Bruce J Baum

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction
    Bruce J Baum
    Molecular Physiology and Therapeutics Branch, and Neurobiology and Pain Therapeutics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19403-7. 2012
  2. ncbi request reprint 5.0 Introduction to Theme 5: New challenges and strategic planning in research
    Bruce J Baum
    NIDCR, USA
    Eur J Dent Educ 6:161. 2002
  3. ncbi request reprint Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
    J Endocrinol 185:363-72. 2005
  4. pmc Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 15:4641-8. 2009
  5. doi request reprint Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1190, USA
    Mol Ther 16:1089-97. 2008
  6. ncbi request reprint Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Mol Ther 12:528-36. 2005
  7. ncbi request reprint Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, Bethesda, MD 20892 1190, USA
    Biochim Biophys Acta 1758:1071-7. 2006
  8. doi request reprint Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    J Gene Med 12:3-10. 2010
  9. ncbi request reprint Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Human Health Services, Bethesda, MD 20892, USA
    Hum Gene Ther 18:142-50. 2007
  10. doi request reprint Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands
    Yuval Samuni
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Gene Ther 19:279-86. 2008

Collaborators

Detail Information

Publications71

  1. pmc Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction
    Bruce J Baum
    Molecular Physiology and Therapeutics Branch, and Neurobiology and Pain Therapeutics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:19403-7. 2012
    ..AdhAQP1 vector delivery to a single parotid gland was safe and transfer of the hAQP1 cDNA increased parotid flow and relieved symptoms in a subset of subjects...
  2. ncbi request reprint 5.0 Introduction to Theme 5: New challenges and strategic planning in research
    Bruce J Baum
    NIDCR, USA
    Eur J Dent Educ 6:161. 2002
  3. ncbi request reprint Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
    J Endocrinol 185:363-72. 2005
    ....
  4. pmc Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 15:4641-8. 2009
    ..The study aims to evaluate if human keratinocyte growth factor (hKGF), secreted after transduction of murine salivary glands with adenoviral vectors, can prevent oral mucositis resulting from radiation...
  5. doi request reprint Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1190, USA
    Mol Ther 16:1089-97. 2008
    ..A vector such as AdLTR(2)EF1alpha-hEPO may prove useful in clinical applications in which extended, but not "permanent," transgene expression is desirable...
  6. ncbi request reprint Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Mol Ther 12:528-36. 2005
    ..0-kb, rAQP5 0.4-kb, and AMY promoters were not cell-type specific in SMGs; however, the Kall promoter was primarily active in ductal cells. These data will facilitate optimal expression cassette design for salivary gland gene transfer...
  7. ncbi request reprint Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, Bethesda, MD 20892 1190, USA
    Biochim Biophys Acta 1758:1071-7. 2006
    ..Based on these results, we are developing a clinical trial to test if the hAQP1 cDNA transfer strategy will be clinically effective in restoring salivary flow in patients with IR-induced parotid hypofunction...
  8. doi request reprint Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    J Gene Med 12:3-10. 2010
    ..One week after the administration of AdhAQP1 to an enrolled, generally healthy patient, E1-containing adenovirus was detected in parotid saliva...
  9. ncbi request reprint Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Human Health Services, Bethesda, MD 20892, USA
    Hum Gene Ther 18:142-50. 2007
    ..We conclude that administration of modest doses of rAAV2 vectors to SGs for therapeutic purposes can be accomplished without significant or permanent injury to the targeted gland or to distant organs of nonhuman primates...
  10. doi request reprint Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands
    Yuval Samuni
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Gene Ther 19:279-86. 2008
    ....
  11. pmc Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:3053-8. 2004
    ..98). These results show that SGs appear to be promising targets with potential clinical applicability for systemic gene therapeutics...
  12. pmc Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland
    Antonis Voutetakis
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Endocrinology 151:4566-72. 2010
    ....
  13. pmc Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1190, USA
    Clin Cancer Res 17:2842-51. 2011
    ..We evaluated the effect of human keratinocyte growth factor (hKGF) gene transfer to murine salivary glands on the prevention of radiation-induced salivary hypofunction...
