Research Topics
Genomes and Genes
| K G BeckerSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Autism, asthma, inflammation, and the hygiene hypothesisKevin G Becker
Gene Expression and Genomics Unit, RRB, TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Med Hypotheses 69:731-40. 2007..This hypothesis is meant to address the apparent rise in the prevalence of autism in the population...- IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzymeAndrea L Wurster
Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, USA
BMC Immunol 13:9. 2012..Different versions of SWI/SNF complexes, including BAF and PBAF, have been described based on unique subunit composition. However, the relative role of BAF and PBAF in Th cell function and cytokine expression has not been reported... 
Male gender bias in autism and pediatric autoimmunityKevin G Becker
Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Autism Res 5:77-83. 2012..It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease...- Aging-kb: a knowledge base for the study of the aging processKevin G Becker
Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, United States
Mech Ageing Dev 132:592-4. 2011..The Aging Wiki allows community participation in describing and defining concepts and terms in the Wiki format. This aging knowledge base provides a simple intuitive interface to the complexities of aging... - Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicinCheryl A Sherman-Baust
Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore MD 21224, USA
J Ovarian Res 4:21. 2011..abstract:.. - Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and genderXiangru Xu
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Genome Biol 8:R234. 2007..The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly understood... - Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brainChristopher D Toscano
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Biol 8:R14. 2007.... - Genetic and environmental pathways to complex diseasesJulia M Gohlke
Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
BMC Syst Biol 3:46. 2009.... - Cortical gene transcription response patterns to water maze training in aged miceSung Soo Park
Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
BMC Neurosci 12:63. 2011..We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training... - Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic informationYonqing Zhang
Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
BMC Med Genomics 3:1. 2010..Likewise, mouse genetic models of disease often have pleiotropic and overlapping phenotypes. Moreover, phenotypic descriptions in the literature in both human and mouse are often poorly characterized and difficult to compare directly... - Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stabilityChris Cheadle
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
BMC Genomics 6:75. 2005..One reason for this difficulty may result from the intricate convergence of both transcriptional and mRNA turnover events which, together, directly influence steady-state mRNA levels... - Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovaryAlexei A Sharov
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
BMC Biol 6:24. 2008..In addition, we compared a group of mice on ad libitum (AL) feeding with a group on lifespan-extending 40% calorie restriction (CR)... 
The common genetic hypothesis of autoimmune/inflammatory diseaseK G Becker
DNA Array Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Curr Opin Allergy Clin Immunol 1:399-405. 2001....- The common variants/multiple disease hypothesis of common complex genetic disordersKevin G Becker
Gene Expression and Genomics Unit, TRIAD Technology Center, National Institute on Aging, National Institutes on Health, Room 208, 333 Cassell Drive, Baltimore, MD 21224, USA
Med Hypotheses 62:309-17. 2004..Common deleterious alleles, found at a relatively high frequency in the population may play a role in related clinical phenotypes in the context of different genetic backgrounds and under different environmental conditions... - Assembly and use of a broadly applicable neural cDNA microarrayT Barrett
Transgenic and Knockout Facility Section, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Restor Neurol Neurosci 18:127-35. 2001..This selected set of brain-relevant cDNAs should be widely useful in the analysis of gene expression patterns from brain tissues as well as neural cell lines... - PubMatrix: a tool for multiplex literature miningKevin G Becker
Gene Expression and Genomics Unit, National Institutes of Health, Baltimore, MD, USA
BMC Bioinformatics 4:61. 2003..PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence... - The sharing of cDNA microarray dataK G Becker
Gerontology Research Center, Room 4 D16, 5600 Nathan Shock Drive, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Nat Rev Neurosci 2:438-40. 2001..There is great interest in the sharing of cDNA microarray data, but several issues related to format, quality and validation will need to be resolved before microarray data can be meaningfully integrated into other molecular databases... - Deciphering the gene expression profile of long-lived snell miceKevin G Becker
