Research Topics
Genomes and Genes
| Michael A BeavenSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Division of labor: specialization of sphingosine kinases in mast cellsMichael A Beaven
National Heart, Lung, and Blood Institute, National Institutes of Health, Room 8N109 Bldg 10, Bethesda, MD 20892, USA
Immunity 26:271-3. 2007..Olivera et al. (2007) show that SphK2 regulates mast cell activation whereas SphK1 enhances susceptibility to antigen challenge in vivo...- Our perception of the mast cell from Paul Ehrlich to nowMichael A Beaven
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Eur J Immunol 39:11-25. 2009..This once enigmatic cell of Paul Ehrlich has proved to be both adaptable and multifunctional... - Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and FgrWahn Soo Choi
Laboratory of Molecular Immunology, National, Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Mol Cell Biol 24:6980-92. 2004..The findings provide the first description of a mechanism for activation of PLD2 in a physiological setting and of a role for Fgr in Fc epsilon RI-mediated signaling... - Phospholipase d promotes lipid microdomain-associated signaling events in mast cellsFelipe A Lisboa
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
J Immunol 183:5104-12. 2009..Collectively, these findings suggest that PLD activity plays an important role in promoting IgE-dependent signaling events within lipid microdomains in mast cells... - The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cellsHye Sun Kuehn
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 181:7706-12. 2008..These data demonstrate that strategies to decrease mast cell production of ROS and eicosanoids would have to target both ERK1/2- and PI3K/Btk-dependent pathways... - Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kitShoko Iwaki
Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1881, USA
J Biol Chem 280:40261-70. 2005..These data demonstrate, for the first time, that Btk is a key regulator of a Kit-mediated amplification pathway that augments Fc epsilonRI-mediated mast cell activation... - Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cellsThomas R Hundley
National Institutes of Health, Bethesda, MD 20892 1760, USA
Blood 104:2410-7. 2004..The findings, in total, indicated that a combination of FcepsilonRI and Kit-mediated signals and transcriptional processes were required for optimal physiologic responses of human mast cells to antigen... - Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator releaseHye Sun Kuehn
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive MSC 1881, Bethesda, MD 20892 1881, USA
Cell Signal 20:625-36. 2008..These responses were critical for the promotion of degranulation. This is the first report of synergistic activation between PLCgamma and PLCbeta that permits reinforcement of signals for degranulation in mast cells... - Stem cell factor programs the mast cell activation phenotypeTomonobu Ito
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 188:5428-37. 2012.... - An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cellsZe Peng
Laboratory of Molecular Immunology, National, Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Immunol 174:5201-8. 2005..These results suggested that the production of phosphatidic acid by PLD facilitates activation of PKC and, in turn, degranulation, although additional PLD-dependent processes appear to be critical for Ag-mediated degranulation... - Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell lineHong Tao Ma
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 180:2233-9. 2008..These and other observations suggest that the Sr(2+)-permeable TRPC5 associates with STIM1 and Orai1 in a stoichiometric manner to enhance entry of Ca(2+) to generate a signal for degranulation... - FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cellsHuihong Qiao
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
Blood 107:610-8. 2006..The synergistic interactions of TLR ligands and antigen might have relevance to the exacerbation of IgE-mediated allergic diseases by infectious agents... - Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activationBettina M Jensen
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C206, 10 Center Drive, MSC 1881, Bethesda, MD 20892 1881, USA
J Pharmacol Exp Ther 324:128-38. 2008.... - Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulatorSeung Kiel Park
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Immunol 46:2133-9. 2009..Production of IL-3 and MCP-1, but not degranulation, is also enhanced. The upregulation of SLAP may thus serve to limit the duration of cytokine production in Ag-stimulated cells... - Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cellsAhmed Chahdi
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD 20892-1760, USA
Mol Immunol 38:1269-76. 2002..As the expressed PLD1 was associated with secretory granules and PLD2 with the plasma membrane, the two isoforms may serve distinct but complementary functions in secretion... - Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator releaseHye Sun Kuehn
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 286:391-402. 2011..These findings are consistent with the conclusion that activation of mTORC2, downstream of PI3K, represents a critical signaling locus for chemotaxis and chemokine release from PGE(2)-activated mast cells... - Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cellsHye Sun Kuehn
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive MSC 1881, Bethesda, MD 20892 1881, USA
