Research Topics
| Gerald S BaronSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-resGerald S Baron
Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, Hamilton, MT 59840, USA
J Virol 80:2106-17. 2006..Our observations provide evidence that infection of cells is aided by the association of PrP-res with membranes and/or other microsomal constituents...- GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cellsJonathan O Speare
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, Hamilton, MT 59840, USA
EMBO J 29:782-94. 2010..These data demonstrate GPI anchoring facilitates the propagation and spread of protein aggregation and thus may enhance the transmissibility and pathogenesis of prion diseases relative to other protein misfolding diseases... 
Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoformGerald S Baron
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
J Biol Chem 278:14883-92. 2003..Thus, of the two forms of raft membrane association by PrP-sen, only the GPI anchor-directed form resists conversion induced by exogenous PrP-res...- Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectraGerald S Baron
Laboratory of Persistent Viral Diseases, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Biochemistry 50:4479-90. 2011..Our IR data provide evidence that similar core structures also comprise wild-type PrP(res)... - Inhibition of protease-resistant prion protein accumulation in vitro by curcuminByron Caughey
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
J Virol 77:5499-502. 2003..Nonetheless, other studies have shown that curcumin is nontoxic and can penetrate the brain, properties that give curcumin advantages over inhibitors previously identified as potential prophylactic and/or therapeutic anti-TSE compounds... - Hemin interactions and alterations of the subcellular localization of prion proteinKil S Lee
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
J Biol Chem 282:36525-33. 2007..These hemin-PrPC interactions suggest that PrPC may participate in hemin homeostasis, sensing, and/or uptake and that hemin might affect PrPC functions... - Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteinsGregory J Raymond
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
J Virol 86:11763-78. 2012..These observations provide insight into the minimal elements required to create prions in vitro and suggest that the PrP(C) GPI anchor can modulate the propagation of synthetic TSE strains... - Getting a grip on prions: oligomers, amyloids, and pathological membrane interactionsByron Caughey
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Annu Rev Biochem 78:177-204. 2009.... - Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting diseaseGregory J Raymond
Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Labs, 903 S. 4th St, Hamilton, MT 59840, USA
J Virol 80:596-604. 2006..This demonstrates the utility of these cells in a rapid in vitro screening assay for PrP(CWD) inhibitors and suggests that these compounds have potential to be active against CWD in vivo... - Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cellsAna Cristina Magalhães
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Neurosci 25:5207-16. 2005..These experiments visualize and characterize the initial steps associated with prion infection and transport within neuronal cells... - A solid-phase assay for identification of modulators of prion protein interactionsLaura Maxson
Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th St, Hamilton, MT 59840, USA
Anal Biochem 323:54-64. 2003.... - Prions and their partners in crimeByron Caughey
National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA
Nature 443:803-10. 2006.... - Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuICSarah Vascellari
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
PLoS ONE 7:e48969. 2012..Overall, we conclude that these new mouse-adapted prion seeding assays detect diverse types of PrP(Sc)... - Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteinsYuzuru Taguchi
Laboratory of Persistent Viral Diseases and Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
Mol Biol Cell 20:233-44. 2009..IDEAL-labeling extends the use of biarsenical derivatives to extracellular proteins and beyond microscopic imaging... - Are cheetahs on the run from prion-like amyloidosis?Byron Caughey
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 598940, USA
Proc Natl Acad Sci U S A 105:7113-4. 2008 - New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural productsDavid A Kocisko
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
J Virol 77:10288-94. 2003..The fact that many are either approved human drugs or edible natural products should facilitate their use in animal testing and clinical trials... - Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranesGerald S Baron
Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
EMBO J 21:1031-40. 2002....