expression changes during human naive CD4+ T cell activation
    Krista Hess
    Laboratory of Immunology, National Institutes on Aging, National Institute of Health, Baltimore, MD 21224, USA
    Int Immunol 16:1711-21. 2004
    ....
  65. ncbi request reprint Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis
    Nataly Strunnikova
    National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1859, USA
    Invest Ophthalmol Vis Sci 45:3767-77. 2004
    ..To detail, by DNA microarrays and cellular structure labeling, the in vitro responses of retinal pigment epithelial (RPE) cells to a nonlethal dose of the oxidant agent hydroquinone (HQ)...
  66. pmc Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatum
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD, USA
    PLoS ONE 4:e7812. 2009
    ..Further analysis of the molecular and cellular pathways regulated by these genes should help to provide some insight into the neuroadaptive potentials of the brain when repeatedly exposed to drugs of abuse...
  67. pmc A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells
    Tandis Vazin
    Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH, DHHS, Baltimore, MD, USA
    PLoS ONE 4:e6606. 2009
    ..The molecular nature of this effect, which has been termed "SDIA" is so far unknown. Recently, we found that factors secreted by PA6 cells provided lineage-specific instructions to induce DA differentiation of human ESC (hESC)...
  68. ncbi request reprint Application of z-score transformation to Affymetrix data
    Chris Cheadle
    Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Appl Bioinformatics 2:209-17. 2003
    ..Z-score transformation provides a useful tool for comparisons between experiments and between laboratories that use the Affymetrix platform...
  69. ncbi request reprint National Institute on Aging microarray facility--resources for gerontology research
    Nancy L Nadon
    Office of Biological Resources and Resource Development, National Institute on Aging, 7201 Wisconsin Ave, GW2C231, Bethesda, MD 20892
    J Gerontol A Biol Sci Med Sci 60:413-5. 2005
    ..This article introduces the National Institute on Aging Microarray Facility, developed to provide DNA microarrays to the biogerontology research community and to promote the use of this new technology...
  70. ncbi request reprint A rapid method for microarray cross platform comparisons using gene expression signatures
    Chris Cheadle
    Genomics Core, Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Mason Lord Bldg, Center Tower, Rm 664, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Mol Cell Probes 21:35-46. 2007
    ....
  71. ncbi request reprint Gene expression in the conversion of early-phase to late-phase long-term potentiation
    Philip R Lee
    Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1048:259-71. 2005
    ..Natl. Acad. Sci. USA 99: 3962-3967) showing that this conversion can be induced by antidromic stimulation of CA1 neurons in the absence of excitatory synaptic activity...
  72. pmc Possible angiogenic roles for claudin-4 in ovarian cancer
    Jianghong Li
    Laboratory of Cellular and Molecular Biology, National Institute on Aging NIH, Baltimore, MD, USA
    Cancer Biol Ther 8:1806-14. 2009
    ..Our data suggest a novel function for claudin-4 in cancer and provide an additional rationale for its common overexpression in human tumors...
  73. pmc Ubiquitin-mediated proteolysis of HuR by heat shock
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
    EMBO J 28:1271-82. 2009
    ..Our findings reveal that HS transiently lowers HuR by proteolysis linked to K182 ubiquitination and that HuR reduction enhances cell survival following HS...
  74. pmc VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
    Fan Zhang
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:6152-7. 2009
    ..Our work thus indicates that the function of VEGF-B in the vascular system is to act as a "survival," rather than an "angiogenic" factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases...
  75. ncbi request reprint Stability regulation of mRNA and the control of gene expression
    Chris Cheadle
    Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1058:196-204. 2005
    ..It is proposed that the regulation of mRNA stability in response to external stimuli contributes significantly to observed changes in gene expression as measured by high throughput systems...
  76. pmc Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration
    Manik C Ghosh
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 114:1366-73. 2009
    ..Together, these data demonstrate that Wnt5A is a critical mediator of CXCL12-CXCR4 signaling and migration in human and murine T cells...
  77. pmc Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian rats
    Jean Lud Cadet
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 5:e15643. 2010
    ..Our results also implicate 5-HT as a potential player in these METH-induced alterations in gene expression because the METH injection also caused significant increases in 5-HIAA/5-HT ratios on the DA-depleted side...
  78. pmc Gonadal transcriptome alterations in response to dietary energy intake: sensing the reproductive environment
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4146. 2009
    ....
  79. pmc Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway
    Shang Yi Tsai
    Cellular Pathobiology Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 106:22468-73. 2009
    ..These results implicate Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation and suggest a free radical-sensitive ER-mitochondrion-Rac1.GTP pathway in the regulation of dendritic spine formation in the hippocampus...
  80. pmc Single round of antigen receptor signaling programs naive B cells to receive T cell help
    Bazarragchaa Damdinsuren
    Gene Regulation Section, Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
    Immunity 32:355-66. 2010
    ..We propose that transient BCR signals prime B cells to receive T cell help by increasing the probability of B-T encounter and creating a cellular environment that is hyper-responsive to CD40 signaling...
  81. pmc Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells
    Peisu Zhang
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    Curr Biol 18:1489-94. 2008
    ..Thus, in addition to protecting telomeres, TRF2 possesses a novel role in stabilization of REST thereby controlling neural tumor and stem cell fate...