DNA Array Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Sci Aging Knowledge Environ 2002:pe4. 2002..In this Perspective, the author argues that although the authors have developed a solid analytical approach, further refinements are needed to produce robust conclusions... - BBID: the biological biochemical image databaseK G Becker
DNA Array Unit, RRB NCTS, National Institutes on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Bioinformatics 16:745-6. 2000..Pathway information is annotated and can be queried in the study of complex gene expression. In this way, complex regulatory pathways can be tested empirically in an efficient manner in the context of large-scale gene-expression systems... - Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?K G Becker
Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Diabetes 48:1353-8. 1999..This supports a hypothesis that the underlying genetic susceptibility to type 1 diabetes may be shared with other clinically distinct autoimmune diseases such as systemic lupus erythemastosus, multiple sclerosis, and Crohn's Disease... - Application of cDNA microarrays to examine gene expression differences in schizophreniaM P Vawter
Section on Plasticity and Development, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Brain Res Bull 55:641-50. 2001..Identification of patterns of changes in gene expression may lead to a better understanding of the pathophysiology of schizophrenia disorders... - C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brainK G Becker
Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Int J Dev Neurosci 15:891-9. 1997..These data suggest that C2H2-171 may play an important role in vertebrate brain development and function... - Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseasesK G Becker
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 95:9979-84. 1998..This nonrandom clustering supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes... - Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behaviorXiangru Xu
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
J Neurochem 114:323-34. 2010..The data further suggest that modification of dietary energy intake could provide a novel potential approach to addiction treatments... - Gene expression profile in early stage of retinoic acid-induced differentiation of human SH-SY5Y neuroblastoma cellsM E Truckenmiller
Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Restor Neurol Neurosci 18:67-80. 2001..We employed a broad human 15K microarray (15,000 genes) and focused Neuroarray (1152 genes) to examine changes in gene expression early in the process of differentiation (6 hr), before morphology or growth changes are observed... - Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expressionAna Lustig
Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Int J Med Sci 6:51-64. 2009..These studies provide valuable insight into the cellular and molecular mechanisms associated with thymic aging... - Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanKevin J Pearson
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cell Metab 8:157-68. 2008..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife... - A genomic-scale view of the cAMP response element-enhancer decoy: a tumor target-based genetic toolYee Sook Cho
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:15626-31. 2002..The CRE-decoy ODN, therefore, may serve as a target-based genetic tool to treat cancer and other diseases in which CRE-directed transcription is abnormally used... - Gene expression response to cisplatin treatment in drug-sensitive and drug-resistant ovarian cancer cellsJ Li
Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, USA
Oncogene 26:2860-72. 2007..The pathways important in cisplatin response, as well as the genes found differentially expressed between cisplatin-resistant and -sensitive cells, may represent targets for therapy aimed at reversing drug resistance... - Radioactive 33-P probes in hybridization to glass cDNA microarrays using neural tissuesL W Whitney
Molecular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Neurosci Methods 106:9-13. 2001.... - The use of microarrays to characterize neuropsychiatric disorders: postmortem studies of substance abuse and schizophreniaE Lehrmann
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
Curr Mol Med 3:437-46. 2003.... - The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in miceR H Bonow
Molecular Neuroscience Unit, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
Pharmacogenomics J 9:116-26. 2009..Overall, altered expression of these genes may underlie some of the inflammatory and behavioral effects of neuroinflammation... - Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortexI N Krasnova
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
Genes Brain Behav 7:193-202. 2008..Differences in the transcriptional responses in the hippocampus and cortex suggest the primary importance of the hippocampus for recent memory processing associated with cocaine-induced CPP... - A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicityT Barrett
Research Resources Branch, Laboratory of Genetics, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA
