Heidi Barth

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 82:3466-79. 2008
  2. pmc Mouse models for the study of HCV infection and virus-host interactions
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Hepatol 49:134-42. 2008
  3. pmc Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Virol 80:10579-90. 2006
  4. pmc Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes
    Heidi Barth
    Dept of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Virol 79:5774-85. 2005
  5. pmc Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C
    Daniel Steinmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 78:9030-40. 2004
  6. ncbi request reprint Uptake and presentation of hepatitis C virus-like particles by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Blood 105:3605-14. 2005
  7. doi request reprint Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion
    Anita Haberstroh
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Gastroenterology 135:1719-1728.e1. 2008
  8. pmc Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection
    Xiping Zhao
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Clin Invest 109:221-32. 2002
  9. pmc Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Hepatology 54:1135-48. 2011
  10. pmc Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles
    Marco Hoffmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Innate Immun 1:446-54. 2009

Collaborators

Detail Information

Publications19

  1. pmc Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 82:3466-79. 2008
    ....
  2. pmc Mouse models for the study of HCV infection and virus-host interactions
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Hepatol 49:134-42. 2008
    ..Finally, the perspective of these models for future HCV research as well as the design of novel small animal models is discussed...
  3. pmc Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Virol 80:10579-90. 2006
    ..Mapping of viral and cellular determinants of HCV-HS interaction sets the stage for the development of novel HS-based antiviral strategies targeting viral attachment and entry...
  4. pmc Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes
    Heidi Barth
    Dept of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Virol 79:5774-85. 2005
    ..Furthermore, the structural and functional similarities between human and tupaia SR-BI indicate that PTH represent a useful model system to characterize the molecular interaction of the HCV envelope and SR-BI on primary hepatocytes...
  5. pmc Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C
    Daniel Steinmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 78:9030-40. 2004
    ....
  6. ncbi request reprint Uptake and presentation of hepatitis C virus-like particles by human dendritic cells
    Heidi Barth
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Blood 105:3605-14. 2005
    ..Furthermore, HCV-LP-mediated DC activation and efficient antigen presentation may explain the marked immunogenicity of HCV-LPs in vivo...
  7. doi request reprint Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion
    Anita Haberstroh
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Gastroenterology 135:1719-1728.e1. 2008
    ..Retroviral HCV pseudotypes (HCVpp) and recombinant cell culture-derived HCV (HCVcc) have been successfully used to study viral entry and antibody-mediated neutralization...
  8. pmc Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection
    Xiping Zhao
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Clin Invest 109:221-32. 2002
    ..Thus, primary Tupaia hepatocytes provide a potential model for the study of HCV infection of hepatocytes...
  9. pmc Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Hepatology 54:1135-48. 2011
    ..Furthermore, our results suggest that serum neutralizing antibodies may contribute to early control of viral replication and spread after homologous HCV rechallenges but may not be sufficient for a long-term protective immunity...
  10. pmc Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles
    Marco Hoffmann
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Innate Immun 1:446-54. 2009
    ..Impairment of interaction between TLR and the core in infectious viral particles may contribute to escape from innate antiviral immune responses...
  11. pmc Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation
    Takanobu Kato
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 48:732-40. 2008
    ..A common mutation G838R in the NS2 region emerged early in both chimpanzees. This mutation enhances viral assembly, leading to an increase in viral production in transfected or infected cells...
  12. ncbi request reprint Hepatitis C virus entry: molecular biology and clinical implications
    Heidi Barth
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Hepatology 44:527-35. 2006
    ..Clinical implications of this important process for the pathogenesis of HCV infection and novel therapeutic interventions are discussed...
  13. ncbi request reprint Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate
    Heidi Barth
    Department of Medicine II, University of Freiburg, D 79106 Freiburg, Germany
    J Biol Chem 278:41003-12. 2003
    ..Docking of E2 to cellular HSPG may be the initial step in the interaction between HCV and the cell surface resulting in receptor-mediated entry and initiation of infection...
  14. pmc Binding of hepatitis C virus-like particles derived from infectious clone H77C to defined human cell lines
    Sabine Wellnitz
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    J Virol 76:1181-93. 2002
    ....
  15. pmc CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection
    Daisuke Akazawa
    Pharmaceutical Research Laboratories, Toray Industries, Inc, Kanagawa, Japan
    J Virol 81:5036-45. 2007
    ..In conclusion, CD81 expression is an important determinant of HCV permissiveness of Huh7 cell clones harboring different characteristics...
  16. ncbi request reprint Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81
    Mirjam B Zeisel
    Institut National de la Sante et de la Recherche Medicale INSERM, U748, Strasbourg, France
    Hepatology 46:1722-31. 2007
    ..Conclusion: Our data suggest that SR-BI (i) represents a key host factor for HCV entry, (ii) is implicated in the same HCV entry pathway as CD81, and (iii) targets an entry step closely linked to HCV-CD81 interaction...
  17. ncbi request reprint Neutralizing antibodies in hepatitis C virus infection
    Mirjam B Zeisel
    Inserm Unite 748, Universite Louis Pasteur, 3 Rue Koeberle, Strasbourg F 67000, France
    World J Gastroenterol 13:4824-30. 2007
    ..This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis...
  18. ncbi request reprint Analysis of the effect of IL-12 therapy on immunoregulatory T-cell subsets in patients with chronic hepatitis C infection
    Heidi Barth
    Medizinische Klinik, Innere Medizin II, Eberhard Karls Universitat, Tubingen, Germany
    Hepatogastroenterology 50:201-6. 2003
    ..Aim of this study was to investigate the influence of IL-12 therapy on the production of immunoregulatory type 1/type 2-cytokines by peripheral blood mononuclear cells from patients with chronic hepatitis C...
  19. pmc Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I
    Sharookh B Kapadia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 81:374-83. 2007
    ....