  82. pmc Adipocyte gene expression is altered in formerly obese mice and as a function of diet composition
    Ryan S Miller
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nutr 138:1033-8. 2008
    ..Furthermore, there were 398 genes with altered expression in HF mice that persisted in WR mice. Genes with persistently altered expression following obesity may play a role in rebound weight gain following weight reduction...
  83. ncbi request reprint Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome
    Kasper J Kyng
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Oncogene 24:5026-42. 2005
    ..Our results suggest that aberrant DNA damage-induced gene regulation may contribute to the aging process and the premature aging in WS...
  84. pmc Identification and analysis of plasticity-induced late-response genes
    Suk Jin Hong
    Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:2145-50. 2004
    ..Our results provide a molecular dissection of the activity-dependent long-lasting neuronal responses induced by NMDA receptor activation...
  85. ncbi request reprint Microarray analysis in Tourette syndrome postmortem putamen
    John J Hong
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 North Wolfe Street, Baltimore, MD 21287 1000, USA
    J Neurol Sci 225:57-64. 2004
    ....
  86. ncbi request reprint Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 118:70-7. 2006
    ....
  87. ncbi request reprint Molecular analysis of bovine spongiform encephalopathy infection by cDNA arrays
    G Peter Sawiris
    Research Service, VA Maryland Healthcare System, Baltimore, MD, USA
    J Gen Virol 88:1356-62. 2007
    ....
  88. pmc Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus
    Ana Lustig
    Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Immunol 245:42-61. 2007
    ....
  89. ncbi request reprint Rule-based human gene normalization in biomedical text with confidence estimation
    William W Lau
    Center for Information Technology, National Institutes of Health, Bethesda, MD 20892 5624, USA
    Comput Syst Bioinformatics Conf 6:371-9. 2007
    ..The feature weights were tuned by the Nealder-Mead simplex method. An F-score of .7622 and an AUC (area under the recall-precision curve) of .7461 were achieved on the test data using the set of weights optimized to the training data...
  90. ncbi request reprint Comparison of gene expression profile between human chondrons and chondrocytes: a cDNA microarray study
    Z Zhang
    Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charles Street, Clark Hall 102, Baltimore, MD 21218, USA
    Osteoarthritis Cartilage 14:449-59. 2006
    ..This current study was designed to investigate the effects of the chondron PCM on the gene expression profile of chondrocytes...
  91. ncbi request reprint Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion
    Catherine L Neary
    Cellular Biochemistry Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1750, USA
    Oncogene 23:8847-56. 2004
    ..Differential expression of PKA R subunits may therefore serve as a tumor-target-based gene therapy for PC3M prostate and other cancers...
  92. ncbi request reprint Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging
    Monchou Fann
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Immunol Rev 205:190-206. 2005
    ..Our analysis provides the gene expression portraits of CD28(null) memory phenotype CD8(+) T cells and alteration from their CD28(+) counterparts and suggests potential mechanisms of T-cell aging...
  93. pmc Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responses
    Bronwen Martin
    Laboratory of Neurosciences, Research Resources Branch, NIA, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 284:2493-511. 2009
    ....
  94. ncbi request reprint Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice
    H Lu
    Laboratory of Molecular Gerontology, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Death Dis 5:e1226. 2014
    ..In conclusion, dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to symptoms in RTS patients. ..
  95. ncbi request reprint Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1
    K G Becker
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 41:502-4. 1997
  96. ncbi request reprint NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression
    P D Drew
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 15:1037-45. 1995
    ..These results provide a molecular mechanism by which TNF-alpha and IFN-gamma synergistically induce the expression of a variety of genes involved in immune responses, including MHC class I...
  97. ncbi request reprint Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc finger
    K G Becker
    Neuroimmunology Branch, Building 10, Room 5B16, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 8:287-9. 1997
  98. ncbi request reprint CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion
    Michael Mayne
    Department of Pharmacology and Therapeutics, University of Manitoba, Division of Neuroscience, St Boniface Hospital Research Centre, Winnipeg, Canada
    Eur J Immunol 34:1217-27. 2004
    ..These studies suggest that overabundance of CYFIP2 protein facilitates increased adhesion properties of T cells from MS patients...
  99. ncbi request reprint Microarray technology and its application on nicotine research
    Ming D Li
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
    Mol Neurobiol 25:265-85. 2002
    ..Lastly, given the early stage of microarray research on nicotine, we elaborate on the need for an efficient analysis of genetic networks to further enhance our understanding of the mechanisms involved in nicotine abuse and addiction...
  100. ncbi request reprint DSCR1(Adapt78) modulates expression of SOD1
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    FASEB J 18:62-9. 2004
    ..These data also have importance for our understanding of Down's syndrome, Alzheimer's disease, and other human pathologies...
  101. ncbi request reprint Gene expression profiling of oxidative stress on atrial fibrillation in humans
    Young Hoon Kim
    Department of Internal Medicine, College of Medicine, Korea University, Seoul, 136 701 Korea
    Exp Mol Med 35:336-49. 2003
    ..It showed that the intracellular mechanism of oxidative stress plays a pivotal role in the pathologic progression of AF and offers novel insight into potential treatment with antioxidants...