Neurobiol Dis 8:822-33. 2001..This is the first work to describe a gene expression profile for a neuronal subtype and to identify gene expression changes during methamphetamine neurotoxicity... - Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cellsK Liu
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Immunol 166:7335-44. 2001.... - Antisense DNAs as multisite genomic modulators identified by DNA microarrayY S Cho
Cellular Biochemistry Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA
Proc Natl Acad Sci U S A 98:9819-23. 2001.... - Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexityIsabel Lopez de Silanes
Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Gene Expr 12:49-59. 2004.... - The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cellsKasper J Kyng
Laboratory of Molecular Gerontology, National Institute on Aging, 5600 Nathan Schock Drive, National Institute of Health, Baltimore, MD 21224, USA
Oncogene 22:1135-49. 2003..Some major defects are in the transcription of genes involved in DNA repair, signal transduction, and ribosomal functions... - Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approachKrystyna Mazan-Mamczarz
Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
Cancer Res 68:7730-5. 2008..These findings further support the feasibility of using a ribonomics approach for the identification of cancer-related pathways... - Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neuronsTao Xie
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurosci 24:7043-50. 2004..The present findings may have therapeutic implications for neuropathological conditions involving DA neurons... - Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitisMary J Mattapallil
Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Invest Ophthalmol Vis Sci 49:1957-70. 2008..The primary objective of this study was to identify the non-MHC genes involved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their protein products for immunotherapy... - Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotypeK Mazan-Mamczarz
Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
Oncogene 27:6151-63. 2008.... - Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissuesAshani T Weeraratna
Laboratory of Immunology, National Institutes of Health, Baltimore, MD 21224, USA
Exp Cell Res 313:450-61. 2007..Together, these findings open up new avenues of investigation and possible therapeutic strategies targeting inflammation and amyloid clearance in AD patients... - Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicityTao Xie
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurosci 22:274-83. 2002..The precise role of COX1 and other genes in METH neurotoxicity remains to be elucidated... - Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancerG Peter Sawiris
Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cancer Res 62:2923-8. 2002.... - Analysis of microarray data using Z score transformationChris Cheadle
DNA Array Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21221, USA
J Mol Diagn 5:73-81. 2003..The results provided by these methods can be as rigorous and are no more arbitrary than other test methods, and, in addition, they have the advantage that they can be easily adapted to standard spreadsheet programs... - AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expressionM E Truckenmiller
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Exp Neurol 175:318-37. 2002..These data suggest that the AF5 cell line may be useful as an in vitro model system for studies of neural differentiation... - CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasisX F Liu
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
Oncogene 31:1673-82. 2012..CAPC expressing tumors showed a decrease in the number of proliferating cells and a large increase in ECM. The role of CAPC in the suppression of tumor growth and metastasis may be through its alteration of the tumor microenvironment... - Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuseE Lehrmann
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
Pharmacogenomics J 3:27-40. 2003..These data suggest that cocaine abuse targets a distinct subset of genes in the dlPFC, resulting in either a state of acute activation in which increased gene expression predominates, or a relatively destimulated, refractory phase... - CCG repeats in cDNAs from human brainJ J Kleiderlein
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hum Genet 103:666-73. 1998..This list of cDNAs should expedite the search for expansion mutations associated with diseases of the central nervous system... - Analysis of gene expression in mutiple sclerosis lesions using cDNA microarraysL W Whitney
Molecular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1400, USA
Ann Neurol 46:425-8. 1999..Thus, cDNA microarray technology represents a powerful new tool for the identification of genes not previously associated with the MS disease process... - Transcriptional changes common to human cocaine, cannabis and phencyclidine abuseElin Lehrmann
Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
