Thomas R Bauer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1203, USA
    Exp Hematol 33:706-12. 2005
  2. pmc Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC1203, Bldg 10 CRC, Rm 3 3264, Bethesda, MD 20892 1203, USA
    Blood 108:3313-20. 2006
  3. ncbi request reprint Very low levels of donor CD18+ neutrophils following allogeneic hematopoietic stem cell transplantation reverse the disease phenotype in canine leukocyte adhesion deficiency
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 12C 116, 10 Center Dr, MSC1907, Bethesda, MD 20892 1907, USA
    Blood 103:3582-9. 2004
  4. pmc Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch of the Center for Cancer Research at the National Cancer Institute of the National Institutes of Health in Bethesda, Maryland 20892, USA
    ILAR J 50:168-86. 2009
  5. ncbi request reprint Mixed chimeric hematopoietic stem cell transplant reverses the disease phenotype in canine leukocyte adhesion deficiency
    Kate E Creevy
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Vet Immunol Immunopathol 95:113-21. 2003
  6. pmc Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency
    Robert A Sokolic
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 11:755-63. 2005
  7. ncbi request reprint Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors
    Thomas R Bauer
    Experimental Transplantation and Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC1203, Building 10 CRC, Room 3 3330, Bethesda, Maryland 20892, USA
    Nat Med 14:93-7. 2008
  8. pmc Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 21:964-72. 2013
  9. ncbi request reprint Leukocyte adhesion deficiency in children and Irish setter dogs
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center MSC1907, Building 10, Room 12C116, Bethesda, MD 20892, USA
    Pediatr Res 55:363-7. 2004
  10. pmc Gene therapy for canine leukocyte adhesion deficiency with lentiviral vectors using the murine stem cell virus and human phosphoglycerate kinase promoters
    Michael J Hunter
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1203, USA
    Hum Gene Ther 22:689-96. 2011

Detail Information

Publications15

  1. ncbi request reprint Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1203, USA
    Exp Hematol 33:706-12. 2005
    ....
  2. pmc Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC1203, Bldg 10 CRC, Rm 3 3264, Bethesda, MD 20892 1203, USA
    Blood 108:3313-20. 2006
    ....
  3. ncbi request reprint Very low levels of donor CD18+ neutrophils following allogeneic hematopoietic stem cell transplantation reverse the disease phenotype in canine leukocyte adhesion deficiency
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 12C 116, 10 Center Dr, MSC1907, Bethesda, MD 20892 1907, USA
    Blood 103:3582-9. 2004
    ..These results demonstrate the value of a disease-specific, large-animal model for identifying the lowest therapeutic level required for successful cellular and gene therapy...
  4. pmc Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systems
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch of the Center for Cancer Research at the National Cancer Institute of the National Institutes of Health in Bethesda, Maryland 20892, USA
    ILAR J 50:168-86. 2009
    ....
  5. ncbi request reprint Mixed chimeric hematopoietic stem cell transplant reverses the disease phenotype in canine leukocyte adhesion deficiency
    Kate E Creevy
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Vet Immunol Immunopathol 95:113-21. 2003
    ..These results indicate that mixed hematopoietic chimerism reverses the clinical phenotype in CLAD and represents a potential therapeutic approach for the human disease leukocyte adhesion deficiency...
  6. pmc Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency
    Robert A Sokolic
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 11:755-63. 2005
    ..These results indicate that a nonmyeloablative conditioning regimen with chemotherapy alone is capable of generating stable mixed chimerism and reversal of the disease phenotype in CLAD...
  7. ncbi request reprint Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors
    Thomas R Bauer
    Experimental Transplantation and Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC1203, Building 10 CRC, Room 3 3330, Bethesda, Maryland 20892, USA
    Nat Med 14:93-7. 2008
    ..These results represent the first successful use of a foamy virus vector to treat a genetic disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human hematopoietic diseases...
  8. pmc Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 21:964-72. 2013
    ....
  9. ncbi request reprint Leukocyte adhesion deficiency in children and Irish setter dogs
    Thomas R Bauer
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center MSC1907, Building 10, Room 12C116, Bethesda, MD 20892, USA
    Pediatr Res 55:363-7. 2004
    ....
  10. pmc Gene therapy for canine leukocyte adhesion deficiency with lentiviral vectors using the murine stem cell virus and human phosphoglycerate kinase promoters
    Michael J Hunter
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1203, USA
    Hum Gene Ther 22:689-96. 2011
    ..In this regard, the hPGK promoter directed low levels of expression of CD18 on neutrophils compared to the MSCV promoter, likely contributing to the suboptimal clinical outcome with the hPGK vector...
  11. pmc Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with nonmyeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation
    Tanya H Burkholder
    Division of Veterinary Resources, Office of Research Services, National Institutes of Health, 9000 Rockville Pike, Bldg 28, Rm 104, Bethesda, MD 20892 0001, USA
    Blood 108:1767-9. 2006
    ..These results are encouraging for children and adults of childbearing age who receive similar conditioning regimens prior to allogeneic transplantation...
  12. ncbi request reprint Canine leukocyte adhesion deficiency colony for investigation of novel hematopoietic therapies
    Kate E Creevy
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Rm 12C 116, 10 Center Drive, Bethesda, MD 20892, USA
    Vet Immunol Immunopathol 94:11-22. 2003
    ....
  13. pmc Gene therapy of canine leukocyte adhesion deficiency using lentiviral vectors with human CD11b and CD18 promoters driving canine CD18 expression
    Michael J Hunter
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1203, USA
    Mol Ther 19:113-21. 2011
    ..These studies using endogenous leukocyte integrin proximal promoters represent an important step in the development of gene therapy for children with LAD-1...
  14. ncbi request reprint The genetic immunodeficiency disease, leukocyte adhesion deficiency, in humans, dogs, cattle, and mice
    Yu Chen Gu
    Experimental Transplantation and Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Comp Med 54:363-72. 2004
    ..The success of this approach is dependent on the relationship of the phenotype in the animal to the phenotype of the disease in humans...
  15. pmc Leukocyte integrin activation mediates transient neutropenia after G-CSF administration
    Robert E Donahue
    Hematology Branch, National Heart, Lung, and Blood Institute, Rockville, MD, USA
    Blood 118:4209-14. 2011
    ..These results demonstrate that the leukocyte integrin on circulating neutrophils is transiently activated after G-CSF administration and mediates the transient neutropenia observed after G-CSF administration...