  14. ncbi request reprint Effect of serotype 5 adenoviral and serotype 2 adeno- associated viral vector-mediated gene transfer to salivary glands on the composition of saliva
    Jianghua Wang
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892 1190, USA
    Hum Gene Ther 17:455-63. 2006
    ....
  15. doi request reprint A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    Hum Gene Ther Methods 23:169-81. 2012
    ....
  16. pmc Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer
    Antonis Voutetakis
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Gene Ther 19:1401-5. 2008
    ..We conclude that RSP proteins are faithfully secreted into saliva in all model species tested, whereas patterns of CSP protein secretion are variable...
  17. ncbi request reprint Re-engineering primary epithelial cells from rhesus monkey parotid glands for use in developing an artificial salivary gland
    Simon D Tran
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 1190, USA
    Tissue Eng 12:2939-48. 2006
    ..Together these results demonstrate that it is feasible to individually prepare RPG cells for eventual use in a prototype artificial salivary gland...
  18. ncbi request reprint Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model
    Ana P Cotrim
    Gene Therapy and Therapeutics Branch and Biostatistics Core, Division of Clinical Research and Health Promotion, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:7564-8. 2005
    ..The purpose of this study was to examine pharmacokinetic characteristics of the stable nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) with respect to radioprotection of the salivary glands...
  19. pmc Salivary epithelial cells: an unassuming target site for gene therapeutics
    Paola Perez
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Int J Biochem Cell Biol 42:773-7. 2010
    ....
  20. ncbi request reprint Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 17:1122-33. 2006
    ..In aggregate, these findings show that localized delivery of AdhAQP1 to salivary glands appears to occur without significant toxicity...
  21. ncbi request reprint Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors
    Marc R Kok
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    J Gene Med 7:432-41. 2005
    ..There are no reported studies on immune responsiveness of rAAV2 vector administration to SGs...
  22. pmc Development of a gene transfer-based treatment for radiation-induced salivary hypofunction
    Bruce J Baum
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Oral Oncol 46:4-8. 2010
    ..A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway...
  23. ncbi request reprint Modifying the NH2 and COOH termini of aquaporin-5: effects on localization in polarized epithelial cells
    Robert B Wellner
    Gene Transfer Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1190, USA
    Tissue Eng 11:1449-58. 2005
    ....
  24. doi request reprint Gene therapy of salivary diseases
    Bruce J Baum
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 666:3-20. 2010
    ....
  25. ncbi request reprint Advances in vector-mediated gene transfer
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, DHHS, Building 10, Room 1N113, MSC 1190, Bethesda, MD 20892 1190, USA
    Immunol Lett 90:145-9. 2003
    ..The status of relevant pre-clinical gene transfer studies is reviewed, with an emphasis on use of adenoviral and adeno-associated viral vectors. Current limitations of effective organ-directed gene transfer are also discussed...
  26. pmc Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function
    Bradford E Hall
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 90:543-55. 2010
    ....
  27. pmc Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands
    Yuval Samuni
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, USA
    Biochem Biophys Res Commun 373:136-9. 2008
    ..0001 and p=0.0083, respectively). These in vivo studies demonstrate for the first time that hGH, in an N- as well as C-terminal position, influences the secretion of a constitutive pathway protein...
  28. ncbi request reprint Partial redirection of transgenic human growth hormone secretion from rat salivary glands
    Jianghua Wang
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Gene Ther 16:571-83. 2005
    ..03). Although this mutant is unlikely to be therapeutically beneficial, these results suggest that the final destination of a transgenic secretory protein may be controlled by reengineering its sorting determinants...
  29. pmc Production and sorting of transgenic, modified human parathyroid hormone in vivo in rat salivary glands
    Janik Adriaansen
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Biochem Biophys Res Commun 391:768-72. 2010
    ....
  30. pmc Radioprotectors and mitigators of radiation-induced normal tissue injury
    Deborah Citrin
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncologist 15:360-71. 2010
    ..Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing...
