Gerald S Baron

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res
    Gerald S Baron
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, Hamilton, MT 59840, USA
    J Virol 80:2106-17. 2006
  2. pmc Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC
    Sarah Vascellari
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 7:e48969. 2012
  3. pmc GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells
    Jonathan O Speare
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, Hamilton, MT 59840, USA
    EMBO J 29:782-94. 2010
  4. pmc Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning
    Yuzuru Taguchi
    Rocky Mountain Laboratories, NIAID, NIH, Laboratory of Persistent Viral Diseases, 903 S 4th St, Hamilton, MT 59840 USA Currently at the Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, T2N 4Z6 Canada
    Chembiochem 14:1597-610, 1510. 2013
  5. ncbi request reprint Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 278:14883-92. 2003
  6. pmc Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Biochemistry 50:4479-90. 2011
  7. pmc Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 80:596-604. 2006
  8. pmc Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:11763-78. 2012
  9. pmc Inhibition of protease-resistant prion protein accumulation in vitro by curcumin
    Byron Caughey
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Virol 77:5499-502. 2003
  10. ncbi request reprint Hemin interactions and alterations of the subcellular localization of prion protein
    Kil S Lee
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 282:36525-33. 2007

Collaborators

Detail Information

Publications19

  1. pmc Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res
    Gerald S Baron
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, Hamilton, MT 59840, USA
    J Virol 80:2106-17. 2006
    ..Our observations provide evidence that infection of cells is aided by the association of PrP-res with membranes and/or other microsomal constituents...
  2. pmc Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC
    Sarah Vascellari
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS ONE 7:e48969. 2012
    ..Overall, we conclude that these new mouse-adapted prion seeding assays detect diverse types of PrP(Sc)...
  3. pmc GPI anchoring facilitates propagation and spread of misfolded Sup35 aggregates in mammalian cells
    Jonathan O Speare
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, Hamilton, MT 59840, USA
    EMBO J 29:782-94. 2010
    ..These data demonstrate GPI anchoring facilitates the propagation and spread of protein aggregation and thus may enhance the transmissibility and pathogenesis of prion diseases relative to other protein misfolding diseases...
  4. pmc Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning
    Yuzuru Taguchi
    Rocky Mountain Laboratories, NIAID, NIH, Laboratory of Persistent Viral Diseases, 903 S 4th St, Hamilton, MT 59840 USA Currently at the Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, T2N 4Z6 Canada
    Chembiochem 14:1597-610, 1510. 2013
    ..Our observations demonstrate that TC-scanning with the FlAsH/TC tag can be a versatile method for probing protein-protein interactions and folding processes. ..
  5. ncbi request reprint Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 278:14883-92. 2003
    ..Thus, of the two forms of raft membrane association by PrP-sen, only the GPI anchor-directed form resists conversion induced by exogenous PrP-res...
  6. pmc Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Biochemistry 50:4479-90. 2011
    ..Our IR data provide evidence that similar core structures also comprise wild-type PrP(res)...
  7. pmc Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Labs, 903 S 4th St, Hamilton, MT 59840, USA
    J Virol 80:596-604. 2006
    ..This demonstrates the utility of these cells in a rapid in vitro screening assay for PrP(CWD) inhibitors and suggests that these compounds have potential to be active against CWD in vivo...
  8. pmc Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:11763-78. 2012
    ..These observations provide insight into the minimal elements required to create prions in vitro and suggest that the PrP(C) GPI anchor can modulate the propagation of synthetic TSE strains...
  9. pmc Inhibition of protease-resistant prion protein accumulation in vitro by curcumin
    Byron Caughey
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    J Virol 77:5499-502. 2003
    ..Nonetheless, other studies have shown that curcumin is nontoxic and can penetrate the brain, properties that give curcumin advantages over inhibitors previously identified as potential prophylactic and/or therapeutic anti-TSE compounds...
  10. ncbi request reprint Hemin interactions and alterations of the subcellular localization of prion protein
    Kil S Lee
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 282:36525-33. 2007
    ..These hemin-PrPC interactions suggest that PrPC may participate in hemin homeostasis, sensing, and/or uptake and that hemin might affect PrPC functions...
  11. pmc Glycosylphosphatidylinositol Anchoring Directs the Assembly of Sup35NM Protein into Non-fibrillar, Membrane-bound Aggregates
    Karen E Marshall
    From the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840
    J Biol Chem 289:12245-63. 2014
    ..This may contribute to differences in pathogenesis and pathology between prion diseases, which uniquely involve aggregation of a GPI-anchored protein, versus other protein misfolding diseases. ..
  12. pmc Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions
    Byron Caughey
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Annu Rev Biochem 78:177-204. 2009
    ....
  13. ncbi request reprint Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells
    Ana Cristina Magalhães
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Neurosci 25:5207-16. 2005
    ..These experiments visualize and characterize the initial steps associated with prion infection and transport within neuronal cells...
  14. ncbi request reprint Prions and their partners in crime
    Byron Caughey
    National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nature 443:803-10. 2006
    ....
  15. ncbi request reprint A solid-phase assay for identification of modulators of prion protein interactions
    Laura Maxson
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Anal Biochem 323:54-64. 2003
    ....
  16. pmc Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins
    Yuzuru Taguchi
    Laboratory of Persistent Viral Diseases and Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Biol Cell 20:233-44. 2009
    ..IDEAL-labeling extends the use of biarsenical derivatives to extracellular proteins and beyond microscopic imaging...
  17. pmc Are cheetahs on the run from prion-like amyloidosis?
    Byron Caughey
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 598940, USA
    Proc Natl Acad Sci U S A 105:7113-4. 2008
  18. pmc New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 77:10288-94. 2003
    ..The fact that many are either approved human drugs or edible natural products should facilitate their use in animal testing and clinical trials...
  19. pmc Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes
    Gerald S Baron
    Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA
    EMBO J 21:1031-40. 2002
    ....