Mireille Basselin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 85:1553-62. 2003
  2. pmc Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat lipopolysaccharide model of neuroinflammation
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 51:1049-56. 2010
  3. pmc Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, Bethesda, MD 20892, USA
    J Alzheimers Dis 17:369-82. 2009
  4. pmc Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 34:1695-709. 2009
  5. pmc Chronic administration of valproic acid reduces brain NMDA signaling via arachidonic acid in unanesthetized rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, MSC 0947, 9 Memorial Drive, Bethesda, MD, 20892, USA
    Neurochem Res 33:2229-40. 2008
  6. doi request reprint Chronic carbamazepine administration attenuates dopamine D2-like receptor-initiated signaling via arachidonic acid in rat brain
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, Bethesda, MD 20892, USA
    Neurochem Res 33:1373-83. 2008
  7. pmc Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 62:934-43. 2007
  8. ncbi request reprint Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, MSC 0947, 9 Memorial Drive, Bethesda, MD 20892, USA
    Neurochem Res 32:1857-67. 2007
  9. ncbi request reprint Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda 20892 0947, Maryland, USA
    J Neurochem 102:761-72. 2007
  10. ncbi request reprint Chronic lithium administration to rats selectively modifies 5-HT2A/2C receptor-mediated brain signaling via arachidonic acid
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:461-72. 2005