J Cell Sci 123:2576-85. 2010..Taken together, these data demonstrate that, by regulating signaling pathways that control F-actin rearrangement, Btk is crucial for the ability of antigen to amplify mast-cell chemotactic responses... - Mechanism of upregulation of the inhibitory regulator, src-like adaptor protein (SLAP), by glucocorticoids in mast cellsSeung Kiel Park
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
Mol Immunol 46:492-7. 2009..In the case of SLAP specifically, this requires activation of gene transcription through the interaction of the glucocorticoid receptor with GRE... - Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cellsTakaaki Hiragun
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
Mol Pharmacol 67:598-603. 2005..These findings identify Dok-1 as mediator of the antiallergic actions of dexamethasone and as a negative regulator of the MAP kinase pathway and downstream release of inflammatory mediators... - Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator releaseHye Sun Kuehn
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
Immunol Lett 141:45-54. 2011.... - Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cellsMarcus V M Andrade
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:7254-62. 2004.... - The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinaseChristine Tkaczyk
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:48474-84. 2003..However, PI 3-kinase may contribute to the later phase of Fc epsilon RI-mediated degranulation in human mast cells... - Cutting edge: dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like adaptor proteinTakaaki Hiragun
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 177:2047-50. 2006..The induction of these inhibitory regulators may contribute to the immunosuppressive activity of dexamethasone in mast cells... - Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survivalYasuko Furumoto
Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:5167-71. 2006..The findings demonstrate that PTEN functions as a key regulator of mast cell homeostasis and FcepsilonRI-responsiveness... - Mastoparan selectively activates phospholipase D2 in cell membranesAhmed Chahdi
Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1760, USA
J Biol Chem 278:12039-45. 2003..Therefore, mastoparan may be useful for investigating the regulation of PLD2, particularly in view of the well studied molecular interactions of mastoparan with certain other strategic signaling proteins... - Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinasesWahn Soo Choi
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1760, USA
Ann N Y Acad Sci 968:198-212. 2002..The pathological/physiological implications of the regulation of PLD by PKA require further evaluation in other cell systems... - Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33Marcus V Andrade
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
Eur J Immunol 41:760-72. 2011..IL-33 may retune mast cell responses to Ag toward enhanced cytokine production and thus determine the symptoms and severity of Ag-dependent allergic and autoimmune diseases... - Regulation of Ca2+ signaling with particular focus on mast cellsHong Tao Ma
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Crit Rev Immunol 29:155-86. 2009.... - Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticariaNevenka Medic
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
Cell Calcium 50:473-80. 2011..From these data, we conclude that TRPM8 is unlikely to directly regulate mast cell activation in cold urticaria. Thus, alternative mechanisms likely exist for the pathogenesis of this disease... - Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases?Hong Tao Ma
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Adv Exp Med Biol 716:62-90. 2011.... - Regulation of mast cell responses in health and diseaseAlasdair M Gilfillan
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
Crit Rev Immunol 31:475-529. 2011.... - Phospholipases D1 and D2 regulate different phases of exocytosis in mast cellsWahn Soo Choi
Laboratory of Molecular Immunology and Light Microscopy Core Facility, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:5682-9. 2002.... - Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRIArnold S Kirshenbaum
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA
Leuk Res 27:677-82. 2003..Both LAD 1 and 2 release beta-hexosaminidase following FcepsilonRI or FcgammaRI aggregation. The availability of these cell lines offers an unparalleled circumstance to examine the biology of human mast cells... - Role of ABCC1 in export of sphingosine-1-phosphate from mast cellsPoulami Mitra
Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
Proc Natl Acad Sci U S A 103:16394-9. 2006..Transport of S1P by ABCC1 influenced migration of mast cells toward antigen but not degranulation. These findings have important implications for S1P functions in mast cell-mediated immune responses... - Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cellsJun Ho Lee
Department of Immunology, College of Medicine, Konkuk University, Chungju 380 701, Korea
Blood 108:956-64. 2006..Apparently, the interaction of PLD2 with Syk is an early critical event in the activation of mast cells... - Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of SykJun Ho Lee
Department of Immunology and Physiology, College of Medicine, Konkuk University, Chungju, Korea
J Allergy Clin Immunol 121:1225-31. 2008..Curcumin can block this activation, but the mechanism and the effects of curcumin on IgE-mediated allergic reactions are unknown...