Affiliation: National Institutes of Health
Basselin M, Chang L, Seemann R, Bell J, Rapoport S. Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats. J Neurochem. 2003;85:1553-62 pubmed
Basselin M, Villacreses N, Lee H, Bell J, Rapoport S. Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation. J Neurochem. 2007;102:761-72 pubmed
..To the extent that this up-regulation has neuropathological consequences, lithium might be considered for treating human brain diseases accompanied by neuroinflammation. ..
Basselin M, Nguyen H, Chang L, Bell J, Rapoport S. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. J Alzheimers Dis. 2009;17:369-82 pubmed publisher
..In contrast, the AA signal in response to arecoline was not altered following donepezil. ..
Ramadan E, Blanchard H, Cheon Y, Fox M, Chang L, Chen M, et al
. Transient postnatal fluoxetine leads to decreased brain arachidonic acid metabolism and cytochrome P450 4A in adult mice. Prostaglandins Leukot Essent Fatty Acids. 2014;90:191-7 pubmed publisher
..These changes might contribute to reported altered behavior following early SSRI in rodents. ..
Basselin M, Villacreses N, Langenbach R, Ma K, Bell J, Rapoport S. Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse. J Neurochem. 2006;96:669-79 pubmed
..This response likely reflects selective COX-2-mediated conversion of PLA2-released AA to prostanoids. ..
Basselin M, Chang L, Seemann R, Bell J, Rapoport S. Chronic lithium administration to rats selectively modifies 5-HT2A/2C receptor-mediated brain signaling via arachidonic acid. Neuropsychopharmacology. 2005;30:461-72 pubmed
..These selective effects may be related to lithium's therapeutic efficacy in patients with bipolar disorder, particularly its ability to ameliorate hallucinations in that disease. ..
Basselin M, Fox M, Chang L, Bell J, Greenstein D, Chen M, et al
. Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice. Neuropsychopharmacology. 2009;34:1695-709 pubmed publisher
..Increased baseline AA signaling in humans having polymorphisms with reduced 5-HTT function might be identified using positron emission tomography. ..