J F Battey

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Stem cells: current challenges and future promise
    James F Battey
    National Institutes of Health, Bethesda, Maryland, USA
    Dev Dyn 236:3193-8. 2007
  2. ncbi request reprint A stem cell primer
    James F Battey
    National Institute on Deafness and Other Communication Disorders, National Institute of Health, Bethesda, 20892, USA
    Pediatr Res 59:1R-3R. 2006
  3. ncbi request reprint An action plan for mouse genomics
    J Battey
    National Institute on Deafness and Other Communication Disorders, NIH Building 31, Bethesda, Maryland 20892, USA
    Nat Genet 21:73-5. 1999
  4. pmc International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states
    R T Jensen
    Digestive Diseases Branch, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Pharmacol Rev 60:1-42. 2008
  5. ncbi request reprint Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis
    S O Moldin
    Genetics Research Branch, Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, National Institutes of Health NIH, 6001 Executive Blvd, Room 7189, MSC 9643, Bethesda, Maryland 20892 9643, USA
    Mamm Genome 12:575-81. 2001
  6. ncbi request reprint Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzae
    Xin Xing Gu
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
    Vaccine 21:2107-14. 2003
  7. ncbi request reprint Using genetics to understand auditory function and improve diagnosis
    James F Battey
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD USA
    Ear Hear 24:266-9. 2003
  8. pmc Neuroscience networks: data-sharing in an information age
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland, USA
    PLoS Biol 1:E17. 2003
  9. ncbi request reprint Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892 9669, USA
    Nat Neurosci 7:426-7. 2004
  10. pmc The knockout mouse project
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:921-4. 2004

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Stem cells: current challenges and future promise
    James F Battey
    National Institutes of Health, Bethesda, Maryland, USA
    Dev Dyn 236:3193-8. 2007
    ..Given the remarkable potential, NIH support for research using stem cells is an important priority for the foreseeable future...
  2. ncbi request reprint A stem cell primer
    James F Battey
    National Institute on Deafness and Other Communication Disorders, National Institute of Health, Bethesda, 20892, USA
    Pediatr Res 59:1R-3R. 2006
  3. ncbi request reprint An action plan for mouse genomics
    J Battey
    National Institute on Deafness and Other Communication Disorders, NIH Building 31, Bethesda, Maryland 20892, USA
    Nat Genet 21:73-5. 1999
    ....
  4. pmc International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states
    R T Jensen
    Digestive Diseases Branch, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Pharmacol Rev 60:1-42. 2008
    ..This review summarizes advances in our understanding of the biology/pharmacology of these receptors, including their classification, structure, pharmacology, physiology, and role in pathophysiological conditions...
  5. ncbi request reprint Trans-NIH neuroscience initiatives on mouse phenotyping and mutagenesis
    S O Moldin
    Genetics Research Branch, Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, National Institutes of Health NIH, 6001 Executive Blvd, Room 7189, MSC 9643, Bethesda, Maryland 20892 9643, USA
    Mamm Genome 12:575-81. 2001
    ..Such research tools ultimately will permit the manipulation and analysis of the mouse genome, as a means of gaining insight into the genetic bases of the mammalian nervous system and its complex disorders...
  6. ncbi request reprint Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzae
    Xin Xing Gu
    National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA
    Vaccine 21:2107-14. 2003
    ..The LOS-TT conjugate is well tolerant in adults and a Phase II evaluation of the conjugate in children is planned...
  7. ncbi request reprint Using genetics to understand auditory function and improve diagnosis
    James F Battey
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD USA
    Ear Hear 24:266-9. 2003
  8. pmc Neuroscience networks: data-sharing in an information age
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland, USA
    PLoS Biol 1:E17. 2003
  9. ncbi request reprint Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892 9669, USA
    Nat Neurosci 7:426-7. 2004
  10. pmc The knockout mouse project
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:921-4. 2004
    ..It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain...
  11. ncbi request reprint Technical assessment of the first 20 years of research using mouse embryonic stem cell lines
    Gregory J Downing
    Office of Technology and Industrial Relations, National Cancer Institute, National Institutes of Health, Building 31, Room 10A 52, MSC 2580, 31 Center Drive, Bethesda, MD 20892 2580, USA
    Stem Cells 22:1168-80. 2004
    ..This review concludes with a brief analysis of the most influential mouse ES cell lines of the first 20 years as viewed within the twin contexts of human disease application and contributions to the primary literature...
  12. ncbi request reprint A short primer on stem cells
    Elias A Zerhouni
    National Institutes of Health, USA
    Md Med 6:14-7. 2005
  13. ncbi request reprint Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts
    Ricky J L Haywood-Watson
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, and the Molecular and Cellular Biology Program, Tulane University, New Orleans, LA, USA
    Invest Ophthalmol Vis Sci 47:3074-84. 2006
    ..In this study, the auditory, visual and molecular biological phenotype of Pcdh15av-5J and Pcdh15av-Jfb mice is characterized, and their usefulness as animal models of USH1 is evaluated...
  14. pmc Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration
    Zubair M Ahmed
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, MD 20850, USA
    Mol Vis 14:2227-36. 2008
    ..Does homozygosity for both v and av mutant alleles (i.e., a double homozygous mouse) cause retinal degeneration or an obvious retinal histopathology?..