  31. pmc In vivo secretion of the mouse immunoglobulin G Fc fragment from rat submandibular glands
    Gabor Z Racz
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Gene Med 11:580-7. 2009
    ..In the present study, we studied in vivo the sorting of the mouse immunoglobulin G2b Fc fragment, which is physiologically secreted via the constitutive pathway...
  32. ncbi request reprint Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging
    Ana P Cotrim
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:4928-33. 2007
    ..Mechanistic information was explored by monitoring the presence and bioreduction of Tempol in both tissues noninvasively by magnetic resonance imaging (MRI)...
  33. pmc Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands
    Changyu Zheng
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, 20892, USA
    Toxicol Sci 123:247-55. 2011
    ..Overall, our results are consistent with the notion that administration of the AAV2-TF2.3w-hEpo vector to salivary glands posed no significant risk in mice...
  34. ncbi request reprint Inclusion of Moloney murine leukemia virus elements upstream of the transgene cassette in an E1-deleted adenovirus leads to an unusual genomic integration in epithelial cells
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Virology 313:460-72. 2003
    ..These results suggest that the 2.7 kb of MoMLV sequence included in AdELP-luc have cis-acting functions and mediates an unusual integration event...
  35. pmc Pharmacological protection from radiation ± cisplatin-induced oral mucositis
    Ana P Cotrim
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Int J Radiat Oncol Biol Phys 83:1284-90. 2012
    ..To evaluate if two pharmacological agents, Tempol and D-methionine (D-met), are able to prevent oral mucositis in mice after exposure to ionizing radiation ± cisplatin...
  36. doi request reprint Gene therapy: some history, applications, problems, and prospects
    Ana P Cotrim
    National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, Maryland 20892 1190, USA
    Toxicol Pathol 36:97-103. 2008
    ..There is justifiable optimism that with increased pathobiological understanding and biotechnological improvements, gene therapy will become a standard part of clinical practice within 20 years...
  37. pmc Evaluation of promoters for use in tissue-specific gene delivery
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD, USA
    Methods Mol Biol 434:205-19. 2008
    ..Lastly, have a suitable transfection method to test the plasmid constructs in both the in vitro and the in vivo models...
  38. ncbi request reprint Salivary glands: novel target sites for gene therapeutics
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892 1190, USA
    Trends Mol Med 10:585-90. 2004
    ..Based on pre-clinical studies, we suggest that salivary glands are a valuable, yet under-appreciated, target tissue for both systemic and upper gastrointestinal tract gene therapeutic applications...
  39. ncbi request reprint Salivary gland gene therapy
    Ana P Cotrim
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1190, USA
    Dent Clin North Am 50:157-73, vii. 2006
    ....
  40. ncbi request reprint Synergy between genetic and tissue engineering: creating an artificial salivary gland
    Bruce J Baum
    Gene Transfer Section, NIDCR, National Institute of Health, Bethesda, Maryland, USA
    Periodontol 2000 41:218-23. 2006
  41. ncbi request reprint Localization of AQP5/AQP8 chimeras in MDCK-II cells: exchange of the N- and C-termini
    Robert B Wellner
    Gene Transfer Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Cranciofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 330:172-7. 2005
    ..Our results suggest that, unlike the other AQP targeting/retention signals reported thus far, an AQP8 basolateral targeting/retention motif might reside between the two cytosolic termini...
  42. ncbi request reprint The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model
    Joseph M Vitolo
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:1807-12. 2004
    ..The purpose of this study was to test the ability of the stable-free radical Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl), an established radioprotector, to prevent radiation-induced salivary hypofunction in mice...
  43. ncbi request reprint Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats
    Brian C O'Connell
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Oral Pathol Med 32:414-21. 2003
    ..We examined the distribution and toxicity associated with a single salivary gland administration of a recombinant adenoviral vector, AdCMVH3, encoding human histatin 3...