PLoS ONE 1:e114. 2006..These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers... - A mechanism for the inhibition of neural progenitor cell proliferation by cocaineChun Ting Lee
Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
PLoS Med 5:e117. 2008..To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation... - Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cellsJia Chen
Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
J Neurosci Res 85:1724-33. 2007..These data suggest that increases in 14-3-3 proteins mediate THC-induced neuroprotection under conditions of NMDA-induced cellular stress... - Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excessBronwen Martin
Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Endocrinology 148:4318-33. 2007.... - A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cellsTandis Vazin
Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, NIH, DHHS, Baltimore, MD, USA
PLoS ONE 4:e6606. 2009..The molecular nature of this effect, which has been termed "SDIA" is so far unknown. Recently, we found that factors secreted by PA6 cells provided lineage-specific instructions to induce DA differentiation of human ESC (hESC)... - Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elementsSupriyo De
Research Resources Branch, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
Mol Cell Biol 31:1512-27. 2011..Our findings suggest that BRG1 binding is a useful marker for identifying active cis-regulatory regions in protein-coding and miRNA genes... - Possible angiogenic roles for claudin-4 in ovarian cancerJianghong Li
Laboratory of Cellular and Molecular Biology, National Institute on Aging NIH, Baltimore, MD, USA
Cancer Biol Ther 8:1806-14. 2009..Our data suggest a novel function for claudin-4 in cancer and provide an additional rationale for its common overexpression in human tumors... - Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and malesBronwen Martin
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America
PLoS ONE 3:e2398. 2008.... - Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migrationManik C Ghosh
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Blood 114:1366-73. 2009..Together, these data demonstrate that Wnt5A is a critical mediator of CXCL12-CXCR4 signaling and migration in human and murine T cells... - Methamphetamine preconditioning alters midbrain transcriptional responses to methamphetamine-induced injury in the rat striatumJean Lud Cadet
Molecular Neuropsychiatry Research Branch, DHHS NIH NIDA Intramural Research Program, Baltimore, MD, USA
PLoS ONE 4:e7812. 2009..Further analysis of the molecular and cellular pathways regulated by these genes should help to provide some insight into the neuroadaptive potentials of the brain when repeatedly exposed to drugs of abuse... - VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesisFan Zhang
National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:6152-7. 2009.... - Ubiquitin-mediated proteolysis of HuR by heat shockKotb Abdelmohsen
Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
EMBO J 28:1271-82. 2009..Our findings reveal that HS transiently lowers HuR by proteolysis linked to K182 ubiquitination and that HuR reduction enhances cell survival following HS... - National Institute on Aging microarray facility--resources for gerontology researchNancy L Nadon
Office of Biological Resources and Resource Development, National Institute on Aging, 7201 Wisconsin Ave, GW2C231, Bethesda, MD 20892
J Gerontol A Biol Sci Med Sci 60:413-5. 2005..This article introduces the National Institute on Aging Microarray Facility, developed to provide DNA microarrays to the biogerontology research community and to promote the use of this new technology... - Gene expression in the conversion of early-phase to late-phase long-term potentiationPhilip R Lee
Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1048:259-71. 2005..Natl. Acad. Sci. USA 99: 3962-3967) showing that this conversion can be induced by antidromic stimulation of CA1 neurons in the absence of excitatory synaptic activity... - Application of z-score transformation to Affymetrix dataChris Cheadle
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Appl Bioinformatics 2:209-17. 2003..Z-score transformation provides a useful tool for comparisons between experiments and between laboratories that use the Affymetrix platform... - Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissueAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Pediatr Res 53:762-9. 2003..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS... - Stability regulation of mRNA and the control of gene expressionChris Cheadle
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1058:196-204. 2005..It is proposed that the regulation of mRNA stability in response to external stimuli contributes significantly to observed changes in gene expression as measured by high throughput systems... - Methamphetamine-induced gene expression profiles in the striatum of male rat pups exposed to the drug in uteroPierre Antoine H Noailles
