C S Barr

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
  2. pmc The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human
    Qiaoping Yuan
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA
    BMC Genet 13:52. 2012
  3. doi request reprint Non-human primate models of alcohol-related phenotypes: the influence of genetic and environmental factors
    Christina S Barr
    Section of Comparative Behavioral Genomics, NIH NIAAA LNG, Rockville, MD 20852, USA
    Curr Top Behav Neurosci 13:223-49. 2013
  4. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
  5. ncbi request reprint Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 64:369-76. 2007
  6. pmc Strategies for performing genotype-phenotype association studies in nonhuman primates
    Christina S Barr
    Laboratories of Neurogenetics and Clinical and Translational Studies, NIH NIAAA, 5625 Fishers Lane, Rm 3S 32, Rockville, MD 20852, USA
    Methods 49:56-62. 2009
  7. ncbi request reprint Non-human primate models of inheritance vulnerability to alcohol use disorders
    Christina S Barr
    NIH NIAAA, Laboratory of Clinical and Translational Studies, Poolesville, MD 20837, USA
    Addict Biol 11:374-85. 2006
  8. ncbi request reprint Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates
    Christina S Barr
    National Institute on Alcoholism and Alcohol Abuse, Laboratory of Clinical Studies and National Institute of Child Health and Human Development, Laboratory of Comparative Ethology, National Institutes of Health, Poolesville, MD, USA
    Arch Gen Psychiatry 61:1146-52. 2004
  9. pmc Functional CRH variation increases stress-induced alcohol consumption in primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institutes on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:14593-8. 2009
  10. pmc Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
    Christina S Barr
    Primate Unit, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Proc Natl Acad Sci U S A 101:12358-63. 2004