  44. ncbi request reprint 5.3 Global challenges in research and strategic planning
    Bruce J Baum
    NIDCR, Bethesda, MD, USA
    Eur J Dent Educ 6:179-84. 2002
    ..Global networks for mutual information exchange are imperative to overcome resource limitations in individual institutions, as is dedicated funding for research in the dental educational setting...
  45. ncbi request reprint Integration efficiency of a hybrid adenoretroviral vector
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg 10, Room 1N113, MSC 1190, Bethesda, MD 20892 1190, USA
    Biochem Biophys Res Commun 300:115-20. 2003
    ..These data provide the first quantitative evidence of the frequency for genomic integration with this hybrid vector...
  46. ncbi request reprint Evaluation of radiation-induced oral mucositis by optical coherence tomography
    Thierry M Muanza
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:5121-7. 2005
    ..Optical coherence tomography (OCT) imaging was evaluated to determine if radiation-induced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings...
  47. ncbi request reprint Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands
    Seshagiri R Nandula
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 56:1798-805. 2007
    ..The aim of this study was to delineate the precise function of TGFbeta signaling in salivary gland inflammation...
  48. ncbi request reprint Utilizing endocrine secretory pathways in salivary glands for systemic gene therapeutics
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1190, USA
    J Cell Physiol 199:1-7. 2004
    ..Existing studies suggest that clinical benefits will result from salivary gland targeted systemic gene therapeutics...
  49. ncbi request reprint Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands
    Ana P Cotrim
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892 1190, USA
    Mol Ther 15:2101-6. 2007
    ..Furthermore, our results suggest that a local transient treatment directed at protecting SG endothelial cells may be beneficial for patients undergoing IR for head and neck cancer...
  50. ncbi request reprint Further evidence for AQP8 expression in the myoepithelium of rat submandibular and parotid glands
    Robert B Wellner
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 10 Center Drive, Bldg 10, Rm 1N113, MSC 1190, Bethesda, MD 20892, USA
    Pflugers Arch 451:642-5. 2006
    ..Am J Physiol Renal Physiol 281:F1047-F1057, 2001), we report that AQP8 is expressed in the myoepithelial cells, but not in the acinar cells, of both the rat SMG and PG...
  51. ncbi request reprint Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome
    Marc R Kok
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 14:1605-18. 2003
    ....
  52. ncbi request reprint Expression of the aquaporin 8 water channel in a rat salivary epithelial cell
    A T M Shamsul Hoque
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Physiol 191:336-41. 2002
    ..Similarly, when grown on coverslips and then exposed to a hypertonic solution, SMIE cells shrunk as a function of time. Together, these results suggest that SMIE cells endogenously express functional AQP8 water channels...
  53. ncbi request reprint Can biomedical science be made relevant in dental education? A North American perspective
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892 110, USA
    Eur J Dent Educ 7:49-55; discussion 56-9. 2003
  54. ncbi request reprint Inadequate training in the biological sciences and medicine for dental students: an impending crisis for dentistry
    Bruce J Baum
    Gene Transfer Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1190, USA
    J Am Dent Assoc 138:16, 18, 20 passim. 2007
  55. pmc Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus
    Anne M Rowzee
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    PLoS ONE 8:e59222. 2013
    ..The ability to remediate a diabetic phenotype in a model of type 1 diabetes mellitus is the first step in an effort that may lead to a possible therapy for diabetes...
  56. ncbi request reprint Gene transfer to salivary glands
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Cytol 213:93-146. 2002
    ..Several examples are given, using adenoviral-mediated gene transfer, for addressing both biological and clinical questions. Additionally, benefits and shortcomings affecting the utility of this technology are discussed...
  57. ncbi request reprint Centromere protein C is a target of autoantibodies in Sjögren's syndrome and is uniformly associated with antibodies to Ro and La
    Stanley R Pillemer
    National Institute of Health, National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
    J Rheumatol 31:1121-5. 2004
    ..To determine which centromere proteins are recognized in Sjögren's syndrome (SS) and whether antibodies recognizing centromere proteins (CENP) B and CENP C identify a specific serologic subset...