Molecular Neuropsychiatry Branch, NIDA/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Dev Brain Res 147:153-62. 2003..Thus, during development, METH exposure in utero might cause significant long-term changes in gene expression that might constitute, in part, some of the substrates for the behavioral and cognitive anomalies reported in the literature... - Kinetic assessment of general gene expression changes during human naive CD4+ T cell activationKrista Hess
Laboratory of Immunology, National Institutes on Aging, National Institute of Health, Baltimore, MD 21224, USA
Int Immunol 16:1711-21. 2004.... - Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary studyMarquis P Vawter
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Schizophr Res 58:11-20. 2002..These results are subject to limitations based on variations inherent to human subjects and tissue samples, possible effects of neuroleptic treatment, and the requirement for verification using independent techniques... - Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoyYoon S Cho-Chung
Cellular Biochemistry Section, BRL, CCR, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1750, USA
Ann N Y Acad Sci 968:22-36. 2002..Thus, a complex circuitry of cAMP signaling comprises cAMP growth regulatory function, and deregulation of the effector molecule by this circuitry may underlie cancer genesis and tumor progression... - Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysisNataly Strunnikova
National Eye Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-1859, USA
Invest Ophthalmol Vis Sci 45:3767-77. 2004.... - A rapid method for microarray cross platform comparisons using gene expression signaturesChris Cheadle
Genomics Core, Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Mason Lord Bldg, Center Tower, Rm 664, 5200 Eastern Avenue, Baltimore, MD 21224, USA
Mol Cell Probes 21:35-46. 2007.... - Methamphetamine-induced dopamine-independent alterations in striatal gene expression in the 6-hydroxydopamine hemiparkinsonian ratsJean Lud Cadet
Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse National Institutes of Health Department of Health and Human Services, Baltimore, Maryland, United States of America
PLoS ONE 5:e15643. 2010..Our results also implicate 5-HT as a potential player in these METH-induced alterations in gene expression because the METH injection also caused significant increases in 5-HIAA/5-HT ratios on the DA-depleted side... - Identification and analysis of plasticity-induced late-response genesSuk Jin Hong
Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:2145-50. 2004..Our results provide a molecular dissection of the activity-dependent long-lasting neuronal responses induced by NMDA receptor activation... - Microarray analysis in Tourette syndrome postmortem putamenJohn J Hong
Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 North Wolfe Street, Baltimore, MD 21287-1000, USA
J Neurol Sci 225:57-64. 2004.... - Gene expression responses to DNA damage are altered in human aging and in Werner SyndromeKasper J Kyng
Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Oncogene 24:5026-42. 2005..Our results suggest that aberrant DNA damage-induced gene regulation may contribute to the aging process and the premature aging in WS... - Gonadal transcriptome alterations in response to dietary energy intake: sensing the reproductive environmentBronwen Martin
Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
PLoS ONE 4:e4146. 2009.... - Adipocyte gene expression is altered in formerly obese mice and as a function of diet compositionRyan S Miller
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Nutr 138:1033-8. 2008..Furthermore, there were 398 genes with altered expression in HF mice that persisted in WR mice. Genes with persistently altered expression following obesity may play a role in rebound weight gain following weight reduction... - Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathwayShang Yi Tsai
Cellular Pathobiology Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 106:22468-73. 2009..These results implicate Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation and suggest a free radical-sensitive ER-mitochondrion-Rac1.GTP pathway in the regulation of dendritic spine formation in the hippocampus... - Single round of antigen receptor signaling programs naive B cells to receive T cell helpBazarragchaa Damdinsuren
Gene Regulation Section, Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
Immunity 32:355-66. 2010..We propose that transient BCR signals prime B cells to receive T cell help by increasing the probability of B-T encounter and creating a cellular environment that is hyper-responsive to CD40 signaling... - Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypesKathleen C Barnes
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Allergy Clin Immunol 118:70-7. 2006.... - Rule-based human gene normalization in biomedical text with confidence estimationWilliam W Lau
Center for Information Technology, National Institutes of Health, Bethesda, MD 20892 5624, USA
Comput Syst Bioinformatics Conf 6:371-9. 2007..The feature weights were tuned by the Nealder-Mead simplex method. An F-score of .7622 and an AUC (area under the recall-precision curve) of .7461 were achieved on the test data using the set of weights optimized to the training data... - Molecular analysis of bovine spongiform encephalopathy infection by cDNA arraysG Peter Sawiris
