Heidi Barth

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 82:3466-79. 2008
  2. ncbi Mouse models for the study of HCV infection and virus-host interactions
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Hepatol 49:134-42. 2008
  3. ncbi Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    J Virol 80:10579-90. 2006
  4. ncbi Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes
    Heidi Barth
    Dept. of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    J Virol 79:5774-85. 2005
  5. ncbi Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C
    Daniel Steinmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 78:9030-40. 2004
  6. ncbi Uptake and presentation of hepatitis C virus-like particles by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    Blood 105:3605-14. 2005
  7. ncbi Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion
    Anita Haberstroh
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Gastroenterology 135:1719-1728.e1. 2008
  8. ncbi Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection
    Xiping Zhao
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Clin Invest 109:221-32. 2002
  9. ncbi Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Hepatology 54:1135-48. 2011
  10. ncbi Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles
    Marco Hoffmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Innate Immun 1:446-54. 2009

Collaborators

Detail Information

Publications19

  1. ncbi Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 82:3466-79. 2008
    ....
  2. ncbi Mouse models for the study of HCV infection and virus-host interactions
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Hepatol 49:134-42. 2008
    ..Finally, the perspective of these models for future HCV research as well as the design of novel small animal models is discussed...
  3. ncbi Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    J Virol 80:10579-90. 2006
    ..Mapping of viral and cellular determinants of HCV-HS interaction sets the stage for the development of novel HS-based antiviral strategies targeting viral attachment and entry...
  4. ncbi Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes
    Heidi Barth
    Dept. of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    J Virol 79:5774-85. 2005
    ..Furthermore, the structural and functional similarities between human and tupaia SR-BI indicate that PTH represent a useful model system to characterize the molecular interaction of the HCV envelope and SR-BI on primary hepatocytes...
  5. ncbi Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C
    Daniel Steinmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 78:9030-40. 2004
    ....
  6. ncbi Uptake and presentation of hepatitis C virus-like particles by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    Blood 105:3605-14. 2005
    ..Furthermore, HCV-LP-mediated DC activation and efficient antigen presentation may explain the marked immunogenicity of HCV-LPs in vivo...
  7. ncbi Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion
    Anita Haberstroh
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Gastroenterology 135:1719-1728.e1. 2008
    ..Retroviral HCV pseudotypes (HCVpp) and recombinant cell culture-derived HCV (HCVcc) have been successfully used to study viral entry and antibody-mediated neutralization...
  8. ncbi Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection
    Xiping Zhao
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Clin Invest 109:221-32. 2002
    ..Thus, primary Tupaia hepatocytes provide a potential model for the study of HCV infection of hepatocytes...
  9. ncbi Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Hepatology 54:1135-48. 2011
    ..CONCLUSION: Our study shows that protective immunity against HCV reinfection is orchestrated by a complex network of innate and adaptive immune responses...
  10. ncbi Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles
    Marco Hoffmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Innate Immun 1:446-54. 2009
    ..Impairment of interaction between TLR and the core in infectious viral particles may contribute to escape from innate antiviral immune responses...
  11. ncbi Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation
    Takanobu Kato
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 48:732-40. 2008
    ..CONCLUSION: Our study shows that the HCV JFH-1 strain causes attenuated infection and low pathogenicity in chimpanzees and is capable of adapting in vivo with a unique mutation conferring an enhanced replicative phenotype...
  12. ncbi Hepatitis C virus entry: molecular biology and clinical implications
    Heidi Barth
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Hepatology 44:527-35. 2006
    ..Clinical implications of this important process for the pathogenesis of HCV infection and novel therapeutic interventions are discussed...
  13. ncbi Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate
    Heidi Barth
    Department of Medicine II, University of Freiburg, D-79106 Freiburg, Germany
    J Biol Chem 278:41003-12. 2003
    ..Docking of E2 to cellular HSPG may be the initial step in the interaction between HCV and the cell surface resulting in receptor-mediated entry and initiation of infection...
  14. ncbi Binding of hepatitis C virus-like particles derived from infectious clone H77C to defined human cell lines
    Sabine Wellnitz
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 76:1181-93. 2002
    ....
  15. ncbi CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection
    Daisuke Akazawa
    Pharmaceutical Research Laboratories, Toray Industries, Inc, Kanagawa, Japan
    J Virol 81:5036-45. 2007
    ..In conclusion, CD81 expression is an important determinant of HCV permissiveness of Huh7 cell clones harboring different characteristics...
  16. ncbi Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81
    Mirjam B Zeisel
    Institut National de la Sante et de la Recherche Medicale INSERM, U748, Strasbourg, France
    Hepatology 46:1722-31. 2007
    ..Conclusion: Our data suggest that SR-BI (i) represents a key host factor for HCV entry, (ii) is implicated in the same HCV entry pathway as CD81, and (iii) targets an entry step closely linked to HCV-CD81 interaction...
  17. ncbi Neutralizing antibodies in hepatitis C virus infection
    Mirjam B Zeisel
    Inserm Unite 748, Universite Louis Pasteur, 3 Rue Koeberle, Strasbourg F 67000, France
    World J Gastroenterol 13:4824-30. 2007
    ..This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis...
  18. ncbi Analysis of the effect of IL-12 therapy on immunoregulatory T-cell subsets in patients with chronic hepatitis C infection
    Heidi Barth
    Medizinische Klinik, Innere Medizin II, , , Germany
    Hepatogastroenterology 50:201-6. 2003
    ..The significantly enhanced production of BCG-induced TNF-alpha may, however, indicate an activation of antigen presenting cells or natural killer cells...
  19. ncbi Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I
    Sharookh B Kapadia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 81:374-83. 2007
    ....