  58. ncbi request reprint Etanercept in Sjögren's syndrome: a twelve-week randomized, double-blind, placebo-controlled pilot clinical trial
    Vidya Sankar
    National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Rheum 50:2240-5. 2004
    ..To assess the safety and potential efficacy of etanercept in the treatment of Sjögren's syndrome (SS)...
  59. ncbi request reprint Long-term expression after infection by the hybrid vector AdLTR-luc is from integrated transgene
    Changyu Zheng
    Gene Therapy and Therapeutics Branch, National Institutes of Health, Bethesda, Maryland 20892 1190, USA
    Biochem Biophys Res Commun 291:34-40. 2002
    ..Similar analyses of low molecular weight DNA extracts indicated the absence of intact extrachromosomal vector. These data demonstrate that long-term luciferase expression after infection by AdLTR-luc is derived from the integrated cDNA...
  60. ncbi request reprint Will dentistry be left behind at the healthcare station?
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    J Am Coll Dent 71:27-30. 2004
    ..It is argued that education must be changed to teach the context and understanding of this technology. The alternative will be to concede important aspects of oral health care to physicians and others trained in their use...
  61. ncbi request reprint Expanding horizons: modern science enters the mouth
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, MD 20892, USA
    Refuat Hapeh Vehashinayim 21:7-13, 99. 2004
    ..It is important for dentists and dentistry to prepare for this occurrence...
  62. ncbi request reprint Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream
    Seiichi Yamano
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 13:287-98. 2002
    ....
  63. ncbi request reprint Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer
    Xing Yan
    Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, School of Stomatology, Capital Medical University, Beijing, PR China
    J Gene Med 9:779-87. 2007
    ....
  64. ncbi request reprint Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig
    Jun Li
    Salivary Gland Disease Center and Molecular Laboratory for Gene Therapy, Faculty of Stomatology, Capital University of Medical Sciences, Beijing, PR China
    Int J Radiat Oncol Biol Phys 62:1510-6. 2005
    ..To evaluate the effects of a solitary megadose protocol of ionizing radiation (IR) on the structure and function of the miniature pig (minipig) parotid gland...
  65. ncbi request reprint Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Arch Otolaryngol Head Neck Surg 129:247-50. 2003
  66. ncbi request reprint Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study
    Simon D Tran
    National Institute of Dental and Craniofacial Research, Gene Therapy and Therapeutics Branch National Institutes of Health, Bethesda, MD 20892 1190, USA
    Lancet 361:1084-8. 2003
    ..We aimed to determine whether fusion events are important in vivo...
  67. ncbi request reprint The impact of gene therapy on dentistry: a revisiting after six years
    Bruce J Baum
    Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    J Am Dent Assoc 133:35-44. 2002
    ..The procedure involves the transfer of genes to patients for clinical benefit. Transferred genes can b e used for either reparative or pharmacological purposes...
  68. ncbi request reprint Developing a convenient large animal model for gene transfer to salivary glands in vivo
    Jun Li
    Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, Faculty of Stomatology, Capital University of Medical Sciences, Beijing, P R China
    J Gene Med 6:55-63. 2004
    ..The purpose of this study was to perform an initial assessment of the efficacy and safety of adenoviral-vector-mediated gene transfer to parotid glands of miniature pigs...
  69. ncbi request reprint Ethics in science
    Bruce J Baum
    Oral Dis 13:125. 2007
  70. ncbi request reprint Risk factors for positive minor salivary gland biopsy findings in Sjögren's syndrome and dry mouth patients
    Michael T Brennan
    National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 47:189-95. 2002
    ..To investigate risk factors for positive minor salivary gland biopsy results in Sjögren's syndrome (SS) and dry mouth patients...
  71. ncbi request reprint Xerostomia and the geriatric patient
    Jonathan A Ship
    Department of Oral Medicine, Bluestone Center for Clinical Research, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA
    J Am Geriatr Soc 50:535-43. 2002
    ..Treatments for salivary problems are based upon establishing a diagnosis, protecting oral and pharyngeal health, stimulating remaining glands, and replacing lost salivary fluids...