  15. ncbi request reprint Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function
    Kiyoto Kurima
    Section on Gene Structure and Function, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland 20850, USA
    Nat Genet 30:277-84. 2002
    ..Tmc1 mRNA is expressed in hair cells of the postnatal mouse cochlea and vestibular end organs and is required for normal function of cochlear hair cells...
  16. pmc Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides
    L h Wang
    Digestive Diseases Branch, National Institutes of Health, Bethesda, MD 20892
    Biochem J 286:641-8. 1992
    ....
  17. ncbi request reprint Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells
    M H Corjay
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 266:18771-9. 1991
    ..These results indicate heterogeneity of bombesin receptor subtypes exists in human lung carcinoma cells and should be considered in the design of bombesin receptor antagonists intended to inhibit tumor cell growth...
  18. pmc Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells
    J F Battey
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 88:395-9. 1991
    ..Expression of the GRP receptor cDNA in model systems potentially provides a powerful assay for the development of subtype-specific receptor antagonists that may prove to be of therapeutic importance in human small cell lung carcinoma...
  19. ncbi request reprint Expression and characterization of cloned human bombesin receptors
    R V Benya
    Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Mol Pharmacol 47:10-20. 1995
    ..Minimal native huNMB-R data are available for comparison, but in general the huNMB-R is similar to the rat NMB receptor in its pharmacology and cell biology...
  20. ncbi request reprint Receptor-activated currents in mouse fibroblasts expressing transfected bombesin receptor subtype cDNAs
    K Kusano
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Am J Physiol 265:C869-76. 1993
    ..However, at these concentrations, these four antagonists had little effect on NmB Rt responses, thereby showing a specificity of these antagonists for the GRP receptors...
  21. ncbi request reprint BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells
    Z Fathi
    Department of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:5979-84. 1993
    ..These results suggest a role for BN-like peptides and their receptors in mammalian reproductive physiology and also indicate that BRS-3 could serve as a potential therapeutic target for human lung carcinoma...
  22. ncbi request reprint The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding
    Z Fathi
    Laboratory of Biological Chemistry, Development Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20892
    J Biol Chem 268:14622-6. 1993
    ..These results suggest that ILe216 in TM-V of NMB-R may be critical for high affinity NMB binding...
  23. pmc Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice
    L L Hampton
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 95:3188-92. 1998
    ..These data suggest that selective agonists for the GRP-R may be useful in inducing satiety...
  24. ncbi request reprint Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3
    R R Ryan
    Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:13613-24. 1998
    ....
  25. ncbi request reprint Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor
    E Sainz
    Laboratory of Molecular Biology, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:15927-32. 1998
    ..In contrast, these four amino acid substitutions in BRS-3 did not result in the formation of a high affinity binding site for the recently described non-peptide NMB-R antagonist PD168368...
  26. ncbi request reprint Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter
    H C Weber
    Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Gene 244:137-49. 2000
    ....
  27. ncbi request reprint Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells
    Nelson D LopezJimenez
    Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorder, National Institutes of Health, Rockville, Maryland, USA
    J Neurochem 98:68-77. 2006
    ..These results provide the first evidence for a role of TRPP channels in taste receptor cell function...
  28. pmc Signatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear
    Linda M Peters
    Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Genomics 89:197-206. 2007
    ..Utilization of these resources will increase the number of known transcription units and expand our knowledge of the tissue-specific regulation of the transcriptome...
  29. ncbi request reprint A new spontaneous mutation in the mouse Ames waltzer gene, Pcdh15
    Lori L Hampton
    G Protein Coupled Receptors Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Hear Res 180:67-75. 2003
    ..The new allele of Ames waltzer, designated Pcdh15(av-Jfb), may aid in studying the histopathology associated with Usher syndrome type 1F, which is caused by a functional null allele of PCDH15...
  30. ncbi request reprint Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear
    Gleb P Shumyatsky
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 111:905-18. 2002
    ..These experiments provide genetic evidence that GRP and its neural circuitry operate as a negative feedback regulating fear and establish a causal relationship between Grpr gene expression, LTP, and amygdala-dependent memory for fear...
  31. pmc Factors contributing to obesity in bombesin receptor subtype-3-deficient mice
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21205, USA
    Endocrinology 149:971-8. 2008
    ..However, our finding that pair-feeding did not completely normalize fat distribution and plasma leptin levels suggests there is also a metabolic dysregulation that may contribute to, or sustain, their obese phenotype...
  32. ncbi request reprint Research education and training in otolaryngology: meeting summary and research opportunities
    Jennifer R Grandis
    Departments of Otolaryngology and Pharmacology, Eye and Ear Institute Building, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Otolaryngol Head Neck Surg 135:361-7. 2006
  33. ncbi request reprint Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract
    Robert E Carroll
    Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center West Side Division, 840 South Wood Street m c 787, Chicago, IL 60612, USA
    Mech Dev 113:121-30. 2002
    ..Thus, this study shows for the first time that GRP/GRP-R play a transient and non-critical role in intestinal development, yet provides a rationale for their re-appearance in colon cancer...