Collaborators

Detail Information

Publications31

  1. pmc Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques
    Stephen G Lindell
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Arch Gen Psychiatry 67:423-31. 2010
    ..In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence...
  2. pmc The rhesus macaque is three times as diverse but more closely equivalent in damaging coding variation as compared to the human
    Qiaoping Yuan
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA
    BMC Genet 13:52. 2012
    ....
  3. doi request reprint Non-human primate models of alcohol-related phenotypes: the influence of genetic and environmental factors
    Christina S Barr
    Section of Comparative Behavioral Genomics, NIH NIAAA LNG, Rockville, MD 20852, USA
    Curr Top Behav Neurosci 13:223-49. 2013
    ..Studies in primates may also reveal selective factors have driven maintenance or fixation of alleles that increase risk for alcohol use disorders in modern humans...
  4. pmc CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques
    Christina S Barr
    Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 65:934-44. 2008
    ..As such, CRH gene variation may influence risk for alcohol use and dependence...
  5. ncbi request reprint Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Arch Gen Psychiatry 64:369-76. 2007
    ..In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders...
  6. pmc Strategies for performing genotype-phenotype association studies in nonhuman primates
    Christina S Barr
    Laboratories of Neurogenetics and Clinical and Translational Studies, NIH NIAAA, 5625 Fishers Lane, Rm 3S 32, Rockville, MD 20852, USA
    Methods 49:56-62. 2009
    ....
  7. ncbi request reprint Non-human primate models of inheritance vulnerability to alcohol use disorders
    Christina S Barr
    NIH NIAAA, Laboratory of Clinical and Translational Studies, Poolesville, MD 20837, USA
    Addict Biol 11:374-85. 2006
    ..Non-human primate models may also have translational value for understanding of how variants within addiction and abuse vulnerability genes influence alcohol-induced neuroadaptation, neuropathology and treatment response...
  8. ncbi request reprint Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates
    Christina S Barr
    National Institute on Alcoholism and Alcohol Abuse, Laboratory of Clinical Studies and National Institute of Child Health and Human Development, Laboratory of Comparative Ethology, National Institutes of Health, Poolesville, MD, USA
    Arch Gen Psychiatry 61:1146-52. 2004
    ....
  9. pmc Functional CRH variation increases stress-induced alcohol consumption in primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institutes on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:14593-8. 2009
    ..Our data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals...
  10. pmc Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
    Christina S Barr
    Primate Unit, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
    Proc Natl Acad Sci U S A 101:12358-63. 2004
    ..This interactive effect may underlie the increased incidence of certain stress-related disorders in women...
  11. ncbi request reprint Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress
    Christina S Barr
    Labortatory of Clinical Studies, Primate Unit, National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, PO Box 529, Building 112, Poolesville, MD 20837, USA
    Alcohol Clin Exp Res 27:812-7. 2003
    ..In addition, we have demonstrated that macaques separated from their mothers and reared in peer-only groups are more likely to consume alcohol as adults...
  12. ncbi request reprint The utility of the non-human primate; model for studying gene by environment interactions in behavioral research
    C S Barr
    NIAAA DICBR, NIH, Clinical Studies, Primate Unit, Bldg 112, Poolesville, MD 20837, USA
    Genes Brain Behav 2:336-40. 2003
    ....
  13. ncbi request reprint The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables
    Christina S Barr
    V Research Fellow, NIH Animal Center, Building 112, P O Box 529, Poolesville, MD 20837 0529, USA
    Ann N Y Acad Sci 1021:221-33. 2004
    ....
  14. ncbi request reprint Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta)
    C S Barr
    National Institutes of Health, NIAAA, NIH Animal Center, Poolesville, Maryland 20837, USA
    Alcohol Clin Exp Res 28:1114-9. 2004
    ..We wanted to determine whether sex and early life parental absence would interact to influence alcohol-induced alterations in LHPA-axis activity after exposure to ethanol in macaques...
  15. pmc DRD1 5'UTR variation, sex and early infant stress influence ethanol consumption in rhesus macaques
    T K Newman
    Laboratory of Clinical and Translational Studies, NIAAA, Bethesda, MD, USA
    Genes Brain Behav 8:626-30. 2009
    ..Our work demonstrates a potential role for the dopamine D1 receptor gene in modulating alcohol consumption, especially in the context of early environmental stress...
  16. pmc Genetic and early environmental contributions to alcohol's aversive and physiological effects
    Peter G Roma
    Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC, USA
    Pharmacol Biochem Behav 91:134-9. 2008
    ....
  17. doi request reprint Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center Poolesville, Maryland 20837 0529, USA
    Alcohol Clin Exp Res 32:1217-28. 2008
    ....
  18. pmc Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates
    Christina S Barr
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:5277-81. 2008
    ..These findings suggest a role for OPRM1 variation in the expression of attachment behavior in human subjects, especially as a function of separation from the caregiver...
  19. ncbi request reprint Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm
    Simona Spinelli
    National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, P O Box 529, Poolesville, MD 20837, USA
    Dev Psychopathol 19:977-87. 2007
    ....
  20. pmc Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic-hypothalamic-pituitary-adrenal axis regulation in monkeys
    Gary W Kraemer
    Department of Kinesiology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Biol Psychiatry 63:317-24. 2008
    ..This study determined whether moderate FA-exposure interacts with polymorphism in the 5-HT transporter gene to increase the incidence or severity of fetal alcohol effects in rhesus monkeys...
  21. ncbi request reprint Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques
    Christina S Barr
    Laboratory of Clinical Studies, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Poolesville, Maryland 20837, USA
    Biol Psychiatry 55:733-8. 2004
    ..We wanted to determine whether serotonin transporter gene promoter variation (rh-5HTTLPR) and rearing condition would interact to influence endocrine responses to stress in infant rhesus macaques...
  22. ncbi request reprint Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey
    George M Anderson
    Departments of Child Psychiatry and Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Psychopharmacology (Berl) 178:339-46. 2005
    ..Fundamental questions remain regarding the actions of the selective serotonin reuptake inhibitors (SSRIs)...
  23. ncbi request reprint Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
    Timothy K Newman
    Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
    Biol Psychiatry 57:167-72. 2005
    ..We tested the hypothesis that a repeat polymorphism in the rhesus macaque MAOA gene promoter region influences aggressive behavior in male subjects...
  24. ncbi request reprint Age-dependent variation in behavior following acute ethanol administration in male and female adolescent rhesus macaques (Macaca mulatta)
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, Poolesville, Maryland 20837 0529, USA
    Alcohol Clin Exp Res 31:228-37. 2007
    ....
  25. pmc A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior
    Rickard L Sjoberg
    Uppsala University Centre for Clinical Research, Central Hospital, Vasteras, Sweden
    Neuropsychopharmacology 33:425-30. 2008
    ....
  26. pmc Dissociation between the aversive and pharmacokinetic effects of ethanol in female Fischer and Lewis rats
    Peter G Roma
    Psychopharmacology Laboratory, Department of Psychology, American University, 4400 Massachusetts Avenue, NW, Washington, DC, USA
    Behav Brain Res 182:51-6. 2007
    ....
  27. ncbi request reprint Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence
    Wolfgang H Sommer
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, Maryland 20892 1108, USA
    Biol Psychiatry 63:139-45. 2008
    ..A history of alcohol dependence recruits increased voluntary alcohol intake and sensitivity to stress. Corticotropin-releasing hormone (CRH) has been implicated in this transition, but underlying molecular mechanisms remain unclear...
  28. ncbi request reprint Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence
    Johan Kakko
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 63:172-7. 2008
    ..Maintenance treatment with methadone normalizes HPA axis activity. Here, we examined HPA axis activity under maintenance treatment with the increasingly utilized partial opiate agonist buprenorphine...
  29. doi request reprint The effects of nicotine on ethanol-induced conditioned taste aversions in Long-Evans rats
    Jennifer A Rinker
    Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA
    Psychopharmacology (Berl) 197:409-19. 2008
    ..Overall drug acceptability is thought to be a function of the balance between its rewarding and aversive effects, the latter of which is reportedly affected by polydrug use...
  30. ncbi request reprint Restoring the addicted brain
    David Goldman
    National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    N Engl J Med 347:843-5. 2002
  31. ncbi request reprint Results of cerebrospinal fluid analysis, neurologic examination findings, and age at the onset of seizures as predictors for results of magnetic resonance imaging of the brain in dogs examined because of seizures: 115 cases (1992-2000)
    William W Bush
    Department of Neurology, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Am Vet Med Assoc 220:781-4. 2002
    ..To determine whether neurologic examination findings, results of CSF analysis, or age at the onset of seizures could be used to predict whether results of magnetic resonance imaging (MRI) would be normal or abnormal in dogs with seizures...