Research Service, VA Maryland Healthcare System, Baltimore, MD, USA
J Gen Virol 88:1356-62. 2007.... - Transcriptome analysis of age-, gender- and diet-associated changes in murine thymusAna Lustig
Laboratory of Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Cell Immunol 245:42-61. 2007.... - Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cellsPeisu Zhang
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
Curr Biol 18:1489-94. 2008..Thus, in addition to protecting telomeres, TRF2 possesses a novel role in stabilization of REST thereby controlling neural tumor and stem cell fate... - Comparison of gene expression profile between human chondrons and chondrocytes: a cDNA microarray studyZ Zhang
Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charles Street, Clark Hall 102, Baltimore, MD 21218, USA
Osteoarthritis Cartilage 14:449-59. 2006..This current study was designed to investigate the effects of the chondron PCM on the gene expression profile of chondrocytes... - Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell agingMonchou Fann
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Immunol Rev 205:190-206. 2005..Our analysis provides the gene expression portraits of CD28(null) memory phenotype CD8(+) T cells and alteration from their CD28(+) counterparts and suggests potential mechanisms of T-cell aging... - Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversionCatherine L Neary
Cellular Biochemistry Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA
Oncogene 23:8847-56. 2004..Differential expression of PKA R subunits may therefore serve as a tumor-target-based gene therapy for PC3M prostate and other cancers... - Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responsesBronwen Martin
Laboratory of Neurosciences, Research Resources Branch, NIA, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
J Biol Chem 284:2493-511. 2009.... - Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1K G Becker
Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 41:502-4. 1997 - NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expressionP D Drew
Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Interferon Cytokine Res 15:1037-45. 1995..These results provide a molecular mechanism by which TNF-alpha and IFN-gamma synergistically induce the expression of a variety of genes involved in immune responses, including MHC class I... - Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc fingerK G Becker
Neuroimmunology Branch, Building 10, Room 5B16, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Mamm Genome 8:287-9. 1997 - Resveratrol improves health and survival of mice on a high-calorie dietJoseph A Baur
Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 444:337-42. 2006..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing... - Microarray technology and its application on nicotine researchMing D Li
Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
Mol Neurobiol 25:265-85. 2002..Lastly, given the early stage of microarray research on nicotine, we elaborate on the need for an efficient analysis of genetic networks to further enhance our understanding of the mechanisms involved in nicotine abuse and addiction... - Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's diseaseVellareddy Anantharam
Parkinson s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011 1250, USA
Neurochem Int 50:834-47. 2007..Utilizing this in vitro model to identify novel oxidative stress-regulated genes may be useful in unraveling the molecular mechanisms underlying dopaminergic degeneration in Parkinson's disease... - Transcriptional profiling of aging in human muscle reveals a common aging signatureJacob M Zahn
Department of Developmental Biology, Stanford University Medical Center, Stanford, California, USA
PLoS Genet 2:e115. 2006.... - Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortexIrina N Krasnova
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health DHHS, Bethesda, MD 20892, USA
Neurotox Res 11:107-30. 2007..Our results point towards specific molecular targets that might be involved in disease process mediated by altered developmental DA regulation... - Microarray screening of suppression subtractive hybridization-PCR cDNA libraries identifies novel RNAs regulated by dehydration in the rat supraoptic nucleusMohamed T Ghorbel
The Molecular Neuroendocrinology Research Group, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, United Kingdom
Physiol Genomics 24:163-72. 2006..Four transcripts were shown by in situ hybridization (ISH) to be significantly up- or downregulated in the SON after dehydration. These genes may represent novel effectors or mediators of SON physiological remodeling... - Effect of genistein on the expression of bone metabolism genes in ovariectomized mice using a cDNA microarrayJae-Eun Pie
Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang 430-714, Korea
J Nutr Biochem 17:157-64. 2006..The present study suggests that GEN modulates bone metabolism-related gene expression, including calciotropic receptor, cytokines, growth factors and bone matrix proteins...