Detail Information

Publications35

  1. ncbi request reprint Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 85:1553-62. 2003
    ....
  2. pmc Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat lipopolysaccharide model of neuroinflammation
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 51:1049-56. 2010
    ..This study demonstrates, for the first time, that lithium can increase brain 17-hydroxy-DHA formation, indicating a new and potentially important therapeutic action of lithium...
  3. pmc Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, Bethesda, MD 20892, USA
    J Alzheimers Dis 17:369-82. 2009
    ..In contrast, the AA signal in response to arecoline was not altered following donepezil...
  4. pmc Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 34:1695-709. 2009
    ..Increased baseline AA signaling in humans having polymorphisms with reduced 5-HTT function might be identified using positron emission tomography...
  5. pmc Chronic administration of valproic acid reduces brain NMDA signaling via arachidonic acid in unanesthetized rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, MSC 0947, 9 Memorial Drive, Bethesda, MD, 20892, USA
    Neurochem Res 33:2229-40. 2008
    ..These results, taken with evidence that carbamazepine and lithium also block k* responses to NMDA in rat brain, suggest that mood stabilizers act in bipolar disorder in part by downregulating glutamatergic signaling involving AA...
  6. doi request reprint Chronic carbamazepine administration attenuates dopamine D2-like receptor-initiated signaling via arachidonic acid in rat brain
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, Bethesda, MD 20892, USA
    Neurochem Res 33:1373-83. 2008
    ..These findings are consistent with the hypothesis that effective mood stabilizers generally downregulate brain AA signaling via D2-like receptors, and that this signaling is upregulated in bipolar disorder...
  7. pmc Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 62:934-43. 2007
    ..Lithium in rats also attenuates brain N-methyl-D-aspartic acid receptor (NMDAR) signaling via AA. We hypothesized that, like chronic lithium, chronic CBZ administration to rats would reduce NMDAR-mediated signaling via AA...
  8. ncbi request reprint Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, MSC 0947, 9 Memorial Drive, Bethesda, MD 20892, USA
    Neurochem Res 32:1857-67. 2007
    ....
  9. ncbi request reprint Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda 20892 0947, Maryland, USA
    J Neurochem 102:761-72. 2007
    ..To the extent that this up-regulation has neuropathological consequences, lithium might be considered for treating human brain diseases accompanied by neuroinflammation...
  10. ncbi request reprint Chronic lithium administration to rats selectively modifies 5-HT2A/2C receptor-mediated brain signaling via arachidonic acid
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:461-72. 2005
    ..These selective effects may be related to lithium's therapeutic efficacy in patients with bipolar disorder, particularly its ability to ameliorate hallucinations in that disease...
  11. ncbi request reprint Chronic lithium chloride administration to unanesthetized rats attenuates brain dopamine D2-like receptor-initiated signaling via arachidonic acid
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:1064-75. 2005
    ..The results suggest that downregulation by lithium of D2-like receptor signaling involving PLA2 and AA may contribute to lithium's therapeutic efficacy in bipolar disorder...
  12. ncbi request reprint Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 31:1659-74. 2006
    ..The results show that it is possible to image NMDA signaling via PLA2 activation and AA release in vivo, and that chronic lithium blocks this signaling, consistent with its suggested mechanism of action in BD...
  13. ncbi request reprint Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
    J Neurochem 96:669-79. 2006
    ..This response likely reflects selective COX-2-mediated conversion of PLA2-released AA to prostanoids...
  14. ncbi request reprint Chronic lithium chloride administration to rats elevates glucose metabolism in wide areas of brain, while potentiating negative effects on metabolism of dopamine D2-like receptor stimulation
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, 9 Memorial Drive, Bethesda, MD 20892 0947, USA
    Psychopharmacology (Berl) 187:303-11. 2006
    ..Knowing these effects may elucidate and localize the therapeutic action of lithium in bipolar disorder...
  15. pmc Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats
    Epolia Ramadan
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 61:1256-64. 2011
    ..We hypothesized that valproate (VPA), with mood-stabilizing properties, would also reduce D(2)-like-mediated signaling via AA...
  16. pmc Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 31:486-93. 2011
    ..Positron emission tomography with [1-(11)C]AA could be used to test whether brain AA metabolism is upregulated in HIV-1-infected patients, in relation to cognitive and behavioral disturbances...
  17. pmc Lamotrigine blocks NMDA receptor-initiated arachidonic acid signalling in rat brain: implications for its efficacy in bipolar disorder
    Epolia Ramadan
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Neuropsychopharmacol 15:931-43. 2012
    ..Since markers of the AA cascade and of NMDAR signalling are up-regulated in the post-mortem BD brain, mood stabilizers generally may be effective in BD by dampening NMDAR signalling and the AA cascade...
  18. pmc Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse
    Epolia Ramadan
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Neurosci 122:373-80. 2012
    ..We hypothesized that tonic overactivation of D(2)-like receptors in DAT(-/-) mice due to the excess DA would not increase brain AA signaling, because of compensatory downregulation of postsynaptic DA signaling mechanisms...
  19. pmc Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammation
    Matthew Kellom
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 9, 1S 126, Bethesda, MD, USA
    BMC Neurosci 13:50. 2012
    ..5 ng/h) and a high-dose (250 ng/h) of LPS on neuroinflammatory, AA cascade, and pre- and post-synaptic markers in rat brain. We used artificial cerebrospinal fluid-infused brains as controls...
  20. pmc Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder
    Hiren R Modi
    Brain Physiology and Metabolism Section, National Institute on Aging, Laboratory of Neurosciences, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1831:880-6. 2013
    ..We tested whether non-teratogenic VPA analogues might also inhibit Acsl4 catalyzed acylation, and thus have a potential anti-BD action...
  21. pmc Extracellular-derived calcium does not initiate in vivo neurotransmission involving docosahexaenoic acid
    Epolia Ramadan
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 51:2334-40. 2010
    ..DHA signaling may be mediated by iPLA(2), plasmalogen PLA(2), or other enzymes insensitive to low concentrations of Ca(2+). Greater AA than DHA release during glutamate-induced excitotoxicity could cause brain cell damage...
  22. ncbi request reprint Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, 9000 Rockville Pike, Bldg, 9, 1S 126, Bethesda, MD 20892, USA
    J Neuroinflammation 9:19. 2012
    ..Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats. Journal of Neuroinflammation 8:101...
  23. pmc Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats
    Lisa Chang
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 29:648-58. 2009
    ..The effect shows rapid desensitization and is produced at a nicotine dose equivalent to smoking one cigarette in humans...
  24. pmc Transient postnatal fluoxetine leads to decreased brain arachidonic acid metabolism and cytochrome P450 4A in adult mice
    Epolia Ramadan
    Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Prostaglandins Leukot Essent Fatty Acids 90:191-7. 2014
    ..These changes might contribute to reported altered behavior following early SSRI in rodents. ..
  25. pmc Chronic lithium feeding reduces upregulated brain arachidonic acid metabolism in HIV-1 transgenic rat
    Epolia Ramadan
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg 9, Rm 1S126 MSC 0947, Bethesda, MD 20892, USA
    J Neuroimmune Pharmacol 7:701-13. 2012
    ..Lithium may improve cognitive dysfunction and be neuroprotective in HIV-1 patients with HAND through a comparable effect...
  26. pmc Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 87:154-71. 2012
    ..The method has been extended for the use with positron emission tomography (PET), and can be employed to determine how human brain AA/DHA signaling and consumption are influenced by diet, aging, disease and genetics...
  27. pmc Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Prostaglandins Other Lipid Mediat 96:109-13. 2011
    ..Thus, quantitative imaging of DHA incorporation from plasma into brain can be used as an in vivo biomarker of brain DHA metabolism and neurotransmission...
  28. pmc Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA(2)β (VIA)-deficient mice
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 51:3166-73. 2010
    ..Positron emission tomography might be used to image disturbed brain DHA metabolism in patients with PLA2G6 mutations...
  29. pmc Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats
    Ameer Y Taha
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Prostaglandins Leukot Essent Fatty Acids 87:91-101. 2012
    ..The profound changes in heart, plasma and liver lipid concentrations suggest a direct effect of chronic exposure to the HIV-1 virus on peripheral lipid (including PUFA) metabolism...
  30. pmc Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats
    Jagadeesh Sridhara Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, Bethesda, MD 20892, USA
    J Neuroinflammation 8:101. 2011
    ..We recently reported upregulated brain AA metabolism in 7- to 9-month-old HIV-1 Tg rats. We hypothesized that these HIV-1 Tg rats also would show upregulated brain inflammatory and AA cascade markers and a deficit of synaptic proteins...
  31. ncbi request reprint Altered brain lipid composition in cyclooxygenase-2 knockout mouse
    Kaizong Ma
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 48:848-54. 2007
    ..A lifetime absence of COX-2 produces multiple changes in brain lipid composition. These changes may be related to reported changes in fatty acid kinetics and in resistance to neuroinflammation and excitotoxicity in the COX-2(-/-) mouse...
  32. pmc Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neurochem Res 36:139-45. 2011
    ..The ability of ASA to increase anti-inflammatory LXA₄ and 15-epi-LXA₄ and reduce pro-inflammatory PGE₂ and TXB₂ suggests considering aspirin further for treating clinical neuroinflammation...
  33. pmc Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder
    Jakob A Shimshoni
    National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1811:163-9. 2011
    ..Our aim was to identify a rat Acsl isoenzyme that could be inhibited by VPA in vitro...
  34. pmc Bipolar disorder and mechanisms of action of mood stabilizers
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Brain Res Rev 61:185-209. 2009
    ..This review presents ways to test these suggestions...
  35. pmc Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4
    Hiren R Modi
    Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Bipolar Disord 16:875-80. 2014
    ..However, VPA is teratogenic. We tested whether valnoctamide (VCD), a non-teratogenic amide derivative of a VPA chiral isomer, which had antimanic potency in a phase III BD trial, also inhibits recombinant Acsl4...